메뉴 건너뛰기




Volumn 20, Issue 1, 2014, Pages 62-68

Pathogenic conversion of Foxp3 + T cells into TH17 cells in autoimmune arthritis

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CCR6; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 17; INTERLEUKIN 23 RECEPTOR; MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA; TRANSCRIPTION FACTOR FOXP3; TRANSCRIPTION FACTOR SOX4;

EID: 84891838421     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.3432     Document Type: Article
Times cited : (898)

References (42)
  • 1
    • 2442484053 scopus 로고    scopus 로고
    • + regulatory T cells for immunologic self-tolerance and negative control of immune responses
    • + regulatory T cells for immunologic self-tolerance and negative control of immune responses. Annu. Rev. Immunol. 22, 531-562 (2004).
    • (2004) Annu. Rev. Immunol , vol.22 , pp. 531-562
    • Sakaguchi, S.1
  • 2
    • 0347785480 scopus 로고    scopus 로고
    • Control of regulatory T cell development by the transcription factor Foxp3
    • Hori, S., Nomura, T. &Sakaguchi, S. Control of regulatory T cell development by the transcription factor Foxp3. Science 299, 1057-1061 (2003).
    • (2003) Science , vol.299 , pp. 1057-1061
    • Hori, S.1    Nomura, T.2    Sakaguchi, S.3
  • 5
    • 33847125247 scopus 로고    scopus 로고
    • Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression
    • Wan, Y.Y. &Flavell, R.A. Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression. Nature 445, 766-770 (2007).
    • (2007) Nature , vol.445 , pp. 766-770
    • Wan, Y.Y.1    Flavell, R.A.2
  • 6
    • 33846485153 scopus 로고    scopus 로고
    • Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice
    • Kim, J.M., Rasmussen, J.P. &Rudensky, A.Y. Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice. Nat. Immunol. 8, 191-197 (2007).
    • (2007) Nat. Immunol , vol.8 , pp. 191-197
    • Kim, J.M.1    Rasmussen, J.P.2    Rudensky, A.Y.3
  • 7
    • 69049107358 scopus 로고    scopus 로고
    • Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo
    • Zhou, X. et al. Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo. Nat. Immunol. 10, 1000-1007 (2009).
    • (2009) Nat. Immunol , vol.10 , pp. 1000-1007
    • Zhou, X.1
  • 8
    • 46749138596 scopus 로고    scopus 로고
    • Molecular antagonism and plasticity of regulatory and inflammatory T cell programs
    • Yang, X.O. et al. Molecular antagonism and plasticity of regulatory and inflammatory T cell programs. Immunity 29, 44-56 (2008).
    • (2008) Immunity , vol.29 , pp. 44-56
    • Yang, X.O.1
  • 9
    • 70449532980 scopus 로고    scopus 로고
    • + Treg cell number and acquisition of effector cell phenotype during lethal infection
    • + Treg cell number and acquisition of effector cell phenotype during lethal infection. Immunity 31, 772-786 (2009).
    • (2009) Immunity , vol.31 , pp. 772-786
    • Oldenhove, G.1
  • 10
    • 77957371028 scopus 로고    scopus 로고
    • Stability of the regulatory T cell lineage in vivo
    • Rubtsov, Y.P. et al. Stability of the regulatory T cell lineage in vivo. Science 329, 1667-1671 (2010).
    • (2010) Science , vol.329 , pp. 1667-1671
    • Rubtsov, Y.P.1
  • 11
    • 84857416489 scopus 로고    scopus 로고
    • + T cells reflects promiscuous Foxp3 expression in conventional T cells but not reprogramming of regulatory T cells
    • + T cells reflects promiscuous Foxp3 expression in conventional T cells but not reprogramming of regulatory T cells. Immunity 36, 262-275 (2012).
    • (2012) Immunity , vol.36 , pp. 262-275
    • Miyao, T.1
  • 12
    • 60549115770 scopus 로고    scopus 로고
    • + T cells: A committed regulatory T-cell lineage and an uncommitted minor population retaining plasticity
    • + T cells: a committed regulatory T-cell lineage and an uncommitted minor population retaining plasticity. Proc. Natl. Acad. Sci. USA 106, 1903-1908 (2009).
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 1903-1908
    • Komatsu, N.1
  • 13
    • 36549019912 scopus 로고    scopus 로고
    • Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model
    • Hirota, K. et al. Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model. J. Exp. Med. 204, 2803-2812 (2007).
    • (2007) J. Exp. Med , vol.204 , pp. 2803-2812
    • Hirota, K.1
  • 14
    • 78651474359 scopus 로고    scopus 로고
    • Local microbleeding facilitates IL-6- and IL-17-dependent arthritis in the absence of tissue antigen recognition by activated T cells
    • Murakami, M. et al. Local microbleeding facilitates IL-6- and IL-17-dependent arthritis in the absence of tissue antigen recognition by activated T cells. J. Exp. Med. 208, 103-114 (2011).
    • (2011) J. Exp. Med , vol.208 , pp. 103-114
    • Murakami, M.1
  • 16
    • 33947583822 scopus 로고    scopus 로고
    • Osteoimmunology: Shared mechanisms and crosstalk between the immune and bone systems
    • Takayanagi, H. Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems. Nat. Rev. Immunol. 7, 292-304 (2007).
    • (2007) Nat. Rev. Immunol , vol.7 , pp. 292-304
    • Takayanagi, H.1
  • 17
    • 77953497686 scopus 로고    scopus 로고
    • Complement drives Th17 cell differentiation and triggers autoimmune arthritis
    • Hashimoto, M. et al. Complement drives Th17 cell differentiation and triggers autoimmune arthritis. J. Exp. Med. 207, 1135-1143 (2010).
    • (2010) J. Exp. Med , vol.207 , pp. 1135-1143
    • Hashimoto, M.1
  • 18
    • 77953913586 scopus 로고    scopus 로고
    • Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells
    • Wu, H.J. et al. Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells. Immunity 32, 815-827 (2010).
    • (2010) Immunity , vol.32 , pp. 815-827
    • Wu, H.J.1
  • 19
    • 3042856262 scopus 로고    scopus 로고
    • Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus
    • Srinivas, S. et al. Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus. BMC Dev. Biol. 1, 4 (2001).
    • (2001) BMC Dev. Biol , vol.1 , pp. 4
    • Srinivas, S.1
  • 20
    • 84878244870 scopus 로고    scopus 로고
    • The plasticity and stability of regulatory T cells
    • Sakaguchi, S. et al. The plasticity and stability of regulatory T cells. Nat. Rev. Immunol. 13, 461-467 (2013).
    • (2013) Nat. Rev. Immunol , vol.13 , pp. 461-467
    • Sakaguchi, S.1
  • 21
    • 84871768044 scopus 로고    scopus 로고
    • T cells out of control-impaired immune regulation in the inflamed joint
    • Wehrens, E.J., Prakken, B.J. &van Wijk, F. T cells out of control-impaired immune regulation in the inflamed joint. Nat. Rev. Rheumatol. 9, 34-42 (2013).
    • (2013) Nat. Rev. Rheumatol , vol.9 , pp. 34-42
    • Wehrens, E.J.1    Prakken, B.J.2    Van Wijk, F.3
  • 22
    • 84869148187 scopus 로고    scopus 로고
    • T cell receptor stimulation-induced epigenetic changes and Foxp3 expression are independent and complementary events required for Treg cell development
    • Ohkura, N. et al. T cell receptor stimulation-induced epigenetic changes and Foxp3 expression are independent and complementary events required for Treg cell development. Immunity 37, 785-799 (2012).
    • (2012) Immunity , vol.37 , pp. 785-799
    • Ohkura, N.1
  • 23
    • 77950527805 scopus 로고    scopus 로고
    • Genomic definition of multiple ex vivo regulatory T cell subphenotypes
    • Feuerer, M. et al. Genomic definition of multiple ex vivo regulatory T cell subphenotypes. Proc. Natl. Acad. Sci. USA 107, 5919-5924 (2010).
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 5919-5924
    • Feuerer, M.1
  • 24
    • 37149026641 scopus 로고    scopus 로고
    • Treg cells suppress osteoclast formation: A new link between the immune system and bone
    • Zaiss, M.M. et al. Treg cells suppress osteoclast formation: a new link between the immune system and bone. Arthritis Rheum. 56, 4104-4112 (2007).
    • (2007) Arthritis Rheum , vol.56 , pp. 4104-4112
    • Zaiss, M.M.1
  • 25
    • 33751521013 scopus 로고    scopus 로고
    • Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction
    • Sato, K. et al. Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction. J. Exp. Med. 203, 2673-2682 (2006).
    • (2006) J. Exp. Med , vol.203 , pp. 2673-2682
    • Sato, K.1
  • 26
    • 77958584113 scopus 로고    scopus 로고
    • H17 cells in the absence of TGF-β signalling
    • H17 cells in the absence of TGF-β signalling. Nature 467, 967-971 (2010).
    • (2010) Nature , vol.467 , pp. 967-971
    • Ghoreschi, K.1
  • 27
    • 84866532132 scopus 로고    scopus 로고
    • H17 cells
    • H17 cells. Nat. Immunol. 13, 991-999 (2012).
    • (2012) Nat. Immunol , vol.13 , pp. 991-999
    • Lee, Y.1
  • 28
    • 84876798411 scopus 로고    scopus 로고
    • H17 cells by inducible salt-sensing kinase SGK1
    • H17 cells by inducible salt-sensing kinase SGK1. Nature 496, 513-517 (2013).
    • (2013) Nature , vol.496 , pp. 513-517
    • Wu, C.1
  • 30
    • 84876780175 scopus 로고    scopus 로고
    • A network of high-mobility group box transcription factors programs innate interleukin-17 production
    • Malhotra, N. et al. A network of high-mobility group box transcription factors programs innate interleukin-17 production. Immunity 38, 681-693 (2013).
    • (2013) Immunity , vol.38 , pp. 681-693
    • Malhotra, N.1
  • 31
    • 84872079829 scopus 로고    scopus 로고
    • SOX4 enables oncogenic survival signals in acute lymphoblastic leukemia
    • Ramezani-Rad, P. et al. SOX4 enables oncogenic survival signals in acute lymphoblastic leukemia. Blood 121, 148-155 (2013).
    • (2013) Blood , vol.121 , pp. 148-155
    • Ramezani-Rad, P.1
  • 32
    • 0035320679 scopus 로고    scopus 로고
    • + regulatory T cells induced by an agonist self-peptide
    • + regulatory T cells induced by an agonist self-peptide. Nat. Immunol. 2, 301-306 (2001).
    • (2001) Nat. Immunol , vol.2 , pp. 301-306
    • Jordan, M.S.1
  • 33
    • 84855548027 scopus 로고    scopus 로고
    • Re-establishing immunological self-tolerance in autoimmune disease
    • Sakaguchi, S., Powrie, F. &Ransohoff, R.M. Re-establishing immunological self-tolerance in autoimmune disease. Nat. Med. 18, 54-58 (2012).
    • (2012) Nat. Med , vol.18 , pp. 54-58
    • Sakaguchi, S.1    Powrie, F.2    Ransohoff, R.M.3
  • 34
    • 79951682333 scopus 로고    scopus 로고
    • Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5
    • Yang, X.P. et al. Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5. Nat. Immunol. 12, 247-254 (2011).
    • (2011) Nat. Immunol , vol.12 , pp. 247-254
    • Yang, X.P.1
  • 35
    • 43049174722 scopus 로고    scopus 로고
    • Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction
    • Tang, Q. et al. Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction. Immunity 28, 687-697 (2008).
    • (2008) Immunity , vol.28 , pp. 687-697
    • Tang, Q.1
  • 36
    • 84864481289 scopus 로고    scopus 로고
    • Inhibition of IL-6 function corrects Th17/Treg imbalance in rheumatoid arthritis patients
    • Samson, M. et al. Inhibition of IL-6 function corrects Th17/Treg imbalance in rheumatoid arthritis patients. Arthritis Rheum. 64, 2499-2503 (2012).
    • (2012) Arthritis Rheum , vol.64 , pp. 2499-2503
    • Samson, M.1
  • 37
    • 33846446041 scopus 로고    scopus 로고
    • Anti-TNF-α therapy induces a distinct regulatory T cell population in patients with rheumatoid arthritis via TGF-β
    • Nadkarni, S., Mauri, C. &Ehrenstein, M.R. Anti-TNF-α therapy induces a distinct regulatory T cell population in patients with rheumatoid arthritis via TGF-β. J. Exp. Med. 204, 33-39 (2007).
    • (2007) J. Exp. Med , vol.204 , pp. 33-39
    • Nadkarni, S.1    Mauri, C.2    Ehrenstein, M.R.3
  • 38
    • 84875153425 scopus 로고    scopus 로고
    • Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-α in rheumatoid arthritis
    • Nie, H. et al. Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-α in rheumatoid arthritis. Nat. Med. 19, 322-328 (2013).
    • (2013) Nat. Med , vol.19 , pp. 322-328
    • Nie, H.1
  • 39
    • 84874721851 scopus 로고    scopus 로고
    • Genetics and epigenetics of rheumatoid arthritis
    • Viatte, S. et al. Genetics and epigenetics of rheumatoid arthritis. Nat. Rev. Rheumatol. 9, 141-153 (2013).
    • (2013) Nat. Rev. Rheumatol , vol.9 , pp. 141-153
    • Viatte, S.1
  • 40
    • 0036754255 scopus 로고    scopus 로고
    • Antigen-specific T cell sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responses
    • Nakae, S. et al. Antigen-specific T cell sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responses. Immunity 17, 375-387 (2002).
    • (2002) Immunity , vol.17 , pp. 375-387
    • Nakae, S.1
  • 41
    • 80053938104 scopus 로고    scopus 로고
    • Evidence for osteocyte regulation of bone homeostasis through RANKL expression
    • Nakashima, T. et al. Evidence for osteocyte regulation of bone homeostasis through RANKL expression. Nat. Med. 17, 1231-1234 (2011).
    • (2011) Nat. Med , vol.17 , pp. 1231-1234
    • Nakashima, T.1
  • 42
    • 18744366041 scopus 로고    scopus 로고
    • Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts
    • Takayanagi, H. et al. Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts. Dev. Cell 3, 889-901 (2002).
    • (2002) Dev. Cell , vol.3 , pp. 889-901
    • Takayanagi, H.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.