Inhibition of cAMP degradation improves regulatory T cell-mediated suppression

Journal of Immunology

Volumn 182, Issue 7, 2009, Pages 4017-4024

  Bopp, Tobias ^a   Dehzad, Nina ^a   Reuter, Sebastian ^a   Klein, Matthias ^a   Ullrich, Nina ^a   Stassen, Michael ^a   Schild, Hansjörg ^a   Buhl, Roland ^a   Schmitt, Edgar ^a   Taube, Christian ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP; PHOSPHODIESTERASE IV; ROLIPRAM; PHOSPHODIESTERASE INHIBITOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTHMA; BRONCHUS HYPERREACTIVITY; CONTROLLED STUDY; FEMALE; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; RESPIRATORY TRACT INFLAMMATION; TH2 CELL; ANIMAL; CELL CULTURE; COCULTURE; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HYPERSENSITIVITY; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; LUNG DISEASE; METABOLISM; PATHOLOGY; TRANSGENIC MOUSE;

ANIMALS; CELLS, CULTURED; COCULTURE TECHNIQUES; CYCLIC AMP; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 4; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HYPERSENSITIVITY; IMMUNE TOLERANCE; LUNG DISEASES; MICE; MICE, TRANSGENIC; PHOSPHODIESTERASE INHIBITORS; ROLIPRAM; T-LYMPHOCYTES, REGULATORY; TH2 CELLS;

EID: 64249083235     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0803310     Document Type: Article

References (37)

1. Busse, W. W., and R. F. Lemanske, Jr. 2001. Asthma. N. Engl. J. Med. 344: 350-362.
2. Taube, C., A. Dakhama, and E. W. Gelfand. 2004. Insights into the pathogenesis of asthma utilizing murine models. Int. Arch. Allergy Immunol. 135: 173-186. (Pubitemid 39370428)
3. Sakaguchi, S., N. Sakaguchi, M. Asano, M. Itoh, and M. Toda. 1995. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25): breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 155: 1151-1164.
4. Bopp, T., H. Jonuleit, and E. Schmitt. 2007. Regulatory T cells: the renaissance of the suppressor T cells. Ann. Med. 39: 322-334.
5. + regulatory T cells is interleukin 10 dependent. J. Exp. Med. 202: 1539-1547.
6. + T cells regulate airway eosinophilic inflammation by modulating the Th2 cell phenotype. J. Immunol. 172: 3842-3849.
7. Hadeiba, H., and R. M. Locksley. 2003. Lung CD25 CD4 regulatory T cells suppress type 2 immune responses but not bronchial hyperreactivity. J. Immunol. 170: 5502-5510. (Pubitemid 36617838)
8. + regulatory T cells in T helper 2 cell-mediated allergic inflammation in the airways. Am. J. Respir. Crit. Care Med. 164: 680-687.
9. + T cell regulation of airway allergic responses depends on IL-10 induction of TGF-β. J. Immunol. 178: 1433-1442.
10. Bopp, T., C. Becker, M. Klein, S. Klein-Hessling, A. Palmetshofer, E. Serfling, V. Heib, M. Becker, J. Kubach, S. Schmitt, et al. 2007. Cyclic adenosine monophosphate is a key component of regulatory T cell-mediated suppression. J. Exp. Med. 204: 1303-1310. (Pubitemid 46919868)
11. Underwood, D. C., R. R. Osborn, L. B. Novak, J. K. Matthews, S. J. Newsholme, B. J. Undem, J. M. Hand, and T. J. Torphy. 1993. Inhibition of antigen-induced bronchoconstriction and eosinophil infiltration in the guinea pig by the cyclic AMP-specific phosphodiesterase inhibitor, rolipram. J. Pharmacol. Exp. Ther. 266: 306-313.
12. Danahay, H., and K. J. Broadley. 1997. Effects of inhibitors of phosphodiesterase, on antigen-induced bronchial hyperreactivity in conscious sensitized guinea-pigs and airway leukocyte infiltration. Br. J. Pharmacol. 120: 289-297. (Pubitemid 27039279)
13. Turner, C. R., C. J. Andresen, W. B. Smith, and J. W. Watson. 1994. Effects of rolipram on responses to acute and chronic antigen exposure in monkeys. Am. J. Respir. Crit. Care Med. 149: 1153-1159.
14. Kanehiro, A., T. Ikemura, M. J. Makela, M. Lahn, A. Joetham, A. Dakhama, and E. W. Gelfand. 2001. Inhibition of phosphodiesterase 4 attenuates airway hyper-responsiveness and airway inflammation in a model of secondary allergen challenge. Am. J. Respir. Crit. Care Med. 163: 173-184. (Pubitemid 32095268)
15. + T regulatory cells on development, functional activation, and proliferation of Th2 cells. J. Immunol. 173: 267-274.
16. + regulatory thymocytes because of their responsiveness to different cytokines. Blood 103: 3117-3121.
17. + immunoregulatory T cells is antigen nonspecific. J. Immunol. 164: 183-190.
18. Deaglio, S., K. M. Dwyer, W. Gao, D. Friedman, A. Usheva, A. Erat, J. F. Chen, K. Enjyoji, J. Linden, M. Oukka, et al. 2007. Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression. J. Exp. Med. 204: 1257-1265. (Pubitemid 46919862)
19. Kobie, J. J., P. R. Shah, L. Yang, J. A. Rebhahn, D. J. Fowell, and T. R. Mosmann. 2006. T regulatory and primed uncommitted CD4 T cells express CD73, which suppresses effector CD4 T cells by converting 5′-adenosine monophosphate to adenosine. J. Immunol. 177: 6780-6786.
20. + regulatory T cells. J. Exp. Med. 201: 181-187.
21. Klein, M., S. Klein-Hessling, A. Palmetshofer, E. Serfling, C. Tertilt, T. Bopp, V. Heib, M. Becker, C. Taube, H. Schild, et al. 2006. Specific and redundant roles for NFAT transcription factors in the expression of mast cell-derived cytokines. J. Immunol. 177: 6667-6674. (Pubitemid 44715030)
22. Abrams, J. S., M. G. Roncarolo, H. Yssel, U. Andersson, G. J. Gleich, and J. E. Silver. 1992. Strategies of anti-cytokine monoclonal antibody development: immunoassay of IL-10 and IL-5 in clinical samples. Immunol. Rev. 127: 5-24.
23. Taube, C., C. Duez, Z. H. Cui, K. Takeda, Y. H. Rha, J. W. Park, A. Balhorn, D. D. Donaldson, A. Dakhama, and E. W. Gelfand. 2002. The role of IL-13 in established allergic airway disease. J. Immunol. 169: 6482-6489. (Pubitemid 36903499)
24. Cieslewicz, G., A. Tomkinson, A. Adler, C. Duez, J. Schwarze, K. Takeda, K. A. Larson, J. J. Lee, C. G. Irvin, and E. W. Gelfand. 1999. The late, but not early, asthmatic response is dependent on IL-5 and correlates with eosinophil infiltration. J. Clin. Invest. 104: 301-308.
25. Reuter, S., A. Heinz, M. Sieren, R. Wiewrodt, E. Gelfand, M. Stassen, R. Buhl, and C. Taube. 2008. Mast cell-derived tumour necrosis factor is essential for allergic airway disease. Eur. Respir. J. 31: 773-782.
26. Naganuma, M., E. B. Wiznerowicz, C. M. Lappas, J. Linden, M. T. Worthington, and P. B. Ernst. 2006. Cutting edge: critical role for A2A adenosine receptors in the T cell-mediated regulation of colitis. J. Immunol. 177: 2765-2769. (Pubitemid 44277790)
27. Abrahamsen, H., G. Baillie, J. Ngai, T. Vang, K. Nika, A. Ruppelt, T. Mustelin, M. Zaccolo, M. Houslay, and K. Tasken. 2004. TCR- and CD28-mediated recruitment of phosphodiesterase 4 to lipid rafts potentiates TCR signaling. J. Immunol. 173: 4847-4858. (Pubitemid 39387765)
28. Hammad, H., M. Kool, T. Soullie, S. Narumiya, F. Trottein, H. C. Hoogsteden, and B. N. Lambrecht. 2007. Activation of the D prostanoid 1 receptor suppresses asthma by modulation of lung dendritic cell function and induction of regulatory T cells. J. Exp. Med. 204: 357-367. (Pubitemid 46294551)
29. Cohn, L., R. J. Homer, A. Marinov, J. Rankin, and K. Bottomly. 1997. Induction of airway mucus production By T helper 2 (Th2) cells: a critical role for interleukin 4 in cell recruitment but not mucus production. J. Exp. Med. 186: 1737-1747. (Pubitemid 27506286)
30. + regulatory T cells reverse established allergic airway inflammation and prevent airway remodeling. J. Allergy Clin. Immunol. 122: 617-624.
31. Xystrakis, E., Z. Urry, and C. M. Hawrylowicz. 2007. Regulatory T cell therapy as individualized medicine for asthma and allergy. Curr. Opin. Allergy Clin. Immunol. 7: 535-541. (Pubitemid 350076450)
32. high regulatory T cells. Blood 104: 895-903.
33. + T-regulatory cells can markedly inhibit allogeneic dendritic cell-stimulated MLR cultures. Blood 104: 453-461.
34. Karagiannidis, C., M. Akdis, P. Holopainen, N. J. Woolley, G. Hense, B. Ruckert, P. Y. Mantel, G. Menz, C. A. Akdis, K. Blaser, and C. B. Schmidt-Weber. 2004. Glucocorticoids upregulate FOXP3 expression and regulatory T cells in asthma. J. Allergy Clin. Immunol. 114: 1425-1433. (Pubitemid 39575901)
35. Xystrakis, E., S. Kusumakar, S. Boswell, E. Peek, Z. Urry, D. F. Richards, T. Adikibi, C. Pridgeon, M. Dallman, T. K. Loke, et al. 2006. Reversing the defective induction of IL-10-secreting regulatory T cells in glucocorticoid-resistant asthma patients. J. Clin. Invest. 116: 146-155. (Pubitemid 43121799)
36. Lipworth, B. J. 2005. Phosphodiesterase-4 inhibitors for asthma and chronic obstructive pulmonary disease. Lancet 365: 167-175. (Pubitemid 40091808)
37. Bousquet, J., M. Aubier, J. Sastre, J. L. Izquierdo, L. M. Adler, P. Hofbauer, K. D. Rost, U. Harnest, B. Kroemer, A. Albrecht, and D. Bredenbroker. 2006. Comparison of roflumilast, an oral anti-inflammatory, with beclomethasone dipropionate in the treatment of persistent asthma. Allergy 61: 72-78. (Pubitemid 43381194)