Hypomethylation at the regulatory T cell-specific demethylated region in CD25hiT cells is decoupled from FOXP3 expression at the inflamed site in childhood arthritis

Journal of Immunology

Volumn 193, Issue 6, 2014, Pages 2699-2708

  Bending, David ^a   Pesenacker, Anne M ^a,c   Ursu, Simona ^a   Wu, Qiong ^b   Lom, Hannah ^a   Thirugnanabalan, Balathas ^a   Wedderburn, Lucy R ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; DEUBIQUITINASE; GAMMA INTERFERON; INTERLEUKIN 17; INTERLEUKIN 2; PROGRAMMED DEATH 1 RECEPTOR; TRANSCRIPTION FACTOR FOXP3; TUMOR NECROSIS FACTOR ALPHA; BIOLOGICAL MARKER; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, HUMAN; IL17A PROTEIN, HUMAN; IL2 PROTEIN, HUMAN; IL2RA PROTEIN, HUMAN; INTERLEUKIN 2 RECEPTOR ALPHA;

ADULT; ARTICLE; CD127+ T LYMPHOCYTE; CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; DISEASE SEVERITY; DNA METHYLATION; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; INTRACELLULAR SIGNALING; JUVENILE RHEUMATOID ARTHRITIS; LYMPHOCYTE COUNT; LYMPHOCYTE PROLIFERATION; MALE; PHENOTYPE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; UPREGULATION; BIOSYNTHESIS; CELL PROLIFERATION; CHEMISTRY; CYTOLOGY; GENETICS; IMMUNOLOGY; INFLAMMATION; METHYLATION; SIGNAL TRANSDUCTION;

ADULT; ARTHRITIS, JUVENILE; BIOLOGICAL MARKERS; CELL PROLIFERATION; CHILD; CTLA-4 ANTIGEN; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; INFLAMMATION; INTERFERON-GAMMA; INTERLEUKIN-17; INTERLEUKIN-2; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; MALE; METHYLATION; SIGNAL TRANSDUCTION; T-LYMPHOCYTES, REGULATORY; TUMOR NECROSIS FACTOR-ALPHA; UBIQUITIN-SPECIFIC PROTEASES;

EID: 84907070734     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1400599     Document Type: Article

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