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Volumn 119, Issue 19, 2012, Pages 4430-4440

Functionally distinct subsets of human FOXP3+ Treg cells that phenotypically mirror effector Th cells

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD45RA ANTIGEN; CD45RO ANTIGEN; CHEMOKINE RECEPTOR CCR10; CHEMOKINE RECEPTOR CCR4; CHEMOKINE RECEPTOR CCR6; CHEMOKINE RECEPTOR CXCR3; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GAMMA INTERFERON; INDUCIBLE T CELL COSTIMULATOR; INTERFERON REGULATORY FACTOR 4; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 22; INTERLEUKIN 4; INTERLEUKIN 7 RECEPTOR; KI 67 ANTIGEN; MESSENGER RNA; RETINOID RELATED ORPHAN RECEPTOR GAMMA; STAT3 PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR FOXP3; TRANSCRIPTION FACTOR GATA 3; TRANSCRIPTION FACTOR HELIOS; TRANSCRIPTION FACTOR T BET; UNCLASSIFIED DRUG;

EID: 84861039642     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2011-11-392324     Document Type: Article
Times cited : (324)

References (50)
  • 1
    • 77952313777 scopus 로고    scopus 로고
    • Differentiation of effector CD4 T cell populations (-)
    • Zhu J, Yamane H, Paul WE. Differentiation of effector CD4 T cell populations (-). Annu Rev Immunol. 2010;28:445-489.
    • (2010) Annu Rev Immunol. , vol.28 , pp. 445-489
    • Zhu, J.1    Yamane, H.2    Paul, W.E.3
  • 2
    • 67651154105 scopus 로고    scopus 로고
    • Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells
    • Duhen T, Geiger R, Jarrossay D, Lanzavecchia A, Sallusto F. Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells. Nat Immunol. 2009;10(8):857-863.
    • (2009) Nat Immunol. , vol.10 , Issue.8 , pp. 857-863
    • Duhen, T.1    Geiger, R.2    Jarrossay, D.3    Lanzavecchia, A.4    Sallusto, F.5
  • 3
    • 67649161002 scopus 로고    scopus 로고
    • IL-22- producing "T22" T cells account for upregulated IL-22 in atopic dermatitis despite reduced IL-17- producing TH17 T cells
    • Nograles KE, Zaba LC, Shemer A, et al. IL-22- producing "T22" T cells account for upregulated IL-22 in atopic dermatitis despite reduced IL-17- producing TH17 T cells. J Allergy Clin Immunol. 2009;123(6):1244-1252.e2.
    • (2009) J Allergy Clin Immunol. , vol.123 , Issue.6
    • Nograles, K.E.1    Zaba, L.C.2    Shemer, A.3
  • 4
    • 67651171182 scopus 로고    scopus 로고
    • Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from T(H)-17, T(H)1 and T(H)2 cells
    • Trifari S, Kaplan CD, Tran EH, Crellin NK, Spits H. Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from T(H)-17, T(H)1 and T(H)2 cells. Nat Immunol. 2009;10(8):864-871.
    • (2009) Nat Immunol. , vol.10 , Issue.8 , pp. 864-871
    • Trifari, S.1    Kaplan, C.D.2    Tran, E.H.3    Crellin, N.K.4    Spits, H.5
  • 6
    • 0032536869 scopus 로고    scopus 로고
    • Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes
    • DOI 10.1084/jem.187.6.875
    • Sallusto F, Lenig D, Mackay CR, Lanzavecchia A. Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes. J Exp Med. 1998;187(6):875-883. (Pubitemid 28141661)
    • (1998) Journal of Experimental Medicine , vol.187 , Issue.6 , pp. 875-883
    • Sallusto, F.1    Lenig, D.2    Mackay, C.R.3    Lanzavecchia, A.4
  • 9
    • 40449141770 scopus 로고    scopus 로고
    • Human T cells that are able to produce IL-17 express the chemokine receptor CCR6
    • Singh SP, Zhang HH, Foley JF, Hedrick MN, Farber JM. Human T cells that are able to produce IL-17 express the chemokine receptor CCR6. J Immunol. 2008;180(1):214-221.
    • (2008) J Immunol. , vol.180 , Issue.1 , pp. 214-221
    • Singh, S.P.1    Zhang, H.H.2    Foley, J.F.3    Hedrick, M.N.4    Farber, J.M.5
  • 10
    • 65249175159 scopus 로고    scopus 로고
    • C-C chemokine receptor 6-regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE
    • Reboldi A, Coisne C, Baumjohann D, et al. C-C chemokine receptor 6-regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE. Nat Immunol. 2009;10(5):514-523.
    • (2009) Nat Immunol. , vol.10 , Issue.5 , pp. 514-523
    • Reboldi, A.1    Coisne, C.2    Baumjohann, D.3
  • 11
    • 79251500661 scopus 로고    scopus 로고
    • Phenotypical and functional specialization of FOXP3(-) regulatory T cells
    • Campbell DJ, Koch MA. Phenotypical and functional specialization of FOXP3(-) regulatory T cells. Nat Rev Immunol. 2011;11(2):119-130.
    • (2011) Nat Rev Immunol. , vol.11 , Issue.2 , pp. 119-130
    • Campbell, D.J.1    Koch, M.A.2
  • 12
    • 43949105866 scopus 로고    scopus 로고
    • Regulatory T cells and immune tolerance
    • DOI 10.1016/j.cell.2008.05.009, PII S0092867408006247
    • Sakaguchi S, Yamaguchi T, Nomura T, Ono M. Regulatory T cells and immune tolerance. Cell. 2008;133(5):775-787. (Pubitemid 351707693)
    • (2008) Cell , vol.133 , Issue.5 , pp. 775-787
    • Sakaguchi, S.1    Yamaguchi, T.2    Nomura, T.3    Ono, M.4
  • 13
    • 33847242598 scopus 로고    scopus 로고
    • Foxp3 occupancy and regulation of key target genes during T-cell stimulation
    • Marson A, Kretschmer K, Frampton GM, et al. Foxp3 occupancy and regulation of key target genes during T-cell stimulation. Nature. 2007; 445(7130):931-935.
    • (2007) Nature. , vol.445 , Issue.7130 , pp. 931-935
    • Marson, A.1    Kretschmer, K.2    Frampton, G.M.3
  • 14
    • 33847220736 scopus 로고    scopus 로고
    • Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells
    • Zheng Y, Josefowicz SZ, Kas A, Chu TT, Gavin MA, Rudensky AY. Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells. Nature. 2007;445(7130):936-940.
    • (2007) Nature. , vol.445 , Issue.7130 , pp. 936-940
    • Zheng, Y.1    Josefowicz, S.Z.2    Kas, A.3    Chu, T.T.4    Gavin, M.A.5    Rudensky, A.Y.6
  • 15
    • 70049113279 scopus 로고    scopus 로고
    • CD4+ regulatory T cells control TH17 responses in a Stat3-dependent manner
    • Chaudhry A, Rudra D, Treuting P, et al. CD4+ regulatory T cells control TH17 responses in a Stat3-dependent manner. Science. 2009; 326(5955):986-991.
    • (2009) Science. , vol.326 , Issue.5955 , pp. 986-991
    • Chaudhry, A.1    Rudra, D.2    Treuting, P.3
  • 16
    • 65749103365 scopus 로고    scopus 로고
    • The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation
    • Koch MA, Tucker-Heard G, Perdue NR, Killebrew JR, Urdahl KB, Campbell DJ. The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation. Nat Immunol. 2009;10(6):595-602.
    • (2009) Nat Immunol. , vol.10 , Issue.6 , pp. 595-602
    • Koch, M.A.1    Tucker-Heard, G.2    Perdue, N.R.3    Killebrew, J.R.4    Urdahl, K.B.5    Campbell, D.J.6
  • 17
    • 62649165369 scopus 로고    scopus 로고
    • Regulatory T-cell suppressor program coopts transcription factor IRF4 to control T(H)2 responses
    • Zheng Y, Chaudhry A, Kas A, et al. Regulatory T-cell suppressor program coopts transcription factor IRF4 to control T(H)2 responses. Nature. 2009;458(7236):351-356.
    • (2009) Nature. , vol.458 , Issue.7236 , pp. 351-356
    • Zheng, Y.1    Chaudhry, A.2    Kas, A.3
  • 18
    • 33745832286 scopus 로고    scopus 로고
    • + regulatory T cells
    • Lim HW, Broxmeyer HE, Kim CH. Regulation of trafficking receptor expression in human forkhead box P3+ regulatory T cells. J Immunol. 2006; 177(2):840-851. (Pubitemid 44036584)
    • (2006) Journal of Immunology , vol.177 , Issue.2 , pp. 840-851
    • Lim, H.W.1    Broxmeyer, H.E.2    Kim, C.H.3
  • 19
    • 46949111560 scopus 로고    scopus 로고
    • Foxp3+regulatory T cells maintain immune homeostasis in the skin
    • Dudda JC, Perdue N, Bachtanian E, Campbell DJ. Foxp3+regulatory T cells maintain immune homeostasis in the skin. J Exp Med. 2008;205(7):1559-1565.
    • (2008) J Exp Med. , vol.205 , Issue.7 , pp. 1559-1565
    • Dudda, J.C.1    Perdue, N.2    Bachtanian, E.3    Campbell, D.J.4
  • 20
    • 79955549815 scopus 로고    scopus 로고
    • CXCR3 deficiency exacerbates liver disease and abrogates tolerance in a mouse model of immunemediated hepatitis
    • Erhardt A, Wegscheid C, Claass B, et al. CXCR3 deficiency exacerbates liver disease and abrogates tolerance in a mouse model of immunemediated hepatitis. J Immunol. 2011;186(9): 5284-5293.
    • (2011) J Immunol. , vol.186 , Issue.9 , pp. 5284-5293
    • Erhardt, A.1    Wegscheid, C.2    Claass, B.3
  • 22
    • 67649525179 scopus 로고    scopus 로고
    • CCR6 regulates EAE pathogenesis by controlling regulatory CD4+ T-cell recruitment to target tissues
    • Villares R, Cadenas V, Lozano M, et al. CCR6 regulates EAE pathogenesis by controlling regulatory CD4+ T-cell recruitment to target tissues. Eur J Immunol. 2009;39(6):1671-1681.
    • (2009) Eur J Immunol. , vol.39 , Issue.6 , pp. 1671-1681
    • Villares, R.1    Cadenas, V.2    Lozano, M.3
  • 23
    • 58849124250 scopus 로고    scopus 로고
    • CCR6 regulates the migration of inflammatory and regulatory T cells
    • Yamazaki T, Yang XO, Chung Y, et al. CCR6 regulates the migration of inflammatory and regulatory T cells. J Immunol. 2008;181(12):8391-8401.
    • (2008) J Immunol. , vol.181 , Issue.12 , pp. 8391-8401
    • Yamazaki, T.1    Yang, X.O.2    Chung, Y.3
  • 24
    • 77951638740 scopus 로고    scopus 로고
    • Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells
    • Thornton AM, Korty PE, Tran DQ, et al. Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells. J Immunol. 2010;184(7):3433- 3441.
    • (2010) J Immunol. , vol.184 , Issue.7 , pp. 3433-3441
    • Thornton, A.M.1    Korty, P.E.2    Tran, D.Q.3
  • 25
    • 53749094183 scopus 로고    scopus 로고
    • CTLA-4 control over Foxp3+ regulatory T cell function
    • Wing K, Onishi Y, Prieto-Martin P, et al. CTLA-4 control over Foxp3+ regulatory T cell function. Science. 2008;322(5899):271-275.
    • (2008) Science. , vol.322 , Issue.5899 , pp. 271-275
    • Wing, K.1    Onishi, Y.2    Prieto-Martin, P.3
  • 26
    • 0033523607 scopus 로고    scopus 로고
    • An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation
    • Asseman C, Mauze S, Leach MW, Coffman RL, Powrie F. An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation. J Exp Med. 1999;190(7):995-1004.
    • (1999) J Exp Med. , vol.190 , Issue.7 , pp. 995-1004
    • Asseman, C.1    Mauze, S.2    Leach, M.W.3    Coffman, R.L.4    Powrie, F.5
  • 27
    • 41549159660 scopus 로고    scopus 로고
    • Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces
    • Rubtsov YP, Rasmussen JP, Chi EY, et al. Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces. Immunity. 2008;28(4):546-558.
    • (2008) Immunity. , vol.28 , Issue.4 , pp. 546-558
    • Rubtsov, Y.P.1    Rasmussen, J.P.2    Chi, E.Y.3
  • 28
    • 66649115650 scopus 로고    scopus 로고
    • Human memory FOXP3+ Tregs secrete IL-17 ex vivo and constitutively express the T(H)17 lineagespecific transcription factor RORgamma t
    • Ayyoub M, Deknuydt F, Raimbaud I, et al. Human memory FOXP3+ Tregs secrete IL-17 ex vivo and constitutively express the T(H)17 lineagespecific transcription factor RORgamma t. Proc Natl Acad Sci U S A. 2009;106(21):8635- 8640.
    • (2009) Proc Natl Acad Sci U S A. , vol.106 , Issue.21 , pp. 8635-8640
    • Ayyoub, M.1    Deknuydt, F.2    Raimbaud, I.3
  • 29
    • 65549088243 scopus 로고    scopus 로고
    • IL- 17-producing human peripheral regulatory T cells retain suppressive function
    • Beriou G, Costantino CM, Ashley CW, et al. IL- 17-producing human peripheral regulatory T cells retain suppressive function. Blood. 2009;113(18): 4240-4249.
    • (2009) Blood. , vol.113 , Issue.18 , pp. 4240-4249
    • Beriou, G.1    Costantino, C.M.2    Ashley, C.W.3
  • 30
    • 79955028001 scopus 로고    scopus 로고
    • Plasticity of human regulatory T cells in healthy subjects and patients with type 1 diabetes
    • McClymont SA, Putnam AL, Lee MR, et al. Plasticity of human regulatory T cells in healthy subjects and patients with type 1 diabetes. J Immunol. 2011;186(7):3918-3926.
    • (2011) J Immunol. , vol.186 , Issue.7 , pp. 3918-3926
    • McClymont, S.A.1    Putnam, A.L.2    Lee, M.R.3
  • 31
    • 63849183918 scopus 로고    scopus 로고
    • Identification of IL-17-producing FOXP3+ regulatory T cells in humans
    • Voo KS, Wang YH, Santori FR, et al. Identification of IL-17-producing FOXP3+ regulatory T cells in humans. Proc Natl Acad Sci U S A. 2009; 106(12):4793-4798.
    • (2009) Proc Natl Acad Sci U S A. , vol.106 , Issue.12 , pp. 4793-4798
    • Voo, K.S.1    Wang, Y.H.2    Santori, F.R.3
  • 32
    • 70449532980 scopus 로고    scopus 로고
    • Decrease of Foxp3+ Treg cell number and acquisition of effector cell phenotype during lethal infection
    • Oldenhove G, Bouladoux N, Wohlfert EA, et al. Decrease of Foxp3+ Treg cell number and acquisition of effector cell phenotype during lethal infection. Immunity. 2009;31(5):772-786.
    • (2009) Immunity. , vol.31 , Issue.5 , pp. 772-786
    • Oldenhove, G.1    Bouladoux, N.2    Wohlfert, E.A.3
  • 33
    • 79958134797 scopus 로고    scopus 로고
    • Identification of T helper type 1-like, Foxp3+regulatory T cells in human autoimmune disease
    • Dominguez-Villar M, Baecher-Allan CM, Hafler DA. Identification of T helper type 1-like, Foxp3+regulatory T cells in human autoimmune disease. Nat Med. 2011;17(6):673-675.
    • (2011) Nat Med. , vol.17 , Issue.6 , pp. 673-675
    • Dominguez-Villar, M.1    Baecher-Allan, C.M.2    Hafler, D.A.3
  • 34
    • 80053130719 scopus 로고    scopus 로고
    • An essential role of the transcription factor GATA-3 for the function of regulatory T cells
    • Wang Y, Su MA, Wan YY. An essential role of the transcription factor GATA-3 for the function of regulatory T cells. Immunity. 2011;35(3):337-348.
    • (2011) Immunity. , vol.35 , Issue.3 , pp. 337-348
    • Wang, Y.1    Su, M.A.2    Wan, Y.Y.3
  • 35
    • 80555136815 scopus 로고    scopus 로고
    • GATA3 controls Foxp3+ regulatory T cell fate during inflammation in mice
    • Wohlfert EA, Grainger JR, Bouladoux N, et al. GATA3 controls Foxp3+ regulatory T cell fate during inflammation in mice. J Clin Invest. 2011; 121(11):4503-4515.
    • (2011) J Clin Invest. , vol.121 , Issue.11 , pp. 4503-4515
    • Wohlfert, E.A.1    Grainger, J.R.2    Bouladoux, N.3
  • 37
    • 77649220954 scopus 로고    scopus 로고
    • Mechanisms underlying lineage commitment and plasticity of helper CD4+ T cells
    • O'Shea JJ, Paul WE. Mechanisms underlying lineage commitment and plasticity of helper CD4+ T cells. Science. 2010;327(5969):1098-1102.
    • (2010) Science. , vol.327 , Issue.5969 , pp. 1098-1102
    • O'shea, J.J.1    Paul, W.E.2
  • 42
    • 77951480584 scopus 로고    scopus 로고
    • IL-10 production by CD4+ effector T cells: A mechanism for selfregulation
    • Jankovic D, Kugler DG, Sher A. IL-10 production by CD4+ effector T cells: a mechanism for selfregulation. Mucosal Immunol. 2010;3(3):239-246.
    • (2010) Mucosal Immunol. , vol.3 , Issue.3 , pp. 239-246
    • Jankovic, D.1    Kugler, D.G.2    Sher, A.3
  • 43
    • 33847163271 scopus 로고    scopus 로고
    • - Th1 cells are the source of IL-10-mediated immune suppression in chronic cutaneous leishmaniasis
    • DOI 10.1084/jem.20061886
    • Anderson CF, Oukka M, Kuchroo VJ, Sacks D. CD4(+)CD25(+)Foxp3(-) Th1 cells are the source of IL-10-mediated immune suppression in chronic cutaneous leishmaniasis. J Exp Med. 2007; 204(2):285-297. (Pubitemid 46294545)
    • (2007) Journal of Experimental Medicine , vol.204 , Issue.2 , pp. 285-297
    • Anderson, C.F.1    Oukka, M.2    Kuchroo, V.J.3    Sacks, D.4
  • 44
    • 66049149509 scopus 로고    scopus 로고
    • Identification and characterization of IL-10/IFNgamma- producing effector-like T cells with regulatory function in human blood
    • Häringer B, Lozza L, Steckel B, Geginat J. Identification and characterization of IL-10/IFNgamma- producing effector-like T cells with regulatory function in human blood. J Exp Med. 2009; 206(5):1009-1017.
    • (2009) J Exp Med. , vol.206 , Issue.5 , pp. 1009-1017
    • Häringer, B.1    Lozza, L.2    Steckel, B.3    Geginat, J.4
  • 45
    • 65749091607 scopus 로고    scopus 로고
    • A protective function for interleukin 17A in T cellmediated intestinal inflammation
    • O'Connor W Jr, Kamanaka M, Booth CJ, et al. A protective function for interleukin 17A in T cellmediated intestinal inflammation. Nat Immunol. 2009;10(6):603-609.
    • (2009) Nat Immunol. , vol.10 , Issue.6 , pp. 603-609
    • O'Connor Jr., W.1    Kamanaka, M.2    Booth, C.J.3
  • 46
    • 0030587910 scopus 로고    scopus 로고
    • IFN-γ Plays a Critical Down-Regulatory Role in the Induction and Effector Phase of Myelin Oligodendrocyte Glycoprotein-Induced Autoimmune Encephalomyelitis
    • Willenborg DO, Fordham S, Bernard CC, Cowden WB, Ramshaw IA. IFN-gamma plays a critical down-regulatory role in the induction and effector phase of myelin oligodendrocyte glycoprotein- induced autoimmune encephalomyelitis. J Immunol. 1996;157(8):3223-3227. (Pubitemid 126449130)
    • (1996) Journal of Immunology , vol.157 , Issue.8 , pp. 3223-3227
    • Willenborg, D.O.1    Fordham, S.2    Bernard, C.C.A.3    Cowden, W.B.4    Ramshaw, I.A.5
  • 48
    • 44049104564 scopus 로고    scopus 로고
    • H-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt
    • DOI 10.1038/ni.1610, PII NI.1610
    • Manel N, Unutmaz D, Littman DR. The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat. Nat Immunol. 2008;9(6):641-649. (Pubitemid 351714729)
    • (2008) Nature Immunology , vol.9 , Issue.6 , pp. 641-649
    • Manel, N.1    Unutmaz, D.2    Littman, D.R.3
  • 49
    • 78650628082 scopus 로고    scopus 로고
    • Human RORgammat+ TH17 cells preferentially differentiate from naive FOXP3+Treg in the presence of lineage-specific polarizing factors
    • Valmori D, Raffin C, Raimbaud I, Ayyoub M. Human RORgammat+ TH17 cells preferentially differentiate from naive FOXP3+Treg in the presence of lineage-specific polarizing factors. Proc Natl Acad Sci U S A. 2010;107(45):19402-19407.
    • (2010) Proc Natl Acad Sci U S A. , vol.107 , Issue.45 , pp. 19402-19407
    • Valmori, D.1    Raffin, C.2    Raimbaud, I.3    Ayyoub, M.4
  • 50
    • 34247890248 scopus 로고    scopus 로고
    • DCs metabolize sunlight-induced vitamin D3 to 'program' T cell attraction to the epidermal chemokine CCL27
    • DOI 10.1038/ni1433, PII NI1433
    • Sigmundsdottir H, Pan J, Debes GF, et al. DCs metabolize sunlight-induced vitamin D3 to 'program' T cell attraction to the epidermal chemokine CCL27. Nat Immunol. 2007;8(3):285-293. (Pubitemid 46745378)
    • (2007) Nature Immunology , vol.8 , Issue.3 , pp. 285-293
    • Sigmundsdottir, H.1    Pan, J.2    Debes, G.F.3    Alt, C.4    Habtezion, A.5    Soler, D.6    Butcher, E.C.7


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