T-cell tolerance and the multi-functional role of IL-2R signaling in T-regulatory cells

Immunological Reviews

Volumn 241, Issue 1, 2011, Pages 63-76

  Cheng, Guoyan ^a   Yu, Aixin ^a   Malek, Thomas R ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

IL 2R signaling thresholds; Immunotherapy; Interleukin 2; Lineage plasticity and stability; T regulatory cells; Tolerance suppression

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; STAT5 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 1; TRANSCRIPTION FACTOR FOXP3;

ALLOTRANSPLANTATION; AUTOIMMUNE DISEASE; CELL DIFFERENTIATION; CELL GROWTH; CELL LINEAGE; CELL MATURATION; CELL SURVIVAL; CELL THERAPY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; CYTOLOGY; DNA METHYLATION; EFFECTOR CELL; ENZYME ACTIVATION; GENETIC REGULATION; GENETIC TRANSCRIPTION; GRAFT RECIPIENT; HISTONE MODIFICATION; HOMEOSTASIS; HUMAN; IMMUNOLOGICAL TOLERANCE; IMMUNOTHERAPY; LYMPHOCYTE PROLIFERATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REGULATORY T LYMPHOCYTE; REVIEW; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TEFF CELL; THYMUS; TRANSCRIPTION REGULATION;

ANIMALS; HUMANS; IMMUNE TOLERANCE; IMMUNOSUPPRESSION; IMMUNOTHERAPY; INTERLEUKIN-2; RECEPTORS, INTERLEUKIN-2; SIGNAL TRANSDUCTION; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, REGULATORY;

EID: 79954559096     PISSN: 01052896     EISSN: 1600065X     Source Type: Journal    
DOI: 10.1111/j.1600-065X.2011.01004.x     Document Type: Review

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