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Volumn 188, Issue 3, 2012, Pages 1091-1097

Repression of cyclic adenosine monophosphate upregulation disarms and expands human regulatory T cells

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE; CYCLIC AMP; PHOSPHODIESTERASE; TRANSCRIPTION FACTOR NFAT; TRANSCRIPTION FACTOR NFATC1; UNCLASSIFIED DRUG;

EID: 84856574460     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1102045     Document Type: Article
Times cited : (36)

References (47)
  • 1
    • 39449126502 scopus 로고    scopus 로고
    • + regulatory T cell: A jack of all trades, master of regulation
    • DOI 10.1038/ni1572, PII NI1572
    • Tang, Q., and J. A. Bluestone. 2008. The Foxp3+ regulatory T cell: a jack of all trades, master of regulation. Nat. Immunol. 9: 239-244. (Pubitemid 351267321)
    • (2008) Nature Immunology , vol.9 , Issue.3 , pp. 239-244
    • Tang, Q.1    Bluestone, J.A.2
  • 2
    • 0031821875 scopus 로고    scopus 로고
    • + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production
    • DOI 10.1084/jem.188.2.287
    • Thornton, A. M., and E. M. Shevach. 1998. CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J. Exp. Med. 188: 287-296. (Pubitemid 28357757)
    • (1998) Journal of Experimental Medicine , vol.188 , Issue.2 , pp. 287-296
    • Thornton, A.M.1    Shevach, E.M.2
  • 3
    • 0023938335 scopus 로고
    • The adenylate cyclase-cAMP-protein kinase A pathway and regulation of the immune response
    • Kammer, G. M. 1988. The adenylate cyclase-cAMP-protein kinase A pathway and regulation of the immune response. Immunol. Today 9: 222-229.
    • (1988) Immunol. Today , vol.9 , pp. 222-229
    • Kammer, G.M.1
  • 4
    • 0032848914 scopus 로고    scopus 로고
    • Cyclic nucleotide-dependent protein kinases: Intracellular receptors for cAMP and cGMP action
    • DOI 10.1080/10408369991239213
    • Francis, S. H., and J. D. Corbin. 1999. Cyclic nucleotide-dependent protein kinases: intracellular receptors for cAMP and cGMP action. Crit. Rev. Clin. Lab. Sci. 36: 275-328. (Pubitemid 29431414)
    • (1999) Critical Reviews in Clinical Laboratory Sciences , vol.36 , Issue.4 , pp. 275-328
    • Francis, S.H.1    Corbin, J.D.2
  • 6
    • 77957019251 scopus 로고    scopus 로고
    • Cyclic adenosine monophosphate and IL-10 coordinately contribute to nTreg cell-mediated suppression of dendritic cell activation
    • Fassbender, M., B. Gerlitzki, N. Ullrich, C. Lupp, M. Klein, M. P. Radsak, E. Schmitt, T. Bopp, and H. Schild. 2010. Cyclic adenosine monophosphate and IL-10 coordinately contribute to nTreg cell-mediated suppression of dendritic cell activation. Cell. Immunol. 265: 91-96.
    • (2010) Cell. Immunol. , vol.265 , pp. 91-96
    • Fassbender, M.1    Gerlitzki, B.2    Ullrich, N.3    Lupp, C.4    Klein, M.5    Radsak, M.P.6    Schmitt, E.7    Bopp, T.8    Schild, H.9
  • 9
    • 0024210533 scopus 로고
    • Cyclic AMP-responsive DNA-binding protein: Structure based on a cloned placental cDNA
    • Hoeffler, J. P., T. E. Meyer, Y. Yun, J. L. Jameson, and J. F. Habener. 1988. Cyclic AMP-responsive DNA-binding protein: structure based on a cloned placental cDNA. Science 242: 1430-1433. (Pubitemid 19008071)
    • (1988) Science , vol.242 , Issue.4884 , pp. 1430-1433
    • Hoeffler, J.P.1    Meyer, T.E.2    Yun, Y.3    Jameson, J.L.4    Habener, J.F.5
  • 11
    • 33845904901 scopus 로고    scopus 로고
    • Regulatory T cell-mediated suppression: Potential role of ICER
    • DOI 10.1189/jlb.0706474
    • Bodor, J., Z. Fehervari, B. Diamond, and S. Sakaguchi. 2007. Regulatory T cell-mediated suppression: potential role of ICER. J. Leukoc. Biol. 81: 161-167. (Pubitemid 46021265)
    • (2007) Journal of Leukocyte Biology , vol.81 , Issue.1 , pp. 161-167
    • Bodor, J.1    Fehervari, Z.2    Diamond, B.3    Sakaguchi, S.4
  • 14
    • 59649119933 scopus 로고    scopus 로고
    • MiR-142-3p restricts cAMP production in CD4+CD25- T cells and CD4+CD25+ TREG cells by targeting AC9 mRNA
    • Huang, B., J. Zhao, Z. Lei, S. Shen, D. Li, G. X. Shen, G. M. Zhang, and Z. H. Feng. 2009. miR-142-3p restricts cAMP production in CD4+CD25- T cells and CD4+CD25+ TREG cells by targeting AC9 mRNA. EMBO Rep. 10: 180-185.
    • (2009) EMBO Rep. , vol.10 , pp. 180-185
    • Huang, B.1    Zhao, J.2    Lei, Z.3    Shen, S.4    Li, D.5    Shen, G.X.6    Zhang, G.M.7    Feng, Z.H.8
  • 16
    • 79960418125 scopus 로고    scopus 로고
    • Connexin 43 signaling enhances the generation of Foxp3+ regulatory T cells
    • Kuczma, M., J. R. Lee, and P. Kraj. 2011. Connexin 43 signaling enhances the generation of Foxp3+ regulatory T cells. J. Immunol. 187: 248-257.
    • (2011) J. Immunol. , vol.187 , pp. 248-257
    • Kuczma, M.1    Lee, J.R.2    Kraj, P.3
  • 17
    • 35748965021 scopus 로고    scopus 로고
    • Rapid suppression of cytokine transcription in human CD4+CD25 T cells by CD4+Foxp3+ regulatory T cells: Independence of IL-2 consumption, TGF-beta, and various inhibitors of TCR signaling
    • Oberle, N., N. Eberhardt, C. S. Falk, P. H. Krammer, and E. Suri-Payer. 2007. Rapid suppression of cytokine transcription in human CD4+CD25 T cells by CD4+Foxp3+ regulatory T cells: independence of IL-2 consumption, TGF-beta, and various inhibitors of TCR signaling. J. Immunol. 179: 3578-3587.
    • (2007) J. Immunol. , vol.179 , pp. 3578-3587
    • Oberle, N.1    Eberhardt, N.2    Falk, C.S.3    Krammer, P.H.4    Suri-Payer, E.5
  • 18
    • 69849103644 scopus 로고    scopus 로고
    • Protection from graftversus- Host disease by HIV-1 envelope protein gp120-mediated activation of human CD4+CD25+ regulatory T cells
    • Becker, C., C. Taube, T. Bopp, C. Becker, K. Michel, J. Kubach, S. Reuter, N. Dehzad, M. F. Neurath, K. Reifenberg, et al. 2009. Protection from graftversus- host disease by HIV-1 envelope protein gp120-mediated activation of human CD4+CD25+ regulatory T cells. Blood 114: 1263-1269.
    • (2009) Blood , vol.114 , pp. 1263-1269
    • Becker, C.1    Taube, C.2    Bopp, T.3    Becker, C.4    Michel, K.5    Kubach, J.6    Reuter, S.7    Dehzad, N.8    Neurath, M.F.9    Reifenberg, K.10
  • 20
    • 16644367325 scopus 로고    scopus 로고
    • Regulatory T-cells in antitumor therapy: Isolation and functional testing of CD4+CD25+ regulatory T-cells
    • Jonuleit, H., and E. Schmitt. 2005. Regulatory T-cells in antitumor therapy: isolation and functional testing of CD4+CD25+ regulatory T-cells. Methods Mol. Med. 109: 285-296.
    • (2005) Methods Mol. Med. , vol.109 , pp. 285-296
    • Jonuleit, H.1    Schmitt, E.2
  • 21
    • 0026026348 scopus 로고
    • Actions of vasopressin and isoprenaline on the ionic transport across the isolated frog skin in the presence and the absence of adenyl cyclase inhibitors MDL12330A and SQ22536
    • Lippe, C., and C. Ardizzone. 1991. Actions of vasopressin and isoprenaline on the ionic transport across the isolated frog skin in the presence and the absence of adenyl cyclase inhibitors MDL12330A and SQ22536. Comp. Biochem. Physiol. C. 99: 209-211.
    • (1991) Comp. Biochem. Physiol. C. , vol.99 , pp. 209-211
    • Lippe, C.1    Ardizzone, C.2
  • 22
    • 0036729478 scopus 로고    scopus 로고
    • Cyclic nucleotide research - Still expanding after half a century
    • DOI 10.1038/nrm911
    • Beavo, J. A., and L. L. Brunton. 2002. Cyclic nucleotide research - still expanding after half a century. Nat. Rev. Mol. Cell Biol. 3: 710-718. (Pubitemid 34987792)
    • (2002) Nature Reviews Molecular Cell Biology , vol.3 , Issue.9 , pp. 710-718
    • Beavo, J.A.1    Brunton, L.L.2
  • 23
    • 33751217713 scopus 로고    scopus 로고
    • Role of cAMP phosphodiesterase 4 in regulation of T-cell function
    • Bjørgo, E., and K. Taskén. 2006. Role of cAMP phosphodiesterase 4 in regulation of T-cell function. Crit. Rev. Immunol. 26: 443-451. (Pubitemid 44785490)
    • (2006) Critical Reviews in Immunology , vol.26 , Issue.5 , pp. 443-451
    • Bjorgo, E.1    Tasken, K.2
  • 24
    • 0037443097 scopus 로고    scopus 로고
    • PDE4 cAMP phosphodiesterases: Modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalization
    • DOI 10.1042/BJ20021698
    • Houslay, M. D., and D. R. Adams. 2003. PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalization. Biochem. J. 370: 1-18. (Pubitemid 36259414)
    • (2003) Biochemical Journal , vol.370 , Issue.1 , pp. 1-18
    • Houslay, M.D.1    Adams, D.R.2
  • 28
    • 0023017930 scopus 로고
    • Antibody binding to CD5 (Tp67) and Tp44 T cell surface molecules: Effects on cyclic nucleotides, cytoplasmic free calcium, and cAMP-mediated suppression
    • Ledbetter, J. A., M. Parsons, P. J. Martin, J. A. Hansen, P. S. Rabinovitch, and C. H. June. 1986. Antibody binding to CD5 (Tp67) and Tp44 T cell surface molecules: effects on cyclic nucleotides, cytoplasmic free calcium, and cAMP-mediated suppression. J. Immunol. 137: 3299-3305. (Pubitemid 17181705)
    • (1986) Journal of Immunology , vol.137 , Issue.10 , pp. 3299-3305
    • Ledbetter, J.A.1    Parsons, M.2    Martin, P.J.3
  • 29
    • 0028068218 scopus 로고
    • Cyclic AMP sensitive signalling by the CD28 marker requires concomitant stimulation by the T-Cell antigen receptor (TCR/CD3) complex
    • DOI 10.1111/j.1365-3083.1994.tb03451.x
    • Skålhegg, B. S., A. M. Rasmussen, K. Taskén, V. Hansson, T. Jahnsen, and T. Lea. 1994. Cyclic AMP sensitive signalling by the CD28 marker requires concomitant stimulation by the T-cell antigen receptor (TCR/CD3) complex. Scand. J. Immunol. 40: 201-208. (Pubitemid 24251738)
    • (1994) Scandinavian Journal of Immunology , vol.40 , Issue.2 , pp. 201-208
    • Skalhegg, B.S.1    Rasmussen, A.M.2    Tasken, K.3    Hansson, V.4    Jahnsen, T.5    Lea, T.6
  • 30
    • 33751513977 scopus 로고    scopus 로고
    • + T lymphocytes with increased intracellular cAMP levels exert regulatory functions by releasing extracellular cAMP
    • DOI 10.1189/jlb.0106072
    • Vendetti, S., M. Patrizio, A. Riccomi, and M. T. De Magistris. 2006. Human CD4+ T lymphocytes with increased intracellular cAMP levels exert regulatory functions by releasing extracellular cAMP. J. Leukoc. Biol. 80: 880-888. (Pubitemid 44835906)
    • (2006) Journal of Leukocyte Biology , vol.80 , Issue.4 , pp. 880-888
    • Vendetti, S.1    Patrizio, M.2    Riccomi, A.3    De Magistris, M.T.4
  • 31
    • 77956632089 scopus 로고    scopus 로고
    • Elevated cyclic AMP levels in T lymphocytes transformed by human T-cell lymphotropic virus type 1
    • Kress, A. K., G. Schneider, K. Pichler, M. Kalmer, B. Fleckenstein, and R. Grassmann. 2010. Elevated cyclic AMP levels in T lymphocytes transformed by human T-cell lymphotropic virus type 1. J. Virol. 84: 8732-8742.
    • (2010) J. Virol. , vol.84 , pp. 8732-8742
    • Kress, A.K.1    Schneider, G.2    Pichler, K.3    Kalmer, M.4    Fleckenstein, B.5    Grassmann, R.6
  • 33
    • 72949095439 scopus 로고    scopus 로고
    • Distinct metabolism of cyclic adenosine monophosphate in regulatory and helper CD4+ T cells
    • Bazhin, A. V., S. Kahnert, S. Kimpfler, D. Schadendorf, and V. Umansky. 2010. Distinct metabolism of cyclic adenosine monophosphate in regulatory and helper CD4+ T cells. Mol. Immunol. 47: 678-684.
    • (2010) Mol. Immunol. , vol.47 , pp. 678-684
    • Bazhin, A.V.1    Kahnert, S.2    Kimpfler, S.3    Schadendorf, D.4    Umansky, V.5
  • 34
    • 0037100399 scopus 로고    scopus 로고
    • Inhibition of antigen-specific T cell proliferation and cytokine production by protein kinase A type I
    • Aandahl, E. M., W. J. Moretto, P. A. Haslett, T. Vang, T. Bryn, K. Tasken, and D. F. Nixon. 2002. Inhibition of antigen-specific T cell proliferation and cytokine production by protein kinase A type I. J. Immunol. 169: 802-808. (Pubitemid 34753436)
    • (2002) Journal of Immunology , vol.169 , Issue.2 , pp. 802-808
    • Aandahl, E.M.1    Moretto, W.J.2    Haslett, P.A.3    Vang, T.4    Bryn, T.5    Tasken, K.6    Nixon, D.F.7
  • 35
    • 0034129005 scopus 로고    scopus 로고
    • Intercellular communication in the immune system: Differential expression of connexin40 and 43, and perturbation of gap junction channel functions in peripheral blood and tonsil human lymphocyte subpopulations
    • DOI 10.1046/j.1365-2567.2000.00991.x
    • Oviedo-Orta, E., T. Hoy, and W. H. Evans. 2000. Intercellular communication in the immune system: differential expression of connexin40 and 43, and perturbation of gap junction channel functions in peripheral blood and tonsil human lymphocyte subpopulations. Immunology 99: 578-590. (Pubitemid 30201005)
    • (2000) Immunology , vol.99 , Issue.4 , pp. 578-590
    • Oviedo-Orta, E.1    Hoy, T.2    Evans, W.H.3
  • 37
    • 70349566221 scopus 로고    scopus 로고
    • Cutting edge: Regulatory T cells do not require stimulation through their TCR to suppress
    • Szymczak-Workman, A. L., C. J. Workman, and D. A. Vignali. 2009. Cutting edge: regulatory T cells do not require stimulation through their TCR to suppress. J. Immunol. 182: 5188-5192.
    • (2009) J. Immunol. , vol.182 , pp. 5188-5192
    • Szymczak-Workman, A.L.1    Workman, C.J.2    Vignali, D.A.3
  • 39
  • 40
    • 33845491455 scopus 로고    scopus 로고
    • high T cells gives rise to homogeneous regulatory T-cell lines upon in vitro expansion
    • DOI 10.1182/blood-2006-06-027409
    • Hoffmann, P., R. Eder, T. J. Boeld, K. Doser, B. Piseshka, R. Andreesen, and M. Edinger. 2006. Only the CD45RA+ subpopulation of CD4+CD25high T cells gives rise to homogeneous regulatory T-cell lines upon in vitro expansion. Blood 108: 4260-4267. (Pubitemid 44913302)
    • (2006) Blood , vol.108 , Issue.13 , pp. 4260-4267
    • Hoffmann, P.1    Eder, R.2    Boeld, T.J.3    Doser, K.4    Piseshka, B.5    Andreesen, R.6    Edinger, M.7
  • 41
    • 33845379986 scopus 로고    scopus 로고
    • + regulatory T cells of both healthy subjects and type 1 diabetic patients
    • Battaglia, M., A. Stabilini, B. Migliavacca, J. Horejs-Hoeck, T. Kaupper, and M. G. Roncarolo. 2006. Rapamycin promotes expansion of functional CD4 +CD25+FOXP3+ regulatory T cells of both healthy subjects and type 1 diabetic patients. J. Immunol. 177: 8338-8347. (Pubitemid 44893795)
    • (2006) Journal of Immunology , vol.177 , Issue.12 , pp. 8338-8347
    • Battaglia, M.1    Stabilini, A.2    Migliavacca, B.3    Horejs-Hoeck, J.4    Kaupper, T.5    Roncarolo, M.-G.6
  • 42
    • 0023224873 scopus 로고
    • Inhibition of adenylate cyclase by IL 2 in human T lymphocytes is mediated by protein kinase C
    • DOI 10.1016/0006-291X(87)91303-9
    • Beckner, S. K., and W. L. Farrar. 1987. Inhibition of adenylate cyclase by IL 2 in human T lymphocytes is mediated by protein kinase C. Biochem. Biophys. Res. Commun. 145: 176-182. (Pubitemid 17088421)
    • (1987) Biochemical and Biophysical Research Communications , vol.145 , Issue.1 , pp. 176-182
    • Beckner, S.K.1    Farrar, W.L.2
  • 45
    • 33644907736 scopus 로고    scopus 로고
    • Overexpression of phosphodiesterases in experimental autoimmune myasthenia gravis: Suppression of disease by a phosphodiesterase inhibitor
    • DOI 10.1096/fj.05-4909fje
    • Aricha, R., T. Feferman, M. C. Souroujon, and S. Fuchs. 2006. Overexpression of phosphodiesterases in experimental autoimmune myasthenia gravis: suppression of disease by a phosphodiesterase inhibitor. FASEB J. 20: 374-376. (Pubitemid 46671176)
    • (2006) FASEB Journal , vol.20 , Issue.2 , pp. 374-376
    • Aricha, R.1    Feferman, T.2    Souroujon, M.C.3    Fuchs, S.4
  • 46
    • 34250884676 scopus 로고    scopus 로고
    • + T lymphocytes by adenosine-protein kinase A type I signaling
    • DOI 10.1158/0008-5472.CAN-06-4249
    • Raskovalova, T., A. Lokshin, X. Huang, Y. Su, M. Mandic, H. M. Zarour, E. K. Jackson, and E. Gorelik. 2007. Inhibition of cytokine production and cytotoxic activity of human antimelanoma specific CD8+ and CD4+ T lymphocytes by adenosine-protein kinase A type I signaling. Cancer Res. 67: 5949-5956. (Pubitemid 46985031)
    • (2007) Cancer Research , vol.67 , Issue.12 , pp. 5949-5956
    • Raskovalova, T.1    Lokshin, A.2    Huang, X.3    Su, Y.4    Mandic, M.5    Zarour, H.M.6    Jackson, E.K.7    Gorelik, E.8
  • 47
    • 50649108394 scopus 로고    scopus 로고
    • Cooperation of adenosine and prostaglandin E2 (PGE2) in amplification of cAMP-PKA signaling and immunosuppression
    • Su, Y., X. Huang, T. Raskovalova, L. Zacharia, A. Lokshin, E. Jackson, and E. Gorelik. 2008. Cooperation of adenosine and prostaglandin E2 (PGE2) in amplification of cAMP-PKA signaling and immunosuppression. Cancer Immunol. Immunother. 57: 1611-1623.
    • (2008) Cancer Immunol. Immunother. , vol.57 , pp. 1611-1623
    • Su, Y.1    Huang, X.2    Raskovalova, T.3    Zacharia, L.4    Lokshin, A.5    Jackson, E.6    Gorelik, E.7


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