메뉴 건너뛰기




Volumn 443, Issue 3, 2012, Pages 587-601

Regulation and cellular functions of class II phosphoinositide 3-kinases

Author keywords

Cell migration; Glucose transport; Insulin secretion; Phosphoinositide; Phosphoinositide 3 kinase (PI3K)

Indexed keywords

GLUCOSE; INSULIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE C2 ALPHA; PHOSPHATIDYLINOSITOL 3 KINASE C2 BETA; PHOSPHATIDYLINOSITOL 3 KINASE C2 GAMMA; POTASSIUM CHANNEL; UNCLASSIFIED DRUG;

EID: 84860206692     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20120008     Document Type: Review
Times cited : (135)

References (100)
  • 1
    • 0037205048 scopus 로고    scopus 로고
    • The phosphoinositide 3-kinase pathway
    • Cantley, L. C. (2002) The phosphoinositide 3-kinase pathway. Science 296, 1655-1657
    • (2002) Science , vol.296 , pp. 1655-1657
    • Cantley, L.C.1
  • 3
    • 33746257209 scopus 로고    scopus 로고
    • The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
    • DOI 10.1038/nrg1879, PII NRG1879
    • Engelman, J. A., Luo, J. and Cantley, L. C. (2006) The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Nat. Rev. Genet. 7, 606-619 (Pubitemid 44100518)
    • (2006) Nature Reviews Genetics , vol.7 , Issue.8 , pp. 606-619
    • Engelman, J.A.1    Luo, J.2    Cantley, L.C.3
  • 5
    • 77950914672 scopus 로고    scopus 로고
    • PI3K/Akt signalling pathway specific inhibitors: A novel strategy to sensitize cancer cells to anti-cancer drugs
    • Falasca, M. (2010) PI3K/Akt signalling pathway specific inhibitors: a novel strategy to sensitize cancer cells to anti-cancer drugs. Curr. Pharm. Des. 16, 1410-1416
    • (2010) Curr. Pharm. Des. , vol.16 , pp. 1410-1416
    • Falasca, M.1
  • 6
    • 79952109959 scopus 로고    scopus 로고
    • Phosphoinositide signalling pathways in metabolic regulation
    • Foukas, L. C. and Withers, D. J. (2010) Phosphoinositide signalling pathways in metabolic regulation. Curr. Top. Microbiol. Immunol. 346, 115-141
    • (2010) Curr. Top. Microbiol. Immunol. , vol.346 , pp. 115-141
    • Foukas, L.C.1    Withers, D.J.2
  • 7
    • 34247141906 scopus 로고    scopus 로고
    • Role of class II phosphoinositide 3-kinase in cell signalling
    • DOI 10.1042/BST0350211
    • Falasca, M. and Maffucci, T. (2007) Role of class II phosphoinositide 3-kinase in cell signalling. Biochem. Soc. Trans. 35, 211-214 (Pubitemid 46596470)
    • (2007) Biochemical Society Transactions , vol.35 , Issue.2 , pp. 211-214
    • Falasca, M.1    Maffucci, T.2
  • 9
    • 39749141485 scopus 로고    scopus 로고
    • The regulation and function of Class III PI3Ks: Novel roles for Vps34
    • Backer, J. M. (2008) The regulation and function of Class III PI3Ks: novel roles for Vps34. Biochem. J. 410, 1-17
    • (2008) Biochem. J. , vol.410 , pp. 1-17
    • Backer, J.M.1
  • 10
    • 0029612196 scopus 로고
    • A family of phosphoinositide 3-kinases in Drosophila identifies a new mediator of signal transduction
    • DOI 10.1016/S0960-9822(95)00278-8
    • MacDougall, L. K., Domin, J. and Waterfield, M. D. (1995) A family of phosphoinositide 3-kinases in Drosophila identifies a new mediator of signal transduction. Curr. Biol. 5, 1404-1415 (Pubitemid 3008923)
    • (1995) Current Biology , vol.5 , Issue.12 , pp. 1404-1415
    • MacDougall, L.K.1    Domin, J.2    Waterfield, M.D.3
  • 11
    • 0030884527 scopus 로고    scopus 로고
    • Cloning of a human phosphoinositide 3-kinase with a C2 domain that displays reduced sensitivity to the inhibitor wortmannin
    • Domin, J., Pages, F., Volinia, S., Rittenhouse, S. E., Zvelebil, M. J., Stein, R. C. and Waterfield, M. D. (1997) Cloning of a human phosphoinositide 3-kinase with a C2 domain that displays reduced sensitivity to the inhibitor wortmannin. Biochem. J. 326, 139-147 (Pubitemid 27386928)
    • (1997) Biochemical Journal , vol.326 , Issue.1 , pp. 139-147
    • Domin, J.1    Pages, F.2    Volinia, S.3    Rittenhouse, S.E.4    Zvelebil, M.J.5    Stein, R.C.6    Waterfield, M.D.7
  • 12
    • 0031575938 scopus 로고    scopus 로고
    • Identification and cDNA cloning of a novel mammalian C2 domain-containing phosphoinositide 3-kinase, hsC2-P13K
    • DOI 10.1006/bbrc.1997.6495
    • Brown, R. A., Ho, L.K.F., Weber-Hall, S. J., Shipley, J. M. and Fry, M. J. (1997) Identification and cDNA cloning of a novel mammalian C2 domain-containing phosphoinositide 3-kinase, HsC2-PI3K. Biochem. Biophys. Res. Comm. 233, 537-544 (Pubitemid 27226663)
    • (1997) Biochemical and Biophysical Research Communications , vol.233 , Issue.2 , pp. 537-544
    • Brown, R.A.1    Ho, L.K.F.2    Weber-Hall, S.J.3    Shipley, J.M.4    Fry, M.J.5
  • 14
    • 0032534892 scopus 로고    scopus 로고
    • cDNA cloning of a third human C2-domain-containing Class II phosphoinositide 3-kinase, PI3k-C2γ, and chromosomal assignment of this gene (PIK3C2G) to 12p12
    • DOI 10.1006/geno.1998.5621
    • Rozycka, M., Lu, Y. J., Brown, R. A., Lau, M. R., Shipley, J. M. and Fry, M. J. (1998) cDNA cloning of a third human C2-domain-containing class II phosphoinositide 3-kinase, PI3K-C2γ, and chromosomal assignment of this gene (PIK3C2G) to 12p12. Genomics 54, 569-574 (Pubitemid 29036246)
    • (1998) Genomics , vol.54 , Issue.3 , pp. 569-574
    • Rozycka, M.1    Lu, Y.-J.2    Brown, R.A.3    Lau, M.R.4    Shipley, J.M.5    Fry, M.J.6
  • 15
    • 0029884657 scopus 로고    scopus 로고
    • Mouse p170 is a novel phosphatidylinositol 3-kinase containing a C2 domain
    • Virbasius, J. V., Guilherme, A. and Czech, M. P. (1996) Mouse p170 is a novel phosphatidylinositol 3-kinase containing a C2 domain. J. Biol. Chem. 271, 13304-13307
    • (1996) J. Biol. Chem. , vol.271 , pp. 13304-13307
    • Virbasius, J.V.1    Guilherme, A.2    Czech, M.P.3
  • 17
    • 0034024403 scopus 로고    scopus 로고
    • Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors
    • DOI 10.1128/MCB.20.11.3817-3830.2000
    • Arcaro, A., Zvelebil, M. J., Wallasch, C., Ullrich, A., Waterfield, M. D. and Domin, J. (2000) Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors. Mol. Cell. Biol. 20, 3817-3830 (Pubitemid 30314481)
    • (2000) Molecular and Cellular Biology , vol.20 , Issue.11 , pp. 3817-3830
    • Arcaro, A.1    Zvelebil, M.J.2    Wallasch, C.3    Ullrich, A.4    Waterfield, M.D.5    Domin, J.6
  • 18
    • 0035103107 scopus 로고    scopus 로고
    • The class II phosphoinositide 3-kinase C2α is activated by clathrin and regulates clathrin-mediated membrane trafficking
    • DOI 10.1016/S1097-2765(01)00191-5
    • Gaidarov, I., Smith, M. E., Domin, J. and Keen, J. H. (2001) The class II phosphoinositide 3-kinase C2α is activated by clathrin and regulates clathrin-mediated membrane trafficking. Mol. Cell 7, 443-449 (Pubitemid 32206511)
    • (2001) Molecular Cell , vol.7 , Issue.2 , pp. 443-449
    • Gaidarov, I.1    Smith, M.E.K.2    Domin, J.3    Keen, J.H.4
  • 19
    • 0042466604 scopus 로고    scopus 로고
    • Insulin induces phosphatidylinositol-3-phosphate formation through TC10 activation
    • DOI 10.1093/emboj/cdg402
    • Maffucci, T., Brancaccio, A., Piccolo, E., Stein, R. C. and Falasca, M. (2003) Insulin induces phosphatidylinositol-3-phosphate formation through TC10 activation. EMBO J. 22, 4178-4189 (Pubitemid 37021746)
    • (2003) EMBO Journal , vol.22 , Issue.16 , pp. 4178-4189
    • Maffucci, T.1    Brancaccio, A.2    Piccolo, E.3    Stein, R.C.4    Falasca, M.5
  • 21
    • 26244461921 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase C2α is essential for ATP-dependent priming of neurosecretory granule exocytosis
    • DOI 10.1091/mbc.E05-02-0171
    • Meunier, F. A., Osborne, S. L., Hammond, G. R., Cooke, F. T., Parker, P. J., Domin, J. and Schiavo, G. (2005) Phosphatidylinositol 3-kinase C2α is essential for ATP-dependent priming of neurosecretory granule exocytosis. Mol. Biol. Cell 16, 4841-4851 (Pubitemid 41416464)
    • (2005) Molecular Biology of the Cell , vol.16 , Issue.10 , pp. 4841-4851
    • Meunier, F.A.1    Osborne, S.L.2    Hammond, G.R.V.3    Cooke, F.T.4    Parker, P.J.5    Doming, J.6    Schiavo, G.7
  • 22
    • 59449105295 scopus 로고    scopus 로고
    • 2+ -regulated pool of phosphatidylinositol-3-phosphate produced by phosphatidylinositol 3-kinase C2α on neurosecretory vesicles
    • 2+ -regulated pool of phosphatidylinositol-3- phosphate produced by phosphatidylinositol 3-kinase C2α on neurosecretory vesicles. Mol. Biol. Cell 19, 5593-5603
    • (2008) Mol. Biol. Cell , vol.19 , pp. 5593-5603
    • Wen, P.J.1    Osborne, S.L.2    Morrow, I.C.3    Parton, R.G.4    Domin, J.5    Meunier, F.A.6
  • 24
    • 77953516805 scopus 로고    scopus 로고
    • Insulin-feedback via PI3K-C2α activated PKBα/Akt1 is required for glucose-stimulated insulin secretion
    • Leibiger, B., Moede, T., Uhles, S., Barker, C. J., Creveaux, M., Domin, J., Berggren, P. O. and Leibiger, I. B. (2010) Insulin-feedback via PI3K-C2α activated PKBα/Akt1 is required for glucose-stimulated insulin secretion. FASEB J. 24, 1824-1837
    • (2010) FASEB J. , vol.24 , pp. 1824-1837
    • Leibiger, B.1    Moede, T.2    Uhles, S.3    Barker, C.J.4    Creveaux, M.5    Domin, J.6    Berggren, P.O.7    Leibiger, I.B.8
  • 25
    • 22344452002 scopus 로고    scopus 로고
    • Class II phosphoinositide 3-kinase defines a novel signaling pathway in cell migration
    • DOI 10.1083/jcb.200408005
    • Maffucci, T., Cooke, F. T., Foster, F. M., Traer, C. J., Fry, M. J. and Falasca, M. (2005) Class II phosphoinositide 3-kinase defines a novel signaling pathway in cell migration. J. Cell Biol. 169, 789-799 (Pubitemid 41002884)
    • (2005) Journal of Cell Biology , vol.169 , Issue.5 , pp. 789-799
    • Maffucci, T.1    Cooke, F.T.2    Foster, F.M.3    Traer, C.J.4    Fry, M.J.5    Falasca, M.6
  • 27
    • 27744606985 scopus 로고    scopus 로고
    • The class II phosphoinositide 3-kinase PI3K-C2β regulates cell migration by a PtdIns(3)P dependent mechanism
    • DOI 10.1002/jcp.20478
    • Domin, J., Harper, L., Aubyn, D., Wheeler, M., Florey, O., Haskard, D., Yuan, M. and Zicha, D. (2005) The class II phosphoinositide 3-kinase PI3K-C2β regulates cell migration by a PtdIns3P dependent mechanism. J. Cell. Physiol. 205, 452-462 (Pubitemid 41598860)
    • (2005) Journal of Cellular Physiology , vol.205 , Issue.3 , pp. 452-462
    • Domin, J.1    Harper, L.2    Aubyn, D.3    Wheeler, M.4    Florey, O.5    Haskard, D.6    Yuan, M.7    Zicha, D.8
  • 29
    • 0033591247 scopus 로고    scopus 로고
    • Insulin activates the α isoform of class II phosphoinositide 3-kinase
    • Brown, R. A., Domin, J., Arcaro, A., Waterfield, M. D. and Shepherd, P. R. (1999) Insulin activates the α isoform of class II phosphoinositide 3-kinase. J. Biol. Chem. 274, 14529-14532
    • (1999) J. Biol. Chem. , vol.274 , pp. 14529-14532
    • Brown, R.A.1    Domin, J.2    Arcaro, A.3    Waterfield, M.D.4    Shepherd, P.R.5
  • 30
    • 0032476036 scopus 로고    scopus 로고
    • The CC chemokine monocyte chemotactic peptide-1 activates both the class I p85/p110 phosphatidylinositol 3-kinase and the class II PI3K-C2α
    • DOI 10.1074/jbc.273.40.25987
    • Turner, S. J., Domin, J., Waterfield, M. D., Ward, S. G. and Westwick, J. (1998) The CC chemokine monocyte chemotactic peptide-1 activates both the class I p85/p110 phosphatidylinositol 3-kinase and the class II PI3K-C2α. J. Biol. Chem. 273, 25987-25995 (Pubitemid 28475831)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.40 , pp. 25987-25995
    • Turner, S.J.1    Domin, J.2    Waterfield, M.D.3    Ward, S.G.4    Westwick, J.5
  • 31
    • 0038392645 scopus 로고    scopus 로고
    • TNF-α and leptin activate the α-isoform of class II phosphoinositide 3-kinase
    • DOI 10.1016/S0006-291X(03)00933-1
    • Ktori, C., Shepherd, P. R. and O'Rourke, L. (2003) TNF-α and leptin activate the α-isoform of class II phosphoinositide 3-kinase. Biochem. Biophys. Res. Commun. 306, 139-143 (Pubitemid 36629417)
    • (2003) Biochemical and Biophysical Research Communications , vol.306 , Issue.1 , pp. 139-143
    • Ktori, C.1    Shepherd, P.R.2    O'Rourke, L.3
  • 32
    • 0036791759 scopus 로고    scopus 로고
    • Two distinct phosphoinositide 3-kinases mediate polypeptide growth factor-stimulated PKB activation
    • Arcaro, A., Khanzada, U. K., Vanhaesebroeck, B., Tetley, T. D., Waterfield, M. D. and Seckl, M. J. (2002) Two distinct phosphoinositide 3-kinases mediate polypeptide growth factor-stimulated PKB activation. EMBO J. 21, 5097-5108
    • (2002) EMBO J. , vol.21 , pp. 5097-5108
    • Arcaro, A.1    Khanzada, U.K.2    Vanhaesebroeck, B.3    Tetley, T.D.4    Waterfield, M.D.5    Seckl, M.J.6
  • 33
    • 31944448792 scopus 로고    scopus 로고
    • The N-terminus of phosphoinositide 3-kinase-C2β regulates lipid kinase activity and binding to clathrin
    • DOI 10.1002/jcp.20507
    • Wheeler, M. and Domin, J. (2006) The N-terminus of phosphoinositide 3-kinase-C2βregulates lipid kinase activity and binding to clathrin. J. Cell. Physiol. 206, 586-593 (Pubitemid 43191032)
    • (2006) Journal of Cellular Physiology , vol.206 , Issue.3 , pp. 586-593
    • Wheeler, M.1    Domin, J.2
  • 35
    • 0032730956 scopus 로고    scopus 로고
    • The α-isoform of class II phosphoinositide 3-kinase is more effectively activated by insulin receptors than IGF receptors, and activation requires receptor NPEY motifs
    • DOI 10.1016/S0014-5793(99)01388-5, PII S0014579399013885
    • Ursø, B., Brown, R. A., O'Rahilly, S., Shepherd, P. R. and Siddle, K. (1999) The α-isoform of class II phosphoinositide 3-kinase is more effectively activated by insulin receptors than IGF receptors, and activation requires receptor NPEY motifs. FEBS Lett. 460, 423-426 (Pubitemid 29518412)
    • (1999) FEBS Letters , vol.460 , Issue.3 , pp. 423-426
    • Urso, B.1    Brown, R.A.2    O'Rahilly, S.3    Shepherd, P.R.4    Siddle, K.5
  • 37
    • 78649753178 scopus 로고    scopus 로고
    • PI3KC2α, a class II PI3K, is required for dynamin-independent internalization pathways
    • Krag, C., Malmberg, E. K. and Salcini, A. E. (2010) PI3KC2α, a class II PI3K, is required for dynamin-independent internalization pathways. J. Cell Sci. 123, 4240-4250
    • (2010) J. Cell Sci. , vol.123 , pp. 4240-4250
    • Krag, C.1    Malmberg, E.K.2    Salcini, A.E.3
  • 39
    • 0035930577 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase C2α contains a nuclear localization sequence and associates with nuclear speckles
    • Didichenko, S. A. and Thelen, M. (2001) Phosphatidylinositol 3-kinase C2α contains a nuclear localization sequence and associates with nuclear speckles. J. Biol. Chem. 276, 48135-48142
    • (2001) J. Biol. Chem. , vol.276 , pp. 48135-48142
    • Didichenko, S.A.1    Thelen, M.2
  • 40
    • 68749119758 scopus 로고    scopus 로고
    • Epidermal growth factor stimulates translocation of the class II phosphoinositide 3-kinase PI3K-C2β to the nucleus
    • Banfic, H., Visnjic, D., Mise, N., Balakrishnan, S., Deplano, S., Korchev, Y. E. and Domin, J. (2009) Epidermal growth factor stimulates translocation of the class II phosphoinositide 3-kinase PI3K-C2β to the nucleus. Biochem. J. 422, 53-60
    • (2009) Biochem. J. , vol.422 , pp. 53-60
    • Banfic, H.1    Visnjic, D.2    Mise, N.3    Balakrishnan, S.4    Deplano, S.5    Korchev, Y.E.6    Domin, J.7
  • 42
    • 29044435307 scopus 로고    scopus 로고
    • Increase in phosphotidylinositide-3 kinase activity by nitrotyrosylation of lysates of platelets from patients with systemic sclerosis
    • DOI 10.1016/j.bbagen.2005.09.001, PII S0304416505002783
    • Chiang, T. M. and Postlethwaite, A. E. (2006) Increase in phosphotidylinositide-3 kinase activity by nitrotyrosylation of lysates of platelets from patients with systemic sclerosis. Biochim. Biophys. Acta 1760, 32-37 (Pubitemid 41790628)
    • (2006) Biochimica et Biophysica Acta - General Subjects , vol.1760 , Issue.1 , pp. 32-37
    • Chiang, T.M.1    Postlethwaite, A.E.2
  • 46
    • 84861709195 scopus 로고    scopus 로고
    • Attenuation of the β-catenin/TCF4 complex in colorectal cancer cells induces several growth-suppressive microRNAs that target cancer promoting genes
    • doi:10.1038/onc.2011.453
    • Schepeler, T., Holm, A., Halvey, P., Nordentoft, I., Lamy, P., Riising, E. M., Christensen, L. L., Thorsen, K., Liebler, D. C., Helin, K. et al. (2011) Attenuation of the β-catenin/TCF4 complex in colorectal cancer cells induces several growth-suppressive microRNAs that target cancer promoting genes. Oncogene, doi:10.1038/onc.2011.453
    • (2011) Oncogene
    • Schepeler, T.1    Holm, A.2    Halvey, P.3    Nordentoft, I.4    Lamy, P.5    Riising, E.M.6    Christensen, L.L.7    Thorsen, K.8    Liebler, D.C.9    Helin, K.10
  • 48
    • 79958047958 scopus 로고    scopus 로고
    • Class II phosphoinositide 3-kinase C2α: What we learned so far
    • Mazza, S. and Maffucci, T. (2011) Class II phosphoinositide 3-kinase C2α: what we learned so far. Int. J. Biochem. Mol. Biol. 2, 168-182
    • (2011) Int. J. Biochem. Mol. Biol. , vol.2 , pp. 168-182
    • Mazza, S.1    Maffucci, T.2
  • 49
    • 72049110528 scopus 로고    scopus 로고
    • Rethinking phosphatidylinositol 3-monophosphate
    • Falasca, M. and Maffucci, T. (2009) Rethinking phosphatidylinositol 3-monophosphate. Biochim. Biophys. Acta 1793, 1795-1803
    • (2009) Biochim. Biophys. Acta , vol.1793 , pp. 1795-1803
    • Falasca, M.1    Maffucci, T.2
  • 50
    • 0347480266 scopus 로고    scopus 로고
    • Expression of Myotubularin by an Adenoviral Vector Demonstrates Its Function as a Phosphatidylinositol 3-Phosphate [Ptdlns(3)P] Phosphatase in Muscle Cell Lines: Involvement of Ptdlns(3)P in Insulin-Stimulated Glucose Transport
    • DOI 10.1210/me.2003-0261
    • Chaussade, C., Pirola, L., Bonnafous, S., Blondeau, F., Brenz-Verca, S., Tronchere, H., Portis, F., Rusconi, S., Payrastre, B., Laporte, J. and Van Obberghen, E. (2003) Expression of myotubularin by an adenoviral vector demonstrates its function as a phosphatidylinositol 3-phosphate [PtdIns(3)P ] phosphatase in muscle cell lines: involvement of PtdIns(3)P in insulin-stimulated glucose transport. Mol. Endocrinol. 17, 2448-2460 (Pubitemid 37542209)
    • (2003) Molecular Endocrinology , vol.17 , Issue.12 , pp. 2448-2460
    • Chaussade, C.1    Pirola, L.2    Bonnafous, S.3    Blondeau, F.4    Brenz-Verca, S.5    Tronchere, H.6    Portis, F.7    Rusconi, S.8    Payrastre, B.9    Laporte, J.10    Van Obberghen, E.11
  • 51
    • 23344431984 scopus 로고    scopus 로고
    • Insulin regulates the membrane arrival, fusion, and C-terminal unmasking of glucose transporter-4 via distinct phosphoinositides
    • DOI 10.1074/jbc.M500501200
    • Ishiki, M., Randhawa, V. K., Poon, V., Jebailey, J. and Klip, A. (2005) Insulin regulates the membrane arrival, fusion, and C-terminal unmasking of glucose transporter-4 via distinct phosphoinositides. J. Biol. Chem. 280, 28792-28802 (Pubitemid 41105781)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.31 , pp. 28792-28802
    • Ishiki, M.1    Randhawa, V.K.2    Poon, V.3    JeBailey, L.4    Klip, A.5
  • 53
    • 33746975370 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-phosphate [PtdIns(3)P] is generated at the plasma membrane by an inositol polyphosphate 5-phosphatase: Endogenous PtdIns(3)P can promote GLUT4 translocation to the plasma membrane
    • DOI 10.1128/MCB.00203-06
    • Kong, A. M., Horan, K. A., Sriratana, A., Bailey, C. G., Collyer, L. J., Nandurkar, H. H., Shisheva, A., Layton, M. J., Rasko, J. E., Rowe, T. and Mitchell, C. A. (2006) Phosphatidylinositol 3-phosphate (PtdIns3P) is generated at the plasma membrane by an inositol polyphosphate 5-phosphatase: endogenous PtdIns3P can promote GLUT4 translocation to the plasma membrane. Mol. Cell. Biol. 26, 6065-6081 (Pubitemid 44204526)
    • (2006) Molecular and Cellular Biology , vol.26 , Issue.16 , pp. 6065-6081
    • Kong, A.M.1    Horan, K.A.2    Sriratana, A.3    Bailey, C.G.4    Collyer, L.J.5    Nandurkar, H.H.6    Shisheva, A.7    Layton, M.J.8    Rasko, J.E.J.9    Rowe, T.10    Mitchell, C.A.11
  • 54
    • 0035265835 scopus 로고    scopus 로고
    • Selective insulin signaling through A and B insulin receptors regulates transcription of insulin and glucokinase genes in pancreatic β cells
    • DOI 10.1016/S1097-2765(01)00203-9
    • Leibiger, B., Leibiger, I. B., Moede, T., Kemper, S., Kulkarni, R. N., Kahn, C. R., de Vargas, L. M. and Berggren, P. O. (2001) Selective insulin signaling through A and B insulin receptors regulates transcription of insulin and glucokinase genes in pancreatic β cells. Mol. Cell 7, 559-570 (Pubitemid 32706348)
    • (2001) Molecular Cell , vol.7 , Issue.3 , pp. 559-570
    • Leibiger, B.1    Leibiger, I.B.2    Moede, T.3    Kemper, S.4    Kulkarni, R.N.5    Kahn, C.R.6    De Vargas, L.M.7    Berggren, P.-O.8
  • 55
    • 33847174231 scopus 로고    scopus 로고
    • 2+ -induced, Rho- and Rho kinase-dependent regulation of myosin phosphatase and contraction in isolated vascular smooth muscle cells
    • 2+ -induced, Rho- and Rho kinase-dependent regulation of myosin phosphatase and contraction in isolated vascular smooth muscle cells. Mol. Pharmacol. 71, 912-920
    • (2007) Mol. Pharmacol. , vol.71 , pp. 912-920
    • Yoshioka, K.1    Sugimoto, N.2    Takuwa, N.3    Takuwa, Y.4
  • 59
    • 13844271421 scopus 로고    scopus 로고
    • Suppression of the α-isoform of class II phosphoinositide 3-kinase gene expression leads to apoptotic cell death
    • DOI 10.1016/j.bbrc.2005.01.091
    • Kang, S., Song, J., Kang, J., Kang, H., Lee, D., Lee, Y. and Park, D. (2005) Suppression of the α-isoform of class II phosphoinositide 3-kinase gene expression leads to apoptotic cell death. Biochem. Biophys. Res. Commun. 329, 6-10 (Pubitemid 40255412)
    • (2005) Biochemical and Biophysical Research Communications , vol.329 , Issue.1 , pp. 6-10
    • Kang, S.1    Song, J.2    Kang, J.3    Kang, H.4    Lee, D.5    Lee, Y.6    Park, D.7
  • 60
  • 61
    • 35148819807 scopus 로고    scopus 로고
    • PI3Kγ is the dominant isoform involved in migratory responses of human T lymphocytes: Effects of ex vivo maintenance and limitations of non-viral delivery of siRNA
    • DOI 10.1016/j.cellsig.2007.08.006, PII S0898656807002537
    • Smith, L. D., Hickman, E. S., Parry, R. V., Westwick, J. and Ward, S. G. (2007) PI3Kγ is the dominant isoform involved in migratory responses of human T lymphocytes: effects of ex vivo maintenance and limitations of non-viral delivery of siRNA. Cell. Signalling 19, 2528-2539 (Pubitemid 47542298)
    • (2007) Cellular Signalling , vol.19 , Issue.12 , pp. 2528-2539
    • Smith, L.D.1    Hickman, E.S.2    Parry, R.V.3    Westwick, J.4    Ward, S.G.5
  • 63
    • 30044440424 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-phosphate indirectly activates KCa3.1 via 14 amino acids in the carboxy terminus of KCa3.1
    • Srivastava, S., Choudhury, P., Li, Z., Liu, G., Nadkarni, V., Ko, K., Coetzee, W. A. and Skolnik, E. Y. (2006) Phosphatidylinositol 3-phosphate indirectly activates KCa3.1 via 14 amino acids in the carboxy terminus of KCa3.1. Mol. Biol. Cell 17, 146-1454
    • (2006) Mol. Biol. Cell , vol.17 , pp. 146-1454
    • Srivastava, S.1    Choudhury, P.2    Li, Z.3    Liu, G.4    Nadkarni, V.5    Ko, K.6    Coetzee, W.A.7    Skolnik, E.Y.8
  • 65
    • 84869503510 scopus 로고    scopus 로고
    • Intersectin 1 is required for neuroblastoma tumorigenesis
    • doi:10.1038/onc.2011.643
    • Russo, A. and O'Bryan, J. P. (2012) Intersectin 1 is required for neuroblastoma tumorigenesis. Oncogene, doi:10.1038/onc.2011.643
    • (2012) Oncogene
    • Russo, A.1    O'Bryan, J.P.2
  • 66
    • 77953512871 scopus 로고    scopus 로고
    • Bcr-Abl contributes to impaired chemotaxis and aberrant homing of leukemic cells
    • Bcr-Abl contributes to impaired chemotaxis and aberrant homing of leukemic cells. Leuk. Lymphoma 51, 1098-1107
    • (2010) Leuk. Lymphoma , vol.51 , pp. 1098-1107
    • Yu, W.1    Sun, X.2    Tang, H.3    Tao, Y.4    Dai, Z.5
  • 68
    • 28544448230 scopus 로고    scopus 로고
    • The class II phosphoinositide 3-kinase C2β is not essential for epidermal differentiation
    • DOI 10.1128/MCB.25.24.11122-11130.2005
    • Harada, K., Truong, A. B., Cai, T. and Khavari, P. A. (2005) The class II phosphoinositide 3-kinase C2β is not essential for epidermal differentiation. Mol. Cell. Biol. 25, 11122-11130 (Pubitemid 41747152)
    • (2005) Molecular and Cellular Biology , vol.25 , Issue.24 , pp. 11122-11130
    • Harada, K.1    Truong, A.B.2    Cai, T.3    Khavari, P.A.4
  • 69
    • 78751613872 scopus 로고    scopus 로고
    • The α-isoform of class II phosphoinositide 3-kinase is necessary for the activation of ERK but not Akt/PKB
    • Cui, Z. G., Hong, N. Y., Kang, H. K., Lee, D. H., Lee, Y. K. and Park, D. B. (2011) The α-isoform of class II phosphoinositide 3-kinase is necessary for the activation of ERK but not Akt/PKB. Mol. Cell. Biochem. 346, 95-101
    • (2011) Mol. Cell. Biochem. , vol.346 , pp. 95-101
    • Cui, Z.G.1    Hong, N.Y.2    Kang, H.K.3    Lee, D.H.4    Lee, Y.K.5    Park, D.B.6
  • 70
    • 79957621364 scopus 로고    scopus 로고
    • Myotubularin regulates Akt-dependent survival signaling via phosphatidylinositol 3-phosphate
    • Razidlo, G. L., Katafiasz, D. and Taylor, G. S. (2011) Myotubularin regulates Akt-dependent survival signaling via phosphatidylinositol 3-phosphate. J. Biol. Chem. 286, 20005-20019
    • (2011) J. Biol. Chem. , vol.286 , pp. 20005-20019
    • Razidlo, G.L.1    Katafiasz, D.2    Taylor, G.S.3
  • 71
    • 34548565732 scopus 로고    scopus 로고
    • Bacteria-generated PtdIns(3) P recruits VAMP8 to facilitate phagocytosis
    • DOI 10.1111/j.1600-0854.2007.00613.x
    • Dai, S., Zhang, Y., Weimbs, T., Yaffe, M. B. and Zhou, D. (2007) Bacteria-generated PtdIns(3)P recruits VAMP8 to facilitate phagocytosis. Traffic 8, 1365-1374 (Pubitemid 47394241)
    • (2007) Traffic , vol.8 , Issue.10 , pp. 1365-1374
    • Dai, S.1    Zhang, Y.2    Weimbs, T.3    Yaffe, M.B.4    Zhou, D.5
  • 73
    • 0346725912 scopus 로고    scopus 로고
    • Calpain facilitates GLUT4 vesicle translocation during insulin-stimulated glucose uptake in adipocytes
    • DOI 10.1042/BJ20030681
    • Paul, D. S., Harmon, A. W., Winston, C. P. and Patel, Y. M. (2003) Calpain facilitates GLUT4 vesicle translocation during insulin-stimulated glucose uptake in adipocytes. Biochem. J. 376, 625-632 (Pubitemid 38058061)
    • (2003) Biochemical Journal , vol.376 , Issue.3 , pp. 625-632
    • Paul, D.S.1    Harmon, A.W.2    Winston, C.P.3    Patel, Y.M.4
  • 74
    • 18044377755 scopus 로고    scopus 로고
    • Calpain inhibition and insulin action in cultured human muscle cells
    • DOI 10.1016/j.ymgme.2005.01.003
    • Logie, L. J., Brown, A. E., Yeaman, S. J. and Walker, M. (2005) Calpain inhibition and insulin action in cultured human muscle cells. Mol. Genet. Metab. 85, 54-60 (Pubitemid 40603025)
    • (2005) Molecular Genetics and Metabolism , vol.85 , Issue.1 , pp. 54-60
    • Logie, L.J.1    Brown, A.E.2    Yeaman, S.J.3    Walker, M.4
  • 75
    • 34447248794 scopus 로고    scopus 로고
    • Targeted suppression of calpain-10 expression impairs insulin-stimulated glucose uptake in cultured primary human skeletal muscle cells
    • DOI 10.1016/j.ymgme.2007.05.001, PII S1096719207001606
    • Brown, A. E., Yeaman, S. J. and Walker, M. (2007) Targeted suppression of calpain-10 expression impairs insulin-stimulated glucose uptake in cultured primary human skeletal muscle cells. Mol. Genet. Metab. 91, 318-324 (Pubitemid 47043514)
    • (2007) Molecular Genetics and Metabolism , vol.91 , Issue.4 , pp. 318-324
    • Brown, A.E.1    Yeaman, S.J.2    Walker, M.3
  • 76
    • 11244322076 scopus 로고    scopus 로고
    • Evidence that an isoform of calpain-10 is a regulator of exocytosis in pancreatic β-cells
    • DOI 10.1210/me.2004-0064
    • Marshall, C., Hitman, G. A., Partridge, C. J., Clark, A., Ma, H., Shearer, T. R. and Turner, M. D. (2005) Evidence that an isoform of calpain-10 is a regulator of exocytosis in pancreatic β-cells. Mol. Endocrinol. 19, 213-224 (Pubitemid 40065971)
    • (2005) Molecular Endocrinology , vol.19 , Issue.1 , pp. 213-224
    • Marshall, C.1    Hitman, G.A.2    Partridge, C.J.3    Clark, A.4    Ma, H.5    Shearer, T.R.6    Turner, M.D.7
  • 82
    • 0242499482 scopus 로고    scopus 로고
    • Genetic Alterations and Aberrant Expression of Genes Related to the Phosphatidyl-Inositol-3′ Kinase/Protein Kinase B (Akt) Signal Transduction Pathway in Glioblastomas
    • Knobbe, C. B. and Reifenberger, G. (2003) Genetic alterations and aberrant expression of genes related to the phosphatidyl-inositol-3′- kinase/protein kinase B (Akt) signal transduction pathway in glioblastomas. Brain Pathol. 13, 507-518 (Pubitemid 37420695)
    • (2003) Brain Pathology , vol.13 , Issue.4 , pp. 507-518
    • Knobbe, C.B.1    Reifenberger, G.2
  • 83
    • 75049085593 scopus 로고    scopus 로고
    • A survey of glioblastoma genomic amplifications and deletions
    • Rao, S. K., Edwards, J., Joshi, A. D., Siu, I. M. and Riggins, G. J. (2010) A survey of glioblastoma genomic amplifications and deletions. J. Neurooncol. 96, 169-179
    • (2010) J. Neurooncol. , vol.96 , pp. 169-179
    • Rao, S.K.1    Edwards, J.2    Joshi, A.D.3    Siu, I.M.4    Riggins, G.J.5
  • 86
    • 58149165340 scopus 로고    scopus 로고
    • Pathogenetic pathways leading to glioblastoma multiforme: Association between gene expressions and resistance to erlotinib
    • Löw, S., Vougioukas, V. I., Hielscher, T., Schmidt, U., Unterberg, A. and Halatsch, M. E. (2008) Pathogenetic pathways leading to glioblastoma multiforme: association between gene expressions and resistance to erlotinib. Anticancer Res. 28, 3729-3732
    • (2008) Anticancer Res. , vol.28 , pp. 3729-3732
    • Löw, S.1    Vougioukas, V.I.2    Hielscher, T.3    Schmidt, U.4    Unterberg, A.5    Halatsch, M.E.6
  • 87
    • 58249090328 scopus 로고    scopus 로고
    • Parallel RNAi and compound screens identify the PDK1 pathway as a target for tamoxifen sensitization
    • Iorns, E., Lord, C. J. and Ashworth, A. (2009) Parallel RNAi and compound screens identify the PDK1 pathway as a target for tamoxifen sensitization. Biochem. J. 417, 361-370
    • (2009) Biochem. J. , vol.417 , pp. 361-370
    • Iorns, E.1    Lord, C.J.2    Ashworth, A.3
  • 88
    • 80052230677 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase-C2β inhibits cisplatin-mediated apoptosis via the Akt pathway in oesophageal squamous cell carcinoma
    • Liu, Z., Sun, C., Zhang, Y., Ji, Z. and Yang, G. (2011) Phosphatidylinositol 3-kinase-C2β inhibits cisplatin-mediated apoptosis via the Akt pathway in oesophageal squamous cell carcinoma. J. Int. Med. Res. 39, 1319-1332
    • (2011) J. Int. Med. Res. , vol.39 , pp. 1319-1332
    • Liu, Z.1    Sun, C.2    Zhang, Y.3    Ji, Z.4    Yang, G.5
  • 89
    • 80053934578 scopus 로고    scopus 로고
    • Somatic deletions of genes regulating MSH2 protein stability cause DNA mismatch repair deficiency and drug resistance in human leukemia cells
    • Diouf, B., Cheng, Q., Krynetskaia, N. F., Yang, W., Cheok, M., Pei, D., Fan, Y., Cheng, C., Krynetskiy, E. Y., Geng, H. et al. (2011) Somatic deletions of genes regulating MSH2 protein stability cause DNA mismatch repair deficiency and drug resistance in human leukemia cells. Nat. Med. 17, 1298-12303
    • (2011) Nat. Med. , vol.17 , pp. 1298-12303
    • Diouf, B.1    Cheng, Q.2    Krynetskaia, N.F.3    Yang, W.4    Cheok, M.5    Pei, D.6    Fan, Y.7    Cheng, C.8    Krynetskiy, E.Y.9    Geng, H.10
  • 90
    • 59849125052 scopus 로고    scopus 로고
    • Mutations in phosphoinositide metabolizing enzymes and human disease
    • McCrea, H. J. and De Camilli, P. (2009) Mutations in phosphoinositide metabolizing enzymes and human disease. Physiology 24, 8-16
    • (2009) Physiology , vol.24 , pp. 8-16
    • McCrea, H.J.1    De Camilli, P.2
  • 91
    • 47649106149 scopus 로고    scopus 로고
    • Endosomal phosphoinositides and human diseases
    • Nicot, A. S. and Laporte, J. (2008) Endosomal phosphoinositides and human diseases. Traffic 9, 1240-1249
    • (2008) Traffic , vol.9 , pp. 1240-1249
    • Nicot, A.S.1    Laporte, J.2
  • 92
    • 77955458776 scopus 로고    scopus 로고
    • Drosophila Mtm and class II PI3K coregulate a PI(3)P pool with cortical and endolysosomal functions
    • Velichkova, M., Juan, J., Kadandale, P., Jean, S., Ribeiro, I., Raman, V., Stefan, C. and Kiger, A. A. (2010) Drosophila Mtm and class II PI3K coregulate a PI(3)P pool with cortical and endolysosomal functions. J. Cell Biol. 190, 407-425
    • (2010) J. Cell Biol. , vol.190 , pp. 407-425
    • Velichkova, M.1    Juan, J.2    Kadandale, P.3    Jean, S.4    Ribeiro, I.5    Raman, V.6    Stefan, C.7    Kiger, A.A.8
  • 93
    • 79952271221 scopus 로고    scopus 로고
    • Phosphoinositide regulation of integrin trafficking required for muscle attachment and maintenance
    • Ribeiro, I., Yuan, L., Tanentzapf, G., Dowling, J. J. and Kiger, A. (2011) Phosphoinositide regulation of integrin trafficking required for muscle attachment and maintenance. PLoS Genet. 7, e1001295
    • (2011) PLoS Genet. , vol.7
    • Ribeiro, I.1    Yuan, L.2    Tanentzapf, G.3    Dowling, J.J.4    Kiger, A.5
  • 94
    • 4344571667 scopus 로고    scopus 로고
    • Impaired glucose-stimulated insulin secretion, enhanced intraperitoneal insulin tolerance, and increased β-cell mass in mice lacking the p110γ isoform of phosphoinositide 3-kinase
    • DOI 10.1210/en.2004-0028
    • MacDonald, P. E., Joseph, J. W., Yau, D., Diao, J., Asghar, Z., Dai, F., Oudit, G. Y., Patel, M. M., Backx, P. H. and Wheeler, M. B. (2004) Impaired glucose-stimulated insulin secretion, enhanced intraperitoneal insulin tolerance, and increased β-cell mass in mice lacking the p110γ isoform of phosphoinositide 3-kinase. Endocrinology 145, 4078-4083 (Pubitemid 39120555)
    • (2004) Endocrinology , vol.145 , Issue.9 , pp. 4078-4083
    • MacDonald, P.E.1    Joseph, J.W.2    Yau, D.3    Diao, J.4    Asghar, Z.5    Dai, F.6    Oudit, G.Y.7    Patel, M.M.8    Backx, P.H.9    Wheeler, M.B.10
  • 97
    • 84863012304 scopus 로고    scopus 로고
    • Two PI 3-kinases and one PI 3-phosphatase together establish the cyclic waves of phagosomal PtdIns(3)P critical for the degradation of apoptotic cells
    • Lu, N., Shen, Q., Mahoney, T. R., Neukomm, L. J., Wang, Y. and Zhou, Z. (2012) Two PI 3-kinases and one PI 3-phosphatase together establish the cyclic waves of phagosomal PtdIns(3)P critical for the degradation of apoptotic cells. PLoS Biol. 10, e1001245
    • (2012) PLoS Biol. , vol.10
    • Lu, N.1    Shen, Q.2    Mahoney, T.R.3    Neukomm, L.J.4    Wang, Y.5    Zhou, Z.6
  • 98
    • 34447543013 scopus 로고    scopus 로고
    • Myotubularin lipid phosphatase binds the hVPS15/hVPS34 lipid kinase complex on endosomes
    • DOI 10.1111/j.1600-0854.2007.00586.x
    • Cao, C., Laporte, J., Backer, J. M., Wandinger-Ness, A. and Stein, M. P. (2007) Myotubularin lipid phosphatase binds the hVPS15/hVPS34 lipid kinase complex on endosomes. Traffic 8, 1052-1067 (Pubitemid 47074038)
    • (2007) Traffic , vol.8 , Issue.8 , pp. 1052-1067
    • Cao, C.1    Laporte, J.2    Backer, J.M.3    Wandinger-Ness, A.4    Stein, M.-P.5
  • 99
    • 54249096642 scopus 로고    scopus 로고
    • Sequential actions of myotubularin lipid phosphatases regulate endosomal PI(3)P and growth factor receptor trafficking
    • Cao, C., Backer, J. M., Laporte, J., Bedrick, E. J. and Wandinger-Ness, A. (2008) Sequential actions of myotubularin lipid phosphatases regulate endosomal PI(3)P and growth factor receptor trafficking. Mol. Biol. Cell 19, 3334-3346
    • (2008) Mol. Biol. Cell , vol.19 , pp. 3334-3346
    • Cao, C.1    Backer, J.M.2    Laporte, J.3    Bedrick, E.J.4    Wandinger-Ness, A.5
  • 100
    • 0141668947 scopus 로고    scopus 로고
    • Genetic Analysis of the Myotubularin Family of Phosphatases in Caenorhabditis elegans
    • DOI 10.1074/jbc.M303259200
    • Xue, Y., Fares, H., Grant, B., Li, Z., Rose, A. M., Clark, S. G. and Skolnik, E. Y. (2003) Genetic analysis of the myotubularin family of phosphatases in Caenorhabditis elegans. J. Biol. Chem. 278, 34380-34386 (Pubitemid 37553283)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.36 , pp. 34380-34386
    • Xue, Y.1    Fares, H.2    Grant, B.3    Li, Z.4    Rose, A.M.5    Clark, S.G.6    Skolnik, E.Y.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.