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Volumn 8, Issue 2, 2015, Pages 265-278

Retinoic acid primes human dendritic cells to induce gut-homing, IL-10-producing regulatory T cells

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA4 INTEGRIN; BETA7 INTEGRIN; CD3 ANTIBODY; CHEMOKINE RECEPTOR CCR9; INTERLEUKIN 10; MONOCLONAL ANTIBODY CD28; RETINOIC ACID; TOLL LIKE RECEPTOR; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA; ALDH1A2 PROTEIN, HUMAN; ALPHA E INTEGRINS; ALPHA INTEGRIN; LEUKOCYTE ANTIGEN; RETINAL DEHYDROGENASE; RETINOIC ACID RECEPTOR;

EID: 84922739874     PISSN: 19330219     EISSN: 19353456     Source Type: Journal    
DOI: 10.1038/mi.2014.64     Document Type: Article
Times cited : (186)

References (52)
  • 1
    • 79960438236 scopus 로고    scopus 로고
    • The role of retinoic acid in tolerance and immunity
    • Hall, J.A., Grainger, J.R., Spencer, S.P. & Belkaid, Y. The role of retinoic acid in tolerance and immunity. Immunity 35, 13-22 (2011).
    • (2011) Immunity , vol.35 , pp. 13-22
    • Hall, J.A.1    Grainger, J.R.2    Spencer, S.P.3    Belkaid, Y.4
  • 2
    • 0033725067 scopus 로고    scopus 로고
    • Metabolism of vitamin A and its active metabolite all-trans-retinoic acid in small intestinal enterocytes
    • Lampen, A., Meyer, S., Arnhold, T. & Nau, H. Metabolism of vitamin A and its active metabolite all-trans-retinoic acid in small intestinal enterocytes. J. Pharmacol. Exp. Ther. 295, 979-985 (2000).
    • (2000) J. Pharmacol. Exp. Ther. , vol.295 , pp. 979-985
    • Lampen, A.1    Meyer, S.2    Arnhold, T.3    Nau, H.4
  • 3
    • 56149099480 scopus 로고    scopus 로고
    • Cutting edge: Instructive role of peripheral tissue cells in the imprinting of Tcell homing receptor patterns
    • Edele, F., et al. Cutting edge: instructive role of peripheral tissue cells in the imprinting of Tcell homing receptor patterns. J. Immunol. 181, 3745-3749 (2008).
    • (2008) J. Immunol. , vol.181 , pp. 3745-3749
    • Edele, F.1
  • 4
    • 70049103635 scopus 로고    scopus 로고
    • Human intestinal epithelial cells promote the differentiation of tolerogenic dendritic cells
    • Iliev, I.D., et al. Human intestinal epithelial cells promote the differentiation of tolerogenic dendritic cells. Gut 58, 1481-1489 (2009).
    • (2009) Gut , vol.58 , pp. 1481-1489
    • Iliev, I.D.1
  • 6
    • 34547769253 scopus 로고    scopus 로고
    • All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation
    • Benson, M.J., Pino-Lagos, K., Rosemblatt, M. & Noelle, R.J. All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation. J. Exp. Med. 204, 1765-1774 (2007).
    • (2007) J. Exp. Med. , vol.204 , pp. 1765-1774
    • Benson, M.J.1    Pino-Lagos, K.2    Rosemblatt, M.3    Noelle, R.J.4
  • 7
    • 34547788180 scopus 로고    scopus 로고
    • A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism
    • Coombes, J.L., et al. A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism. J. Exp. Med. 204, 1757-1764 (2007).
    • (2007) J. Exp. Med. , vol.204 , pp. 1757-1764
    • Coombes, J.L.1
  • 8
    • 34447503805 scopus 로고    scopus 로고
    • Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid
    • Mucida, D., et al. Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid. Science 317, 256-260 (2007).
    • (2007) Science , vol.317 , pp. 256-260
    • Mucida, D.1
  • 9
    • 34547757390 scopus 로고    scopus 로고
    • Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid
    • Sun, C.M., et al. Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid. J. Exp. Med. 204, 1775-1785 (2007).
    • (2007) J. Exp. Med. , vol.204 , pp. 1775-1785
    • Sun, C.M.1
  • 10
    • 0027521572 scopus 로고
    • Interleukin-10- deficient mice develop chronic enterocolitis
    • Kuhn, R., Lohler, J., Rennick, D., Rajewsky, K. & Muller, W. Interleukin-10- deficient mice develop chronic enterocolitis. Cell 75, 263-274 (1993).
    • (1993) Cell , vol.75 , pp. 263-274
    • Kuhn, R.1    Lohler, J.2    Rennick, D.3    Rajewsky, K.4    Muller, W.5
  • 11
    • 0032412057 scopus 로고    scopus 로고
    • Resident enteric bacteria are necessary for development of spontaneous colitis and immune system activation in interleukin-10- deficient mice
    • Sellon, R.K., et al. Resident enteric bacteria are necessary for development of spontaneous colitis and immune system activation in interleukin-10- deficient mice. Infect. Immun. 66, 5224-5231 (1998).
    • (1998) Infect. Immun. , vol.66 , pp. 5224-5231
    • Sellon, R.K.1
  • 12
    • 81855181637 scopus 로고    scopus 로고
    • Gut-tropic T cells that express integrin alpha4beta7 and CCR9 are required for induction of oral immune tolerance in mice
    • Cassani, B., et al. Gut-tropic T cells that express integrin alpha4beta7 and CCR9 are required for induction of oral immune tolerance in mice. Gastroenterology 141, 2109-2118 (2011).
    • (2011) Gastroenterology , vol.141 , pp. 2109-2118
    • Cassani, B.1
  • 13
    • 63049111279 scopus 로고    scopus 로고
    • Contrasting roles for all-trans retinoic acid in TGF-betamediated induction of Foxp3 and Il10 genes in developing regulatory T cells
    • Maynard, C.L., Hatton, R.D., Helms, W.S., Oliver, J.R., Stephensen, C.B. & Weaver, C.T. Contrasting roles for all-trans retinoic acid in TGF-betamediated induction of Foxp3 and Il10 genes in developing regulatory T cells. J. Exp. Med. 206, 343-357 (2009).
    • (2009) J. Exp. Med. , vol.206 , pp. 343-357
    • Maynard, C.L.1    Hatton, R.D.2    Helms, W.S.3    Oliver, J.R.4    Stephensen, C.B.5    Weaver, C.T.6
  • 14
    • 79959921794 scopus 로고    scopus 로고
    • MyD88 and retinoic acid signaling pathways interact to modulate gastrointestinal activities of dendritic cells
    • Villablanca, E.J., et al. MyD88 and retinoic acid signaling pathways interact to modulate gastrointestinal activities of dendritic cells. Gastroenterology 141, 176-185 (2011).
    • (2011) Gastroenterology , vol.141 , pp. 176-185
    • Villablanca, E.J.1
  • 15
    • 79959396339 scopus 로고    scopus 로고
    • Bile retinoids imprint intestinal CD103+ dendritic cells with the ability to generate gut-tropic T cells
    • Jaensson-Gyllenback, E., et al. Bile retinoids imprint intestinal CD103+ dendritic cells with the ability to generate gut-tropic T cells. Mucosal. Immunol. 4, 438-447 (2011).
    • (2011) Mucosal. Immunol. , vol.4 , pp. 438-447
    • Jaensson-Gyllenback, E.1
  • 16
    • 70349310093 scopus 로고    scopus 로고
    • De novo generation and enhanced suppression of human CD4+CD25+ regulatory T cells by retinoic acid
    • Wang, J., Huizinga, T.W. & Toes, R.E. De novo generation and enhanced suppression of human CD4+CD25+ regulatory T cells by retinoic acid. J. Immunol. 183, 4119-4126 (2009).
    • (2009) J. Immunol. , vol.183 , pp. 4119-4126
    • Wang, J.1    Huizinga, T.W.2    Toes, R.E.3
  • 17
    • 35748934494 scopus 로고    scopus 로고
    • Vitamin A metabolites induce gut-homing FoxP3+ regulatory T cells
    • Kang, S.G., Lim, H.W., Andrisani, O.M., Broxmeyer, H.E. & Kim, C.H. Vitamin A metabolites induce gut-homing FoxP3+ regulatory T cells. J. Immunol. 179, 3724-3733 (2007).
    • (2007) J. Immunol. , vol.179 , pp. 3724-3733
    • Kang, S.G.1    Lim, H.W.2    Andrisani, O.M.3    Broxmeyer, H.E.4    Kim, C.H.5
  • 18
    • 55749091152 scopus 로고    scopus 로고
    • Regulatory T cells in inflammatory bowel disease
    • Boden, E.K. & Snapper, S.B. Regulatory T cells in inflammatory bowel disease. Curr. Opin. Gastroenterol. 24, 733-741 (2008).
    • (2008) Curr. Opin. Gastroenterol. , vol.24 , pp. 733-741
    • Boden, E.K.1    Snapper, S.B.2
  • 19
    • 0027531528 scopus 로고
    • Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death
    • Kulkarni, A.B., et al. Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death. Proc.Natl Acad. Sci. USA 90, 770-774 (1993).
    • (1993) Proc. Natl Acad. Sci. USA , vol.90 , pp. 770-774
    • Kulkarni, A.B.1
  • 20
    • 0026799402 scopus 로고
    • Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease
    • Shull, M.M., et al. Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease. Nature 359, 693-699 (1992).
    • (1992) Nature , vol.359 , pp. 693-699
    • Shull, M.M.1
  • 21
    • 63449095324 scopus 로고    scopus 로고
    • Regulation of multi-organ inflammation in the regulatory T cell-deficient scurfy mice
    • Sharma, R., Sung, S.S., Fu, S.M. & Ju, S.T. Regulation of multi-organ inflammation in the regulatory T cell-deficient scurfy mice. J. Biomed. Sci. 16, 20 (2009).
    • (2009) J. Biomed. Sci. , vol.16 , pp. 20
    • Sharma, R.1    Sung, S.S.2    Fu, S.M.3    Ju, S.T.4
  • 22
    • 0035675798 scopus 로고    scopus 로고
    • IPEX is a unique X-linked syndrome characterized by immune dysfunction, polyendocrinopathy, enteropathy, and a variety of autoimmune phenomena
    • Bennett, C.L. & Ochs, H.D. IPEX is a unique X-linked syndrome characterized by immune dysfunction, polyendocrinopathy, enteropathy, and a variety of autoimmune phenomena. Curr. Opin. Pediatr. 13, 533-538 (2001).
    • (2001) Curr. Opin. Pediatr. , vol.13 , pp. 533-538
    • Bennett, C.L.1    Ochs, H.D.2
  • 23
    • 0032536530 scopus 로고    scopus 로고
    • The orphan receptor CRF2-4 is an essential subunit of the interleukin 10 receptor
    • Spencer, S.D., et al. The orphan receptor CRF2-4 is an essential subunit of the interleukin 10 receptor. J. Exp. Med. 187, 571-578 (1998).
    • (1998) J. Exp. Med. , vol.187 , pp. 571-578
    • Spencer, S.D.1
  • 24
    • 55049111426 scopus 로고    scopus 로고
    • Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility
    • Franke, A., et al. Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility. Nat. Genet. 40, 1319-1323 (2008).
    • (2008) Nat. Genet. , vol.40 , pp. 1319-1323
    • Franke, A.1
  • 25
    • 70949087383 scopus 로고    scopus 로고
    • Inflammatory bowel disease and mutations affecting the interleukin-10 receptor
    • Glocker, E.O., et al. Inflammatory bowel disease and mutations affecting the interleukin-10 receptor. N. Engl. J. Med. 361, 2033-2045 (2009).
    • (2009) N. Engl. J. Med. , vol.361 , pp. 2033-2045
    • Glocker, E.O.1
  • 26
    • 9244237038 scopus 로고    scopus 로고
    • Tcell-specific inactivation of the interleukin 10 gene in mice results in enhanced T cell responses but normal innate responses to lipopolysaccharide or skin irritation
    • Roers, A., et al. Tcell-specific inactivation of the interleukin 10 gene in mice results in enhanced T cell responses but normal innate responses to lipopolysaccharide or skin irritation. J. Exp. Med. 200, 1289-1297 (2004).
    • (2004) J. Exp. Med. , vol.200 , pp. 1289-1297
    • Roers, A.1
  • 27
    • 70049099836 scopus 로고    scopus 로고
    • Intestinal lamina propria dendritic cell subsets have different origin and functions
    • Varol, C., et al. Intestinal lamina propria dendritic cell subsets have different origin and functions. Immunity 31, 502-512 (2009).
    • (2009) Immunity , vol.31 , pp. 502-512
    • Varol, C.1
  • 28
    • 78650645161 scopus 로고    scopus 로고
    • Generation of mucosal dendritic cells from bone marrow reveals a critical role of retinoic acid
    • Feng, T., Cong, Y., Qin, H., Benveniste, E.N. & Elson, C.O. Generation of mucosal dendritic cells from bone marrow reveals a critical role of retinoic acid. J. Immunol. 185, 5915-5925 (2010).
    • (2010) J. Immunol. , vol.185 , pp. 5915-5925
    • Feng, T.1    Cong, Y.2    Qin, H.3    Benveniste, E.N.4    Elson, C.O.5
  • 29
    • 63649135273 scopus 로고    scopus 로고
    • GM-CSF and IL-4 synergistically trigger dendritic cells to acquire retinoic acid-producing capacity
    • Yokota, A., et al. GM-CSF and IL-4 synergistically trigger dendritic cells to acquire retinoic acid-producing capacity. Int. Immunol. 21, 361-377 (2009).
    • (2009) Int. Immunol. , vol.21 , pp. 361-377
    • Yokota, A.1
  • 30
    • 51049092467 scopus 로고    scopus 로고
    • Small intestinal CD103+ dendritic cells display unique functional properties that are conserved between mice and humans
    • Jaensson, E., et al. Small intestinal CD103+ dendritic cells display unique functional properties that are conserved between mice and humans. J. Exp. Med. 205, 2139-2149 (2008).
    • (2008) J. Exp. Med. , vol.205 , pp. 2139-2149
    • Jaensson, E.1
  • 31
    • 33745834029 scopus 로고    scopus 로고
    • Effect of all-trans-retinoic acid on the differentiation, maturation and functions of dendritic cells derived from cord blood monocytes
    • Tao, Y., Yang, Y. & Wang, W. Effect of all-trans-retinoic acid on the differentiation, maturation and functions of dendritic cells derived from cord blood monocytes. FEMS Immunol. Med. Microbiol. 47, 444-450 (2006).
    • (2006) FEMS Immunol. Med. Microbiol. , vol.47 , pp. 444-450
    • Tao, Y.1    Yang, Y.2    Wang, W.3
  • 32
    • 76749171573 scopus 로고    scopus 로고
    • All-trans retinoic acid inhibits the differentiation, maturation, and function of human monocyte-derived dendritic cells
    • Jin, C.J., et al. All-trans retinoic acid inhibits the differentiation, maturation, and function of human monocyte-derived dendritic cells. Leuk. Res. 34, 513-520 (2010).
    • (2010) Leuk. Res. , vol.34 , pp. 513-520
    • Jin, C.J.1
  • 33
    • 33845639549 scopus 로고    scopus 로고
    • Direct and indirect effects of retinoic acid on human Th2 cytokine and chemokine expression by human T lymphocytes
    • Dawson, H.D., et al. Direct and indirect effects of retinoic acid on human Th2 cytokine and chemokine expression by human T lymphocytes. BMC Immunol. 7, 27 (2006).
    • (2006) BMC Immunol. , vol.7 , pp. 27
    • Dawson, H.D.1
  • 34
    • 8344225289 scopus 로고    scopus 로고
    • Circulating endogenous retinoic acid concentrations among participants enrolled in a randomized placebo-controlled clinical trial of retinyl palmitate
    • Sedjo, R.L., et al. Circulating endogenous retinoic acid concentrations among participants enrolled in a randomized placebo-controlled clinical trial of retinyl palmitate. Cancer Epidemiol. Biomarkers Prev. 13, 1687-1692 (2004).
    • (2004) Cancer Epidemiol. Biomarkers Prev. , vol.13 , pp. 1687-1692
    • Sedjo, R.L.1
  • 35
    • 0004489759 scopus 로고
    • Vitamin A and carotene: The absence of the liver oil vitamin A from carotene. VI. the conversion of carotene to vitamin A in vivo
    • Moore, T. Vitamin A and carotene: the absence of the liver oil vitamin A from carotene. VI. The conversion of carotene to vitamin A in vivo. Biochem. J. 24, 692-702 (1930).
    • (1930) Biochem. J. , vol.24 , pp. 692-702
    • Moore, T.1
  • 36
    • 80054863891 scopus 로고    scopus 로고
    • Preferential expression of integrin alphavbeta8 promotes generation of regulatory T cells by mouse CD103+ dendritic cells
    • Paidassi, H., et al. Preferential expression of integrin alphavbeta8 promotes generation of regulatory T cells by mouse CD103+ dendritic cells. Gastroenterology 141, 1813-1820 (2011).
    • (2011) Gastroenterology , vol.141 , pp. 1813-1820
    • Paidassi, H.1
  • 37
    • 80054866424 scopus 로고    scopus 로고
    • Intestinal dendritic cells specialize to activate transforming growth factor-beta and induce Foxp3+ regulatory Tcells viaintegrinal phavbeta8
    • Worthington, J.J., Czajkowska, B.I., Melton, A.C. & Travis, M.A. Intestinal dendritic cells specialize to activate transforming growth factor-beta and induce Foxp3+ regulatoryTcells viaintegrinalphavbeta8.Gastroenterology141, 1802-1812(2011).
    • (2011) Gastroenterology , vol.141 , pp. 1802-1812
    • Worthington, J.J.1    Czajkowska, B.I.2    Melton, A.C.3    Travis, M.A.4
  • 38
    • 0032529414 scopus 로고    scopus 로고
    • Low dose TGF-beta attenuates IL-12 responsiveness in murine Th cells
    • Gorham, J.D., Guler, M.L., Fenoglio, D., Gubler, U. & Murphy, K.M. Low dose TGF-beta attenuates IL-12 responsiveness in murine Th cells. J. Immunol. 161, 1664-1670 (1998).
    • (1998) J. Immunol. , vol.161 , pp. 1664-1670
    • Gorham, J.D.1    Guler, M.L.2    Fenoglio, D.3    Gubler, U.4    Murphy, K.M.5
  • 39
    • 0037013930 scopus 로고    scopus 로고
    • Mechanism of transforming growth factor beta-induced inhibition of T helper type 1 differentiation
    • Gorelik, L., Constant, S. & Flavell, R.A. Mechanism of transforming growth factor beta-induced inhibition of T helper type 1 differentiation. J. Exp. Med. 195, 1499-1505 (2002).
    • (2002) J. Exp. Med. , vol.195 , pp. 1499-1505
    • Gorelik, L.1    Constant, S.2    Flavell, R.A.3
  • 40
    • 18644381773 scopus 로고    scopus 로고
    • TGF-beta 1 uses distinct mechanisms to inhibit IFN-gamma expression inCD4+ Tcells at priming and at recall: Differential involvement of Stat4 and T-bet
    • Lin, J.T., Martin, S.L., Xia, L. & Gorham, J.D. TGF-beta 1 uses distinct mechanisms to inhibit IFN-gamma expression inCD4+ Tcells at priming and at recall: differential involvement of Stat4 and T-bet. J. Immunol. 174, 5950-5958 (2005).
    • (2005) J. Immunol. , vol.174 , pp. 5950-5958
    • Lin, J.T.1    Martin, S.L.2    Xia, L.3    Gorham, J.D.4
  • 42
    • 33847144180 scopus 로고    scopus 로고
    • Conventional T-bet(+)Foxp3(-) Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection
    • Jankovic, D., et al. Conventional T-bet(+)Foxp3(-) Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection. J. Exp. Med. 204, 273-283 (2007).
    • (2007) J. Exp. Med. , vol.204 , pp. 273-283
    • Jankovic, D.1
  • 43
    • 0024408824 scopus 로고
    • Twotypes of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones
    • Fiorentino, D.F., Bond, M.W. & Mosmann, T.R. Twotypes of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones. J. Exp. Med. 170, 2081-2095 (1989).
    • (1989) J. Exp. Med. , vol.170 , pp. 2081-2095
    • Fiorentino, D.F.1    Bond, M.W.2    Mosmann, T.R.3
  • 44
    • 36248965294 scopus 로고    scopus 로고
    • TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology
    • McGeachy, M.J., et al. TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology. Nat. Immunol. 8, 1390-1397 (2007).
    • (2007) Nat. Immunol. , vol.8 , pp. 1390-1397
    • McGeachy, M.J.1
  • 45
    • 68649116551 scopus 로고    scopus 로고
    • Interleukin-10 production by Th1 cells requires interleukin-12- induced STAT4 transcription factor and ERK MAP kinase activation by high antigen dose
    • Saraiva, M., Christensen, J.R., Veldhoen, M., Murphy, T.L., Murphy, K.M. & OGarra, A. Interleukin-10 production by Th1 cells requires interleukin-12- induced STAT4 transcription factor and ERK MAP kinase activation by high antigen dose. Immunity 31, 209-219 (2009).
    • (2009) Immunity , vol.31 , pp. 209-219
    • Saraiva, M.1    Christensen, J.R.2    Veldhoen, M.3    Murphy, T.L.4    Murphy, K.M.5    Ogarra, A.6
  • 46
    • 0032528172 scopus 로고    scopus 로고
    • Retinoic acid induced mitogen-activated protein (MAP)/extracellular signal-regulated kinase (ERK) kinase-dependent MAP kinase activation needed to elicit HL-60 cell differentiation and growth arrest
    • Yen, A., Roberson, M.S., Varvayanis, S. & Lee, A.T. Retinoic acid induced mitogen-activated protein (MAP)/extracellular signal-regulated kinase (ERK) kinase-dependent MAP kinase activation needed to elicit HL-60 cell differentiation and growth arrest. Cancer Res. 58, 3163-3172 (1998).
    • (1998) Cancer Res. , vol.58 , pp. 3163-3172
    • Yen, A.1    Roberson, M.S.2    Varvayanis, S.3    Lee, A.T.4
  • 47
    • 79251570885 scopus 로고    scopus 로고
    • Retinoic acidinduced CCR9 expression requires transient TCR stimulation and cooperativity between NFATc2 and the retinoic acid receptor/retinoid X receptor complex
    • Ohoka, Y., Yokota, A., Takeuchi, H., Maeda, N. & Iwata, M. Retinoic acidinduced CCR9 expression requires transient TCR stimulation and cooperativity between NFATc2 and the retinoic acid receptor/retinoid X receptor complex. J. Immunol. 186, 733-744 (2011).
    • (2011) J. Immunol. , vol.186 , pp. 733-744
    • Ohoka, Y.1    Yokota, A.2    Takeuchi, H.3    Maeda, N.4    Iwata, M.5
  • 48
    • 78649720282 scopus 로고    scopus 로고
    • Biology of interleukin-10
    • Sabat, R., et al. Biology of interleukin-10. Cytokine Growth Factor Rev. 21, 331-344 (2010).
    • (2010) Cytokine Growth Factor Rev. , vol.21 , pp. 331-344
    • Sabat, R.1
  • 49
    • 84874141619 scopus 로고    scopus 로고
    • The cellular and molecular mechanisms of immuno-suppression by human type 1 regulatory T cells
    • Gregori, S., Goudy, K.S. & Roncarolo, M.G. The cellular and molecular mechanisms of immuno-suppression by human type 1 regulatory T cells. Front. Immunol. 3, 30 (2012).
    • (2012) Front. Immunol. , vol.3 , pp. 30
    • Gregori, S.1    Goudy, K.S.2    Roncarolo, M.G.3
  • 50
    • 79954620910 scopus 로고    scopus 로고
    • Th17 cells express interleukin-10 receptor and are controlled by Foxp3 and Foxp3+ regulatory CD4+ T cells in an interleukin-10-dependent manner
    • Huber, S., et al. Th17 cells express interleukin-10 receptor and are controlled by Foxp3 and Foxp3+ regulatory CD4+ T cells in an interleukin-10-dependent manner. Immunity 34, 554-565 (2011).
    • (2011) Immunity , vol.34 , pp. 554-565
    • Huber, S.1
  • 51
    • 0037083298 scopus 로고    scopus 로고
    • Microbial compounds selectively induce Th1 cellpromoting or Th2 cell-promoting dendritic cells in vitro with diverse th cellpolarizing signals
    • de Jong, E.C., et al. Microbial compounds selectively induce Th1 cellpromoting or Th2 cell-promoting dendritic cells in vitro with diverse th cellpolarizing signals. J. Immunol. 168, 1704-1709 (2002).
    • (2002) J. Immunol. , vol.168 , pp. 1704-1709
    • De Jong, E.C.1
  • 52
    • 79957816138 scopus 로고    scopus 로고
    • Vitamin D3 targets epidermal and dermal dendritic cells for induction of distinct regulatory Tcells
    • van der Aar, A.M., et al. Vitamin D3 targets epidermal and dermal dendritic cells for induction of distinct regulatory Tcells. J. Allergy Clin. Immunol. 127, 1532-1540 (2011).
    • (2011) J. Allergy Clin. Immunol. , vol.127 , pp. 1532-1540
    • Van Der Aar, A.M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.