PI3K in cancer: Divergent roles of isoforms, modes of activation and therapeutic targeting

Nature Reviews Cancer

Volumn 15, Issue 1, 2015, Pages 7-24

  Thorpe, Lauren M ^a,b   Yuzugullu, Haluk ^a,b   Zhao, Jean J ^a,b  

^a DANA FARBER CANCER INSTITUTE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITOR; G PROTEIN COUPLED RECEPTOR; GUANOSINE TRIPHOSPHATASE; ISOPROTEIN; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; ANTINEOPLASTIC AGENT; ISOENZYME; POLYPHOSPHOINOSITIDE;

ALEXANDER DISEASE; BLADDER CANCER; BREAST CANCER; CANCER RESISTANCE; CANCER THERAPY; CLINICAL TRIAL (TOPIC); COLORECTAL CANCER; DRUG TARGETING; ENDOMETRIUM CANCER; GENE MUTATION; GLIOBLASTOMA; HEAD AND NECK CANCER; HOSPITAL; HUMAN; INTRACELLULAR SIGNALING; KIDNEY CANCER; LEUKEMIA; LIVER CANCER; LUNG CANCER; LYMPHOMA; MELANOMA; NEOPLASM; NONHUMAN; OVARY CANCER; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN FUNCTION; REVIEW; SARCOMA; THYROID CANCER; THYROID GLAND; UPREGULATION; UTERINE CERVIX CANCER; ANIMAL; ANTAGONISTS AND INHIBITORS; DRUG RESISTANCE; ENZYMOLOGY; METABOLISM; MOLECULARLY TARGETED THERAPY; NEOPLASMS; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; ANTINEOPLASTIC AGENTS; DRUG RESISTANCE, NEOPLASM; HUMANS; ISOENZYMES; MOLECULAR TARGETED THERAPY; NEOPLASMS; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHATIDYLINOSITOL PHOSPHATES; SIGNAL TRANSDUCTION;

EID: 84925545317     PISSN: 1474175X     EISSN: 14741768     Source Type: Journal    
DOI: 10.1038/nrc3860     Document Type: Review

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