Ligation of cytotoxic T lymphocyte antigen-4 to T cell receptor inhibits T cell activation and directs differentiation into Foxp3+ regulatory T cells

Journal of Biological Chemistry

Volumn 287, Issue 14, 2012, Pages 11098-11107

  Karman, Jozsef ^a   Jiang, Ji Lei ^a   Gumlaw, Nathan ^a   Zhao, Hongmei ^a   Campos Rivera, Juanita ^a   Sancho, Jose ^a   Zhang, Jinhua ^a   Jiang, Canwen ^a,b   Cheng, Seng H ^a   Zhu, Yunxiang ^a  

^a GENZYME CORPORATION   (United States)

^b ALCON RESEARCH LTD   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN PRESENTING CELLS; CYTOTOXIC T LYMPHOCYTE ANTIGEN-4; DUAL FUNCTION; FUSION PROTEINS; IMMUNE MODULATION; LYMPHOCYTE ACTIVATION; MTOR SIGNALING; MUTANT MICE; T CELL ACTIVATION; T CELL RECEPTOR; T CELLS; T-CELL RECEPTORS; T-CELL RESPONSE;

ANTIGENS; CELL MEMBRANES;

CYTOLOGY;

B7 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; IMMUNOMODULATING AGENT; INTERLEUKIN 10; INTERLEUKIN 2; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MAMMALIAN TARGET OF RAPAMYCIN; MUTANT CD80 ANTIGEN LYMPHOCYTE ACTIVATION ANTIGEN 3 FUSION PROTEIN; PROTEIN KINASE B; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CONTACT; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG DESIGN; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; HAMSTER; IMMUNOMODULATION; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE FUNCTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CROSS LINKING; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PURIFICATION; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE INHIBITION;

ANIMALS; AUTOCRINE COMMUNICATION; CELL DIFFERENTIATION; CTLA-4 ANTIGEN; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION REGULATION; HLA ANTIGENS; MICE; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, ANTIGEN, T-CELL; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; SUBSTRATE SPECIFICITY; T-LYMPHOCYTES, REGULATORY; TOR SERINE-THREONINE KINASES; TRANSFORMING GROWTH FACTOR BETA;

EID: 84859499803     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.283705     Document Type: Article

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