β-Catenin confers resistance to PI3K and AKT inhibitors and subverts FOXO3a to promote metastasis in colon cancer

Nature Medicine

Volumn 18, Issue 6, 2012, Pages 892-901

  Tenbaum, Stephan P ^a   Ordóñez Morán, Paloma ^b,k   Puig, Isabel ^a   Chicote, Irene ^a   Arqués, Oriol ^a   Landolfi, Stefania ^c   Fernández, Yolanda ^d   Herance, José Raúl ^e   Gispert, Juan D ^e   Mendizabal, Leire ^f   Aguilar, Susana ^g,h   Ramón Y Cajal, Santiago ^c   Schwartz Jr , Simó ^d   Vivancos, Ana ^f   Espín, Eloy ^c   Rojas, Santiago ^e   Baselga, José ^i,j   Tabernero, Josep ^c   Muñoz, Alberto ^b   Palmer, Héctor G ^a  

^a VALL D HEBRON UNIVERSITY HOSPITAL   (Spain)

^b INSTITUTO DE INVESTIGACIONES BIOMÉDICAS ALBERTO SOLS   (Spain)

^c HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

^d UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^e Barcelona Biomedical Research Park   (Spain)

^f Genomics Cancer Group   (Spain)

^g UNIVERSITY COLLEGE LONDON   (United Kingdom)

^h IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

ⁱ HARVARD MEDICAL SCHOOL   (United States)

^j HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^k EPFL   (Switzerland)

more..

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; BUPARLISIB; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; TRANSCRIPTION FACTOR FKHRL1; TRICIRIBINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COLON CANCER; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG RESPONSE; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN CELL; METASTASIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; WNT SIGNALING PATHWAY;

ANIMALS; APOPTOSIS; BETA CATENIN; CELL LINE, TUMOR; CELL NUCLEUS; CHLORPROPAMIDE; COLONIC NEOPLASMS; DOXYCYCLINE; DRUG RESISTANCE, NEOPLASM; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; MICE; MICE, SCID; NEOPLASM METASTASIS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; TAMOXIFEN; WNT SIGNALING PATHWAY;

MUS;

EID: 84862013453     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.2772     Document Type: Article

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