Molecular determinants of PI3Kγ-mediated activation downstream of G-protein-coupled receptors (GPCRs)

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 47, 2013, Pages 18862-18867

  Vadas, Oscar ^a,e   Dbouk, Hashem A ^b,f   Shymanets, Aliaksei ^c   Perisic, Olga ^a   Burke, John E ^a   Saab, Widian F Abi ^b   Khalil, Bassem D ^b   Harteneck, Christian ^c   Bresnick, Anne R ^d   Nürnberg, Bernd ^c   Backer, Jonathan M ^b   Williams, Roger L ^a  

^a MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^b Departments of Molecular Pharmacology   (United Kingdom)

^c UNIVERSITY OF TÜBINGEN   (Germany)

^d ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^e UNIVERSITY OF GENEVA   (Switzerland)

^f UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ADRENERGIC RECEPTOR KINASE; G BETA GAMMA HETERODIMER; G PROTEIN COUPLED RECEPTOR; HETERODIMER; PHOSPHATIDYLINOSITOL 3 KINASE GAMMA; PROTEIN; PROTEIN P101; PROTEIN P110 GAMMA; PROTEIN P85; PROTEIN P87; PROTEIN RAB5; UNCLASSIFIED DRUG;

AFFECT; ARTICLE; BINDING SITE; CELL TRANSFORMATION; CHEMOTAXIS; CONFORMATIONAL TRANSITION; DEUTERIUM HYDROGEN EXCHANGE; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ASSAY; ENZYME BINDING; LIPID MEMBRANE; MASS SPECTROMETRY; MEMBRANE BINDING; PRIORITY JOURNAL; PROTEIN EXPRESSION;

HDX-MS; ONCOGENE; PIK3CG; PIK3R5; PIP3;

ANIMALS; CHEMOTAXIS; CLASS IB PHOSPHATIDYLINOSITOL 3-KINASE; DEUTERIUM EXCHANGE MEASUREMENT; ENZYME ACTIVATION; HEK293 CELLS; HUMANS; MASS SPECTROMETRY; MICE; MICROSCOPY, CONFOCAL; MODELS, MOLECULAR; NIH 3T3 CELLS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTEIN CONFORMATION; RAS PROTEINS; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION;

EID: 84888121509     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1304801110     Document Type: Article

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