Foxp3 Transcription Factor Is Proapoptotic and Lethal to Developing Regulatory T Cells unless Counterbalanced by Cytokine Survival Signals

Immunity

Volumn 38, Issue 6, 2013, Pages 1116-1128

  Tai, Xuguang ^a   Erman, Batu ^b   Alag, Amala ^a   Mu, Jie ^a   Kimura, Motoko ^a   Katz, Gil ^a   Guinter, Terry ^a   McCaughtry, Tom ^a   Etzensperger, Ruth ^a   Feigenbaum, Lionel ^c   Singer, DinahS ^a   Singer, Alfred ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b SABANCI UNIVERSITY   (Turkey)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIM PROTEIN; CYTOKINE; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; DUAL SPECIFICITY PHOSPHATASE 6; IMMUNOGLOBULIN HEAVY CHAIN; INTERLEUKIN 15; INTERLEUKIN 2; INTERLEUKIN 7; LYMPHOCYTE ANTIGEN RECEPTOR; MESSENGER RNA; OX40 LIGAND; PROTEIN BCL 2; PUMA PROTEIN; STAT5 PROTEIN; STAT5B PROTEIN; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR FOXP3;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CD4+ T LYMPHOCYTE; CELL DEATH; CELL LINE; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; DELETION MUTANT; DNA BINDING; FEMALE; IMMUNOLOGICAL TOLERANCE; LYMPHOCYTE COUNT; LYMPHOCYTE DIFFERENTIATION; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REGULATORY T LYMPHOCYTE; SPLEEN CELL; T LYMPHOCYTE SUBPOPULATION; THYMOCYTE; THYMUS; TRANSGENE; TRANSIENT TRANSFECTION; X CHROMOSOME INACTIVATION;

ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CELL SURVIVAL; CELLS, CULTURED; CYTOKINES; DUAL SPECIFICITY PHOSPHATASE 6; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; INTERLEUKIN RECEPTOR COMMON GAMMA SUBUNIT; LYMPHOPOIESIS; MALE; MAP KINASE KINASE 4; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; T-LYMPHOCYTES, REGULATORY; TUMOR SUPPRESSOR PROTEINS;

EID: 84879601640     PISSN: 10747613     EISSN: 10974180     Source Type: Journal    
DOI: 10.1016/j.immuni.2013.02.022     Document Type: Article

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