IL-17+ regulatory T Cells in the microenvironments of chronic inflammation and cancer

Journal of Immunology

Volumn 186, Issue 7, 2011, Pages 4388-4395

  Kryczek, Ilona ^a   Wu, Ke ^a   Zhao, Ende ^a,b   Wei, Shuang ^a   Vatan, Linhua ^a   Szeliga, Wojciech ^a   Huang, Emina ^a   Greenson, Joel ^a   Chang, Alfred ^a   Roliński, Jacek ^c   Radwan, Piotr ^c   Fang, Jingyuan ^d   Wang, Guobin ^b   Zou, Weiping ^a,b  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^c MEDICAL UNIVERSITY OF LUBLIN   (Poland)

^d SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

APC PROTEIN; CD4 ANTIGEN; CHEMOKINE RECEPTOR CCR6; INTERLEUKIN 17; INTERLEUKIN 2; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; CARCINOMA; CD4+ T LYMPHOCYTE; CELLULAR IMMUNITY; CHRONIC INFLAMMATION; COLON CARCINOMA; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE ASSOCIATION; DISEASE COURSE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOPATHOGENESIS; IMMUNOREGULATION; KIDNEY CARCINOMA; MELANOMA; MEMORY T LYMPHOCYTE; OVARY CANCER; PHENOTYPE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TH17 CELL; ULCERATIVE COLITIS;

CARCINOMA, RENAL CELL; CELLS, CULTURED; CHRONIC DISEASE; COCULTURE TECHNIQUES; COLITIS, ULCERATIVE; COLONIC NEOPLASMS; CYTOKINES; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; GROWTH INHIBITORS; HUMANS; IMMUNE TOLERANCE; INFLAMMATION MEDIATORS; INTERLEUKIN-17; KIDNEY NEOPLASMS; MELANOMA; OVARIAN NEOPLASMS; T-LYMPHOCYTES, REGULATORY;

EID: 79955040909     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1003251     Document Type: Article

References (58)

1. Coussens, L. M., and Z. Werb. 2002. Inflammation and cancer. Nature 420: 860-867. (Pubitemid 36019639)
2. Balkwill, F., and A. Mantovani. 2001. Inflammation and cancer: back to Virchow? Lancet 357: 539-545. (Pubitemid 32173595)
3. Loftus, E. V., Jr., M. D. Silverstein, W. J. Sandborn, W. J. Tremaine, W. S. Harmsen, and A. R. Zinsmeister. 2000. Ulcerative colitis in Olmsted County, Minnesota, 1940-1993: incidence, prevalence, and survival. Gut 46: 336-343. (Pubitemid 30313384)
4. Eaden, J. A., K. R. Abrams, and J. F. Mayberry. 2001. The risk of colorectal cancer in ulcerative colitis: a meta-analysis. Gut 48: 526-535. (Pubitemid 32234798)
5. + T cell trafficking and development by IFN-γ: mechanism and pathological relevance in psoriasis. J. Immunol. 181: 4733-4741.
6. Kryczek, I., L. Zou, P. Rodriguez, G. Zhu, S. Wei, P. Mottram, M. Brumlik, P. Cheng, T. Curiel, L. Myers, et al. 2006. B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma. J. Exp. Med. 203: 871-881.
7. + T-cell pool and tumor trafficking in patients with ovarian carcinoma. Cancer Res. 67: 7487-7494. (Pubitemid 47206578)
8. Curiel, T. J., G. Coukos, L. Zou, X. Alvarez, P. Cheng, P. Mottram, M. Evdemon- Hogan, J. R. Conejo-Garcia, L. Zhang, M. Burow, et al. 2004. Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat. Med. 10: 942-949. (Pubitemid 39273735)
9. Yssel, H., and H. Spits. 2002. Generation and maintenance of cloned human T cell lines. Curr. Protoc. Immunol. 2002: chapter 7:unit 7.19.
10. Olsen, C. H. 2003. Review of the use of statistics in infection and immunity. Infect. Immun. 71: 6689-6692. (Pubitemid 37475294)
11. Baumgart, D. C., and S. R. Carding. 2007. Inflammatory bowel disease: cause and immunobiology. Lancet 369: 1627-1640. (Pubitemid 46722636)
12. Beriou, G., C. M. Costantino, C.W. Ashley, L. Yang, V. K. Kuchroo, C. Baecher- Allan, and D. A. Hafler. 2009. IL-17-producing human peripheral regulatory T cells retain suppressive function. Blood 113: 4240-4249.
13. + regulatory T cells in humans. Proc. Natl. Acad. Sci. USA 106: 4793-4798.
14. Zou, W. 2006. Regulatory T cells, tumour immunity and immunotherapy. Nat. Rev. Immunol. 6: 295-307.
15. Kryczek, I., M. Banerjee, P. Cheng, L. Vatan, W. Szeliga, S. Wei, E. Huang, E. Finlayson, D. Simeone, T. H. Welling, et al. 2009. Phenotype, distribution, generation, and functional and clinical relevance of Th17 cells in the human tumor environments. Blood 114: 1141-1149.
16. Annunziato, F., L. Cosmi, V. Santarlasci, L. Maggi, F. Liotta, B. Mazzinghi, E. Parente, L. Fili, S. Ferri, F. Frosali, et al 2007. Phenotypic and functional features of human Th17 cells. J. Exp. Med. 204: 1849-1861. (Pubitemid 47240944)
17. Hirota, K., H. Yoshitomi, M. Hashimoto, S. Maeda, S. Teradaira, N. Sugimoto, T. Yamaguchi, T. Nomura, H. Ito, T. Nakamura, et al. 2007. Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model. J. Exp. Med. 204: 2803-2812. (Pubitemid 350179551)
18. pos regulatory T cells differentiate into IL-17-producing cells. Blood 112: 2340-2352.
19. Osorio, F., S. Leibundgut-Landmann, M. Lochner, K. Lahl, T. Sparwasser, G. Eberl, and C. Reis e Sousa. 2008. DC activated via dectin-1 convert Treg into IL-17 producers. Eur. J. Immunol. 38: 3274-3281.
20. Xu, L., A. Kitani, I. Fuss, and W. Strober. 2007. Cutting edge: regulatory T cells induce CD4+CD252Foxp32 T cells or are self-induced to become Th17 cells in the absence of exogenous TGF-β. J. Immunol. 178: 6725-6729. (Pubitemid 46847395)
21. + suppressor T cells: more questions than answers. Nat. Rev. Immunol. 2: 389-400. (Pubitemid 37328746)
22. Zou, W. 2005. Immunosuppressive networks in the tumour environment and their therapeutic relevance. Nat. Rev. Cancer 5: 263-274. (Pubitemid 40488632)
23. +regulatory T cells in immunological tolerance to self and non-self. Nat. Immunol. 6: 345-352. (Pubitemid 41716771)
24. von Herrath, M. G., and L. C. Harrison. 2003. Antigen-induced regulatory T cells in autoimmunity. Nat. Rev. Immunol. 3: 223-232. (Pubitemid 37323207)
25. Ahmadzadeh, M., A. Felipe-Silva, B. Heemskerk, D. J. Powell, Jr., J. R. Wunderlich, M. J. Merino, and S. A. Rosenberg. 2008. FOXP3 expression accurately defines the population of intratumoral regulatory T cells that selectively accumulate in metastatic melanoma lesions. Blood 112: 4953-4960.
26. Kryczek, I., R. Liu, G. Wang, K. Wu, X. Shu, W. Szeliga, L. Vatan, E. Finlayson, E. Huang, D. Simeone, et al. 2009. FOXP3 defines regulatory T cells in human tumor and autoimmune disease. Cancer Res. 69: 3995-4000.
27. Kolls, J. K., and A. Lindén. 2004. Interleukin-17 family members and inflammation. Immunity 21: 467-476. (Pubitemid 39370503)
28. Weaver, C. T., L. E. Harrington, P. R. Mangan, M. Gavrieli, and K. M. Murphy. 2006. Th17: an effector CD4 T cell lineage with regulatory T cell ties. Immunity 24: 677-688. (Pubitemid 43867371)
29. Dong, C. 2006. Diversification of T-helper-cell lineages: finding the family root of IL-17-producing cells. Nat. Rev. Immunol. 6: 329-333.
30. H2. Nat. Immunol. 6: 1069-1070. (Pubitemid 41541781)
31. + effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat. Immunol. 6: 1123-1132. (Pubitemid 41541790)
32. Sutton, C., C. Brereton, B. Keogh, K. H. Mills, and E. C. Lavelle. 2006. A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis. J. Exp. Med. 203: 1685-1691. (Pubitemid 44036274)
33. Komiyama, Y., S. Nakae, T. Matsuki, A. Nambu, H. Ishigame, S. Kakuta, K. Sudo, and Y. Iwakura. 2006. IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis. J. Immunol. 177: 566-573. (Pubitemid 43939170)
34. Tato, C. M., and J. J. O'Shea. 2006. Immunology: what does it mean to be just 17? Nature 441: 166-168.
35. Ouyang, W., J. K. Kolls, and Y. Zheng. 2008. The biological functions of T helper 17 cell effector cytokines in inflammation. Immunity 28: 454-467. (Pubitemid 351471762)
36. H17 cells in tumour immunity and immunotherapy. Nat. Rev. Immunol. 10: 248-256.
37. + T cells. Science 327: 1098-1102.
38. H17 and TReg cell lineages: a (co-)evolutionary perspective. Nat. Rev. Immunol. 9: 883-889.
39. H17 and regulatory T cell differentiation mediated by retinoic acid. Science 317: 256-260. (Pubitemid 47076203)
40. H17 and regulatory T cells. Nature 441: 235-238.
41. H17 lineage-specific transcription factor RORγt. Proc. Natl. Acad. Sci. USA 106: 8635-8640.
42. + regulatory T cells suppress pathogenic Th17 cells and are impaired in multiple sclerosis. J. Immunol. 183: 7602-7610.
43. H17 cell differentiation by antagonizing RORγt function. Nature 453: 236-240. (Pubitemid 351667978)
44. + regulatory T cells by TGF-β induction of transcription factor Foxp3. J. Exp. Med. 198: 1875-1886. (Pubitemid 38032120)
45. - T cells to acquire regulatory cell function. Blood 101: 5076-5083. (Pubitemid 36857776)
46. + T cell pool IL-1 subverts IL-2-mediated suppression. J. Immunol. 179: 1423-1426.
47. + T cell precursor. J. Exp. Med. 205: 1903-1916.
48. Precopio, M. L., M. R. Betts, J. Parrino, D. A. Price, E. Gostick, D. R. Ambrozak, T. E. Asher, D. C. Douek, A. Harari, G. Pantaleo, et al. 2007. Immunization with vaccinia virus induces polyfunctional and phenotypically distinctive CD8+ T cell responses. J. Exp. Med. 204: 1405-1416. (Pubitemid 46919878)
49. Almeida, J. R., D. A. Price, L. Papagno, Z. A. Arkoub, D. Sauce, E. Bornstein, T. E. Asher, A. Samri, A. Schnuriger, I. Theodorou, et al. 2007. Superior control of HIV-1 replication by CD8+ T cells is reflected by their avidity, polyfunctionality, and clonal turnover. J. Exp. Med. 204: 2473-2485. (Pubitemid 47529331)
50. Laan, M., Z. H. Cui, H. Hoshino, J. Lötvall, M. Sjöstrand, D. C. Gruenert, B. E. Skoogh, and A. Lindén. 1999. Neutrophil recruitment by human IL-17 via C-X-C chemokine release in the airways. J. Immunol. 162: 2347-2352. (Pubitemid 29288861)
51. Hata, K., A. Andoh, M. Shimada, S. Fujino, S. Bamba, Y. Araki, T. Okuno, Y. Fujiyama, and T. Bamba. 2002. IL-17 stimulates inflammatory responses via NF-kB and MAP kinase pathways in human colonic myofibroblasts. Am. J. Physiol. Gastrointest. Liver Physiol. 282: G1035-G1044. (Pubitemid 34651610)
52. Shimada, M., A. Andoh, K. Hata, K. Tasaki, Y. Araki, Y. Fujiyama, and T. Bamba. 2002. IL-6 secretion by human pancreatic periacinar myofibroblasts in response to inflammatory mediators. J. Immunol. 168: 861-868. (Pubitemid 34049589)
53. Andoh, A., H. Takaya, J. Makino, H. Sato, S. Bamba, Y. Araki, K. Hata, M. Shimada, T. Okuno, Y. Fujiyama, and T. Bamba. 2001. Cooperation of interleukin-17 and interferon-g on chemokine secretion in human fetal intestinal epithelial cells. Clin. Exp. Immunol. 125: 56-63. (Pubitemid 32703366)
54. Pallone, F., and G. Monteleone. 2001. Mechanisms of tissue damage in inflammatory bowel disease. Curr. Opin. Gastroenterol. 17: 307-312. (Pubitemid 32619970)
55. McCormack, G., D. Moriarty, D. P. O'Donoghue, P. A. McCormick, K. Sheahan, and A. W. Baird. 2001. Tissue cytokine and chemokine expression in inflammatory bowel disease. Inflamm. Res. 50: 491-495. (Pubitemid 32999710)
56. Murata, Y., Y. Ishiguro, J. Itoh, A. Munakata, and Y. Yoshida. 1995. The role of proinflammatory and immunoregulatory cytokines in the pathogenesis of ulcerative colitis. J. Gastroenterol. 30(Suppl. 8): 56-60.
57. Baumgart, D. C., and W. J. Sandborn. 2007. Inflammatory bowel disease: clinical aspects and established and evolving therapies. Lancet 369: 1641-1657. (Pubitemid 46722637)
58. + T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages. Cancer Cell 16: 91-102.