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Volumn 9, Issue 10, 2014, Pages

1,25-Dihydroxyvitamin D3 and Its Analog TX527 Promote a Stable Regulatory T Cell Phenotype in T Cells from Type 1 Diabetes Patients

Author keywords

[No Author keywords available]

Indexed keywords

CALCITRIOL; CALCITRIOL DERIVATIVE; CD134 ANTIGEN; CHEMOKINE RECEPTOR CCR10; CHEMOKINE RECEPTOR CXCR6; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GAMMA INTERFERON; HEMOGLOBIN A1C; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 7 RECEPTOR; INTERLEUKIN 9; TRANSCRIPTION FACTOR FOXP3; TUMOR NECROSIS FACTOR ALPHA; TX527; UNCLASSIFIED DRUG; VITAMIN D RECEPTOR; ALKYNE; COLECALCIFEROL; INECALCITOL;

EID: 84926621134     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0109194     Document Type: Article
Times cited : (48)

References (42)
  • 1
    • 0038303191 scopus 로고    scopus 로고
    • The role of T-cells in the pathogenesis of Type 1 diabetes: From cause to cure
    • Roep BO (2003) The role of T-cells in the pathogenesis of Type 1 diabetes: From cause to cure. Diabetologia 46: 305-321.
    • (2003) Diabetologia , vol.46 , pp. 305-321
    • Roep, B.O.1
  • 2
    • 78751662679 scopus 로고    scopus 로고
    • Type 1 diabetes: Etiology, immunology, and therapeutic strategies
    • Van Belle TL, Coppieters KT, von Herrath MG (2011) Type 1 diabetes: Etiology, immunology, and therapeutic strategies. Physiol Rev 91: 79-118.
    • (2011) Physiol Rev , vol.91 , pp. 79-118
    • Van Belle, T.L.1    Coppieters, K.T.2    Von Herrath, M.G.3
  • 3
    • 77951776390 scopus 로고    scopus 로고
    • Genetics, pathogenesis and clinical interventions in type 1 diabetes
    • Bluestone JA, Herold K, Eisenbarth G (2010) Genetics, pathogenesis and clinical interventions in type 1 diabetes. Nature 464: 1293-1300.
    • (2010) Nature , vol.464 , pp. 1293-1300
    • Bluestone, J.A.1    Herold, K.2    Eisenbarth, G.3
  • 4
    • 39449126502 scopus 로고    scopus 로고
    • The Foxp3+ regulatory T cell: A jack of all trades, master of regulation
    • Tang Q, Bluestone JA (2008) The Foxp3+ regulatory T cell: A jack of all trades, master of regulation. Nat Immunol 9: 239-244.
    • (2008) Nat Immunol , vol.9 , pp. 239-244
    • Tang, Q.1    Bluestone, J.A.2
  • 5
    • 47249124078 scopus 로고    scopus 로고
    • Human regulatory T cells: Role in autoimmune disease and therapeutic opportunities
    • Brusko TM, Putnam AL, Bluestone JA (2008) Human regulatory T cells: Role in autoimmune disease and therapeutic opportunities. Immunol Rev 223: 371-390.
    • (2008) Immunol Rev , vol.223 , pp. 371-390
    • Brusko, T.M.1    Putnam, A.L.2    Bluestone, J.A.3
  • 6
    • 0036141438 scopus 로고    scopus 로고
    • Multiple immunoregulatory defects in type-1 diabetes
    • Kukreja A, Cost G, Marker J, Zhang C, Sun Z, et al. (2002) Multiple immunoregulatory defects in type-1 diabetes. J Clin Invest 109: 131-140.
    • (2002) J Clin Invest , vol.109 , pp. 131-140
    • Kukreja, A.1    Cost, G.2    Marker, J.3    Zhang, C.4    Sun, Z.5
  • 7
    • 33847373481 scopus 로고    scopus 로고
    • No alterations in the frequency of FOXP3+ regulatory T-cells in type 1 diabetes
    • Brusko T, Wasserfall C, McGrail K, Schatz R, Viener HL, et al. (2007) No alterations in the frequency of FOXP3+ regulatory T-cells in type 1 diabetes. Diabetes 56: 604-612.
    • (2007) Diabetes , vol.56 , pp. 604-612
    • Brusko, T.1    Wasserfall, C.2    McGrail, K.3    Schatz, R.4    Viener, H.L.5
  • 8
    • 13944270218 scopus 로고    scopus 로고
    • CD4+CD25high regulatory T cells in human autoimmune diabetes
    • Putnam AL, Vendrame F, Dotta F, Gottlieb PA (2005) CD4+CD25high regulatory T cells in human autoimmune diabetes. J Autoimmun 24: 55-62.
    • (2005) J Autoimmun , vol.24 , pp. 55-62
    • Putnam, A.L.1    Vendrame, F.2    Dotta, F.3    Gottlieb, P.A.4
  • 9
    • 12144249838 scopus 로고    scopus 로고
    • Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes
    • Lindley S, Dayan CM, Bishop A, Roep BO, Peakman M, et al. (2005) Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes. Diabetes 54: 92-99.
    • (2005) Diabetes , vol.54 , pp. 92-99
    • Lindley, S.1    Dayan, C.M.2    Bishop, A.3    Roep, B.O.4    Peakman, M.5
  • 10
    • 17844364504 scopus 로고    scopus 로고
    • Functional defects and the influence of age on the frequency of CD4+ CD25+ Tcells in type 1 diabetes
    • Brusko TM, Wasserfall CH, Clare-Salzler MJ, Schatz DA, Atkinson MA (2005) Functional defects and the influence of age on the frequency of CD4+ CD25+ Tcells in type 1 diabetes. Diabetes 54: 1407-1414.
    • (2005) Diabetes , vol.54 , pp. 1407-1414
    • Brusko, T.M.1    Wasserfall, C.H.2    Clare-Salzler, M.J.3    Schatz, D.A.4    Ma, A.5
  • 11
    • 2942642383 scopus 로고    scopus 로고
    • In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes
    • Tang Q, Henriksen KJ, Bi M, Finger EB, Szot G, et al. (2004) In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes. J Exp Med 199: 1455-1465.
    • (2004) J Exp Med , vol.199 , pp. 1455-1465
    • Tang, Q.1    Henriksen, K.J.2    Bi, M.3    Finger, E.B.4    Szot, G.5
  • 12
    • 62749201002 scopus 로고    scopus 로고
    • Expansion of human regulatory T-cells from patients with type 1 diabetes
    • Putnam AL, Brusko TM, Lee MR, Liu W, Szot GL, et al. (2009) Expansion of human regulatory T-cells from patients with type 1 diabetes. Diabetes 58: 652-662.
    • (2009) Diabetes , vol.58 , pp. 652-662
    • Putnam, A.L.1    Brusko, T.M.2    Lee, M.R.3    Liu, W.4    Szot, G.L.5
  • 13
    • 79955028001 scopus 로고    scopus 로고
    • Plasticity of human regulatory T cells in healthy subjects and patients with type 1 diabetes
    • McClymont SA, Putnam AL, Lee MR, Esensten JH, Liu W, et al. (2011) Plasticity of human regulatory T cells in healthy subjects and patients with type 1 diabetes. J Immunol 186: 3918-3926.
    • (2011) J Immunol , vol.186 , pp. 3918-3926
    • McClymont, S.A.1    Putnam, A.L.2    Lee, M.R.3    Esensten, J.H.4    Liu, W.5
  • 14
    • 38549122739 scopus 로고    scopus 로고
    • Unexpected actions of Vitamin D: New perspectives on the regulation of innate and adaptive immunity
    • Adams JS, Hewison M (2008) Unexpected actions of vitamin D: New perspectives on the regulation of innate and adaptive immunity. Nat Clin Pract Endocrinol Metab 4: 80-90.
    • (2008) Nat Clin Pract Endocrinol Metab , vol.4 , pp. 80-90
    • Adams, J.S.1    Hewison, M.2
  • 15
    • 56149101480 scopus 로고    scopus 로고
    • Vitamin D signaling in immune-mediated disorders: Evolving insights and therapeutic opportunities
    • Baeke F, Van Etten E, Gysemans C, Overbergh L, Mathieu C (2008) Vitamin D signaling in immune-mediated disorders: Evolving insights and therapeutic opportunities. Mol Aspects Med 29: 376-387.
    • (2008) Mol Aspects Med , vol.29 , pp. 376-387
    • Baeke, F.1    Van Etten, E.2    Gysemans, C.3    Overbergh, L.4    Mathieu, C.5
  • 16
    • 84874489590 scopus 로고    scopus 로고
    • Effects of Vitamin D on antigen-specific and non-antigen-specific immune modulation: Relevance for type 1 diabetes
    • Takiishi T, Van Belle T, Gysemans C, Mathieu C (2013) Effects of vitamin D on antigen-specific and non-antigen-specific immune modulation: Relevance for type 1 diabetes. Pediatr Diabetes 14: 81-89.
    • (2013) Pediatr Diabetes , vol.14 , pp. 81-89
    • Takiishi, T.1    Van Belle, T.2    Gysemans, C.3    Mathieu, C.4
  • 18
    • 65049086842 scopus 로고    scopus 로고
    • Dendritic cell tolerogenicity: A key mechanism in immunomodulation by Vitamin D receptor agonists
    • Adorini L, Penna G (2009) Dendritic cell tolerogenicity: A key mechanism in immunomodulation by vitamin D receptor agonists. Hum Immunol 70: 345-352.
    • (2009) Hum Immunol , vol.70 , pp. 345-352
    • Adorini, L.1    Penna, G.2
  • 20
    • 0034652314 scopus 로고    scopus 로고
    • Expression of 1,25-dihydroxyvitamin D(3) receptor in the immune system
    • Veldman CM, Cantorna MT, DeLuca HF (2000) Expression of 1,25-dihydroxyvitamin D(3) receptor in the immune system. Arch Biochem Biophys 374: 334-338.
    • (2000) Arch Biochem Biophys , vol.374 , pp. 334-338
    • Veldman, C.M.1    Cantorna, M.T.2    DeLuca, H.F.3
  • 21
    • 77951253745 scopus 로고    scopus 로고
    • 1,25-Dihydroxyvitamin D3 and IL-2 combine to inhibit T cell production of inflammatory cytokines and promote development of regulatory T cells expressing CTLA-4 and FoxP3
    • Jeffery LE, Burke F, Mura M, Zheng Y, Qureshi OS, et al. (2009) 1,25-Dihydroxyvitamin D3 and IL-2 combine to inhibit T cell production of inflammatory cytokines and promote development of regulatory T cells expressing CTLA-4 and FoxP3. J Immunol 183: 5458-5467.
    • (2009) J Immunol , vol.183 , pp. 5458-5467
    • Jeffery, L.E.1    Burke, F.2    Mura, M.3    Zheng, Y.4    Qureshi, O.S.5
  • 22
    • 79251567975 scopus 로고    scopus 로고
    • The Vitamin D analog, TX527, promotes a human CD4+CD25highCD127low regulatory T cell profile and induces a migratory signature specific for homing to sites of inflammation
    • Baeke F, Korf H, Overbergh L, Verstuyf A, Thorrez L, et al. (2011) The vitamin D analog, TX527, promotes a human CD4+CD25highCD127low regulatory T cell profile and induces a migratory signature specific for homing to sites of inflammation. J Immunol 186: 132-142.
    • (2011) J Immunol , vol.186 , pp. 132-142
    • Baeke, F.1    Korf, H.2    Overbergh, L.3    Verstuyf, A.4    Thorrez, L.5
  • 23
    • 84871995815 scopus 로고    scopus 로고
    • Standards of medical care in diabetes- 2013
    • American Diabetes Association (2013) Standards of medical care in diabetes- 2013. Diabetes Care 36 Suppl 1: S11-66.
    • (2013) Diabetes Care , vol.36 , pp. 11-66
  • 24
    • 77954763264 scopus 로고    scopus 로고
    • Human T lymphocytes are direct targets of 1,25-dihydroxyvitamin D3 in the immune system
    • Baeke F, Korf H, Overbergh L, Van Etten E, Verstuyf A, et al. (2010) Human T lymphocytes are direct targets of 1,25-dihydroxyvitamin D3 in the immune system. J Steroid Biochem Mol Biol 121: 221-227.
    • (2010) J Steroid Biochem Mol Biol , vol.121 , pp. 221-227
    • Baeke, F.1    Korf, H.2    Overbergh, L.3    Van Etten, E.4    Verstuyf, A.5
  • 25
    • 84880968811 scopus 로고    scopus 로고
    • Differential effects of rapamycin and retinoic acid on expansion, stability and suppressive qualities of human CD4(+)CD25(+)FOXP3(+) T regulatory cell subpopulations
    • Scotta C, Esposito M, Fazekasova H, Fanelli G, Edozie FC, et al. (2013) Differential effects of rapamycin and retinoic acid on expansion, stability and suppressive qualities of human CD4(+)CD25(+)FOXP3(+) T regulatory cell subpopulations. Haematologica 98: 1291-1299.
    • (2013) Haematologica , vol.98 , pp. 1291-1299
    • Scotta, C.1    Esposito, M.2    Fazekasova, H.3    Fanelli, G.4    Edozie, F.C.5
  • 26
    • 77449112013 scopus 로고    scopus 로고
    • Regulating human Th17 cells via differential expression of IL-1 receptor
    • Lee WW, Kang SW, Choi J, Lee SH, Shah K, et al. (2010) Regulating human Th17 cells via differential expression of IL-1 receptor. Blood 115: 530-540.
    • (2010) Blood , vol.115 , pp. 530-540
    • Lee, W.W.1    Kang, S.W.2    Choi, J.3    Lee, S.H.4    Shah, K.5
  • 27
    • 58949093000 scopus 로고    scopus 로고
    • Vitamin D status: Measurement, interpretation, and clinical application
    • Holick MF (2009) Vitamin D status: Measurement, interpretation, and clinical application. Ann Epidemiol 19: 73-78.
    • (2009) Ann Epidemiol , vol.19 , pp. 73-78
    • Holick, M.F.1
  • 28
    • 34247890248 scopus 로고    scopus 로고
    • DCs metabolize sunlight-induced vitamin D3 to 'program' T cell attraction to the epidermal chemokine CCL27
    • Sigmundsdottir H, Pan J, Debes GF, Alt C, Habtezion A, et al. (2007) DCs metabolize sunlight-induced vitamin D3 to 'program' T cell attraction to the epidermal chemokine CCL27. Nat Immunol 8: 285-293.
    • (2007) Nat Immunol , vol.8 , pp. 285-293
    • Sigmundsdottir, H.1    Pan, J.2    Debes, G.F.3    Alt, C.4    Habtezion, A.5
  • 29
    • 77952311199 scopus 로고    scopus 로고
    • Control of immunity by the TNFR-related molecule OX40 (CD134
    • Croft M (2010) Control of immunity by the TNFR-related molecule OX40 (CD134). Annu Rev Immunol 28: 57-78.
    • (2010) Annu Rev Immunol , vol.28 , pp. 57-78
    • Croft, M.1
  • 30
    • 84875498856 scopus 로고    scopus 로고
    • Development and maintenance of regulatory T cells
    • Ohkura N, Kitagawa Y, Sakaguchi S (2013) Development and maintenance of regulatory T cells. Immunity 38: 414-423.
    • (2013) Immunity , vol.38 , pp. 414-423
    • Ohkura, N.1    Kitagawa, Y.2    Sakaguchi, S.3
  • 31
    • 58149188480 scopus 로고    scopus 로고
    • The effector T cells of diabetic subjects are resistant to regulation via CD4+ FOXP3+ regulatory T cells
    • Schneider A, Rieck M, Sanda S, Pihoker C, Greenbaum C, et al. (2008) The effector T cells of diabetic subjects are resistant to regulation via CD4+ FOXP3+ regulatory T cells. J Immunol 181: 7350-7355.
    • (2008) J Immunol , vol.181 , pp. 7350-7355
    • Schneider, A.1    Rieck, M.2    Sanda, S.3    Pihoker, C.4    Greenbaum, C.5
  • 32
    • 55449111318 scopus 로고    scopus 로고
    • Increased resistance to CD4+CD25hi regulatory T cell-mediated suppression in patients with type 1 diabetes
    • Lawson JM, Tremble J, Dayan C, Beyan H, Leslie RD, et al. (2008) Increased resistance to CD4+CD25hi regulatory T cell-mediated suppression in patients with type 1 diabetes. Clin Exp Immunol 154: 353-359.
    • (2008) Clin Exp Immunol , vol.154 , pp. 353-359
    • Lawson, J.M.1    Tremble, J.2    Dayan, C.3    Beyan, H.4    Leslie, R.D.5
  • 33
    • 0034028664 scopus 로고    scopus 로고
    • Identification and immune regulation of 25-hydroxyvitamin D-1-alpha-hydroxylase in murine macrophages
    • Overbergh L, Decallonne B, Valckx D, Verstuyf A, Depovere J, et al. (2000) Identification and immune regulation of 25-hydroxyvitamin D-1-alpha-hydroxylase in murine macrophages. Clin Exp Immunol 120: 139-146.
    • (2000) Clin Exp Immunol , vol.120 , pp. 139-146
    • Overbergh, L.1    Decallonne, B.2    Valckx, D.3    Verstuyf, A.4    Depovere, J.5
  • 34
    • 65249120937 scopus 로고    scopus 로고
    • Calcitriol suppresses antiretinal autoimmunity through inhibitory effects on the Th17 effector response
    • Tang J, Zhou R, Luger D, Zhu W, Silver PB, et al. (2009) Calcitriol suppresses antiretinal autoimmunity through inhibitory effects on the Th17 effector response. J Immunol 182: 4624-4632.
    • (2009) J Immunol , vol.182 , pp. 4624-4632
    • Tang, J.1    Zhou, R.2    Luger, D.3    Zhu, W.4    Silver, P.B.5
  • 35
    • 0035497752 scopus 로고    scopus 로고
    • 1alpha,25-Dihydroxyvitamin d3 has a direct effect on naive CD4(+) T cells to enhance the development of Th2 cells
    • Boonstra A, Barrat FJ, Crain C, Heath VL, Savelkoul HF, et al. (2001) 1alpha,25-Dihydroxyvitamin d3 has a direct effect on naive CD4(+) T cells to enhance the development of Th2 cells. J Immunol 167: 4974-4980.
    • (2001) J Immunol , vol.167 , pp. 4974-4980
    • Boonstra, A.1    Barrat, F.J.2    Crain, C.3    Heath, V.L.4    Savelkoul, H.F.5
  • 36
    • 0036467344 scopus 로고    scopus 로고
    • 1,25-dihydroxyvitamin D3 inhibits IFNgamma and IL-4 levels during in vitro polarization of primary murine CD4+ T cells
    • Staeva-Vieira TP, Freedman LP (2002) 1,25-dihydroxyvitamin D3 inhibits IFNgamma and IL-4 levels during in vitro polarization of primary murine CD4+ T cells. J Immunol 168: 1181-1189.
    • (2002) J Immunol , vol.168 , pp. 1181-1189
    • Staeva-Vieira, T.P.1    Freedman, L.P.2
  • 37
    • 66549129834 scopus 로고    scopus 로고
    • Immunomodulatory effects of Vitamin D in multiple sclerosis
    • Correale J, Ysrraelit MC, Gaitan MI (2009) Immunomodulatory effects of Vitamin D in multiple sclerosis. Brain 132: 1146-1160.
    • (2009) Brain , vol.132 , pp. 1146-1160
    • Correale, J.1    Ysrraelit, M.C.2    Gaitan, M.I.3
  • 38
    • 34047174849 scopus 로고    scopus 로고
    • Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production
    • Allan SE, Crome SQ, Crellin NK, Passerini L, Steiner TS, et al. (2007) Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production. Int Immunol 19: 345-354.
    • (2007) Int Immunol , vol.19 , pp. 345-354
    • Allan, S.E.1    Crome, S.Q.2    Crellin, N.K.3    Passerini, L.4    Steiner, T.S.5
  • 39
    • 66949171924 scopus 로고    scopus 로고
    • Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor
    • Miyara M, Yoshioka Y, Kitoh A, Shima T, Wing K, et al. (2009) Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor. Immunity 30: 899-911.
    • (2009) Immunity , vol.30 , pp. 899-911
    • Miyara, M.1    Yoshioka, Y.2    Kitoh, A.3    Shima, T.4    Wing, K.5
  • 40
    • 0037018104 scopus 로고    scopus 로고
    • In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)-and Th2-inducing cytokines
    • Barrat FJ, Cua DJ, Boonstra A, Richards DF, Crain C, et al. (2002) In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)-and Th2-inducing cytokines. J Exp Med 195: 603-616.
    • (2002) J Exp Med , vol.195 , pp. 603-616
    • Barrat, F.J.1    Cua, D.J.2    Boonstra, A.3    Richards, D.F.4    Crain, C.5
  • 41
    • 33750314525 scopus 로고    scopus 로고
    • IL-10 signaling is essential for 1,25-dihydroxyvitamin D3-mediated inhibition of experimental autoimmune encephalomyelitis
    • Spach KM, Nashold FE, Dittel BN, Hayes CE (2006) IL-10 signaling is essential for 1,25-dihydroxyvitamin D3-mediated inhibition of experimental autoimmune encephalomyelitis. J Immunol 177: 6030-6037.
    • (2006) J Immunol , vol.177 , pp. 6030-6037
    • Spach, K.M.1    Nashold, F.E.2    Dittel, B.N.3    Hayes, C.E.4
  • 42
    • 45449095936 scopus 로고    scopus 로고
    • FOXP3 promoter demethylation reveals the committed Treg population in humans
    • Janson PC, Winerdal ME, Marits P, Thorn M, Ohlsson R, et al. (2008) FOXP3 promoter demethylation reveals the committed Treg population in humans. PLoS One 3: E1612.
    • (2008) PLoS One , vol.3 , pp. e1612
    • Janson, P.C.1    Winerdal, M.E.2    Marits, P.3    Thorn, M.4    Ohlsson, R.5


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