Specific role for p85/p110β in GTP-binding-protein-mediated activation of Akt

Biochemical Journal

Volumn 392, Issue 3, 2005, Pages 607-614

  Kubo, Hiroshi ^a   Hazeki, Kaoru ^a   Takasuga, Shunsuke ^a   Hazeki, Osamu ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

Author keywords

Adenosine; Akt; G subunit; GTP binding protein coupled receptor (GPCR); p110 ; Phosphoinositide 3 kinase; Short hairpin RNA (shRNA)

Indexed keywords

CELLS; INSULIN; MUTAGENESIS; PH EFFECTS; RNA; SENSITIVITY ANALYSIS;

ADENOSINE; AKT; GΒΓ SUBUNIT; GTP-BINDING-PROTEIN-COUPLED RECEPTOR (GPCR); P110Β; PHOSPHOINOSITIDE 3-KINASE; SHORT-HAIRPIN RNA (SHRNA);

PROTEINS;

ADENOSINE DERIVATIVE; GUANOSINE TRIPHOSPHATE; INSULIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN P110; PROTEIN P85; PROTEIN SUBUNIT; RECEPTOR PROTEIN; SHORT HAIRPIN RNA; TYROSINE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; POINT MUTATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CATTLE; CHO CELLS; CRICETINAE; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; GTP-BINDING PROTEINS; HUMANS; INSULIN; MICE; PHOSPHATIDYLINOSITOL PHOSPHATES; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, ADENOSINE A1; RECEPTOR, INSULIN;

ANIMALIA; CRICETULUS GRISEUS;

EID: 29644446699     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20050671     Document Type: Article

References (41)

1. Shepherd, P. R., Withers, D. J. and Siddle, K. (1998) Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling. Biochem. J. 333, 471-490
2. Backer, J. M., Myers, Jr, M. G., Shoelson, S. E., Chin, D. J., Sun, X. J., Miralpeix, M., Hu, P., Margolis, B., Skolnik, E. Y., Schlessinger, J. and White, M. F. (1992) Phosphatidylinositol 3′-kinase is activated by association with IRS-1 during insulin stimulation. EMBO J. 11, 3469-3479
3. Carpenter, C. L., Auger, K. R., Chanudhuri, M., Yoakim, M., Schaffhausen, B., Shoelson, S. and Cantley, L. C. (1993) Phosphoinositide 3-kinase is activated by phosphopeptides that bind to the SH2 domains of the 85-kDa subunit. J. Biol. Chem. 268, 9478-9483
4. Yu, J., Zhang, Y., McIlroy, J., Rordorf Nikolic, T., Orr, G. A. and Backer, J. M. (1998) Regulation of the p85/p110 phosphatidylinositol 3′-kinase: stabilization and inhibition of the p110α catalytic subunit by the p85 regulatory subunit. Mol. Cell. Biol. 18, 1379-1387
5. Brock, C., Schaefer, M., Reusch, H. P., Czupalla, C., Michalke, M., Spicher, K., Schultz, G. and Nurnberg, B. (2003) Roles of Gβγ in membrane recruitment and activation of p110γ/p101 phosphoinositide 3-kinase γ. J. Cell Biol. 160, 89-99
6. Stephens, L. R., Eguinoa, A., Erdjument Bromage, H., Lui, M., Cooke, F., Coadwell, J., Smrcka, A. S., Thelen, M., Cadwallader, K., Tempst, P. and Hawkins, P. T. (1997) The Gβγ sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101. Cell 89, 105-114
7. Maier, U., Babich, A. and Nurnberg, B. (1999) Roles of non-catalytic subunits in Gβγ-induced activation of class I Phosphoinositide 3-kinase isoforms β and γ. J. Biol. Chem. 274, 29311-29317
8. Leopoldt, D., Hanck, T., Exner, T., Maier, U., Wetzker, R. and Nurnberg, B. (1998) Gβγ stimulates phosphoinositide 3-kinase-γ by direct interaction with two domains of the catalytic p110 subunit. J. Biol. Chem. 273, 7024-7029
9. Sasaki, T., Irie-Sasaki, J., Jones, R. G., Oliveira-dos-Santos, A. J., Stanford, W. L., Bolon, B., Wakeham, A., Itie, A., Bouchard, D., Kozieradzki, I. et al. (2000) Function of PI3Kγ in thymocyte development, T cell activation, and neutrophil migration. Science (Washington, DC) 287, 1040-1046
10. Okada, T., Hazeki, O., Ui, M. and Katada, T. (1996) Synergistic activation of Ptdlns 3-kinase by tyrosine-phosphorylated peptide and βγ-subunits of GTP-binding proteins. Biochem. J. 317, 475-480
11. Roche, S., Downward, J., Raynal, P. and Courtneidge, S. A. (1998) A function for phosphatidylinositol 3-kinase β(p85α-p110β) in fibroblasts during mitogenesis: requirement for insulin- and lysophosphatidic acid-mediated signal transduction. Mol. Cell. Biol. 18, 7119-7129
12. Graness, A., Adomeit, A., Heinze, R., Wetzker, R. and Liebmann, C. (1998) A novel mitogenic signaling pathway of bradykinin in the human colon carcinoma cell line SW-480 involves sequential activation of a Gq/11 protein, phosphatidylinositol 3-kinase β, and protein kinase Cε. J. Biol. Chem. 273, 32016-32022
13. Laffargue, M., Raynal, P., Yart, A., Peres, C., Wetzker, R., Roche, S., Payrastre, B. and Chap, H. (1999) An epidermal growth factor receptor/Gab1 signaling pathway is required for activation of phosphoinositide 3-kinase by lysophosphatidic acid. J. Biol. Chem. 274, 32835-32841
14. Murga, C., Fukuhara, S. and Gutkind, J. S. (2000) A novel role for phosphatidylinositol 3-kinase β in signaling from G protein-coupled receptors to Akt. J. Biol. Chem. 275, 12069-12073
15. Yart, A., Roche, S., Wetzker, R., Laffargue, M., Tonks, N., Mayeux, P., Chap, H. and Raynal, P. (2002) A function for phosphoinositide 3-kinase β lipid products in coupling βγ to Ras activation in response to lysophosphatidic acid. J. Biol. Chem. 277, 21167-21178
16. Kurosu, H., Maehama, T., Okada, T., Yamamoto, T., Hoshino, S., Fukui, Y., Ui, M., Hazeki, O. and Katada, T. (1997) Heterodimeric phosphoinositide 3-kinase consisting of p85 and p110β is synergistically activated by the βγ subunits of G proteins and phosphotyrosyl peptide. J. Biol. Chem. 272, 24252-24256
17. Ui-Tei, K., Naito, Y., Takahashi, F., Haraguchi, T., Ohki-Hamazaki, H., Juni, A., Ueda, R. and Saigo, K. (2004) Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference. Nucleic Acids Res. 32, 936-948
18. Reynolds, A., Leake, D., Boese, Q., Scaringe, S., Marshall, W. S. and Khvorova, A. (2004) Rational siRNA design for RNA interference. Nat. Biotecnnol. 22, 326-330
19. Vanhaesebroeck, B. and Alessi, D. R. (2000) The PI3K-PDK1 connection: more than just a road to PKB. Biochem. J. 346, 561-576
20. Takasuga, S., Katada, T., Ui, M. and Hazeki, O. (1999) Enhancement by adenosine of insulin-induced activation of phosphoinositide 3-kinase and protein kinase B in rat adipocytes. J. Biol. Chem. 274, 19545-19550
21. Hara, K., Yonezawa, K., Sakaue, H., Ando, A., Kotani, K., Kitamura, T., Kitamura, Y., Ueda, H., Stephens, L., Jackson, T. R. et al. (1994) 1-Phosphatidylinositol 3-kinase activity is required for insulin-stimulated glucose transport but not for RAS activation in CHO cells. Proc. Natl. Acad. Sci. U.S.A. 91, 7415-7419
22. Rahimi, N., Tremblay, E. and Elliott, B. (1996) Phosphatidylinositol 3-kinase activity is required for hepatocyte growth factor-induced mitogenic signals in epithelial cells. J. Biol. Chem. 271, 24850-24855
23. Sajan, M. P., Standaert, M. L., Bandyopadhyay, G., Quon, M. J., Burke, Jr., T. R. and Farese, R. V. (1999) Protein kinase C-ζ and phosphoinositide-dependent protein kinase-1 are required for insulin-induced activation of ERK in rat adipocytes. J. Biol. Chem. 274, 30495-30500
24. 2+ entry mechanism. J. Biol. Chem. 275, 16242-16250
25. Djordjevic, S. and Driscoll, R C. (2002) Structural insight into substrate specificity and regulatory mechanisms of phosphoinositide 3-kinases. Trends Biochem. Sci. 27, 425-432
26. Wymann, M. P., Zvelebil, M. and Laffargue, M. (2003) Phosphoinositide 3-kinase signaling-which way to target? Trends Pharmacol. Sci. 24, 366-376
27. Stoyanov, B., Volinia, S., Hanck, T., Rubio, I., Loubtchenkov, M., Malek, D., Stoyanova, S., Vanhaesebroeck, B., Dhand, R., Nurnberg, B., Gierschik, P., Seedorf, K., Hsuan, J. J., Waterfield, M. D. and Wetzker, R. (1995) Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase. Science (Washington, DC) 269, 690-693
28. Koch, W. J., Hawes, B. E., Inglese, J., Luttrell, L. M. and Lefkowitz, R. J. (1994) Cellular expression of the carboxyl terminus of a G protein-coupled receptor kinase attenuates Gβγ-mediated signaling. J. Biol. Chem. 269, 6193-6197
29. Koch, W. J., Hawes, B. E., Allen, L. F. and Lefkowitz, R. J. (1994) Direct evidence that Gi-coupled receptor stimulation of mitogen-activated protein kinase is mediated by Gβγ activation of p21ras. Proc. Natl. Acad. Sci. U.S.A. 91, 12706-12710
30. Neptune, E. R. and Bourne, H. R. (1997) Receptors induce chemotaxis by releasing the betagamma subunit of Gi, not by activating Gq or Gs. Proc. Natl. Acad. Sci. U.S.A. 94, 14489-14494
31. Jo, H., Sipos, K., Go, Y. M., Law, R., Rong, J. and McDonald, J. M. (1997) Differential effect of shear stress on extracellular signal-regulated kinase and N-terminal Jun kinase in endothelial cells. Gi2- and Gβγ-dependent signaling pathways. J. Biol. Chem. 272, 1395-1401
32. Herrlich, A., Daub, H., Knebel, A., Herrlich, P., Ullrich, A., Schultz, G. and Gudermann, T. (1998) Ligand-independent activation of platelet-derived growth factor receptor is a necessary intermediate in lysophosphatidic, acid-stimulated mitogenic activity in L cells. Proc. Natl. Acad. Sci. U.S.A. 95, 8985-8990
33. Heeneman, S., Haendeler, J., Saito, Y., Ishida, M. and Berk, B. C. (2000) Angiotensin II induces transactivation of two different populations of the platelet-derived growth factor β receptor. Key role for the p66 adaptor protein Shc. J. Biol. Chem. 275, 15926-15932
34. Luttrell, L. M., Delia Rocca, G. J., van Biesen, T., Luttrell, D. K. and Lefkowitz, R. J. (1997) Gβγ subunits mediate Src-dependent phosphorylation of the epidermal growth factor receptor. A scaffold for G protein-coupled receptor-mediated Ras activation. J. Biol. Chem. 272, 4637-4644
35. Bisotto, S. and Fixman, E. D. (2001) Src-family tyrosine kinases, phosphoinositide 3-kinase and Gab1 regulate extracellular signal-regulated kinase 1 activation induced by the type A endothelin-1 G-protein-coupled receptor. Biochem. J. 360, 77-85
36. Alderton, F., Rakhit, S., Kong, K. C., Palmer, T., Sambi, B., Pyne, S. and Pyne, N. J. (2001) Tethering of the platelet-derived growth factor β receptor to G-protein-coupled receptors, A novel platform for integrative signaling by these receptor classes in mammalian cells. J. Biol Chem. 276, 28578-28585
37. 1 receptor to phosphatidylinositol 3-kinase. Endocrinology 19, 2978-2987
38. Foukas, L. C., Beeton, C. A., Jensen, J., Phillips, W. A. and Shepherd, P. R. (2004) Regulation of phosphoinositide 3-kinase by its intrinsic serine kinase activity in vivo. Mol. Cell. Biol. 24, 966-975
39. 2 is a highly selective activator of phospholipid-dependent enzymes. J. Biol. Chem. 275, 13746-13754
40. Czauderna, F., Fechtner, M., Aygun, H., Arnold, W., Klippel, A., Giese, K. and Kaufmann, J. (2003) Functional studies of the PI(3)-kinase signaling pathway employing synthetic and expressed siRNA. Nucleic Acids Res. 31, 670-682
41. 2+ influx by enhancing inositol 1,4,5-trisphosphate production. J. Biol. Chem. 276, 17213-17220