Cutting edge: Memory regulatory T cells require IL-7 and not IL-2 for their maintenance in peripheral tissues

Journal of Immunology

Volumn 190, Issue 9, 2013, Pages 4483-4487

  Gratz, Iris K ^a   Truong, Hong An ^a   Yang, Sara Hsin Yi ^a   Maurano, Megan M ^b   Lee, Karim ^b   Abbas, Abul K ^b   Rosenblum, Michael D ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 7; INTERLEUKIN 7 RECEPTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CD4+ T LYMPHOCYTE; CELL INFILTRATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; EFFECTOR CELL; GENE DELETION; IMMUNOMODULATION; IN VIVO STUDY; LYMPHATIC DRAINAGE; MEMORY T LYMPHOCYTE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY T LYMPHOCYTE; SIGNAL TRANSDUCTION; SKIN APPENDAGE; STEADY STATE;

ANIMALS; ANTIGENS; AUTOIMMUNITY; CD4-POSITIVE T-LYMPHOCYTES; HAIR FOLLICLE; IMMUNOLOGIC MEMORY; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; LYMPH NODES; MICE; MICE, INBRED BALB C; RECEPTORS, INTERLEUKIN-7; SKIN; T-LYMPHOCYTES, REGULATORY;

EID: 84876805126     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1300212     Document Type: Article

References (21)

1. Bennett, C. L., J. Christie, F. Ramsdell, M. E. Brunkow, P. J. Ferguson, L. Whitesell, T. E. Kelly, F. T. Saulsbury, P. F. Chance, and H. D. Ochs. 2001. The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3. Nat. Genet. 27: 20-21. (Pubitemid 32044513)
2. Fontenot, J. D., M. A. Gavin, and A. Y. Rudensky. 2003. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat. Immunol. 4: 330-336. (Pubitemid 36432314)
3. Rosenblum, M. D., I. K. Gratz, J. S. Paw, K. Lee, A. Marshak-Rothstein, and A. K. Abbas. 2011. Response to self antigen imprints regulatory memory in tissues. Nature 480: 538-542.
4. Rowe, J. H., J. M. Ertelt, L. Xin, and S. S. Way. 2012. Pregnancy imprints regulatory memory that sustains anergy to fetal antigen. Nature 490: 102-106.
5. Miyara, M., Y. Yoshioka, A. Kitoh, T. Shima, K. Wing, A. Niwa, C. Parizot, C. Taflin, T. Heike, D. Valeyre, et al. 2009. Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor. Immunity 30: 899-911.
6. Sadlack, B., H. Merz, H. Schorle, A. Schimpl, A. C. Feller, and I. Horak. 1993. Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell 75: 253-261. (Pubitemid 23320289)
7. Barron, L., H. Dooms, K. K. Hoyer, W. Kuswanto, J. Hofmann, W. E. O'Gorman, and A. K. Abbas. 2010. Cutting edge: mechanisms of IL-2-dependent maintenance of functional regulatory T cells. J. Immunol. 185: 6426-6430.
8. von Freeden-Jeffry, U., P. Vieira, L. A. Lucian, T. McNeil, S. E. Burdach, and R. Murray. 1995. Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine. J. Exp. Med. 181: 1519-1526.
9. Puel, A., S. F. Ziegler, R. H. Buckley, and W. J. Leonard. 1998. Defective IL7R expression in T(-)B(+)NK(+) severe combined immunodeficiency. Nat. Genet. 20: 394-397. (Pubitemid 28541642)
10. Schluns, K. S., W. C. Kieper, S. C. Jameson, and L. Lefrançois. 2000. Interleukin-7 mediates the homeostasis of näive and memory CD8 T cells in vivo. Nat. Immunol. 1: 426-432.
11. Kondrack, R. M., J. Harbertson, J. T. Tan, M. E. McBreen, C. D. Surh, and L. M. Bradley. 2003. Interleukin 7 regulates the survival and generation of memory CD4 cells. J. Exp. Med. 198: 1797-1806. (Pubitemid 38032113)
12. Nagao, K., T. Kobayashi, K. Moro, M. Ohyama, T. Adachi, D. Y. Kitashima, S. Ueha, K. Horiuchi, H. Tanizaki, K. Kabashima, et al. 2012. Stress-induced production of chemokines by hair follicles regulates the trafficking of dendritic cells in skin. Nat. Immunol. 13: 744-752.
13. Heath, W. R., and S. N. Mueller. 2012. Hair follicles: gatekeepers to the epidermis. Nat. Immunol. 13: 715-717.
14. Le Saout, C., M. Villard, C. Cabasse, C. Jacquet, N. Taylor, and J. Hernandez. 2010. IL-2 mediates CD4+ T cell help in the breakdown of memory-like CD8+ T cell tolerance under lymphopenic conditions. PLoS ONE 5: e12659.
15. Setoguchi, R., S. Hori, T. Takahashi, and S. Sakaguchi. 2005. Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization. J. Exp. Med. 201: 723-735. (Pubitemid 40395118)
16. Penaranda, C., W. Kuswanto, J. Hofmann, R. Kenefeck, P. Narendran, L. S. K. Walker, J. A. Bluestone, A. K. Abbas, and H. Dooms. 2012. IL-7 receptor blockade reverses autoimmune diabetes by promoting inhibition of effector/memory T cells. Proc. Natl. Acad. Sci. USA 109: 12668-12673.
17. Seddon, B., P. Tomlinson, and R. Zamoyska. 2003. Interleukin 7 and T cell receptor signals regulate homeostasis of CD4 memory cells. Nat. Immunol. 4: 680-686. (Pubitemid 36874445)
18. Matsue, H., P. R. Bergstresser, and A. Takashima. 1993. Keratinocyte-derived IL-7 serves as a growth factor for dendritic epidermal T cells in mice. J. Immunol. 151: 6012-6019. (Pubitemid 23340347)
19. Vang, K. B., J. Yang, S. A. Mahmud, M. A. Burchill, A. L. Vegoe, and M. A. Farrar. 2008. IL-2,-7, and-15, but not thymic stromal lymphopoeitin, redundantly govern CD4+Foxp3+ regulatory T cell development. J. Immunol. 181: 3285-3290.
20. Feau, S., V. Facchinetti, F. Granucci, S. Citterio, D. Jarrossay, S. Seresini, M. P. Protti, A. Lanzavecchia, and P. Ricciardi-Castagnoli. 2005. Dendritic cell-derived IL-2 production is regulated by IL-15 in humans and in mice. Blood 105: 697-702. (Pubitemid 40070755)
21. Granucci, F., S. Feau, V. Angeli, F. Trottein, and P. Ricciardi-Castagnoli. 2003. Early IL-2 production by mouse dendritic cells is the result of microbial-induced priming. J. Immunol. 170: 5075-5081. (Pubitemid 36554737)