메뉴 건너뛰기




Volumn 42, Issue 6, 2012, Pages 1375-1384

Cyclic AMP underpins suppression by regulatory T cells

Author keywords

CD4 + T cells; Costimulatory molecules; Gene regulation; Regulatory T (Treg) cells; Signal transduction

Indexed keywords

B7 ANTIGEN; CD28 ANTIGEN; CYCLIC AMP; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; INTERLEUKIN 2; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR FOXP3;

EID: 84862143798     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201141578     Document Type: Review
Times cited : (68)

References (73)
  • 1
    • 43949105866 scopus 로고    scopus 로고
    • Regulatory T cells and immune tolerance
    • Sakaguchi, S., Yamaguchi, T., Nomura, T. and Ono, M., Regulatory T cells and immune tolerance. Cell 2008. 133: 775-787.
    • (2008) Cell , vol.133 , pp. 775-787
    • Sakaguchi, S.1    Yamaguchi, T.2    Nomura, T.3    Ono, M.4
  • 2
    • 25844504653 scopus 로고    scopus 로고
    • Developmental regulation of Foxp3 expression during ontogeny
    • Fontenot, J. D., Dooley, J. L., Farr, A. G. and Rudensky, A. Y., Developmental regulation of Foxp3 expression during ontogeny. J. Exp. Med. 2005. 202: 901-906.
    • (2005) J. Exp. Med. , vol.202 , pp. 901-906
    • Fontenot, J.D.1    Dooley, J.L.2    Farr, A.G.3    Rudensky, A.Y.4
  • 3
    • 84859416933 scopus 로고    scopus 로고
    • Regulatory T cells: mechanisms of differentiation and function
    • Josefowicz, S. Z., Lu, L-F. and Rudensky, A. Y., Regulatory T cells: mechanisms of differentiation and function. Annu. Rev. Immunol. 2012. 30: 531-564.
    • (2012) Annu. Rev. Immunol. , vol.30 , pp. 531-564
    • Josefowicz, S.Z.1    Lu, L.-F.2    Rudensky, A.Y.3
  • 4
    • 0030007975 scopus 로고    scopus 로고
    • cAMP inducibility of transcriptional repressor ICER in developing and mature human T lymphocytes
    • Bodor, J., Spetz, A. L., Strominger, J. L. and Habener, J. F., cAMP inducibility of transcriptional repressor ICER in developing and mature human T lymphocytes. Proc. Natl. Acad. Sci. U.S.A. 1996. 93: 3536-3541.
    • (1996) Proc. Natl. Acad. Sci. U.S.A. , vol.93 , pp. 3536-3541
    • Bodor, J.1    Spetz, A.L.2    Strominger, J.L.3    Habener, J.F.4
  • 6
    • 0026494982 scopus 로고
    • Signalling through the MHC class II cytoplasmic domain is required for antigen presentation and induces B7 expression
    • Nabavi, N., Freeman, G. J., Gault, A., Godfrey, D., Nadler, L. M. and Glimcher, L. H., Signalling through the MHC class II cytoplasmic domain is required for antigen presentation and induces B7 expression. Nature 1992. 360: 266-268.
    • (1992) Nature , vol.360 , pp. 266-268
    • Nabavi, N.1    Freeman, G.J.2    Gault, A.3    Godfrey, D.4    Nadler, L.M.5    Glimcher, L.H.6
  • 7
    • 39449126502 scopus 로고    scopus 로고
    • The Foxp3+ regulatory T cell: a jack of all trades, master of regulation
    • Tang, Q. and Bluestone, J. A., The Foxp3+ regulatory T cell: a jack of all trades, master of regulation. Nat. Immunol. 2008. 9: 239-244.
    • (2008) Nat. Immunol. , vol.9 , pp. 239-244
    • Tang, Q.1    Bluestone, J.A.2
  • 8
    • 0027741257 scopus 로고
    • Inducibility and negative autoregulation of CREM: an alternative promoter directs the expression of ICER, an early response repressor
    • Molina, C. A., Foulkes, N. S., Lalli, E. and Sassone-Corsi, P., Inducibility and negative autoregulation of CREM: an alternative promoter directs the expression of ICER, an early response repressor. Cell 1993. 75: 875-886.
    • (1993) Cell , vol.75 , pp. 875-886
    • Molina, C.A.1    Foulkes, N.S.2    Lalli, E.3    Sassone-Corsi, P.4
  • 9
    • 34250376423 scopus 로고    scopus 로고
    • Cyclic adenosine monophosphate is a key component of regulatory T cell-mediated suppression
    • Bopp, T., Becker, C., Klein, M., Klein-Hessling, S., Palmetshofer, A., Serfling, E., Heib, V. et al., Cyclic adenosine monophosphate is a key component of regulatory T cell-mediated suppression. J. Exp. Med. 2007. 204: 1303-1310.
    • (2007) J. Exp. Med. , vol.204 , pp. 1303-1310
    • Bopp, T.1    Becker, C.2    Klein, M.3    Klein-Hessling, S.4    Palmetshofer, A.5    Serfling, E.6    Heib, V.7
  • 11
    • 0033840025 scopus 로고    scopus 로고
    • Suppression of T cell function: a potential role for transcriptional repressor ICER
    • Bodor, J., Bodorova, J. and Gress, R., Suppression of T cell function: a potential role for transcriptional repressor ICER. J. Leukoc. Biol. 2000. 67: 774-779.
    • (2000) J. Leukoc. Biol. , vol.67 , pp. 774-779
    • Bodor, J.1    Bodorova, J.2    Gress, R.3
  • 12
    • 34249701932 scopus 로고    scopus 로고
    • ICER/CREM-mediated transcriptional attenuation of IL-2 and its role in suppression by regulatory T cells
    • Bodor, J., Fehervari, Z., Diamond, B. and Sakaguchi, S., ICER/CREM-mediated transcriptional attenuation of IL-2 and its role in suppression by regulatory T cells. Eur. J. Immunol. 2007. 37: 884-895.
    • (2007) Eur. J. Immunol. , vol.37 , pp. 884-895
    • Bodor, J.1    Fehervari, Z.2    Diamond, B.3    Sakaguchi, S.4
  • 13
    • 0034978987 scopus 로고    scopus 로고
    • Suppression of T-cell responsiveness by inducible cAMP early repressor (ICER)
    • Bodor, J., Feigenbaum, L., Bodorova, J., Bare, C., Reitz, M. and Gress, R., Suppression of T-cell responsiveness by inducible cAMP early repressor (ICER). J. Leukoc. Biol. 2001 69: 1053-1059.
    • (2001) J. Leukoc. Biol. , vol.69 , pp. 1053-1059
    • Bodor, J.1    Feigenbaum, L.2    Bodorova, J.3    Bare, C.4    Reitz, M.5    Gress, R.6
  • 14
    • 0030043836 scopus 로고    scopus 로고
    • Defective thymocyte proliferation and IL-2 production in transgenic mice expressing a dominant-negative form of CREB
    • Barton, K., Muthusamy, N., Chanyangam, M., Fischer, C., Clendenin, C. and Leiden, J. M., Defective thymocyte proliferation and IL-2 production in transgenic mice expressing a dominant-negative form of CREB. Nature 1996. 379: 81-85.
    • (1996) Nature , vol.379 , pp. 81-85
    • Barton, K.1    Muthusamy, N.2    Chanyangam, M.3    Fischer, C.4    Clendenin, C.5    Leiden, J.M.6
  • 17
    • 0031821875 scopus 로고    scopus 로고
    • + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production
    • + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J. Exp. Med. 1998. 188: 287-296.
    • (1998) J. Exp. Med. , vol.188 , pp. 287-296
    • Thornton, A.1    Shevach, E.2
  • 19
    • 76749133610 scopus 로고    scopus 로고
    • Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate
    • Zheng, Y., Josefowicz, S., Chaudhry, A., Peng, X. P., Forbush, K. and Rudensky, A. Y., Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate. Nature 2010. 463: 808-812.
    • (2010) Nature , vol.463 , pp. 808-812
    • Zheng, Y.1    Josefowicz, S.2    Chaudhry, A.3    Peng, X.P.4    Forbush, K.5    Rudensky, A.Y.6
  • 21
    • 58149263148 scopus 로고    scopus 로고
    • T cell adhesion primes antigen receptor-induced calcium responses through a transient rise in adenosine 3′,5′-cyclic monophosphate
    • Conche, C., Boulla, G., Trautmann, A. and Randriamampita, C., T cell adhesion primes antigen receptor-induced calcium responses through a transient rise in adenosine 3′, 5′-cyclic monophosphate. Immunity 2009. 30: 33-43.
    • (2009) Immunity , vol.30 , pp. 33-43
    • Conche, C.1    Boulla, G.2    Trautmann, A.3    Randriamampita, C.4
  • 23
    • 70449464560 scopus 로고    scopus 로고
    • Waking up regulatory T cells
    • Taskén, K., Waking up regulatory T cells. Blood 2009. 114: 1136-1137.
    • (2009) Blood , vol.114 , pp. 1136-1137
    • Taskén, K.1
  • 26
    • 34447265236 scopus 로고    scopus 로고
    • CREB/ATF-dependent T cell receptor-induced FoxP3 gene expression: a role for DNA methylation
    • Kim, H. P. and Leonard, W. J., CREB/ATF-dependent T cell receptor-induced FoxP3 gene expression: a role for DNA methylation. J. Exp. Med. 2007. 204: 1543-1551.
    • (2007) J. Exp. Med. , vol.204 , pp. 1543-1551
    • Kim, H.P.1    Leonard, W.J.2
  • 27
    • 0347785480 scopus 로고    scopus 로고
    • Control of regulatory T cell development by the transcription factor Foxp3
    • Hori, S., Nomura, T. and Sakaguchi, S., Control of regulatory T cell development by the transcription factor Foxp3. Science 2003. 299: 1057-1061.
    • (2003) Science , vol.299 , pp. 1057-1061
    • Hori, S.1    Nomura, T.2    Sakaguchi, S.3
  • 28
    • 79952291184 scopus 로고    scopus 로고
    • Regulatory T cells facilitate the nuclear accumulation of inducible cAMP early repressor (ICER) and suppress nuclear factor of activated T cell c1 (NFATc1)
    • Vaeth, M., Gogishvili, T., Bopp, T., Klein, M., Berberich-Siebelt, F., Gattenloehner, S., Avots, A. et al., Regulatory T cells facilitate the nuclear accumulation of inducible cAMP early repressor (ICER) and suppress nuclear factor of activated T cell c1 (NFATc1). Proc. Natl. Acad. Sci. U.S.A. 2011. 108: 2480-2485.
    • (2011) Proc. Natl. Acad. Sci. U.S.A. , vol.108 , pp. 2480-2485
    • Vaeth, M.1    Gogishvili, T.2    Bopp, T.3    Klein, M.4    Berberich-Siebelt, F.5    Gattenloehner, S.6    Avots, A.7
  • 29
    • 33847220736 scopus 로고    scopus 로고
    • Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells
    • Zheng, Y., Josefowicz, S. Z., Kas, A., Chu, T.-T., Gavin, M. A. and Rudensky, A. Y., Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells. Nature 2007. 445: 936-940.
    • (2007) Nature , vol.445 , pp. 936-940
    • Zheng, Y.1    Josefowicz, S.Z.2    Kas, A.3    Chu, T.-T.4    Gavin, M.A.5    Rudensky, A.Y.6
  • 31
    • 42149169184 scopus 로고    scopus 로고
    • Mechanisms of regulatory T-cell suppression - a diverse arsenal for a moving target
    • Sojka, D. K., Huang, Y.-H. and Fowell, D. J., Mechanisms of regulatory T-cell suppression - a diverse arsenal for a moving target. Immunology 2008. 124: 13-22.
    • (2008) Immunology , vol.124 , pp. 13-22
    • Sojka, D.K.1    Huang, Y.-H.2    Fowell, D.J.3
  • 32
    • 77955876612 scopus 로고    scopus 로고
    • Complement regulator CD46 temporally regulates cytokine production by conventional and unconventional T cells
    • Cardone, J., Le Friec, G., Vantourout, P., Roberts, A., Fuchs, A., Jackson, I., Suddason, T. et al., Complement regulator CD46 temporally regulates cytokine production by conventional and unconventional T cells. Nat. Immunol. 2010. 9: 862-871.
    • (2010) Nat. Immunol. , vol.9 , pp. 862-871
    • Cardone, J.1    Le Friec, G.2    Vantourout, P.3    Roberts, A.4    Fuchs, A.5    Jackson, I.6    Suddason, T.7
  • 33
    • 0034978987 scopus 로고    scopus 로고
    • Suppression of T cell-responsiveness by inducible cAMP early repressor (ICER)
    • Bodor, J., Feigenbaum, L., Bodorova, J., Bare, C., Reitz, M. S. and Gress, R. E., Suppression of T cell-responsiveness by inducible cAMP early repressor (ICER). J. Leukoc. Biol. 2001. 69: 1053-1059.
    • (2001) J. Leukoc. Biol. , vol.69 , pp. 1053-1059
    • Bodor, J.1    Feigenbaum, L.2    Bodorova, J.3    Bare, C.4    Reitz, M.S.5    Gress, R.E.6
  • 34
    • 77954166341 scopus 로고    scopus 로고
    • Nonfunctional regulatory T cells and defective control of Th2 cytokine production in natural scurfy mutant mice
    • Lahl, K., Mayer, C. T., Bopp, T., Huehn, J., Loddenkemper, C., Eberl, G., Wirnsberger, G. et al., Nonfunctional regulatory T cells and defective control of Th2 cytokine production in natural scurfy mutant mice. J. Immunol. 2009. 183: 5662-5672.
    • (2009) J. Immunol. , vol.183 , pp. 5662-5672
    • Lahl, K.1    Mayer, C.T.2    Bopp, T.3    Huehn, J.4    Loddenkemper, C.5    Eberl, G.6    Wirnsberger, G.7
  • 37
    • 0035929676 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase phosphorylates and targets inducible cAMP early repressor to ubiquitin-mediated destruction
    • Yehia, G., Schlotter, F., Razavi, R., Alessandrini, A. and Molina, C. A., Mitogen-activated protein kinase phosphorylates and targets inducible cAMP early repressor to ubiquitin-mediated destruction. J. Biol. Chem. 2001. 276: 35272-35279.
    • (2001) J. Biol. Chem. , vol.276 , pp. 35272-35279
    • Yehia, G.1    Schlotter, F.2    Razavi, R.3    Alessandrini, A.4    Molina, C.A.5
  • 38
    • 80052619768 scopus 로고    scopus 로고
    • Evidence that phosphorylation by the mitotic kinase Cdk1 promotes ICER monoubiquitination and nuclear delocalization
    • Memin, E., Genzale, M., Crow, M. and Molina, C. A. Evidence that phosphorylation by the mitotic kinase Cdk1 promotes ICER monoubiquitination and nuclear delocalization. Exp. Cell. Res. 2011. 317: 2490-2502.
    • (2011) Exp. Cell. Res. , vol.317 , pp. 2490-2502
    • Memin, E.1    Genzale, M.2    Crow, M.3    Molina, C.A.4
  • 39
    • 6344233216 scopus 로고    scopus 로고
    • TCR-and CD28-mediated recruitment of phosphodiesterase 4 to lipid rafts potentiates TCR signaling 1
    • Abrahamsen, H., Baillie, G., Ngai, J., Vang, T., Nika, K., Ruppelt, A., Mustelin, T. et al., TCR-and CD28-mediated recruitment of phosphodiesterase 4 to lipid rafts potentiates TCR signaling 1. J. Immunol. 2004. 173: 4847-4858.
    • (2004) J. Immunol. , vol.173 , pp. 4847-4858
    • Abrahamsen, H.1    Baillie, G.2    Ngai, J.3    Vang, T.4    Nika, K.5    Ruppelt, A.6    Mustelin, T.7
  • 40
    • 84856574460 scopus 로고    scopus 로고
    • Repression of cyclic adenosine monophosphate upregulation disarms and expands human regulatory T cells
    • Klein, M., Vaeth, M., Scheel, T., Grabbe, S., Baumgrass, R., Berberich-Siebelt, F., Bopp, T. et al., Repression of cyclic adenosine monophosphate upregulation disarms and expands human regulatory T cells. J. Immunol. 2012. 188: 1091-1097.
    • (2012) J. Immunol. , vol.188 , pp. 1091-1097
    • Klein, M.1    Vaeth, M.2    Scheel, T.3    Grabbe, S.4    Baumgrass, R.5    Berberich-Siebelt, F.6    Bopp, T.7
  • 42
    • 33746228122 scopus 로고    scopus 로고
    • FOXP3 controls regulatory T cell function through cooperation with NFAT
    • Wu, Y., Borde, M., Heissmeyer, V., Feuerer, M., Lapan, A. D., Stroud, J. C., Bates, D. L. et al., FOXP3 controls regulatory T cell function through cooperation with NFAT. Cell 2006. 126: 375-387.
    • (2006) Cell , vol.126 , pp. 375-387
    • Wu, Y.1    Borde, M.2    Heissmeyer, V.3    Feuerer, M.4    Lapan, A.D.5    Stroud, J.C.6    Bates, D.L.7
  • 43
    • 0141483523 scopus 로고    scopus 로고
    • Transcriptional regulation by calcium, calcineurin, and NFAT
    • Hogan, P. G., Chen, L., Nardone, J. and Rao, A., Transcriptional regulation by calcium, calcineurin, and NFAT. Genes Dev. 2003. 17: 2205-2232.
    • (2003) Genes Dev. , vol.17 , pp. 2205-2232
    • Hogan, P.G.1    Chen, L.2    Nardone, J.3    Rao, A.4
  • 44
    • 0032540278 scopus 로고    scopus 로고
    • Role of transcriptional repressor ICER in cyclic AMP-mediated attenuation of cytokine gene expression in human thymocytes
    • Bodor, J. and Habener, J. F., Role of transcriptional repressor ICER in cyclic AMP-mediated attenuation of cytokine gene expression in human thymocytes. J. Biol. Chem. 1998. 273: 9544-9551.
    • (1998) J. Biol. Chem. , vol.273 , pp. 9544-9551
    • Bodor, J.1    Habener, J.F.2
  • 46
    • 4344718846 scopus 로고    scopus 로고
    • Cyclic adenosine 5′-monophosphate response element modulator is responsible for the decreased expression of c-fos and activator protein-1 binding in T cells from patients with systemic lupus erythematosus
    • Kyttaris, V. C., Juang, Y.-T., Tenbrock, K., Weinstein, A. and Tsokos, G. C., Cyclic adenosine 5′-monophosphate response element modulator is responsible for the decreased expression of c-fos and activator protein-1 binding in T cells from patients with systemic lupus erythematosus. J. Immunol. 2004. 173: 3557-3563.
    • (2004) J. Immunol. , vol.173 , pp. 3557-3563
    • Kyttaris, V.C.1    Juang, Y.-T.2    Tenbrock, K.3    Weinstein, A.4    Tsokos, G.C.5
  • 48
    • 0034679567 scopus 로고    scopus 로고
    • Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation
    • Read, S., Malmstrom, V. and Powrie, F., Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation. J. Exp. Med. 2000. 192: 295-302.
    • (2000) J. Exp. Med. , vol.192 , pp. 295-302
    • Read, S.1    Malmstrom, V.2    Powrie, F.3
  • 49
    • 0034679560 scopus 로고    scopus 로고
    • Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4
    • Takahashi, T., Tagami, T., Yamazaki, S., Uede, T., Shimizu, J., Sakaguchi, N., Mak, T. W. et al., Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4. J. Exp. Med. 2000. 192: 303-310.
    • (2000) J. Exp. Med. , vol.192 , pp. 303-310
    • Takahashi, T.1    Tagami, T.2    Yamazaki, S.3    Uede, T.4    Shimizu, J.5    Sakaguchi, N.6    Mak, T.W.7
  • 50
    • 68149155982 scopus 로고    scopus 로고
    • Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti-CTLA-4 antibodies
    • Peggs, K. S., Quezada, S. A., Chambers, C. A., Korman, A. J. and Allison, J. P., Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti-CTLA-4 antibodies. J. Exp. Med. 2009. 206: 1717-1725.
    • (2009) J. Exp. Med. , vol.206 , pp. 1717-1725
    • Peggs, K.S.1    Quezada, S.A.2    Chambers, C.A.3    Korman, A.J.4    Allison, J.P.5
  • 51
    • 3142708571 scopus 로고    scopus 로고
    • Engagement of B7 on effector T cells by regulatory T cells prevents autoimmune disease
    • Paust, S., Lu, L., McCarty, N. and Cantor, H., Engagement of B7 on effector T cells by regulatory T cells prevents autoimmune disease. Proc. Natl. Acad. Sci. U.S.A. 2004. 101: 10398-10403.
    • (2004) Proc. Natl. Acad. Sci. U.S.A. , vol.101 , pp. 10398-10403
    • Paust, S.1    Lu, L.2    McCarty, N.3    Cantor, H.4
  • 52
    • 16244390854 scopus 로고    scopus 로고
    • Regulatory T cells and autoimmune disease
    • Paust, S. and Cantor, H., Regulatory T cells and autoimmune disease. Immunol. Rev. 2005. 204: 195-207.
    • (2005) Immunol. Rev. , vol.204 , pp. 195-207
    • Paust, S.1    Cantor, H.2
  • 53
    • 29244482759 scopus 로고    scopus 로고
    • Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice
    • Tang, Q., Adams, J. Y., Tooley, A. J., Bi, M., Fife, B. T., Serra, P., Santamaria, P. et al., Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice. Nat. Immunol. 2006. 7: 83-92.
    • (2006) Nat. Immunol. , vol.7 , pp. 83-92
    • Tang, Q.1    Adams, J.Y.2    Tooley, A.J.3    Bi, M.4    Fife, B.T.5    Serra, P.6    Santamaria, P.7
  • 55
    • 77957019251 scopus 로고    scopus 로고
    • Cyclic adenosine monophosphate and IL-10 coordinately contribute to nTreg cell-mediated suppression of dendritic cell activation
    • Fassbender, M., Gerlitzki, B., Ullrich, N., Lupp, C., Klein, M., Radsak, M. P., Schmitt, E. et al., Cyclic adenosine monophosphate and IL-10 coordinately contribute to nTreg cell-mediated suppression of dendritic cell activation. Cell Immunol. 2010. 265: 91-96.
    • (2010) Cell Immunol. , vol.265 , pp. 91-96
    • Fassbender, M.1    Gerlitzki, B.2    Ullrich, N.3    Lupp, C.4    Klein, M.5    Radsak, M.P.6    Schmitt, E.7
  • 56
    • 64249090036 scopus 로고    scopus 로고
    • The cyclic AMP response element modulator [1] suppresses CD86 expression and APC function
    • Ahlmann, M., Varga, G., Sturm, K., Lippe, R., Benedyk, K., Viemann, D., Scholzen, T. et al., The cyclic AMP response element modulator [1] suppresses CD86 expression and APC function. J. Immunol. 2009. 182: 4167-4174.
    • (2009) J. Immunol. , vol.182 , pp. 4167-4174
    • Ahlmann, M.1    Varga, G.2    Sturm, K.3    Lippe, R.4    Benedyk, K.5    Viemann, D.6    Scholzen, T.7
  • 57
    • 79955529454 scopus 로고    scopus 로고
    • Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4
    • Qureshi, O. S., Zheng, Y., Nakamura, K., Attridge, K., Manzotti, C., Schmidt, E. M., Baker, J. et al., Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4. Science 2011. 332: 600-603.
    • (2011) Science , vol.332 , pp. 600-603
    • Qureshi, O.S.1    Zheng, Y.2    Nakamura, K.3    Attridge, K.4    Manzotti, C.5    Schmidt, E.M.6    Baker, J.7
  • 58
    • 80053078419 scopus 로고    scopus 로고
    • Functional gap junctions accumulate at the immunological synapse and contribute to T cell activation
    • Mendoza-Naranjo, A., Bouma, G., Pereda, C., Ramirez, M., Webb, K. F., Tittarelli, A., Lopez, M. N. et al. Functional gap junctions accumulate at the immunological synapse and contribute to T cell activation. J. Immunol. 2011. 187: 3121-3132.
    • (2011) J. Immunol. , vol.187 , pp. 3121-3132
    • Mendoza-Naranjo, A.1    Bouma, G.2    Pereda, C.3    Ramirez, M.4    Webb, K.F.5    Tittarelli, A.6    Lopez, M.N.7
  • 59
    • 65349151316 scopus 로고    scopus 로고
    • Regulating the regulators: costimulatory signals control the homeostasis and function of regulatory T cells
    • Bour-Jordan, H. and Bluestone, J. A., Regulating the regulators: costimulatory signals control the homeostasis and function of regulatory T cells. Immunol. Rev. 2009. 229: 41-66.
    • (2009) Immunol. Rev. , vol.229 , pp. 41-66
    • Bour-Jordan, H.1    Bluestone, J.A.2
  • 60
    • 13944260538 scopus 로고    scopus 로고
    • CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2
    • Tai, X., Cowan, M., Feigenbaum, L. and Singer, A., CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2. Nat. Immunol. 2005. 6: 152-162.
    • (2005) Nat. Immunol. , vol.6 , pp. 152-162
    • Tai, X.1    Cowan, M.2    Feigenbaum, L.3    Singer, A.4
  • 61
    • 4544241811 scopus 로고    scopus 로고
    • Tolerance, not immunity, crucially depends on IL-2
    • Malek, T. R. and Bayer, A. L., Tolerance, not immunity, crucially depends on IL-2. Nat. Rev. Immunol. 2004. 4: 665-674.
    • (2004) Nat. Rev. Immunol. , vol.4 , pp. 665-674
    • Malek, T.R.1    Bayer, A.L.2
  • 62
    • 23744517125 scopus 로고    scopus 로고
    • Selective targeting of regulatory T cells with CD28 superagonists allows effective therapy of experimental autoimmune encephalomyelitis
    • Beyersdorf, N., Gaupp, S., Balbach, K., Schmidt, J., Toyka, K. V., Lin, C.-H., Hanke, T. et al., Selective targeting of regulatory T cells with CD28 superagonists allows effective therapy of experimental autoimmune encephalomyelitis. J. Exp. Med. 2005. 202: 445-455.
    • (2005) J. Exp. Med. , vol.202 , pp. 445-455
    • Beyersdorf, N.1    Gaupp, S.2    Balbach, K.3    Schmidt, J.4    Toyka, K.V.5    Lin, C.-H.6    Hanke, T.7
  • 64
    • 33750608522 scopus 로고    scopus 로고
    • Lessons from TGN1412
    • author reply 1570.
    • Hanke, T., Lessons from TGN1412. Lancet 2006. 368: 1569-1570; author reply 1570.
    • (2006) Lancet , vol.368 , pp. 1569-1570
    • Hanke, T.1
  • 65
    • 77956304908 scopus 로고    scopus 로고
    • Monoclonal antibody TGN1412 trial failure explained by species differences in CD28 expression on CD4+ effector memory T-cells
    • Eastwood, D., Findlay, L., Poole, S., Bird, C., Wadhwa, M., Moore, M., Burns, C. et al., Monoclonal antibody TGN1412 trial failure explained by species differences in CD28 expression on CD4+ effector memory T-cells. Br. J. Pharmacol. 2010. 161: 512-526.
    • (2010) Br. J. Pharmacol. , vol.161 , pp. 512-526
    • Eastwood, D.1    Findlay, L.2    Poole, S.3    Bird, C.4    Wadhwa, M.5    Moore, M.6    Burns, C.7
  • 66
    • 64249083235 scopus 로고    scopus 로고
    • Inhibition of cAMP degradation improves regulatory T cell-mediated suppression
    • Bopp, T., Dehzad, N., Reuter, S., Klein, M., Ullrich, N., Stassen, M., Schild, H. et al., Inhibition of cAMP degradation improves regulatory T cell-mediated suppression. J. Immunol. 2009. 182: 4017-4024.
    • (2009) J. Immunol. , vol.182 , pp. 4017-4024
    • Bopp, T.1    Dehzad, N.2    Reuter, S.3    Klein, M.4    Ullrich, N.5    Stassen, M.6    Schild, H.7
  • 67
    • 78751691629 scopus 로고    scopus 로고
    • Can Treg therapy prevent GVHD?
    • Komanduri, K. V. andChamplin, R. E., Can Treg therapy prevent GVHD? Blood 2011. 117: 751-752.
    • (2011) Blood , vol.117 , pp. 751-752
    • Komanduri, K.V.1    Champlin, R.E.2
  • 68
    • 25444454359 scopus 로고    scopus 로고
    • Regulation of immune cells by local-tissue oxygen tension: HIF1 alpha and adenosine receptors
    • Sitkovsky, M. and Lukashev, D., Regulation of immune cells by local-tissue oxygen tension: HIF1 alpha and adenosine receptors. Nat. Rev. Immunol. 2005. 5: 712-721.
    • (2005) Nat. Rev. Immunol. , vol.5 , pp. 712-721
    • Sitkovsky, M.1    Lukashev, D.2
  • 69
    • 0035575975 scopus 로고    scopus 로고
    • Differential effects of physiologically relevant hypoxic conditions on T lymphocyte development and effector functions
    • Caldwell, C. C., Kojima, H., Lukashev, D., Armstrong, J., Farber, M., Apasov, S. G. and Sitkovsky, M. V., Differential effects of physiologically relevant hypoxic conditions on T lymphocyte development and effector functions. J. Immunol. 2001. 167: 6140-6149.
    • (2001) J. Immunol. , vol.167 , pp. 6140-6149
    • Caldwell, C.C.1    Kojima, H.2    Lukashev, D.3    Armstrong, J.4    Farber, M.5    Apasov, S.G.6    Sitkovsky, M.V.7
  • 70
    • 61349158530 scopus 로고    scopus 로고
    • T regulatory cells: hypoxia-adenosinergic suppression and re-direction of the immune response
    • Sitkovsky, M. V., T regulatory cells: hypoxia-adenosinergic suppression and re-direction of the immune response. Trends Immunol. 2009. 30: 102-108.
    • (2009) Trends Immunol. , vol.30 , pp. 102-108
    • Sitkovsky, M.V.1
  • 71
    • 33750832563 scopus 로고    scopus 로고
    • T regulatory and primed uncommitted CD4 T cells express CD73, which suppresses effector CD4 T cells by converting 5′-adenosine monophosphate to adenosine
    • Kobie, J. J., Shah, P. R., Yang, L., Rebhahn, J. A., Fowell, D. J. and Mosmann, T. R., T regulatory and primed uncommitted CD4 T cells express CD73, which suppresses effector CD4 T cells by converting 5′-adenosine monophosphate to adenosine. J. Immunol. 2006. 177: 6780-6786.
    • (2006) J. Immunol. , vol.177 , pp. 6780-6786
    • Kobie, J.J.1    Shah, P.R.2    Yang, L.3    Rebhahn, J.A.4    Fowell, D.J.5    Mosmann, T.R.6
  • 72
    • 34250351459 scopus 로고    scopus 로고
    • Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression
    • Deaglio, S., Dwyer, K. M., Gao, W., Friedman, D., Usheva, A., Erat, A., Chen, J. F. et al., Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression. J. Exp. Med. 2007. 204: 1257-1265.
    • (2007) J. Exp. Med. , vol.204 , pp. 1257-1265
    • Deaglio, S.1    Dwyer, K.M.2    Gao, W.3    Friedman, D.4    Usheva, A.5    Erat, A.6    Chen, J.F.7
  • 73
    • 79960418125 scopus 로고    scopus 로고
    • Connexin 43 signaling enhances the generation of Foxp3+ regulatory T cells
    • Kuczma, M., Lee, J. R. and Kraj, P., Connexin 43 signaling enhances the generation of Foxp3+ regulatory T cells. J. Immunol. 2011. 187: 248-257.
    • (2011) J. Immunol. , vol.187 , pp. 248-257
    • Kuczma, M.1    Lee, J.R.2    Kraj, P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.