Possible role of the 'IDO-ahr axis' in maternal-foetal tolerance

Cell Biology International

Volumn 37, Issue 2, 2013, Pages 105-108

  Hao, Kehong ^a   Zhou, Qian ^a   Chen, Wen ^a,b   Jia, Wenwen ^a,b   Zheng, Jing ^c   Kang, Jiuhong ^a,b   Wang, Kai ^a   Duan, Tony ^a  

^a TONGJI UNIVERSITY SCHOOL OF MEDICINE   (China)

^b TONGJI UNIVERSITY   (China)

^c UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

Ahr; IDO; Maternal foetal tolerance; Placenta; Treg cells

Indexed keywords

AROMATIC HYDROCARBON RECEPTOR; INDOLEAMINE 2,3 DIOXYGENASE; KYNURENINE;

AMINO ACID SYNTHESIS; ANTIGEN SPECIFICITY; ARTICLE; BLOOD PLACENTA BARRIER; CELLULAR DISTRIBUTION; ENZYME ACTIVITY; ENZYME LOCALIZATION; HUMAN; IMMUNOLOGICAL TOLERANCE; IMMUNOREGULATION; LYMPHOCYTE DIFFERENTIATION; NONHUMAN; PLACENTA; PLACENTAL TRANSFER; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY T LYMPHOCYTE; SIGNAL TRANSDUCTION; TROPHOBLAST;

FEMALE; FETUS; HUMANS; IMMUNE TOLERANCE; PLACENTA; PREGNANCY; RECEPTORS, ARYL HYDROCARBON; T-LYMPHOCYTES, REGULATORY;

EID: 84874690840     PISSN: 10656995     EISSN: 10958355     Source Type: Journal    
DOI: 10.1002/cbin.10023     Document Type: Article

References (32)

1. Abbott BD, Schmid JE, Pitt JA, Buckalew AR,Wood CR, Held GA, Diliberto JJ (1999) Adverse reproductive outcomes in the transgenic Ah receptor-deficient mouse. Toxicol Appl Pharmacol 155: 62-70.
2. Aluvihare VR, Kallikourdis M, Betz AG (2004) Regulatory T cells mediate maternal tolerance to the fetus. Nat Immunol 5: 266- 71.
3. Baban B, Chandler P, McCool D, Marshall B, Munn DH, Mellor AL (2004) Indoleamine 2,3-dioxygenase expression is restricted to fetal trophoblast giant cells during murine gestation and is maternal genome specific. J Reprod Immunol 61: 67-77.
4. Blaschitz A, Gauster M, Fuchs D, Lang I, Maschke P, Ulrich D, Karpf E, Takikawa O, Schimek MG, Dohr G, Sedlmayr P (2011) Vascular endothelial expression of indoleamine 2,3-dioxygenase 1 forms a positive gradient towards the feto-maternal interface. PLoS ONE 6: e21774.
5. Fontenot JD, Gavin MA, Rudensky AY (2003) Foxp3 programs the development and function of CD4 {thorn} CD25{thorn} regulatory T cells. Nat Immunol 4: 330-6.
6. Guleria I, Sayegh M H (2007) Maternal acceptance of the fetus: true human tolerance. J Immunol 178: 3345-51.
7. Hao KH, Zhou Q, He QZ, Zheng J, Wang K (2012) Protein expression of aryl hydrocarbon receptors in human placentas from mild preeclamptic and early pregnancies. In: Zheng J, ed. Recent advances in research on the human placenta. Rijeka, Croatia: InTech-Open Access Publisher, pp. 119-26.
8. Heikkinen J, Möttönen M, Alanen A, Lassila O (2004) Phenotypic characterization of regulatory T cells in the human decidua. Clin Exp Immunol 136: 373-8.
9. Hönig A, Rieger L, Kapp M, Sütterlin M, Dietl J, Kämmerer U (2004) Indoleamine 2,3-dioxygenase (IDO) expression in invasive extravillous trophoblast supports role of the enzyme for materno-fetal tolerance. J Reprod Immunol 61: 79-86.
10. Jiang YZ, Wang K, Fang R, Zheng J (2010) Expression of aryl hydrocarbon receptor in human placentas and fetal tissues. J Histochem Cytochem 58: 679-85.
11. Jin LP, Chen QY, Zhang T, Guo PF, Li DJ (2009) The CD4 {thorn} CD25 bright regulatory T cells and CTLA-4 expression in peripheral and decidual lymphocytes are down-regulated in human miscarriage. Clin Immunol 133: 402-10.
12. Kahn DA, Baltimore D (2010) Pregnancy induces a fetal antigen-specific maternal T regulatory cell response that contributes to tolerance. Proc Natl Acad Sci USA 107: 9299- 304.
13. Kerkvliet NI, Steppan LB, VorachekW, Oda S, Farrer D,Wong CP, Pham D, Mourich DV (2009) Activation of aryl hydrocarbon receptor by TCDDprevents diabetes inNODmice and increases Foxp3{thorn} T cells in pancreatic lymph nodes. Immunotherapy 1: 539-47.
14. Li X, Gui S, Wang H (2007) Effect of kidney-replenishing herb on the indoleamine 2,3-dioxygenase of human syncytiotrophoblasts cultured in vitro and the balance of helper T-cell cytokines. Gynecol Endocrinol 23: 653-61.
15. Makrigiannakis A, Karamouti M, Drakakis P, Loutradis D, Antsaklis A (2008) Feto-maternal immunotolerance. Am J Reprod Immunol 60: 482-96.
16. Marshall NB, Kerkvliet NI (2010) Dioxin and immune regulation: emerging role of aryl hydrocarbon receptor in the generation of regulatory T cells. Ann N Y Acad Sci 1183: 25-37.
17. Mei S, Tan J, Chen H, Chen Y, Zhang J (2010) Changes of CD4 {thorn} CD25 high regulatory T cells and FOXP3 expression in unexplained recurrent spontaneous abortion patients. Fertil Steril 94: 2244-7.
18. Mellor AL, Chandler P, Lee GK, Johnson T, Keskin DB, Lee J,Munn DH (2002) Indoleamine 2,3-dioxygenase, immunosuppression and pregnancy. J Reprod Immunol 57: 143-50.
19. Mezrich JD, Fechner JH, Zhang X, Johnson BP, Burlingham WJ, Bradfield CA (2010) An interaction between kynurenine and the aryl hydrocarbon receptor can generate regulatory T cells. J Immunol 185: 3190-8.
20. Mimura J, Fujii-Kuriyama Y (2003) Functional role of AhR in the expression of toxic effects by TCDD. Biochim Biophys Acta 1619: 263-8.
21. Munoz-Suano A, Hamilton AB, Betz AG (2011) Gimme shelter: the immune system during pregnancy. Immunol Rev 241: 20-38.
22. Quintana FJ, Basso AS, Iglesias AH, Korn T, Farez MF, Bettelli E, Caccamo M, Oukka M, Weiner HL (2008) Control of T(reg) and T(H)17 cell differentiation by the aryl hydrocarbon receptor. Nature 453: 65-71.
23. Sasaki Y, Sakai M, Miyazaki S, Higuma S, Shiozaki A, Saito S (2004) Decidual and peripheral blood CD4{thorn}CD25{thorn}regulatory T cells in early pregnancy subjects and spontaneous abortion cases. Mol Hum Reprod 10: 347-53.
24. Schumacher A, Brachwitz N, Sohr S et al. (2009)Human chorionic gonadotropin attracts regulatory T cells into the fetal-maternal interface during early human pregnancy. J Immunol 182: 5488-97.
25. Sedlmayr P (2007) Indoleamine 2,3-dioxygenase in materno-fetal interaction. Curr Drug Metab 8: 205-8.
26. Smialowicz RJ, Burgin DE, Williams WC, Diliberto JJ, Setzer RW, Birnbaum LS (2004) CYP1A2 is not required for 2,3,7, 8-tetrachlorodibenzo-p-dioxin-induced immunosuppression. Toxicology 197: 15-22.
27. Somerset DA, Zheng Y, Kilby MD, Sansom DM, Drayson MT (2004)Normal human pregnancy is associated with an elevation in the immune suppressive CD25{thorn} CD4{thorn} regulatory T-cell subset. Immunology 112: 38-43.
28. Stevens EA, Mezrich JD, Bradfield CA (2009) The aryl hydrocarbon receptor: a perspective on potential roles in the immune system. Immunology 127: 299-311.
29. Sun J, Yu J, Li H, Yang L, Wei F, Yu W, Liu J, Ren X (2011) Upregulated expression of indoleamine 2,3-dioxygenase in CHO cells induces apoptosis of competent T cells and increases proportion of Treg cells. J Exp Clin Cancer Res 30: 82.
30. Trowsdale J, Betz AG (2006)Mothers little helpers: mechanisms of maternal-fetal tolerance. Nat Immunol 7: 241-26
31. Trowsdale J, Betz AG (2006)Mothers little helpers: mechanisms of maternal-fetal tolerance. Nat Immunol 7: 241-26. Vogel CF, Goth SR, Dong B, Pessah IN, Matsumura F (2008) Aryl hydrocarbon receptor signaling mediates expression of indoleamine 2,3-dioxygenase. Biochem Biophys Res Commun 375: 331-5.
32. Wang K, Zhou Q, He Q, Tong G, Zhao Z, Duan T (2011) The possible role of AhR in the protective effects of cigarette smoke on preeclampsia. Med Hypotheses 77: 872-4.