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Volumn 27, Issue 18, 2008, Pages 2561-2574

Oncogenic signaling of class I PI3K isoforms

Author keywords

Inhibitor; M EK; Oncogen ic transformation; PI3K; Ras; Signaling

Indexed keywords

GLYCOGEN SYNTHASE KINASE 3BETA; ISOENZYME; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE KINASE; MUTANT PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RAS PROTEIN; TRANSCRIPTION FACTOR FKHR;

EID: 42249098543     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/sj.onc.1210918     Document Type: Article
Times cited : (91)

References (75)
  • 1
    • 7244232917 scopus 로고    scopus 로고
    • Essential role for the p110delta phosphoinositide 3-kinase in the allergic response
    • Ali K, Bilancio A, Thomas M, Pearce W, Gilfillan AM, Tkaczyk C et al. (2004). Essential role for the p110delta phosphoinositide 3-kinase in the allergic response. Nature 431: 1007-1011.
    • (2004) Nature , vol.431 , pp. 1007-1011
    • Ali, K.1    Bilancio, A.2    Thomas, M.3    Pearce, W.4    Gilfillan, A.M.5    Tkaczyk, C.6
  • 3
    • 0035793086 scopus 로고    scopus 로고
    • A role of the kinase mTOR in cellular transformation induced by the oncoproteins P3k and Akt
    • Aoki M, Blazek E, Vogt PK. (2001). A role of the kinase mTOR in cellular transformation induced by the oncoproteins P3k and Akt. Proc Natl Acad Sci USA 98: 136-141.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 136-141
    • Aoki, M.1    Blazek, E.2    Vogt, P.K.3
  • 4
    • 4544312844 scopus 로고    scopus 로고
    • Proteasomal degradation of the FoxO1 transcriptional regulator in cells transformed by the P3k and Akt oncoproteins
    • e-pub ahead of print: 1 September
    • Aoki M, Jiang H, Vogt PK. (2004). Proteasomal degradation of the FoxO1 transcriptional regulator in cells transformed by the P3k and Akt oncoproteins. Proc Natl Acad Sci USA 101: 13613-13617. e-pub ahead of print: 1 September 2004.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 13613-13617
    • Aoki, M.1    Jiang, H.2    Vogt, P.K.3
  • 5
    • 0034092571 scopus 로고    scopus 로고
    • The catalytic subunit of phosphoinositide 3-kinase: Requirements for oncogenicity
    • Aoki M, Schetter C, Himly M, Batista O, Chang HW, Vogt PK. (2000). The catalytic subunit of phosphoinositide 3-kinase: requirements for oncogenicity. J Biol Chem 275: 6267-6275.
    • (2000) J Biol Chem , vol.275 , pp. 6267-6275
    • Aoki, M.1    Schetter, C.2    Himly, M.3    Batista, O.4    Chang, H.W.5    Vogt, P.K.6
  • 6
    • 24744449495 scopus 로고    scopus 로고
    • PI3Kgamma inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus
    • e-pub ahead of print: 28 August
    • Barber DF, Bartolome A, Hernandez C, Flores JM, Redondo C, Fernandez-Arias C et al. (2005). PI3Kgamma inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus. Nat Med 11: 933-935. e-pub ahead of print: 28 August 2005.
    • (2005) Nat Med , vol.11 , pp. 933-935
    • Barber, D.F.1    Bartolome, A.2    Hernandez, C.3    Flores, J.M.4    Redondo, C.5    Fernandez-Arias, C.6
  • 7
    • 0036185944 scopus 로고    scopus 로고
    • Early embryonic lethality in mice deficient in the p110beta catalytic subunit of PI 3-kinase
    • Bi L, Okabe I, Bernard DJ, Nussbaum RL. (2002). Early embryonic lethality in mice deficient in the p110beta catalytic subunit of PI 3-kinase. Mamm Genome 13: 169-172.
    • (2002) Mamm Genome , vol.13 , pp. 169-172
    • Bi, L.1    Okabe, I.2    Bernard, D.J.3    Nussbaum, R.L.4
  • 8
    • 0033574429 scopus 로고    scopus 로고
    • Proliferative defect and embryonic lethality in mice homozygous for a deletion in the p110alpha subunit of phosphoinositide 3-kinase
    • Bi L, Okabe I, Bernard DJ, Wynshaw-Boris A, Nussbaum RL. (1999). Proliferative defect and embryonic lethality in mice homozygous for a deletion in the p110alpha subunit of phosphoinositide 3-kinase. J Biol Chem 274: 10963-10968.
    • (1999) J Biol Chem , vol.274 , pp. 10963-10968
    • Bi, L.1    Okabe, I.2    Bernard, D.J.3    Wynshaw-Boris, A.4    Nussbaum, R.L.5
  • 9
    • 0033595011 scopus 로고    scopus 로고
    • Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1
    • Biggs III WH, Meisenhelder J, Hunter T, Cavenee WK, Arden KC. (1999). Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1. Proc Natl Acad Sci USA 96: 7421-7426.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 7421-7426
    • Biggs III, W.H.1    Meisenhelder, J.2    Hunter, T.3    Cavenee, W.K.4    Arden, K.C.5
  • 10
    • 33750459743 scopus 로고    scopus 로고
    • A selective inhibitor of the p110delta isoform of PI 3-kinase inhibits AML cell proliferation and survival and increases the cytotoxic effects of VP16
    • Billottet C, Grandage VL, Gale RE, Quattropani A, Rommel C, Vanhaesebroeck B et al. (2006). A selective inhibitor of the p110delta isoform of PI 3-kinase inhibits AML cell proliferation and survival and increases the cytotoxic effects of VP16. Oncogene 25: 6648-6659.
    • (2006) Oncogene , vol.25 , pp. 6648-6659
    • Billottet, C.1    Grandage, V.L.2    Gale, R.E.3    Quattropani, A.4    Rommel, C.5    Vanhaesebroeck, B.6
  • 11
    • 0037938663 scopus 로고    scopus 로고
    • Requirement for the PI3K/Akt pathway in MEK1-mediated growth and prevention of apoptosis: Identification of an Achilles heel in leukemia
    • Blalock WL, Navolanic PM, Steelman LS, Shelton JG, Moye PW, Lee JT et al. (2003). Requirement for the PI3K/Akt pathway in MEK1-mediated growth and prevention of apoptosis: identification of an Achilles heel in leukemia. Leukemia 17: 1058-1067.
    • (2003) Leukemia , vol.17 , pp. 1058-1067
    • Blalock, W.L.1    Navolanic, P.M.2    Steelman, L.S.3    Shelton, J.G.4    Moye, P.W.5    Lee, J.T.6
  • 12
    • 0032500730 scopus 로고    scopus 로고
    • Bifurcation of lipid and protein kinase signals of PI3Kgamma to the protein kinases PKB and MAPK
    • Bondeva T, Pirola L, Bulgarelli-Leva G, Rubio I, Wetzker R, Wymann MP. (1998). Bifurcation of lipid and protein kinase signals of PI3Kgamma to the protein kinases PKB and MAPK. Science 282: 293-296.
    • (1998) Science , vol.282 , pp. 293-296
    • Bondeva, T.1    Pirola, L.2    Bulgarelli-Leva, G.3    Rubio, I.4    Wetzker, R.5    Wymann, M.P.6
  • 13
    • 0035911144 scopus 로고    scopus 로고
    • A specific role of phosphatidylinositol 3-kinase gamma. A regulation of autonomic Ca(2)+ oscillations in cardiac cells
    • Bony C, Roche S, Shuichi U, Sasaki T, Crackower MA, Penninger J et al. (2001). A specific role of phosphatidylinositol 3-kinase gamma. A regulation of autonomic Ca(2)+ oscillations in cardiac cells. J Cell Biol 152: 717-728.
    • (2001) J Cell Biol , vol.152 , pp. 717-728
    • Bony, C.1    Roche, S.2    Shuichi, U.3    Sasaki, T.4    Crackower, M.A.5    Penninger, J.6
  • 14
    • 0025059554 scopus 로고
    • Efficient transformation of chicken embryo fibroblasts by c-Jun requires structural modification in coding and noncoding sequences
    • Bos TJ, Monteclaro FS, Mitsunobu F, Ball Jr AR, Chang CH, Nishimura T et al. (1990). Efficient transformation of chicken embryo fibroblasts by c-Jun requires structural modification in coding and noncoding sequences. Genes Dev 4: 1677-1687.
    • (1990) Genes Dev , vol.4 , pp. 1677-1687
    • Bos, T.J.1    Monteclaro, F.S.2    Mitsunobu, F.3    Ball Jr, A.R.4    Chang, C.H.5    Nishimura, T.6
  • 15
    • 3543028648 scopus 로고    scopus 로고
    • Myc-induced proliferation and transformation require Akt-mediated phosphorylation of FoxO proteins
    • e-pub ahead of print: 8 July
    • Bouchard C, Marquardt J, Bras A, Medema RH, Eilers M. (2004). Myc-induced proliferation and transformation require Akt-mediated phosphorylation of FoxO proteins. EMBO J 23: 2830-2840. e-pub ahead of print: 8 July 2004.
    • (2004) EMBO J , vol.23 , pp. 2830-2840
    • Bouchard, C.1    Marquardt, J.2    Bras, A.3    Medema, R.H.4    Eilers, M.5
  • 16
    • 0033582929 scopus 로고    scopus 로고
    • Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
    • Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, Hu LS et al. (1999). Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 96: 857-868.
    • (1999) Cell , vol.96 , pp. 857-868
    • Brunet, A.1    Bonni, A.2    Zigmond, M.J.3    Lin, M.Z.4    Juo, P.5    Hu, L.S.6
  • 18
    • 24744435115 scopus 로고    scopus 로고
    • Camps M, Ruckle T, Ji H, Ardissone V, Rintelen F, Shaw J et al. (2005). Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis. Nat Med 11: 936-943.e-pub ahead of print: 28 August 2005.
    • Camps M, Ruckle T, Ji H, Ardissone V, Rintelen F, Shaw J et al. (2005). Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis. Nat Med 11: 936-943.e-pub ahead of print: 28 August 2005.
  • 19
    • 0037810249 scopus 로고    scopus 로고
    • Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: Potential targeting for therapeutic intervention
    • Chang F, Steelman LS, Lee JT, Shelton JG, Navolanic PM, Blalock WL et al. (2003). Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention. Leukemia 17: 1263-1293.
    • (2003) Leukemia , vol.17 , pp. 1263-1293
    • Chang, F.1    Steelman, L.S.2    Lee, J.T.3    Shelton, J.G.4    Navolanic, P.M.5    Blalock, W.L.6
  • 20
    • 0000440912 scopus 로고    scopus 로고
    • Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase
    • Chang HW, Aoki M, Fruman D, Auger KR, Bellacosa A, Tsichlis PN et al. (1997). Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase. Science 276: 1848-1850.
    • (1997) Science , vol.276 , pp. 1848-1850
    • Chang, H.W.1    Aoki, M.2    Fruman, D.3    Auger, K.R.4    Bellacosa, A.5    Tsichlis, P.N.6
  • 21
    • 16444380336 scopus 로고    scopus 로고
    • Role of glycogen synthase kinase 3beta in rapamycin-mediated cell cycle regulation and chemosensitivity
    • Dong J, Peng J, Zhang H, Mondesire WH, Jian W, Mills GB et al. (2005). Role of glycogen synthase kinase 3beta in rapamycin-mediated cell cycle regulation and chemosensitivity. Cancer Res 65: 1961-1972.
    • (2005) Cancer Res , vol.65 , pp. 1961-1972
    • Dong, J.1    Peng, J.2    Zhang, H.3    Mondesire, W.H.4    Jian, W.5    Mills, G.B.6
  • 22
    • 33746257209 scopus 로고    scopus 로고
    • The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
    • Engelman JA, Luo J, Cantley LC. (2006). The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Nat Rev Genet 7: 606-619.
    • (2006) Nat Rev Genet , vol.7 , pp. 606-619
    • Engelman, J.A.1    Luo, J.2    Cantley, L.C.3
  • 24
    • 33751225349 scopus 로고    scopus 로고
    • Isoform specific inhibitors of PI3 kinase in glioma
    • e-pub ahead of print: 16 October
    • Fan QW, Weiss WA. (2006). Isoform specific inhibitors of PI3 kinase in glioma. Cell Cycle 5: 2301-2305. e-pub ahead of print: 16 October 2006.
    • (2006) Cell Cycle , vol.5 , pp. 2301-2305
    • Fan, Q.W.1    Weiss, W.A.2
  • 25
    • 17144387901 scopus 로고    scopus 로고
    • PI3-kinase/Akt is constitutively active in primary acute myeloid leukaemia cells and regulates survival and chemoresistance via NF-kappaB, Mapkinase and p53 pathways
    • Grandage VL, Gale RE, Linch DC, Khwaja A. (2005). PI3-kinase/Akt is constitutively active in primary acute myeloid leukaemia cells and regulates survival and chemoresistance via NF-kappaB, Mapkinase and p53 pathways. Leukemia 19: 586-594.
    • (2005) Leukemia , vol.19 , pp. 586-594
    • Grandage, V.L.1    Gale, R.E.2    Linch, D.C.3    Khwaja, A.4
  • 26
    • 34249026448 scopus 로고    scopus 로고
    • Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice
    • Gupta S, Ramjaun AR, Haiko P, Wang Y, Warne PH, Nicke B et al. (2007). Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice. Cell 129: 957-968.
    • (2007) Cell , vol.129 , pp. 957-968
    • Gupta, S.1    Ramjaun, A.R.2    Haiko, P.3    Wang, Y.4    Warne, P.H.5    Nicke, B.6
  • 27
    • 34248369435 scopus 로고    scopus 로고
    • Gymnopoulos M, Elsliger MA, Vogt PK. (2007). Rare cancer-specific mutations in PIK3CA show gain of function. Proc Natl Acad Sci USA 104: 5569-5574.e-pub ahead of print 21 March 2007.
    • Gymnopoulos M, Elsliger MA, Vogt PK. (2007). Rare cancer-specific mutations in PIK3CA show gain of function. Proc Natl Acad Sci USA 104: 5569-5574.e-pub ahead of print 21 March 2007.
  • 28
    • 0034463918 scopus 로고    scopus 로고
    • A rapamycin-sensitive pathway down-regulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1
    • Haruta T, Uno T, Kawahara J, Takano A, Egawa K, Sharma PM et al. (2000). A rapamycin-sensitive pathway down-regulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1. Mol Endocrinol 14: 783-794.
    • (2000) Mol Endocrinol , vol.14 , pp. 783-794
    • Haruta, T.1    Uno, T.2    Kawahara, J.3    Takano, A.4    Egawa, K.5    Sharma, P.M.6
  • 30
    • 33845313646 scopus 로고    scopus 로고
    • Heo WD, Inoue T, Park WS, Kim ML, Park BO, Wandless TJ et al. (2006). PI(3,4,5)P3 and PI(4,5)P2 lipids target proteins with polybasic clusters to the plasma membrane. Science 314: 1458-1461. e-pub ahead of print: 9 November 2006.
    • Heo WD, Inoue T, Park WS, Kim ML, Park BO, Wandless TJ et al. (2006). PI(3,4,5)P3 and PI(4,5)P2 lipids target proteins with polybasic clusters to the plasma membrane. Science 314: 1458-1461. e-pub ahead of print: 9 November 2006.
  • 31
    • 33646370512 scopus 로고    scopus 로고
    • BCR-ABL regulates phosphatidylinositol 3-kinase-p110gamma transcription and activation and is required for proliferation and drug resistance
    • e-pub ahead of print: 16 November
    • Hickey FB, Cotter TG. (2006). BCR-ABL regulates phosphatidylinositol 3-kinase-p110gamma transcription and activation and is required for proliferation and drug resistance. J Biol Chem 281: 2441-2450. e-pub ahead of print: 16 November 2005.
    • (2005) J Biol Chem , vol.281 , pp. 2441-2450
    • Hickey, F.B.1    Cotter, T.G.2
  • 32
    • 0033952239 scopus 로고    scopus 로고
    • The PI 3-kinase isoforms p110(alpha) and p110(beta) have differential roles in PDGF- and insulin-mediated signaling
    • Hooshmand-Rad R, Hajkova L, Klint P, Karlsson R, Vanhaesebroeck B, Claesson-Welsh L et al. (2000). The PI 3-kinase isoforms p110(alpha) and p110(beta) have differential roles in PDGF- and insulin-mediated signaling. J Cell Sci 113: 207-214.
    • (2000) J Cell Sci , vol.113 , pp. 207-214
    • Hooshmand-Rad, R.1    Hajkova, L.2    Klint, P.3    Karlsson, R.4    Vanhaesebroeck, B.5    Claesson-Welsh, L.6
  • 33
    • 21044454703 scopus 로고    scopus 로고
    • Jackson SP, Schoenwaelder SM, Goncalves I, Nesbitt WS, Yap CL, Wright CE et al. (2005). PI 3-kinase p110beta: a new target for antithrombotic therapy. Nat Med 11: 507-514.e-pub ahead of print: 17 April 2005.
    • Jackson SP, Schoenwaelder SM, Goncalves I, Nesbitt WS, Yap CL, Wright CE et al. (2005). PI 3-kinase p110beta: a new target for antithrombotic therapy. Nat Med 11: 507-514.e-pub ahead of print: 17 April 2005.
  • 34
    • 14144252004 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic
    • e-pub ahead of print: 12 January
    • Kang S, Bader AG, Vogt PK. (2005). Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic. Proc Natl Acad Sci USA 102: 802-807. e-pub ahead of print: 12 January 2005.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 802-807
    • Kang, S.1    Bader, A.G.2    Vogt, P.K.3
  • 35
    • 31944448780 scopus 로고    scopus 로고
    • Oncogenic transformation induced by the p110beta, -gamma, and -delta isoforms of class I phosphoinositide 3-kinase
    • e-pub ahead of print: 23 January
    • Kang S, Denley A, Vanhaesebroeck B, Vogt PK. (2006). Oncogenic transformation induced by the p110beta, -gamma, and -delta isoforms of class I phosphoinositide 3-kinase. Proc Natl Acad Sci USA 103: 1289-1294. e-pub ahead of print: 23 January 2006.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 1289-1294
    • Kang, S.1    Denley, A.2    Vanhaesebroeck, B.3    Vogt, P.K.4
  • 36
    • 0021219156 scopus 로고
    • New procedure for DNA transfection with polycation and dimethyl sulfoxide
    • Kawai S, Nishizawa M. (1984). New procedure for DNA transfection with polycation and dimethyl sulfoxide. Mol Cell Biol 4: 1172-1174.
    • (1984) Mol Cell Biol , vol.4 , pp. 1172-1174
    • Kawai, S.1    Nishizawa, M.2
  • 37
    • 2542504461 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase signaling is essential for ABL oncogene-mediated transformation of B-lineage cells
    • e-pub ahead of print: 19 February
    • Kharas MG, Deane JA, Wong S, O'Bosky KR, Rosenberg N, Witte ON et al. (2004). Phosphoinositide 3-kinase signaling is essential for ABL oncogene-mediated transformation of B-lineage cells. Blood 103: 4268-4275. e-pub ahead of print: 19 February 2004.
    • (2004) Blood , vol.103 , pp. 4268-4275
    • Kharas, M.G.1    Deane, J.A.2    Wong, S.3    O'Bosky, K.R.4    Rosenberg, N.5    Witte, O.N.6
  • 38
    • 0037194613 scopus 로고    scopus 로고
    • Phosphatidylinositol-3 kinase inhibitors enhance the anti-leukemia effect of STI571
    • Klejman A, Rushen L, Morrione A, Slupianek A, Skorski T. (2002). Phosphatidylinositol-3 kinase inhibitors enhance the anti-leukemia effect of STI571. Oncogene 21: 5868-5876.
    • (2002) Oncogene , vol.21 , pp. 5868-5876
    • Klejman, A.1    Rushen, L.2    Morrione, A.3    Slupianek, A.4    Skorski, T.5
  • 39
    • 33646383684 scopus 로고    scopus 로고
    • Knight ZA, Gonzalez B, Feldman ME, Zunder ER, Goldenberg DD, Williams O et al. (2006). A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling. Cell 125: 733-747. e-pub ahead of print: 27 April 2006.
    • Knight ZA, Gonzalez B, Feldman ME, Zunder ER, Goldenberg DD, Williams O et al. (2006). A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling. Cell 125: 733-747. e-pub ahead of print: 27 April 2006.
  • 40
    • 4344653856 scopus 로고    scopus 로고
    • Constitutive activation of PI3K is involved in the spontaneous proliferation of primary acute myeloid leukemia cells: Direct evidence of PI3K activation
    • Kubota Y, Ohnishi H, Kitanaka A, Ishida T, Tanaka T. (2004). Constitutive activation of PI3K is involved in the spontaneous proliferation of primary acute myeloid leukemia cells: direct evidence of PI3K activation. Leukemia 18: 1438-1440.
    • (2004) Leukemia , vol.18 , pp. 1438-1440
    • Kubota, Y.1    Ohnishi, H.2    Kitanaka, A.3    Ishida, T.4    Tanaka, T.5
  • 41
    • 0141532180 scopus 로고    scopus 로고
    • Class I phosphoinositide 3-kinase p110beta is required for apoptotic cell and Fcgamma receptor-mediated phagocytosis by macrophages
    • e-pub ahead of print: 16 July
    • Leverrier Y, Okkenhaug K, Sawyer C, Bilancio A, Vanhaesebroeck B, Ridley AJ. (2003). Class I phosphoinositide 3-kinase p110beta is required for apoptotic cell and Fcgamma receptor-mediated phagocytosis by macrophages. J Biol Chem 278: 38437-38442. e-pub ahead of print: 16 July 2003.
    • (2003) J Biol Chem , vol.278 , pp. 38437-38442
    • Leverrier, Y.1    Okkenhaug, K.2    Sawyer, C.3    Bilancio, A.4    Vanhaesebroeck, B.5    Ridley, A.J.6
  • 43
    • 33744457653 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase/Akt signaling pathway and its therapeutical implications for human acute myeloid leukemia
    • Martelli AM, Nyakern M, Tabellini G, Bortul R, Tazzari PL, Evangelisti C et al. (2006). Phosphoinositide 3-kinase/Akt signaling pathway and its therapeutical implications for human acute myeloid leukemia. Leukemia 20: 911-928.
    • (2006) Leukemia , vol.20 , pp. 911-928
    • Martelli, A.M.1    Nyakern, M.2    Tabellini, G.3    Bortul, R.4    Tazzari, P.L.5    Evangelisti, C.6
  • 44
    • 0035224494 scopus 로고    scopus 로고
    • Interactions between the PI3K and Raf signaling pathways can result in the transformation of hematopoietic cells
    • McCubrey JA, Lee JT, Steelman LS, Blalock WL, Moye PW, Chang F et al. (2001). Interactions between the PI3K and Raf signaling pathways can result in the transformation of hematopoietic cells. Cancer Detect Prev 25: 375-393.
    • (2001) Cancer Detect Prev , vol.25 , pp. 375-393
    • McCubrey, J.A.1    Lee, J.T.2    Steelman, L.S.3    Blalock, W.L.4    Moye, P.W.5    Chang, F.6
  • 45
    • 34447503808 scopus 로고    scopus 로고
    • Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit
    • Miled N, Yan Y, Hon WC, Perisic O, Zvelebil M, Inbar Y et al. (2007). Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit. Science 317: 239-242.
    • (2007) Science , vol.317 , pp. 239-242
    • Miled, N.1    Yan, Y.2    Hon, W.C.3    Perisic, O.4    Zvelebil, M.5    Inbar, Y.6
  • 46
    • 0037513474 scopus 로고    scopus 로고
    • Constitutive phosphorylation of Akt/PKB protein in acute myeloid leukemia: Its significance as a prognostic variable
    • Min YH, Eom JI, Cheong JW, Maeng HO, Kim JY, Jeung HK et al. (2003). Constitutive phosphorylation of Akt/PKB protein in acute myeloid leukemia: its significance as a prognostic variable. Leukemia 17: 995-997.
    • (2003) Leukemia , vol.17 , pp. 995-997
    • Min, Y.H.1    Eom, J.I.2    Cheong, J.W.3    Maeng, H.O.4    Kim, J.Y.5    Jeung, H.K.6
  • 47
    • 30944461586 scopus 로고    scopus 로고
    • PTEN and GSK3beta: Key regulators of progression to androgen-independent prostate cancer
    • Mulholland DJ, Dedhar S, Wu H, Nelson CC. (2006). PTEN and GSK3beta: key regulators of progression to androgen-independent prostate cancer. Oncogene 25: 329-337.
    • (2006) Oncogene , vol.25 , pp. 329-337
    • Mulholland, D.J.1    Dedhar, S.2    Wu, H.3    Nelson, C.C.4
  • 48
    • 0030467967 scopus 로고    scopus 로고
    • The C2 domain calcium-binding motif: Structural and functional diversity
    • Nalefski EA, Falke JJ. (1996). The C2 domain calcium-binding motif: structural and functional diversity. Protein Sci 5: 2375-2390.
    • (1996) Protein Sci , vol.5 , pp. 2375-2390
    • Nalefski, E.A.1    Falke, J.J.2
  • 49
    • 0032555778 scopus 로고    scopus 로고
    • Protein kinase C: A paradigm for regulation of protein function by two membrane-targeting modules
    • Newton AC, Johnson JE. (1998). Protein kinase C: a paradigm for regulation of protein function by two membrane-targeting modules. Biochim Biophys Acta 1376: 155-172.
    • (1998) Biochim Biophys Acta , vol.1376 , pp. 155-172
    • Newton, A.C.1    Johnson, J.E.2
  • 50
    • 0037047590 scopus 로고    scopus 로고
    • Impaired B and T cell antigen receptor signaling in p110delta PI 3-kinase mutant mice
    • e-pub ahead of print: 18 July
    • Okkenhaug K, Bilancio A, Farjot G, Priddle H, Sancho S, Peskett E et al. (2002). Impaired B and T cell antigen receptor signaling in p110delta PI 3-kinase mutant mice. Science 297: 1031-1034. e-pub ahead of print: 18 July 2002.
    • (2002) Science , vol.297 , pp. 1031-1034
    • Okkenhaug, K.1    Bilancio, A.2    Farjot, G.3    Priddle, H.4    Sancho, S.5    Peskett, E.6
  • 51
    • 32944457518 scopus 로고    scopus 로고
    • mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt
    • O'Reilly KE, Rojo F, She QB, Solit D, Mills GB, Smith D et al. (2006). mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt. Cancer Res 66: 1500-1508.
    • (2006) Cancer Res , vol.66 , pp. 1500-1508
    • O'Reilly, K.E.1    Rojo, F.2    She, Q.B.3    Solit, D.4    Mills, G.B.5    Smith, D.6
  • 52
    • 33750508152 scopus 로고    scopus 로고
    • Input from Ras is required for maximal PI(3)K signalling in, e-pub ahead of print: 15 October
    • Orme MH, Alrubaie S, Bradley GL, Walker CD, Leevers SJ. (2006). Input from Ras is required for maximal PI(3)K signalling in Drosophila. Nat Cell Biol 8: 1298-1302. e-pub ahead of print: 15 October 2006.
    • (2006) Drosophila. Nat Cell Biol , vol.8 , pp. 1298-1302
    • Orme, M.H.1    Alrubaie, S.2    Bradley, G.L.3    Walker, C.D.4    Leevers, S.J.5
  • 53
    • 0032568662 scopus 로고    scopus 로고
    • C2-domains, structure and function of a universal Ca2+-binding domain
    • Rizo J, Sudhof TC. (1998). C2-domains, structure and function of a universal Ca2+-binding domain. J Biol Chem 273: 15879-15882.
    • (1998) J Biol Chem , vol.273 , pp. 15879-15882
    • Rizo, J.1    Sudhof, T.C.2
  • 54
    • 20144387695 scopus 로고    scopus 로고
    • PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma
    • Saal LH, Holm K, Maurer M, Memeo L, Su T, Wang X et al. (2005). PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma. Cancer Res 65: 2554-2559.
    • (2005) Cancer Res , vol.65 , pp. 2554-2559
    • Saal, L.H.1    Holm, K.2    Maurer, M.3    Memeo, L.4    Su, T.5    Wang, X.6
  • 55
    • 0037369696 scopus 로고    scopus 로고
    • Essential role of phosphoinositide 3-kinase delta in neutrophil directional movement
    • Sadhu C, Masinovsky B, Dick K, Sowell CG, Staunton DE. (2003). Essential role of phosphoinositide 3-kinase delta in neutrophil directional movement. J Immunol 170: 2647-2654.
    • (2003) J Immunol , vol.170 , pp. 2647-2654
    • Sadhu, C.1    Masinovsky, B.2    Dick, K.3    Sowell, C.G.4    Staunton, D.E.5
  • 56
    • 11144358645 scopus 로고    scopus 로고
    • High frequency of mutations of the PIK3CA gene in human cancers
    • e-pub ahead of print: 11 March
    • Samuels Y, Wang Z, Bardelli A, Silliman N, Ptak J, Szabo S et al. (2004). High frequency of mutations of the PIK3CA gene in human cancers. Science 304: 554. e-pub ahead of print: 11 March 2004.
    • (2004) Science , vol.304 , pp. 554
    • Samuels, Y.1    Wang, Z.2    Bardelli, A.3    Silliman, N.4    Ptak, J.5    Szabo, S.6
  • 58
    • 1642332084 scopus 로고    scopus 로고
    • Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation
    • Seoane J, Le HV, Shen L, Anderson SA, Massague J. (2004). Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation. Cell 117: 211-223.
    • (2004) Cell , vol.117 , pp. 211-223
    • Seoane, J.1    Le, H.V.2    Shen, L.3    Anderson, S.A.4    Massague, J.5
  • 59
    • 0030712317 scopus 로고    scopus 로고
    • Further evidence that the inhibition of glycogen synthase kinase-3beta by IGF-1 is mediated by PDK1/PKB-induced phosphorylation of Ser-9 and not by dephosphorylation of Tyr-216
    • Shaw M, Cohen P, Alessi DR. (1997). Further evidence that the inhibition of glycogen synthase kinase-3beta by IGF-1 is mediated by PDK1/PKB-induced phosphorylation of Ser-9 and not by dephosphorylation of Tyr-216. FEBS Lett 416: 307-311.
    • (1997) FEBS Lett , vol.416 , pp. 307-311
    • Shaw, M.1    Cohen, P.2    Alessi, D.R.3
  • 60
    • 0030710188 scopus 로고    scopus 로고
    • Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway
    • Skorski T, Bellacosa A, Nieborowska-Skorska M, Majewski M, Martinez R, Choi JK et al. (1997). Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway. EMBO J 16: 6151-6161.
    • (1997) EMBO J , vol.16 , pp. 6151-6161
    • Skorski, T.1    Bellacosa, A.2    Nieborowska-Skorska, M.3    Majewski, M.4    Martinez, R.5    Choi, J.K.6
  • 62
    • 33750523841 scopus 로고    scopus 로고
    • Gbetagammas and the Ras binding domain of p110gamma are both important regulators of PI(3)Kgamma signalling in neutrophils
    • e-pub ahead of print: 15 October
    • Suire S, Condliffe AM, Ferguson GJ, Ellson CD, Guillou H, Davidson K et al. (2006). Gbetagammas and the Ras binding domain of p110gamma are both important regulators of PI(3)Kgamma signalling in neutrophils. Nat Cell Biol 8: 1303-1309. e-pub ahead of print: 15 October 2006.
    • (2006) Nat Cell Biol , vol.8 , pp. 1303-1309
    • Suire, S.1    Condliffe, A.M.2    Ferguson, G.J.3    Ellson, C.D.4    Guillou, H.5    Davidson, K.6
  • 63
    • 22544444889 scopus 로고    scopus 로고
    • Essential role for the p110delta isoform in phosphoinositide 3-kinase activation and cell proliferation in acute myeloid leukemia
    • Sujobert P, Bardet V, Cornillet-Lefebvre P, Hayflick JS, Prie N, Verdier F et al. (2005). Essential role for the p110delta isoform in phosphoinositide 3-kinase activation and cell proliferation in acute myeloid leukemia. Blood 106: 1063-1066.
    • (2005) Blood , vol.106 , pp. 1063-1066
    • Sujobert, P.1    Bardet, V.2    Cornillet-Lefebvre, P.3    Hayflick, J.S.4    Prie, N.5    Verdier, F.6
  • 64
    • 23844438209 scopus 로고    scopus 로고
    • Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition
    • Sun SY, Rosenberg LM, Wang X, Zhou Z, Yue P, Fu H et al. (2005). Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition. Cancer Res 65: 7052-7058.
    • (2005) Cancer Res , vol.65 , pp. 7052-7058
    • Sun, S.Y.1    Rosenberg, L.M.2    Wang, X.3    Zhou, Z.4    Yue, P.5    Fu, H.6
  • 69
    • 33646364876 scopus 로고    scopus 로고
    • PI 3-kinases: Hidden potentials revealed
    • e-pub ahead of print: 1 May
    • Vogt PK, Bader AG, Kang S. (2006). PI 3-kinases: hidden potentials revealed. Cell Cycle 5: 946-949. e-pub ahead of print: 1 May 2006.
    • (2006) Cell Cycle , vol.5 , pp. 946-949
    • Vogt, P.K.1    Bader, A.G.2    Kang, S.3
  • 70
    • 0033634827 scopus 로고    scopus 로고
    • Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine
    • Walker EH, Pacold ME, Perisic O, Stephens L, Hawkins PT, Wymann MP et al. (2000). Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine. Mol Cell 6: 909-919.
    • (2000) Mol Cell , vol.6 , pp. 909-919
    • Walker, E.H.1    Pacold, M.E.2    Perisic, O.3    Stephens, L.4    Hawkins, P.T.5    Wymann, M.P.6
  • 71
    • 0037350266 scopus 로고    scopus 로고
    • Therapeutic potential of phosphoinositide 3-kinase inhibitors
    • Ward S, Sotsios Y, Dowden J, Bruce I, Finan P. (2003). Therapeutic potential of phosphoinositide 3-kinase inhibitors. Chem Biol 10: 207-213.
    • (2003) Chem Biol , vol.10 , pp. 207-213
    • Ward, S.1    Sotsios, Y.2    Dowden, J.3    Bruce, I.4    Finan, P.5
  • 72
    • 0041802784 scopus 로고    scopus 로고
    • Isoform-specific phosphoinositide 3-kinase inhibitors as therapeutic agents
    • Ward SG, Finan P. (2003). Isoform-specific phosphoinositide 3-kinase inhibitors as therapeutic agents. Curr Opin Pharmacol 3: 426-434.
    • (2003) Curr Opin Pharmacol , vol.3 , pp. 426-434
    • Ward, S.G.1    Finan, P.2
  • 73
    • 7244221431 scopus 로고    scopus 로고
    • Over-expression of the p110beta but not p110alpha isoform of PI 3-kinase inhibits motility in breast cancer cells
    • Yip SC, El-Sibai M, Hill KM, Wu H, Fu Z, Condeelis JS et al. (2004). Over-expression of the p110beta but not p110alpha isoform of PI 3-kinase inhibits motility in breast cancer cells. Cell Motil Cytoskeleton 59: 180-188.
    • (2004) Cell Motil Cytoskeleton , vol.59 , pp. 180-188
    • Yip, S.C.1    El-Sibai, M.2    Hill, K.M.3    Wu, H.4    Fu, Z.5    Condeelis, J.S.6
  • 74
    • 29444449785 scopus 로고    scopus 로고
    • The oncogenic properties of mutant p110alpha and p110beta phosphatidylinositol 3-kinases in human mammary epithelial cells
    • e-pub ahead of print: 8 December
    • Zhao JJ, Liu Z, Wang L, Shin E, Loda MF, Roberts TM. (2005). The oncogenic properties of mutant p110alpha and p110beta phosphatidylinositol 3-kinases in human mammary epithelial cells. Proc Natl Acad Sci USA 102: 18443-18448. e-pub ahead of print: 8 December 2005.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 18443-18448
    • Zhao, J.J.1    Liu, Z.2    Wang, L.3    Shin, E.4    Loda, M.F.5    Roberts, T.M.6
  • 75
    • 0028329630 scopus 로고
    • Activation of MEK family kinases requires phosphorylation of two conserved Ser/Thr residues
    • Zheng CF, Guan KL. (1994). Activation of MEK family kinases requires phosphorylation of two conserved Ser/Thr residues. EMBO J 13: 1123-1131.
    • (1994) EMBO J , vol.13 , pp. 1123-1131
    • Zheng, C.F.1    Guan, K.L.2


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