The phosphatidylinositol 3′-kinase p85α gene is an oncogene in human ovarian and colon tumors

Cancer Research

Volumn 61, Issue 20, 2001, Pages 7426-7429

  Philp, Amanda J ^a   Leet, Christine ^a   Vincan, Elizabeth ^a   Rockman, Steven P ^a   Thomas, Robert J S ^a   Phillips, Wayne A ^a   Campbell, Ian G ^a   Whitehead, Robert H ^b  

^a PETER MACCALLUM CANCER CENTRE   (Australia)

^b ROYAL MELBOURNE HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ONCOPROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN SERINE THREONINE KINASE; HETERODUPLEX; MUTANT PROTEIN; PROTEIN P85; PROTEIN P85 ALPHA; PROTEIN SUBUNIT; SERINE; UNCLASSIFIED DRUG;

AGED; AMINO ACID SEQUENCE; ARTICLE; CELL CULTURE; COLON TUMOR; DRUG ANTAGONISM; FEMALE; GENETICS; HUMAN; MALE; METABOLISM; MOLECULAR GENETICS; MUTATION; ONCOGENE; OVARY TUMOR; PHOSPHORYLATION; SEQUENCE HOMOLOGY; SINGLE STRAND CONFORMATION POLYMORPHISM; AMINO ACID ANALYSIS; AUTOREGULATION; CANCER CELL CULTURE; CARCINOGENESIS; CELL MIGRATION; ENZYME ACTIVATION; HUMAN CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL;

1-PHOSPHATIDYLINOSITOL 3-KINASE; AGED; AMINO ACID SEQUENCE; COLONIC NEOPLASMS; FEMALE; HUMANS; MALE; MOLECULAR SEQUENCE DATA; MUTATION; ONCOGENES; OVARIAN NEOPLASMS; PHOSPHORYLATION; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; SEQUENCE HOMOLOGY, AMINO ACID; TUMOR CELLS, CULTURED;

EID: 0035886016     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Signaling by distinct classes of phosphoinositide 3-kinases
2. Phosphatidylinositol 3-kinases in tumor progression
3. Increased levels of phosphatidylinositol 3-kinase activity in colorectal tumors
4. A specific function for phosphatidylinositol 3-kinase α (p85α-p110α) in cell survival and for phosphatidylinositol 3-kinase β (p85α-p110β) in de novo DNA synthesis of human colon carcinoma cells
5. Frequent activation of AKT2 and induction of apoptosis by inhibition of phosphoinositide-3-OH kinase/Akt pathway in human ovarian cancer
6. PIK3CA is implicated as an oncogene in ovarian cancer
7. PIK3CA as an oncogene in cervical cancer
8. New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway
9. Retention of tissue-specific phenotype in a panel of colon carcinoma cell lines: Relationship to clinical correlates
10. A colon cancer cell line (LIM1215) derived from a patient with inherited nonpolyposis colorectal cancer
11. A new colon carcinoma cell line (LIM1863) that grows as organoids with spontaneous differentiation into crypt-like structures in vitro
12. A new gastric carcinoma cell line (LIM1839) derived from a young Caucasian male
13. A novel gene encoding a B-box protein within the BRCA1 region at 17q21.1
14. P1 3-kinase is a dual specificity enzyme: Autoregulation by an intrinsic protein-serine kinase activity
15. Insulin receptor substrate 1 binds two novel splice variants of the regulatory subunit of phosphatidylinositol 3-kinase in muscle and brain
16. p85α gene generates three isoforms of regulatory subunit for phosphatidylinositol 3-kinase (P1 3-Kinase), p50α, p55α, and p85α, with different P1 3-kinase activity elevating responses to insulin
17. The P13K-PDK1 connection: More than just a road to PKB
18. Akt/PKB localisation and 3′ phosphoinositide generation at sites of epithelial cell-matrix and cell-cell interaction
19. An oncogenic fusion product of the phosphatidylinositol 3-kinase p85β subunit and HUMORF8, a putative deubiquitinating enzyme
20. Identification and characterization of a new oncogene derived from the regulatory subunit of phosphoinositide 3-kinase