Interleukin-12 converts Foxp3+ regulatory T cells to interferonγ-producing Foxp3+ T cells that inhibit colitis

Gastroenterology

Volumn 140, Issue 7, 2011, Pages 2031-2043

  Feng, Ting ^a,b,c   Cao, Anthony T ^c   Weaver, Casey T ^a,d   Elson, Charles O ^a,b   Cong, Yingzi ^a,b,c  

^a University of Alabama at Birmingham   (United States)

^b University of Alabama at Birmingham   (United States)

^c UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^d University of Alabama at Birmingham   (United States)

Author keywords

IBD; Immune Regulation; Inflammation; Inflammatory Bowel Disease; Treg

Indexed keywords

FLAGELLIN; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 17; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN PRESENTING CELL; ARTICLE; BIOTRANSFORMATION; CD4+ T LYMPHOCYTE; COLITIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; EFFECTOR CELL; FLUORESCENCE ACTIVATED CELL SORTING; IN VITRO STUDY; INHIBITION KINETICS; INNATE IMMUNITY; INTESTINE; LAMINA PROPRIA; LYMPHOCYTE DIFFERENTIATION; MICROFLORA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; TH1 CELL; TH17 CELL;

EID: 79958130907     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2011.03.009     Document Type: Article

References (31)

1. W. Strober The multifaceted influence of the mucosal microflora on mucosal dendritic cell responses Immunity 31 2009 377 388
2. M.J. Barnes, and F. Powrie Regulatory T cells reinforce intestinal homeostasis Immunity 31 2009 401 411
3. Y. Belkaid, and K.V. Tarbell Arming Treg cells at the inflammatory site Immunity 30 2009 322 323
4. J.D. Fontenot, M.A. Gavin, and A.Y. Rudensky Foxp3 programs the development and function of CD4+CD25+ regulatory T cells Nat Immunol 4 2003 330 336 (Pubitemid 36432314)
5. S.Z. Josefowicz, and A. Rudensky Control of regulatory T cell lineage commitment and maintenance Immunity 30 2009 616 625
6. S. Floess, J. Freyer, and C. Siewert Epigenetic control of the foxp3 locus in regulatory T cells PLoS Biol 5 2007 e38
7. M.A. Gavin, J.P. Rasmussen, and J.D. Fontenot Foxp3-dependent programme of regulatory T-cell differentiation Nature 445 2007 771 775 (Pubitemid 46279714)
8. Y. Zheng, and A.Y. Rudensky Foxp3 in control of the regulatory T cell lineage Nat Immunol 8 2007 457 462 (Pubitemid 46605910)
9. X.O. Yang, R. Nurieva, and G.J. Martinez Molecular antagonism and plasticity of regulatory and inflammatory T cell programs Immunity 29 2008 44 56
10. F. Osorio, S. Leibund Gut-Landmann, and M. Lochner DC activated via dectin-1 convert Treg into IL-17 producers Eur J Immunol 38 2008 3274 3281
11. M. Tsuji, N. Komatsu, and S. Kawamoto Preferential generation of follicular B helper T cells from Foxp3+ T cells in gut Peyer's patches Science 323 2009 1488 1492
12. L. Xu, A. Kitani, and I. Fuss Cutting edge: regulatory T cells induce CD4+CD25-Foxp3- T cells or are self-induced to become Th17 cells in the absence of exogenous TGF-β J Immunol 178 2007 6725 6729 (Pubitemid 46847395)
13. M.A. Koch, G. Tucker-Heard, and N.R. Perdue The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation Nat Immunol 10 2009 595 602
14. G. Wei, L. Wei, and J. Zhu Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells Immunity 30 2009 155 167
15. X. Zhou, S.L. Bailey-Bucktrout, and L.T. Jeker Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo Nat Immunol 10 2009 1000 1007
16. G. Oldenhove, N. Bouladoux, and E.A. Wohlfert Decrease of Foxp3+ Treg cell number and acquisition of effector cell phenotype during lethal infection Immunity 31 2009 772 786
17. M.J. Lodes, Y. Cong, and C.O. Elson Bacterial flagellin is a dominant antigen in Crohn disease J Clin Invest 113 2004 1296 1306 (Pubitemid 39069929)
18. L.E. Harrington, K.M. Janowski, and J.R. Oliver Memory CD4 T cells emerge from effector T-cell progenitors Nature 452 2008 356 360 (Pubitemid 351430787)
19. Y. Cong, T. Feng, and K. Fujihashi A dominant, coordinated T regulatory cell-IgA response to the intestinal microbiota Proc Natl Acad Sci USA 106 2009 19256 19261
20. T. Feng, L. Wang, and T.R. Schoeb Microbiota innate stimulation is a prerequisite for T cell spontaneous proliferation and induction of experimental colitis J Exp Med 207 2010 1321 1332
21. Y. Cong, S.L. Brandwein, and R.P. McCabe CD4+ T cells reactive to enteric bacterial antigens in spontaneously colitic C3H/HeJBir mice: increased T helper cell type 1 response and ability to transfer disease J Exp Med 187 1998 855 864 (Pubitemid 28141659)
22. C.S. Hsieh, S.E. Macatonia, and C.S. Tripp Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages Science 260 1993 547 549 (Pubitemid 23161621)
23. Y.K. Lee, H. Turner, and C.L. Maynard Late developmental plasticity in the T helper 17 lineage Immunity 30 2009 92 107
24. W. Chen, and J.E. Konkel TGF-β and "adaptive" Foxp3(+) regulatory T cells J Mol Cell Biol 2 2010 30 36
25. D. Mucida, K. Pino-Lagos, and G. Kim Retinoic acid can directly promote TGF-β-mediated Foxp3(+) Treg cell conversion of naive T cells Immunity 30 2009 471 473
26. C.M. Sun, J.A. Hall, and R.B. Blank Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid J Exp Med 204 2007 1775 1785 (Pubitemid 47236316)
27. I.I. Ivanov, K. Atarashi, and N. Manel Induction of intestinal Th17 cells by segmented filamentous bacteria Cell 139 2009 485 498
28. S. Wu, K.J. Rhee, and E. Albesiano A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses Nat Med 15 2009 1016 1022
29. T. Korn, J. Reddy, and W. Gao Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation Nat Med 13 2007 423 431 (Pubitemid 46559831)
30. J.A. Hall, N. Bouladoux, and C.M. Sun Commensal DNA limits regulatory T cell conversion and is a natural adjuvant of intestinal immune responses Immunity 29 2008 637 649
31. S.K. Mazmanian, J.L. Round, and D.L. Kasper A microbial symbiosis factor prevents intestinal inflammatory disease Nature 453 2008 620 625 (Pubitemid 351769307)