-
1
-
-
0037205048
-
The phosphoinositide 3-kinase pathway
-
Cantley, L. C. (2002) The phosphoinositide 3-kinase pathway. Science 296, 1655-1657
-
(2002)
Science
, vol.296
, pp. 1655-1657
-
-
Cantley, L.C.1
-
2
-
-
77951621262
-
The emerging mechanisms of isoform-specific PI3K signalling
-
Vanhaesebroeck, B., Guillermet-Guibert, J., Graupera, M. and Bilanges, B. (2010) The emerging mechanisms of isoform-specific PI3K signalling. Nat. Rev. Mol. Cell Biol. 11, 329-341
-
(2010)
Nat. Rev. Mol. Cell Biol.
, vol.11
, pp. 329-341
-
-
Vanhaesebroeck, B.1
Guillermet-Guibert, J.2
Graupera, M.3
Bilanges, B.4
-
3
-
-
33746257209
-
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
-
DOI 10.1038/nrg1879, PII NRG1879
-
Engelman, J. A., Luo, J. and Cantley, L. C. (2006) The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Nat. Rev. Genet. 7, 606-619 (Pubitemid 44100518)
-
(2006)
Nature Reviews Genetics
, vol.7
, Issue.8
, pp. 606-619
-
-
Engelman, J.A.1
Luo, J.2
Cantley, L.C.3
-
4
-
-
75849118878
-
Targeting the PI3K signaling pathway in cancer
-
Wong, K. K., Engelman, J. A. and Cantley, L. C. (2010) Targeting the PI3K signaling pathway in cancer. Curr. Opin. Genet Dev. 20, 87-90
-
(2010)
Curr. Opin. Genet Dev.
, vol.20
, pp. 87-90
-
-
Wong, K.K.1
Engelman, J.A.2
Cantley, L.C.3
-
5
-
-
77950914672
-
PI3K/Akt signalling pathway specific inhibitors: A novel strategy to sensitize cancer cells to anti-cancer drugs
-
Falasca, M. (2010) PI3K/Akt signalling pathway specific inhibitors: a novel strategy to sensitize cancer cells to anti-cancer drugs. Curr. Pharm. Des. 16, 1410-1416
-
(2010)
Curr. Pharm. Des.
, vol.16
, pp. 1410-1416
-
-
Falasca, M.1
-
6
-
-
79952109959
-
Phosphoinositide signalling pathways in metabolic regulation
-
Foukas, L. C. and Withers, D. J. (2010) Phosphoinositide signalling pathways in metabolic regulation. Curr. Top. Microbiol. Immunol. 346, 115-141
-
(2010)
Curr. Top. Microbiol. Immunol.
, vol.346
, pp. 115-141
-
-
Foukas, L.C.1
Withers, D.J.2
-
7
-
-
34247141906
-
Role of class II phosphoinositide 3-kinase in cell signalling
-
DOI 10.1042/BST0350211
-
Falasca, M. and Maffucci, T. (2007) Role of class II phosphoinositide 3-kinase in cell signalling. Biochem. Soc. Trans. 35, 211-214 (Pubitemid 46596470)
-
(2007)
Biochemical Society Transactions
, vol.35
, Issue.2
, pp. 211-214
-
-
Falasca, M.1
Maffucci, T.2
-
8
-
-
46149106818
-
The p110β isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110γ
-
DOI 10.1073/pnas.0707761105
-
Guillermet-Guibert, J., Bjorklof, K., Salpekar, A., Gonella, C., Ramadani, F., Bilancio, A., Meek, S., Smith, A. J., Okkenhaug, K. and Vanhaesebroeck, B. (2008) The p110βisoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110γ . Proc. Natl. Acad. Sci. U.S.A. 105, 8292-8297 (Pubitemid 351904749)
-
(2008)
Proceedings of the National Academy of Sciences of the United States of America
, vol.105
, Issue.24
, pp. 8292-8297
-
-
Guillermet-Guibert, J.1
Bjorklof, K.2
Salpekar, A.3
Gonella, C.4
Ramadani, F.5
Bilancio, A.6
Meek, S.7
Smith, A.J.H.8
Okkenhaug, K.9
Vanhaesebroeck, B.10
-
9
-
-
39749141485
-
The regulation and function of Class III PI3Ks: Novel roles for Vps34
-
Backer, J. M. (2008) The regulation and function of Class III PI3Ks: novel roles for Vps34. Biochem. J. 410, 1-17
-
(2008)
Biochem. J.
, vol.410
, pp. 1-17
-
-
Backer, J.M.1
-
10
-
-
0029612196
-
A family of phosphoinositide 3-kinases in Drosophila identifies a new mediator of signal transduction
-
DOI 10.1016/S0960-9822(95)00278-8
-
MacDougall, L. K., Domin, J. and Waterfield, M. D. (1995) A family of phosphoinositide 3-kinases in Drosophila identifies a new mediator of signal transduction. Curr. Biol. 5, 1404-1415 (Pubitemid 3008923)
-
(1995)
Current Biology
, vol.5
, Issue.12
, pp. 1404-1415
-
-
MacDougall, L.K.1
Domin, J.2
Waterfield, M.D.3
-
11
-
-
0030884527
-
Cloning of a human phosphoinositide 3-kinase with a C2 domain that displays reduced sensitivity to the inhibitor wortmannin
-
Domin, J., Pages, F., Volinia, S., Rittenhouse, S. E., Zvelebil, M. J., Stein, R. C. and Waterfield, M. D. (1997) Cloning of a human phosphoinositide 3-kinase with a C2 domain that displays reduced sensitivity to the inhibitor wortmannin. Biochem. J. 326, 139-147 (Pubitemid 27386928)
-
(1997)
Biochemical Journal
, vol.326
, Issue.1
, pp. 139-147
-
-
Domin, J.1
Pages, F.2
Volinia, S.3
Rittenhouse, S.E.4
Zvelebil, M.J.5
Stein, R.C.6
Waterfield, M.D.7
-
12
-
-
0031575938
-
Identification and cDNA cloning of a novel mammalian C2 domain-containing phosphoinositide 3-kinase, hsC2-P13K
-
DOI 10.1006/bbrc.1997.6495
-
Brown, R. A., Ho, L.K.F., Weber-Hall, S. J., Shipley, J. M. and Fry, M. J. (1997) Identification and cDNA cloning of a novel mammalian C2 domain-containing phosphoinositide 3-kinase, HsC2-PI3K. Biochem. Biophys. Res. Comm. 233, 537-544 (Pubitemid 27226663)
-
(1997)
Biochemical and Biophysical Research Communications
, vol.233
, Issue.2
, pp. 537-544
-
-
Brown, R.A.1
Ho, L.K.F.2
Weber-Hall, S.J.3
Shipley, J.M.4
Fry, M.J.5
-
13
-
-
15644362968
-
Human phosphoinositide 3-kinase C2β, the role of calcium and the C2 domain in enzyme activity
-
DOI 10.1074/jbc.273.49.33082
-
Arcaro, A., Volinia, S., Zvelebil, M. J., Stein, R., Watton, S. J., Layton, M. J., Gout, I, Ahmadi, K., Downward, J. and Waterfield, M. D. (1998) Human phosphoinositide 3-kinase C2β, the role of calcium and the C2 domain in enzyme activity. J. Biol. Chem. 273, 33082-33090 (Pubitemid 28557705)
-
(1998)
Journal of Biological Chemistry
, vol.273
, Issue.49
, pp. 33082-33090
-
-
Arcaro, A.1
Volinia, S.2
Zvelebil, M.J.3
Stein, R.4
Watton, S.J.5
Layton, M.J.6
Gout, I.7
Ahmadi, K.8
Downward, J.9
Waterfield, M.D.10
-
14
-
-
0032534892
-
cDNA cloning of a third human C2-domain-containing Class II phosphoinositide 3-kinase, PI3k-C2γ, and chromosomal assignment of this gene (PIK3C2G) to 12p12
-
DOI 10.1006/geno.1998.5621
-
Rozycka, M., Lu, Y. J., Brown, R. A., Lau, M. R., Shipley, J. M. and Fry, M. J. (1998) cDNA cloning of a third human C2-domain-containing class II phosphoinositide 3-kinase, PI3K-C2γ, and chromosomal assignment of this gene (PIK3C2G) to 12p12. Genomics 54, 569-574 (Pubitemid 29036246)
-
(1998)
Genomics
, vol.54
, Issue.3
, pp. 569-574
-
-
Rozycka, M.1
Lu, Y.-J.2
Brown, R.A.3
Lau, M.R.4
Shipley, J.M.5
Fry, M.J.6
-
15
-
-
0029884657
-
Mouse p170 is a novel phosphatidylinositol 3-kinase containing a C2 domain
-
Virbasius, J. V., Guilherme, A. and Czech, M. P. (1996) Mouse p170 is a novel phosphatidylinositol 3-kinase containing a C2 domain. J. Biol. Chem. 271, 13304-13307
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 13304-13307
-
-
Virbasius, J.V.1
Guilherme, A.2
Czech, M.P.3
-
16
-
-
0032539734
-
Cloning and characterization of a Novel class II phosphoinositide 3-kinase containing C2 domain
-
DOI 10.1006/bbrc.1998.8294
-
Misawa, H., Ohtsubo, M., Copeland, N. G., Gilbert, D. J., Jenkins, N. A. and Yoshimura, A. (1998) Cloning and characterization of a novel class II phosphoinositide 3-kinase containing C2 domain. Biochem. Biophys. Res. Commun. 244, 531-539 (Pubitemid 28414116)
-
(1998)
Biochemical and Biophysical Research Communications
, vol.244
, Issue.2
, pp. 531-539
-
-
Misawa, H.1
Ohtsubo, M.2
Copeland, N.G.3
Gilbert, D.J.4
Jenkins, N.A.5
Yoshimura, A.6
-
17
-
-
0034024403
-
Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors
-
DOI 10.1128/MCB.20.11.3817-3830.2000
-
Arcaro, A., Zvelebil, M. J., Wallasch, C., Ullrich, A., Waterfield, M. D. and Domin, J. (2000) Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors. Mol. Cell. Biol. 20, 3817-3830 (Pubitemid 30314481)
-
(2000)
Molecular and Cellular Biology
, vol.20
, Issue.11
, pp. 3817-3830
-
-
Arcaro, A.1
Zvelebil, M.J.2
Wallasch, C.3
Ullrich, A.4
Waterfield, M.D.5
Domin, J.6
-
18
-
-
0035103107
-
The class II phosphoinositide 3-kinase C2α is activated by clathrin and regulates clathrin-mediated membrane trafficking
-
DOI 10.1016/S1097-2765(01)00191-5
-
Gaidarov, I., Smith, M. E., Domin, J. and Keen, J. H. (2001) The class II phosphoinositide 3-kinase C2α is activated by clathrin and regulates clathrin-mediated membrane trafficking. Mol. Cell 7, 443-449 (Pubitemid 32206511)
-
(2001)
Molecular Cell
, vol.7
, Issue.2
, pp. 443-449
-
-
Gaidarov, I.1
Smith, M.E.K.2
Domin, J.3
Keen, J.H.4
-
19
-
-
0042466604
-
Insulin induces phosphatidylinositol-3-phosphate formation through TC10 activation
-
DOI 10.1093/emboj/cdg402
-
Maffucci, T., Brancaccio, A., Piccolo, E., Stein, R. C. and Falasca, M. (2003) Insulin induces phosphatidylinositol-3-phosphate formation through TC10 activation. EMBO J. 22, 4178-4189 (Pubitemid 37021746)
-
(2003)
EMBO Journal
, vol.22
, Issue.16
, pp. 4178-4189
-
-
Maffucci, T.1
Brancaccio, A.2
Piccolo, E.3
Stein, R.C.4
Falasca, M.5
-
20
-
-
34948866354
-
The role of phosphoinositide 3-kinase C2α in insulin signaling
-
DOI 10.1074/jbc.M704357200
-
Falasca, M., Hughes, W. E., Dominguez, V., Sala, G., Fostira, F., Fang, M. Q., Cazzolli, R., Shepherd, P. R., James, D. E. and Maffucci, T. (2007) The role of phosphoinositide 3-kinase C2α in insulin signaling. J. Biol. Chem. 282, 28226-28236 (Pubitemid 47529549)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.38
, pp. 28226-28236
-
-
Falasca, M.1
Hughes, W.E.2
Dominguez, V.3
Sala, G.4
Fostira, F.5
Fang, M.Q.6
Cazzolli, R.7
Shepherd, P.R.8
James, D.E.9
Maffucci, T.10
-
21
-
-
26244461921
-
Phosphatidylinositol 3-kinase C2α is essential for ATP-dependent priming of neurosecretory granule exocytosis
-
DOI 10.1091/mbc.E05-02-0171
-
Meunier, F. A., Osborne, S. L., Hammond, G. R., Cooke, F. T., Parker, P. J., Domin, J. and Schiavo, G. (2005) Phosphatidylinositol 3-kinase C2α is essential for ATP-dependent priming of neurosecretory granule exocytosis. Mol. Biol. Cell 16, 4841-4851 (Pubitemid 41416464)
-
(2005)
Molecular Biology of the Cell
, vol.16
, Issue.10
, pp. 4841-4851
-
-
Meunier, F.A.1
Osborne, S.L.2
Hammond, G.R.V.3
Cooke, F.T.4
Parker, P.J.5
Doming, J.6
Schiavo, G.7
-
23
-
-
41449111117
-
PIKfyve negatively regulates exocytosis in neurosecretory cells
-
Osborne, S. L., Wen, P. J., Boucheron, C., Nguyen, H. N., Hayakawa, M., Kaizawa, H., Parker, P. J., Vitale, N. and Meunier, F. A. (2008) PIKfyve negatively regulates exocytosis in neurosecretory cells. J. Biol. Chem. 283, 2804-2813
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 2804-2813
-
-
Osborne, S.L.1
Wen, P.J.2
Boucheron, C.3
Nguyen, H.N.4
Hayakawa, M.5
Kaizawa, H.6
Parker, P.J.7
Vitale, N.8
Meunier, F.A.9
-
24
-
-
77953516805
-
Insulin-feedback via PI3K-C2α activated PKBα/Akt1 is required for glucose-stimulated insulin secretion
-
Leibiger, B., Moede, T., Uhles, S., Barker, C. J., Creveaux, M., Domin, J., Berggren, P. O. and Leibiger, I. B. (2010) Insulin-feedback via PI3K-C2α activated PKBα/Akt1 is required for glucose-stimulated insulin secretion. FASEB J. 24, 1824-1837
-
(2010)
FASEB J.
, vol.24
, pp. 1824-1837
-
-
Leibiger, B.1
Moede, T.2
Uhles, S.3
Barker, C.J.4
Creveaux, M.5
Domin, J.6
Berggren, P.O.7
Leibiger, I.B.8
-
25
-
-
22344452002
-
Class II phosphoinositide 3-kinase defines a novel signaling pathway in cell migration
-
DOI 10.1083/jcb.200408005
-
Maffucci, T., Cooke, F. T., Foster, F. M., Traer, C. J., Fry, M. J. and Falasca, M. (2005) Class II phosphoinositide 3-kinase defines a novel signaling pathway in cell migration. J. Cell Biol. 169, 789-799 (Pubitemid 41002884)
-
(2005)
Journal of Cell Biology
, vol.169
, Issue.5
, pp. 789-799
-
-
Maffucci, T.1
Cooke, F.T.2
Foster, F.M.3
Traer, C.J.4
Fry, M.J.5
Falasca, M.6
-
27
-
-
27744606985
-
The class II phosphoinositide 3-kinase PI3K-C2β regulates cell migration by a PtdIns(3)P dependent mechanism
-
DOI 10.1002/jcp.20478
-
Domin, J., Harper, L., Aubyn, D., Wheeler, M., Florey, O., Haskard, D., Yuan, M. and Zicha, D. (2005) The class II phosphoinositide 3-kinase PI3K-C2β regulates cell migration by a PtdIns3P dependent mechanism. J. Cell. Physiol. 205, 452-462 (Pubitemid 41598860)
-
(2005)
Journal of Cellular Physiology
, vol.205
, Issue.3
, pp. 452-462
-
-
Domin, J.1
Harper, L.2
Aubyn, D.3
Wheeler, M.4
Florey, O.5
Haskard, D.6
Yuan, M.7
Zicha, D.8
-
28
-
-
70349484446
-
+ channel KCa3.1 and CD4 T-cells
-
+ channel KCa3.1 and CD4 T-cells. Mol. Biol. Cell 20, 3783-3791
-
(2009)
Mol. Biol. Cell
, vol.20
, pp. 3783-3791
-
-
Srivastava, S.1
Di, L.2
Zhdanova, O.3
Li, Z.4
Vardhana, S.5
Wan, Q.6
Yan, Y.7
Varma, R.8
Backer, J.9
Wulff, H.10
-
29
-
-
0033591247
-
Insulin activates the α isoform of class II phosphoinositide 3-kinase
-
Brown, R. A., Domin, J., Arcaro, A., Waterfield, M. D. and Shepherd, P. R. (1999) Insulin activates the α isoform of class II phosphoinositide 3-kinase. J. Biol. Chem. 274, 14529-14532
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 14529-14532
-
-
Brown, R.A.1
Domin, J.2
Arcaro, A.3
Waterfield, M.D.4
Shepherd, P.R.5
-
30
-
-
0032476036
-
The CC chemokine monocyte chemotactic peptide-1 activates both the class I p85/p110 phosphatidylinositol 3-kinase and the class II PI3K-C2α
-
DOI 10.1074/jbc.273.40.25987
-
Turner, S. J., Domin, J., Waterfield, M. D., Ward, S. G. and Westwick, J. (1998) The CC chemokine monocyte chemotactic peptide-1 activates both the class I p85/p110 phosphatidylinositol 3-kinase and the class II PI3K-C2α. J. Biol. Chem. 273, 25987-25995 (Pubitemid 28475831)
-
(1998)
Journal of Biological Chemistry
, vol.273
, Issue.40
, pp. 25987-25995
-
-
Turner, S.J.1
Domin, J.2
Waterfield, M.D.3
Ward, S.G.4
Westwick, J.5
-
31
-
-
0038392645
-
TNF-α and leptin activate the α-isoform of class II phosphoinositide 3-kinase
-
DOI 10.1016/S0006-291X(03)00933-1
-
Ktori, C., Shepherd, P. R. and O'Rourke, L. (2003) TNF-α and leptin activate the α-isoform of class II phosphoinositide 3-kinase. Biochem. Biophys. Res. Commun. 306, 139-143 (Pubitemid 36629417)
-
(2003)
Biochemical and Biophysical Research Communications
, vol.306
, Issue.1
, pp. 139-143
-
-
Ktori, C.1
Shepherd, P.R.2
O'Rourke, L.3
-
32
-
-
0036791759
-
Two distinct phosphoinositide 3-kinases mediate polypeptide growth factor-stimulated PKB activation
-
Arcaro, A., Khanzada, U. K., Vanhaesebroeck, B., Tetley, T. D., Waterfield, M. D. and Seckl, M. J. (2002) Two distinct phosphoinositide 3-kinases mediate polypeptide growth factor-stimulated PKB activation. EMBO J. 21, 5097-5108
-
(2002)
EMBO J.
, vol.21
, pp. 5097-5108
-
-
Arcaro, A.1
Khanzada, U.K.2
Vanhaesebroeck, B.3
Tetley, T.D.4
Waterfield, M.D.5
Seckl, M.J.6
-
33
-
-
31944448792
-
The N-terminus of phosphoinositide 3-kinase-C2β regulates lipid kinase activity and binding to clathrin
-
DOI 10.1002/jcp.20507
-
Wheeler, M. and Domin, J. (2006) The N-terminus of phosphoinositide 3-kinase-C2βregulates lipid kinase activity and binding to clathrin. J. Cell. Physiol. 206, 586-593 (Pubitemid 43191032)
-
(2006)
Journal of Cellular Physiology
, vol.206
, Issue.3
, pp. 586-593
-
-
Wheeler, M.1
Domin, J.2
-
34
-
-
33846010781
-
Structural and membrane binding analysis of the phox homology domain of phosphoinositide 3-kinase-C2α
-
DOI 10.1074/jbc.M607079200
-
Stahelin, R. V., Karathanassis, D., Bruzik, K. S., Waterfield, M. D., Bravo, J., Williams, R. L. and Cho, W. (2006) Structural and membrane binding analysis of the Phox homology domain of phosphoinositide 3-kinase-C2α. J. Biol. Chem. 281, 39396-39406 (Pubitemid 46041899)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.51
, pp. 39396-39406
-
-
Stahelin, R.V.1
Karathanassis, D.2
Bruzik, K.S.3
Waterfield, M.D.4
Bravo, J.5
Williams, R.L.6
Cho, W.7
-
35
-
-
0032730956
-
The α-isoform of class II phosphoinositide 3-kinase is more effectively activated by insulin receptors than IGF receptors, and activation requires receptor NPEY motifs
-
DOI 10.1016/S0014-5793(99)01388-5, PII S0014579399013885
-
Ursø, B., Brown, R. A., O'Rahilly, S., Shepherd, P. R. and Siddle, K. (1999) The α-isoform of class II phosphoinositide 3-kinase is more effectively activated by insulin receptors than IGF receptors, and activation requires receptor NPEY motifs. FEBS Lett. 460, 423-426 (Pubitemid 29518412)
-
(1999)
FEBS Letters
, vol.460
, Issue.3
, pp. 423-426
-
-
Urso, B.1
Brown, R.A.2
O'Rahilly, S.3
Shepherd, P.R.4
Siddle, K.5
-
36
-
-
51349091876
-
Insulin stimulates phosphatidylinositol 3-phosphate production via the activation of Rab5
-
Lodhi, I. J., Bridges, D., Chiang, S. H., Zhang, Y., Cheng, A., Geletka, L. M., Weisman, L. S. and Saltiel, A. R. (2008) Insulin stimulates phosphatidylinositol 3-phosphate production via the activation of Rab5. Mol. Biol. Cell 19, 2718-2728
-
(2008)
Mol. Biol. Cell
, vol.19
, pp. 2718-2728
-
-
Lodhi, I.J.1
Bridges, D.2
Chiang, S.H.3
Zhang, Y.4
Cheng, A.5
Geletka, L.M.6
Weisman, L.S.7
Saltiel, A.R.8
-
37
-
-
78649753178
-
PI3KC2α, a class II PI3K, is required for dynamin-independent internalization pathways
-
Krag, C., Malmberg, E. K. and Salcini, A. E. (2010) PI3KC2α, a class II PI3K, is required for dynamin-independent internalization pathways. J. Cell Sci. 123, 4240-4250
-
(2010)
J. Cell Sci.
, vol.123
, pp. 4240-4250
-
-
Krag, C.1
Malmberg, E.K.2
Salcini, A.E.3
-
38
-
-
33748329395
-
Phosphoinositide 3-kinase C2β regulates cytoskeletal organization and cell migration via Rac-dependent mechanisms
-
DOI 10.1091/mbc.E05-11-1083
-
Katso, R. M., Pardo, O. E., Palamidessi, A., Franz, C. M., Marinov, M., De Laurentiis, A., Downward, J., Scita, G., Ridley, A. J., Waterfield, M. D. and Arcaro, A. (2006) Phosphoinositide 3-kinase C2β regulates cytoskeletal organization and cell migration via Rac-dependent mechanisms. Mol. Biol. Cell 17, 3729-3744 (Pubitemid 44330861)
-
(2006)
Molecular Biology of the Cell
, vol.17
, Issue.9
, pp. 3729-3744
-
-
Katso, R.M.1
Pardo, O.E.2
Palamidessi, A.3
Franz, C.M.4
Marinov, M.5
De Laurentiis, A.6
Downward, J.7
Scita, G.8
Ridley, A.J.9
Waterfield, M.D.10
Arcaro, A.11
-
39
-
-
0035930577
-
Phosphatidylinositol 3-kinase C2α contains a nuclear localization sequence and associates with nuclear speckles
-
Didichenko, S. A. and Thelen, M. (2001) Phosphatidylinositol 3-kinase C2α contains a nuclear localization sequence and associates with nuclear speckles. J. Biol. Chem. 276, 48135-48142
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 48135-48142
-
-
Didichenko, S.A.1
Thelen, M.2
-
40
-
-
68749119758
-
Epidermal growth factor stimulates translocation of the class II phosphoinositide 3-kinase PI3K-C2β to the nucleus
-
Banfic, H., Visnjic, D., Mise, N., Balakrishnan, S., Deplano, S., Korchev, Y. E. and Domin, J. (2009) Epidermal growth factor stimulates translocation of the class II phosphoinositide 3-kinase PI3K-C2β to the nucleus. Biochem. J. 422, 53-60
-
(2009)
Biochem. J.
, vol.422
, pp. 53-60
-
-
Banfic, H.1
Visnjic, D.2
Mise, N.3
Balakrishnan, S.4
Deplano, S.5
Korchev, Y.E.6
Domin, J.7
-
41
-
-
36048996570
-
Regulation of neuron survival through an intersectin-phosphoinositide 3′-kinase C2β-AKT pathway
-
Das, M., Scappini, E., Martin, N. P., Wong, K. A., Dunn, S., Chen, Y. J., Miller, S. L., Domin, J. and O'Bryan, J. P. (2007) Regulation of neuron survival through an intersectin-phosphoinositide 3′-kinase C2β-AKT pathway. Mol. Cell. Biol. 27, 7906-7017
-
(2007)
Mol. Cell. Biol.
, vol.27
, pp. 7906-17017
-
-
Das, M.1
Scappini, E.2
Martin, N.P.3
Wong, K.A.4
Dunn, S.5
Chen, Y.J.6
Miller, S.L.7
Domin, J.8
O'Bryan, J.P.9
-
42
-
-
29044435307
-
Increase in phosphotidylinositide-3 kinase activity by nitrotyrosylation of lysates of platelets from patients with systemic sclerosis
-
DOI 10.1016/j.bbagen.2005.09.001, PII S0304416505002783
-
Chiang, T. M. and Postlethwaite, A. E. (2006) Increase in phosphotidylinositide-3 kinase activity by nitrotyrosylation of lysates of platelets from patients with systemic sclerosis. Biochim. Biophys. Acta 1760, 32-37 (Pubitemid 41790628)
-
(2006)
Biochimica et Biophysica Acta - General Subjects
, vol.1760
, Issue.1
, pp. 32-37
-
-
Chiang, T.M.1
Postlethwaite, A.E.2
-
43
-
-
33644991658
-
Class II phosphoinositide 3-kinase α-isoform regulates Rho, myosin phosphatase and contraction in vascular smooth muscle
-
Wang, Y., Yoshioka, K., Azam, M. A., Takuwa, N., Sakurada, S., Kayaba, Y., Sugimoto, N., Inoki, I., Kimura, T., Kuwaki, T. and Takuwa, Y. (2006) Class II phosphoinositide 3-kinase α-isoform regulates Rho, myosin phosphatase and contraction in vascular smooth muscle. Biochem. J. 394, 581-592
-
(2006)
Biochem. J.
, vol.394
, pp. 581-592
-
-
Wang, Y.1
Yoshioka, K.2
Azam, M.A.3
Takuwa, N.4
Sakurada, S.5
Kayaba, Y.6
Sugimoto, N.7
Inoki, I.8
Kimura, T.9
Kuwaki, T.10
Takuwa, Y.11
-
44
-
-
33846448165
-
2+ regulation of phosphoinositide 3-kinase C2α, Rho, and myosin phosphatase in vascular smooth muscle
-
2+ regulation of phosphoinositide 3-kinase C2α, Rho, and myosin phosphatase in vascular smooth muscle. J. Pharmacol. Exp. Ther. 320, 907-916
-
(2007)
J. Pharmacol. Exp. Ther.
, vol.320
, pp. 907-916
-
-
Azam, M.A.1
Yoshioka, K.2
Ohkura, S.3
Takuwa, N.4
Sugimoto, N.5
Sato, K.6
Takuwa, Y.7
-
45
-
-
79952997159
-
Class II phosphoinositide 3-kinase regulates exocytosis of insulin granules in pancreatic βcells
-
Dominguez, V., Raimondi, C., Somanath, S., Bugliani, M., Loder, M. K., Edling, C. E., Divecha, N., da Silva-Xavier, G., Marselli, L., Persaud, S. J. et al. (2011) Class II phosphoinositide 3-kinase regulates exocytosis of insulin granules in pancreatic βcells. J. Biol. Chem. 286, 4216-4225
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 4216-4225
-
-
Dominguez, V.1
Raimondi, C.2
Somanath, S.3
Bugliani, M.4
Loder, M.K.5
Edling, C.E.6
Divecha, N.7
Da Silva-Xavier, G.8
Marselli, L.9
Persaud, S.J.10
-
46
-
-
84861709195
-
Attenuation of the β-catenin/TCF4 complex in colorectal cancer cells induces several growth-suppressive microRNAs that target cancer promoting genes
-
doi:10.1038/onc.2011.453
-
Schepeler, T., Holm, A., Halvey, P., Nordentoft, I., Lamy, P., Riising, E. M., Christensen, L. L., Thorsen, K., Liebler, D. C., Helin, K. et al. (2011) Attenuation of the β-catenin/TCF4 complex in colorectal cancer cells induces several growth-suppressive microRNAs that target cancer promoting genes. Oncogene, doi:10.1038/onc.2011.453
-
(2011)
Oncogene
-
-
Schepeler, T.1
Holm, A.2
Halvey, P.3
Nordentoft, I.4
Lamy, P.5
Riising, E.M.6
Christensen, L.L.7
Thorsen, K.8
Liebler, D.C.9
Helin, K.10
-
47
-
-
84055187661
-
Tripartite motif containing protein 27 negatively regulates CD4 T cells by ubiquitinating and inhibiting the class II PI3K-C2β
-
Cai, X., Srivastava, S., Sun, Y., Li, Z., Wu, H., Zuvela-Jelaska, L., Li, J., Salamon, R. S., Backer, J. M. and Skolnik, E. Y. (2011) Tripartite motif containing protein 27 negatively regulates CD4 T cells by ubiquitinating and inhibiting the class II PI3K-C2β. Proc. Natl. Acad. Sci. U.S.A. 108, 20072-20077
-
(2011)
Proc. Natl. Acad. Sci. U.S.A.
, vol.108
, pp. 20072-20077
-
-
Cai, X.1
Srivastava, S.2
Sun, Y.3
Li, Z.4
Wu, H.5
Zuvela-Jelaska, L.6
Li, J.7
Salamon, R.S.8
Backer, J.M.9
Skolnik, E.Y.10
-
48
-
-
79958047958
-
Class II phosphoinositide 3-kinase C2α: What we learned so far
-
Mazza, S. and Maffucci, T. (2011) Class II phosphoinositide 3-kinase C2α: what we learned so far. Int. J. Biochem. Mol. Biol. 2, 168-182
-
(2011)
Int. J. Biochem. Mol. Biol.
, vol.2
, pp. 168-182
-
-
Mazza, S.1
Maffucci, T.2
-
49
-
-
72049110528
-
Rethinking phosphatidylinositol 3-monophosphate
-
Falasca, M. and Maffucci, T. (2009) Rethinking phosphatidylinositol 3-monophosphate. Biochim. Biophys. Acta 1793, 1795-1803
-
(2009)
Biochim. Biophys. Acta
, vol.1793
, pp. 1795-1803
-
-
Falasca, M.1
Maffucci, T.2
-
50
-
-
0347480266
-
Expression of Myotubularin by an Adenoviral Vector Demonstrates Its Function as a Phosphatidylinositol 3-Phosphate [Ptdlns(3)P] Phosphatase in Muscle Cell Lines: Involvement of Ptdlns(3)P in Insulin-Stimulated Glucose Transport
-
DOI 10.1210/me.2003-0261
-
Chaussade, C., Pirola, L., Bonnafous, S., Blondeau, F., Brenz-Verca, S., Tronchere, H., Portis, F., Rusconi, S., Payrastre, B., Laporte, J. and Van Obberghen, E. (2003) Expression of myotubularin by an adenoviral vector demonstrates its function as a phosphatidylinositol 3-phosphate [PtdIns(3)P ] phosphatase in muscle cell lines: involvement of PtdIns(3)P in insulin-stimulated glucose transport. Mol. Endocrinol. 17, 2448-2460 (Pubitemid 37542209)
-
(2003)
Molecular Endocrinology
, vol.17
, Issue.12
, pp. 2448-2460
-
-
Chaussade, C.1
Pirola, L.2
Bonnafous, S.3
Blondeau, F.4
Brenz-Verca, S.5
Tronchere, H.6
Portis, F.7
Rusconi, S.8
Payrastre, B.9
Laporte, J.10
Van Obberghen, E.11
-
51
-
-
23344431984
-
Insulin regulates the membrane arrival, fusion, and C-terminal unmasking of glucose transporter-4 via distinct phosphoinositides
-
DOI 10.1074/jbc.M500501200
-
Ishiki, M., Randhawa, V. K., Poon, V., Jebailey, J. and Klip, A. (2005) Insulin regulates the membrane arrival, fusion, and C-terminal unmasking of glucose transporter-4 via distinct phosphoinositides. J. Biol. Chem. 280, 28792-28802 (Pubitemid 41105781)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.31
, pp. 28792-28802
-
-
Ishiki, M.1
Randhawa, V.K.2
Poon, V.3
JeBailey, L.4
Klip, A.5
-
52
-
-
85047691831
-
Adipocytes from Munc18c-null mice show increased sensitivity to insulin-stimulated GLUT4 externalization
-
DOI 10.1172/JCI200522681
-
Kanda, H., Tamori, Y., Shinoda, H., Yoshikawa, M., Sakaue, M., Udagawa, J., Otani, H., Tashiro, F., Miyazaki, J. and Kasuga, M. (2005) Adipocytes from Munc18c-null mice show increased sensitivity to insulin-stimulated GLUT4 externalization. J. Clin. Invest. 115, 291-301 (Pubitemid 40385471)
-
(2005)
Journal of Clinical Investigation
, vol.115
, Issue.2
, pp. 291-301
-
-
Kanda, H.1
Tamori, Y.2
Shinoda, H.3
Yoshikawa, M.4
Sakaue, M.5
Udagawa, J.6
Otani, H.7
Tashiro, F.8
Miyazaki, J.-I.9
Kasuga, M.10
-
53
-
-
33746975370
-
Phosphatidylinositol 3-phosphate [PtdIns(3)P] is generated at the plasma membrane by an inositol polyphosphate 5-phosphatase: Endogenous PtdIns(3)P can promote GLUT4 translocation to the plasma membrane
-
DOI 10.1128/MCB.00203-06
-
Kong, A. M., Horan, K. A., Sriratana, A., Bailey, C. G., Collyer, L. J., Nandurkar, H. H., Shisheva, A., Layton, M. J., Rasko, J. E., Rowe, T. and Mitchell, C. A. (2006) Phosphatidylinositol 3-phosphate (PtdIns3P) is generated at the plasma membrane by an inositol polyphosphate 5-phosphatase: endogenous PtdIns3P can promote GLUT4 translocation to the plasma membrane. Mol. Cell. Biol. 26, 6065-6081 (Pubitemid 44204526)
-
(2006)
Molecular and Cellular Biology
, vol.26
, Issue.16
, pp. 6065-6081
-
-
Kong, A.M.1
Horan, K.A.2
Sriratana, A.3
Bailey, C.G.4
Collyer, L.J.5
Nandurkar, H.H.6
Shisheva, A.7
Layton, M.J.8
Rasko, J.E.J.9
Rowe, T.10
Mitchell, C.A.11
-
54
-
-
0035265835
-
Selective insulin signaling through A and B insulin receptors regulates transcription of insulin and glucokinase genes in pancreatic β cells
-
DOI 10.1016/S1097-2765(01)00203-9
-
Leibiger, B., Leibiger, I. B., Moede, T., Kemper, S., Kulkarni, R. N., Kahn, C. R., de Vargas, L. M. and Berggren, P. O. (2001) Selective insulin signaling through A and B insulin receptors regulates transcription of insulin and glucokinase genes in pancreatic β cells. Mol. Cell 7, 559-570 (Pubitemid 32706348)
-
(2001)
Molecular Cell
, vol.7
, Issue.3
, pp. 559-570
-
-
Leibiger, B.1
Leibiger, I.B.2
Moede, T.3
Kemper, S.4
Kulkarni, R.N.5
Kahn, C.R.6
De Vargas, L.M.7
Berggren, P.-O.8
-
55
-
-
33847174231
-
2+ -induced, Rho- and Rho kinase-dependent regulation of myosin phosphatase and contraction in isolated vascular smooth muscle cells
-
2+ -induced, Rho- and Rho kinase-dependent regulation of myosin phosphatase and contraction in isolated vascular smooth muscle cells. Mol. Pharmacol. 71, 912-920
-
(2007)
Mol. Pharmacol.
, vol.71
, pp. 912-920
-
-
Yoshioka, K.1
Sugimoto, N.2
Takuwa, N.3
Takuwa, Y.4
-
56
-
-
78149268896
-
2+ -dependent activation of phosphoinositide 3-kinase class IIα isoform-Rho axis in blood vessels of spontaneously hypertensive rats
-
2+ -dependent activation of phosphoinositide 3-kinase class IIα isoform-Rho axis in blood vessels of spontaneously hypertensive rats. Hypertension 56, 934-941
-
(2010)
Hypertension
, vol.56
, pp. 934-941
-
-
Seok, Y.M.1
Azam, M.A.2
Okamoto, Y.3
Sato, A.4
Yoshioka, K.5
Maeda, M.6
Kim, I.7
Takuwa, Y.8
-
57
-
-
42049089732
-
Down-regulation of class II phosphoinositide 3-kinase α expression below a critical threshold induces apoptotic cell death
-
DOI 10.1158/1541-7786.MCR-07-0262
-
Elis, W., Triantafellow, E., Wolters, N. M., Sian, K. R., Caponigro, G., Borawski, J., Gaither, L. A., Murphy, L. O., Finan, P. M. and Mackeigan, J. P. (2008) Down-regulation of class II phosphoinositide 3-kinase α expression below a critical threshold induces apoptotic cell death. Mol. Cancer Res. 6, 614-623 (Pubitemid 351521843)
-
(2008)
Molecular Cancer Research
, vol.6
, Issue.4
, pp. 614-623
-
-
Elis, W.1
Triantafellow, E.2
Wolters, N.M.3
Sian, K.R.4
Caponigro, G.5
Borawski, J.6
Gaither, L.A.7
Murphy, L.O.8
Finan, P.M.9
MacKeigan, J.P.10
-
58
-
-
67949091004
-
Ablation of phosphoinositide-3-kinase class II α suppresses hepatoma cell proliferation
-
Ng, S. K., Neo, S. Y., Yap, Y. W., Karuturi, R. K., Loh, E. S., Liau, K. H. and Ren, E. C. (2009) Ablation of phosphoinositide-3-kinase class II α suppresses hepatoma cell proliferation. Biochem. Biophys. Res. Commun. 387, 310-315
-
(2009)
Biochem. Biophys. Res. Commun.
, vol.387
, pp. 310-315
-
-
Ng, S.K.1
Neo, S.Y.2
Yap, Y.W.3
Karuturi, R.K.4
Loh, E.S.5
Liau, K.H.6
Ren, E.C.7
-
59
-
-
13844271421
-
Suppression of the α-isoform of class II phosphoinositide 3-kinase gene expression leads to apoptotic cell death
-
DOI 10.1016/j.bbrc.2005.01.091
-
Kang, S., Song, J., Kang, J., Kang, H., Lee, D., Lee, Y. and Park, D. (2005) Suppression of the α-isoform of class II phosphoinositide 3-kinase gene expression leads to apoptotic cell death. Biochem. Biophys. Res. Commun. 329, 6-10 (Pubitemid 40255412)
-
(2005)
Biochemical and Biophysical Research Communications
, vol.329
, Issue.1
, pp. 6-10
-
-
Kang, S.1
Song, J.2
Kang, J.3
Kang, H.4
Lee, D.5
Lee, Y.6
Park, D.7
-
60
-
-
78149470891
-
Overexpression of phosphoinositide-3-kinase class II α enhances mesenchymal stem cell survival in infarcted myocardium
-
Eun, L. Y., Song, B. W., Cha, M. J., Song, H., Kim, I. K., Choi, E., Chang, W., Lim, S., Choi, E. J., Ham, O. et al. (2010) Overexpression of phosphoinositide-3-kinase class II α enhances mesenchymal stem cell survival in infarcted myocardium. Biochem. Biophys. Res. Commun. 402, 272-279
-
(2010)
Biochem. Biophys. Res. Commun.
, vol.402
, pp. 272-279
-
-
Eun, L.Y.1
Song, B.W.2
Cha, M.J.3
Song, H.4
Kim, I.K.5
Choi, E.6
Chang, W.7
Lim, S.8
Choi, E.J.9
Ham, O.10
-
61
-
-
35148819807
-
PI3Kγ is the dominant isoform involved in migratory responses of human T lymphocytes: Effects of ex vivo maintenance and limitations of non-viral delivery of siRNA
-
DOI 10.1016/j.cellsig.2007.08.006, PII S0898656807002537
-
Smith, L. D., Hickman, E. S., Parry, R. V., Westwick, J. and Ward, S. G. (2007) PI3Kγ is the dominant isoform involved in migratory responses of human T lymphocytes: effects of ex vivo maintenance and limitations of non-viral delivery of siRNA. Cell. Signalling 19, 2528-2539 (Pubitemid 47542298)
-
(2007)
Cellular Signalling
, vol.19
, Issue.12
, pp. 2528-2539
-
-
Smith, L.D.1
Hickman, E.S.2
Parry, R.V.3
Westwick, J.4
Ward, S.G.5
-
62
-
-
17644405474
-
+ channel KCa3.1
-
+ channel KCa3.1. Mol. Cell. Biol. 25, 3630-3638
-
(2005)
Mol. Cell. Biol.
, vol.25
, pp. 3630-3638
-
-
Srivastava, S.1
Li, Z.2
Lin, L.3
Liu, G.4
Ko, K.5
Coetzee, W.A.6
Skolnik, E.Y.7
-
63
-
-
30044440424
-
Phosphatidylinositol 3-phosphate indirectly activates KCa3.1 via 14 amino acids in the carboxy terminus of KCa3.1
-
Srivastava, S., Choudhury, P., Li, Z., Liu, G., Nadkarni, V., Ko, K., Coetzee, W. A. and Skolnik, E. Y. (2006) Phosphatidylinositol 3-phosphate indirectly activates KCa3.1 via 14 amino acids in the carboxy terminus of KCa3.1. Mol. Biol. Cell 17, 146-1454
-
(2006)
Mol. Biol. Cell
, vol.17
, pp. 146-1454
-
-
Srivastava, S.1
Choudhury, P.2
Li, Z.3
Liu, G.4
Nadkarni, V.5
Ko, K.6
Coetzee, W.A.7
Skolnik, E.Y.8
-
64
-
-
33746547806
-
Phosphatidylinositol-3 phosphatase myotubularin-related protein 6 negatively regulates CD4 T cells
-
DOI 10.1128/MCB.00352-06
-
Srivastava, S., Ko, K., Choudhury, P., Li, Z., Johnson, A. K., Nadkarni, V., Unutmaz, D., Coetzee, W. A. and Skolnik, E. Y. (2006) Phosphatidylinositol-3 phosphatase myotubularin-related protein 6 negatively regulates CD4 T cells. Mol. Cell. Biol. 26, 5595-5602 (Pubitemid 44134318)
-
(2006)
Molecular and Cellular Biology
, vol.26
, Issue.15
, pp. 5595-5602
-
-
Srivastava, S.1
Ko, K.2
Choudhury, P.3
Li, Z.4
Johnson, A.K.5
Nadkarni, V.6
Unutmaz, D.7
Coetzee, W.A.8
Skolnik, E.Y.9
-
65
-
-
84869503510
-
Intersectin 1 is required for neuroblastoma tumorigenesis
-
doi:10.1038/onc.2011.643
-
Russo, A. and O'Bryan, J. P. (2012) Intersectin 1 is required for neuroblastoma tumorigenesis. Oncogene, doi:10.1038/onc.2011.643
-
(2012)
Oncogene
-
-
Russo, A.1
O'Bryan, J.P.2
-
66
-
-
77953512871
-
Bcr-Abl contributes to impaired chemotaxis and aberrant homing of leukemic cells
-
Bcr-Abl contributes to impaired chemotaxis and aberrant homing of leukemic cells. Leuk. Lymphoma 51, 1098-1107
-
(2010)
Leuk. Lymphoma
, vol.51
, pp. 1098-1107
-
-
Yu, W.1
Sun, X.2
Tang, H.3
Tao, Y.4
Dai, Z.5
-
67
-
-
78751679539
-
Requirement for the class II phosphoinositide 3-kinase C2α in maintenance of glomerular structure and function
-
Harris, D. P., Vogel, P., Wims, M., Moberg, K., Humphries, J., Jhaver, K. G., Dacosta, C. M., Shadoan, M. K., Xu, N., Hansen, G. M. et al. (2011) Requirement for the class II phosphoinositide 3-kinase C2α in maintenance of glomerular structure and function. Mol. Cell. Biol. 31, 63-80
-
(2011)
Mol. Cell. Biol.
, vol.31
, pp. 63-80
-
-
Harris, D.P.1
Vogel, P.2
Wims, M.3
Moberg, K.4
Humphries, J.5
Jhaver, K.G.6
Dacosta, C.M.7
Shadoan, M.K.8
Xu, N.9
Hansen, G.M.10
-
68
-
-
28544448230
-
The class II phosphoinositide 3-kinase C2β is not essential for epidermal differentiation
-
DOI 10.1128/MCB.25.24.11122-11130.2005
-
Harada, K., Truong, A. B., Cai, T. and Khavari, P. A. (2005) The class II phosphoinositide 3-kinase C2β is not essential for epidermal differentiation. Mol. Cell. Biol. 25, 11122-11130 (Pubitemid 41747152)
-
(2005)
Molecular and Cellular Biology
, vol.25
, Issue.24
, pp. 11122-11130
-
-
Harada, K.1
Truong, A.B.2
Cai, T.3
Khavari, P.A.4
-
69
-
-
78751613872
-
The α-isoform of class II phosphoinositide 3-kinase is necessary for the activation of ERK but not Akt/PKB
-
Cui, Z. G., Hong, N. Y., Kang, H. K., Lee, D. H., Lee, Y. K. and Park, D. B. (2011) The α-isoform of class II phosphoinositide 3-kinase is necessary for the activation of ERK but not Akt/PKB. Mol. Cell. Biochem. 346, 95-101
-
(2011)
Mol. Cell. Biochem.
, vol.346
, pp. 95-101
-
-
Cui, Z.G.1
Hong, N.Y.2
Kang, H.K.3
Lee, D.H.4
Lee, Y.K.5
Park, D.B.6
-
70
-
-
79957621364
-
Myotubularin regulates Akt-dependent survival signaling via phosphatidylinositol 3-phosphate
-
Razidlo, G. L., Katafiasz, D. and Taylor, G. S. (2011) Myotubularin regulates Akt-dependent survival signaling via phosphatidylinositol 3-phosphate. J. Biol. Chem. 286, 20005-20019
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 20005-20019
-
-
Razidlo, G.L.1
Katafiasz, D.2
Taylor, G.S.3
-
71
-
-
34548565732
-
Bacteria-generated PtdIns(3) P recruits VAMP8 to facilitate phagocytosis
-
DOI 10.1111/j.1600-0854.2007.00613.x
-
Dai, S., Zhang, Y., Weimbs, T., Yaffe, M. B. and Zhou, D. (2007) Bacteria-generated PtdIns(3)P recruits VAMP8 to facilitate phagocytosis. Traffic 8, 1365-1374 (Pubitemid 47394241)
-
(2007)
Traffic
, vol.8
, Issue.10
, pp. 1365-1374
-
-
Dai, S.1
Zhang, Y.2
Weimbs, T.3
Yaffe, M.B.4
Zhou, D.5
-
72
-
-
34347373451
-
Proteomics analysis of insulin secretory granules
-
DOI 10.1074/mcp.M600443-MCP200
-
Brunner, Y., Couté, Y., Iezzi, M., Foti, M., Fukuda, M., Hochstrasser, D. F., Wollheim, C. B. and Sanchez, J. C. (2007) Proteomics analysis of insulin secretory granules. Mol. Cell. Proteomics 6, 1007-1017 (Pubitemid 47019402)
-
(2007)
Molecular and Cellular Proteomics
, vol.6
, Issue.6
, pp. 1007-1017
-
-
Brunner, Y.1
Coute, Y.2
Iezzi, M.3
Foti, M.4
Fukuda, M.5
Hochstrasser, D.F.6
Wolheim, C.B.7
Sanchez, J.-C.8
-
73
-
-
0346725912
-
Calpain facilitates GLUT4 vesicle translocation during insulin-stimulated glucose uptake in adipocytes
-
DOI 10.1042/BJ20030681
-
Paul, D. S., Harmon, A. W., Winston, C. P. and Patel, Y. M. (2003) Calpain facilitates GLUT4 vesicle translocation during insulin-stimulated glucose uptake in adipocytes. Biochem. J. 376, 625-632 (Pubitemid 38058061)
-
(2003)
Biochemical Journal
, vol.376
, Issue.3
, pp. 625-632
-
-
Paul, D.S.1
Harmon, A.W.2
Winston, C.P.3
Patel, Y.M.4
-
74
-
-
18044377755
-
Calpain inhibition and insulin action in cultured human muscle cells
-
DOI 10.1016/j.ymgme.2005.01.003
-
Logie, L. J., Brown, A. E., Yeaman, S. J. and Walker, M. (2005) Calpain inhibition and insulin action in cultured human muscle cells. Mol. Genet. Metab. 85, 54-60 (Pubitemid 40603025)
-
(2005)
Molecular Genetics and Metabolism
, vol.85
, Issue.1
, pp. 54-60
-
-
Logie, L.J.1
Brown, A.E.2
Yeaman, S.J.3
Walker, M.4
-
75
-
-
34447248794
-
Targeted suppression of calpain-10 expression impairs insulin-stimulated glucose uptake in cultured primary human skeletal muscle cells
-
DOI 10.1016/j.ymgme.2007.05.001, PII S1096719207001606
-
Brown, A. E., Yeaman, S. J. and Walker, M. (2007) Targeted suppression of calpain-10 expression impairs insulin-stimulated glucose uptake in cultured primary human skeletal muscle cells. Mol. Genet. Metab. 91, 318-324 (Pubitemid 47043514)
-
(2007)
Molecular Genetics and Metabolism
, vol.91
, Issue.4
, pp. 318-324
-
-
Brown, A.E.1
Yeaman, S.J.2
Walker, M.3
-
76
-
-
11244322076
-
Evidence that an isoform of calpain-10 is a regulator of exocytosis in pancreatic β-cells
-
DOI 10.1210/me.2004-0064
-
Marshall, C., Hitman, G. A., Partridge, C. J., Clark, A., Ma, H., Shearer, T. R. and Turner, M. D. (2005) Evidence that an isoform of calpain-10 is a regulator of exocytosis in pancreatic β-cells. Mol. Endocrinol. 19, 213-224 (Pubitemid 40065971)
-
(2005)
Molecular Endocrinology
, vol.19
, Issue.1
, pp. 213-224
-
-
Marshall, C.1
Hitman, G.A.2
Partridge, C.J.3
Clark, A.4
Ma, H.5
Shearer, T.R.6
Turner, M.D.7
-
78
-
-
36549076397
-
Association of the PIK3C2G gene polymorphisms with type 2 DM in a Japanese population
-
DOI 10.1016/j.bbrc.2007.10.180, PII S0006291X07023674
-
Daimon, M., Sato, H., Oizumi, T., Toriyama, S., Saito, T., Karasawa, S., Jimbu, Y., Wada, K., Kameda, W., Susa, S. et al. (2008) Association of the PIK3C2G gene polymorphisms with type 2 DM in a Japanese population. Biochem. Biophys. Res. Commun. 365, 466-471 (Pubitemid 350181679)
-
(2008)
Biochemical and Biophysical Research Communications
, vol.365
, Issue.3
, pp. 466-471
-
-
Daimon, M.1
Sato, H.2
Oizumi, T.3
Toriyama, S.4
Saito, T.5
Karasawa, S.6
Jimbu, Y.7
Wada, K.8
Kameda, W.9
Susa, S.10
Yamaguchi, H.11
Emi, M.12
Muramatsu, M.13
Kubota, I.14
Kawata, S.15
Kato, T.16
-
79
-
-
77958032063
-
Key role of phosphoinositide 3-kinase class IB in pancreatic cancer
-
Edling, C. E., Selvaggi, F., Buus, R., Maffucci, T., Di Sebastiano, P., Friess, H., Innocenti, P., Kocher, H. M. and Falasca, M. (2010) Key role of phosphoinositide 3-kinase class IB in pancreatic cancer. Clin. Cancer Res. 16, 4928-4937
-
(2010)
Clin. Cancer Res.
, vol.16
, pp. 4928-4937
-
-
Edling, C.E.1
Selvaggi, F.2
Buus, R.3
Maffucci, T.4
Di Sebastiano, P.5
Friess, H.6
Innocenti, P.7
Kocher, H.M.8
Falasca, M.9
-
80
-
-
36048963331
-
Activation of the PTEN/mTOR/STAT3 pathway in breast cancer stem-like cells is required for viability and maintenance
-
DOI 10.1073/pnas.0702596104
-
Zhou, J., Wulfkuhle, J., Zhang, H., Gu, P., Yang, Y., Deng, J., Margolick, J. B., Liotta, L. A., Petricoin, 3rd, E. and Zhang, Y. (2007) Activation of the PTEN/mTOR/STAT3 pathway in breast cancer stem-like cells is required for viability and maintenance. Proc. Natl. Acad. Sci. U.S.A. 104, 16158-16163 (Pubitemid 350099378)
-
(2007)
Proceedings of the National Academy of Sciences of the United States of America
, vol.104
, Issue.41
, pp. 16158-16163
-
-
Zhou, J.1
Wulfkuhle, J.2
Zhang, H.3
Gu, P.4
Yang, Y.5
Deng, J.6
Margolick, J.B.7
Liotta, L.A.8
Petricoin III, E.9
Zhang, Y.10
-
81
-
-
77950226852
-
Pooled analysis of phosphatidylinositol 3-kinase pathway variants and risk of prostate cancer
-
Koutros, S., Schumacher, F. R., Hayes, R. B., Ma, J., Huang, W. Y., Albanes, D., Canzian, F., Chanock, S. J., Crawford, E. D., Diver, W. R. et al. (2010) Pooled analysis of phosphatidylinositol 3-kinase pathway variants and risk of prostate cancer. Cancer Res. 70, 2389-2396
-
(2010)
Cancer Res.
, vol.70
, pp. 2389-2396
-
-
Koutros, S.1
Schumacher, F.R.2
Hayes, R.B.3
Ma, J.4
Huang, W.Y.5
Albanes, D.6
Canzian, F.7
Chanock, S.J.8
Crawford, E.D.9
Diver, W.R.10
-
82
-
-
0242499482
-
Genetic Alterations and Aberrant Expression of Genes Related to the Phosphatidyl-Inositol-3′ Kinase/Protein Kinase B (Akt) Signal Transduction Pathway in Glioblastomas
-
Knobbe, C. B. and Reifenberger, G. (2003) Genetic alterations and aberrant expression of genes related to the phosphatidyl-inositol-3′- kinase/protein kinase B (Akt) signal transduction pathway in glioblastomas. Brain Pathol. 13, 507-518 (Pubitemid 37420695)
-
(2003)
Brain Pathology
, vol.13
, Issue.4
, pp. 507-518
-
-
Knobbe, C.B.1
Reifenberger, G.2
-
83
-
-
75049085593
-
A survey of glioblastoma genomic amplifications and deletions
-
Rao, S. K., Edwards, J., Joshi, A. D., Siu, I. M. and Riggins, G. J. (2010) A survey of glioblastoma genomic amplifications and deletions. J. Neurooncol. 96, 169-179
-
(2010)
J. Neurooncol.
, vol.96
, pp. 169-179
-
-
Rao, S.K.1
Edwards, J.2
Joshi, A.D.3
Siu, I.M.4
Riggins, G.J.5
-
84
-
-
77955167915
-
Intratumoral patterns of genomic imbalance in glioblastomas
-
Nobusawa, S., Lachuer, J., Wierinckx, A., Kim, Y. H., Huang, J., Legras, C., Kleihues, P. and Ohgaki, H. (2010) Intratumoral patterns of genomic imbalance in glioblastomas. Brain Pathol. 20, 936-944
-
(2010)
Brain Pathol.
, vol.20
, pp. 936-944
-
-
Nobusawa, S.1
Lachuer, J.2
Wierinckx, A.3
Kim, Y.H.4
Huang, J.5
Legras, C.6
Kleihues, P.7
Ohgaki, H.8
-
85
-
-
34848891922
-
Integrative genomic analysis of phosphatidylinositol 3′-kinase family identifies PIK3R3 as a potential therapeutic target in epithelial ovarian cancer
-
DOI 10.1158/1078-0432.CCR-06-2660
-
Zhang, L., Huang, J., Yang, N., Greshock, J., Liang, S., Hasegawa, K., Giannakakis, A., Poulos, N., O'Brien-Jenkins, A., Katsaros, D. et al. (2007) Integrative genomic analysis of phosphatidylinositol 3′-kinase family identifies PIK3R3 as a potential therapeutic target in epithelial ovarian cancer. Clin. Cancer Res. 13, 5314-5321 (Pubitemid 47510355)
-
(2007)
Clinical Cancer Research
, vol.13
, Issue.18
, pp. 5314-5321
-
-
Zhang, L.1
Huang, J.2
Yang, N.3
Greshock, J.4
Liang, S.5
Hasegawa, K.6
Giannakakis, A.7
Poulos, N.8
O'Brien-Jenkins, A.9
Katsaros, D.10
Butzow, R.11
Weber, B.L.12
Coukos, G.13
-
86
-
-
58149165340
-
Pathogenetic pathways leading to glioblastoma multiforme: Association between gene expressions and resistance to erlotinib
-
Löw, S., Vougioukas, V. I., Hielscher, T., Schmidt, U., Unterberg, A. and Halatsch, M. E. (2008) Pathogenetic pathways leading to glioblastoma multiforme: association between gene expressions and resistance to erlotinib. Anticancer Res. 28, 3729-3732
-
(2008)
Anticancer Res.
, vol.28
, pp. 3729-3732
-
-
Löw, S.1
Vougioukas, V.I.2
Hielscher, T.3
Schmidt, U.4
Unterberg, A.5
Halatsch, M.E.6
-
87
-
-
58249090328
-
Parallel RNAi and compound screens identify the PDK1 pathway as a target for tamoxifen sensitization
-
Iorns, E., Lord, C. J. and Ashworth, A. (2009) Parallel RNAi and compound screens identify the PDK1 pathway as a target for tamoxifen sensitization. Biochem. J. 417, 361-370
-
(2009)
Biochem. J.
, vol.417
, pp. 361-370
-
-
Iorns, E.1
Lord, C.J.2
Ashworth, A.3
-
88
-
-
80052230677
-
Phosphatidylinositol 3-kinase-C2β inhibits cisplatin-mediated apoptosis via the Akt pathway in oesophageal squamous cell carcinoma
-
Liu, Z., Sun, C., Zhang, Y., Ji, Z. and Yang, G. (2011) Phosphatidylinositol 3-kinase-C2β inhibits cisplatin-mediated apoptosis via the Akt pathway in oesophageal squamous cell carcinoma. J. Int. Med. Res. 39, 1319-1332
-
(2011)
J. Int. Med. Res.
, vol.39
, pp. 1319-1332
-
-
Liu, Z.1
Sun, C.2
Zhang, Y.3
Ji, Z.4
Yang, G.5
-
89
-
-
80053934578
-
Somatic deletions of genes regulating MSH2 protein stability cause DNA mismatch repair deficiency and drug resistance in human leukemia cells
-
Diouf, B., Cheng, Q., Krynetskaia, N. F., Yang, W., Cheok, M., Pei, D., Fan, Y., Cheng, C., Krynetskiy, E. Y., Geng, H. et al. (2011) Somatic deletions of genes regulating MSH2 protein stability cause DNA mismatch repair deficiency and drug resistance in human leukemia cells. Nat. Med. 17, 1298-12303
-
(2011)
Nat. Med.
, vol.17
, pp. 1298-12303
-
-
Diouf, B.1
Cheng, Q.2
Krynetskaia, N.F.3
Yang, W.4
Cheok, M.5
Pei, D.6
Fan, Y.7
Cheng, C.8
Krynetskiy, E.Y.9
Geng, H.10
-
90
-
-
59849125052
-
Mutations in phosphoinositide metabolizing enzymes and human disease
-
McCrea, H. J. and De Camilli, P. (2009) Mutations in phosphoinositide metabolizing enzymes and human disease. Physiology 24, 8-16
-
(2009)
Physiology
, vol.24
, pp. 8-16
-
-
McCrea, H.J.1
De Camilli, P.2
-
91
-
-
47649106149
-
Endosomal phosphoinositides and human diseases
-
Nicot, A. S. and Laporte, J. (2008) Endosomal phosphoinositides and human diseases. Traffic 9, 1240-1249
-
(2008)
Traffic
, vol.9
, pp. 1240-1249
-
-
Nicot, A.S.1
Laporte, J.2
-
92
-
-
77955458776
-
Drosophila Mtm and class II PI3K coregulate a PI(3)P pool with cortical and endolysosomal functions
-
Velichkova, M., Juan, J., Kadandale, P., Jean, S., Ribeiro, I., Raman, V., Stefan, C. and Kiger, A. A. (2010) Drosophila Mtm and class II PI3K coregulate a PI(3)P pool with cortical and endolysosomal functions. J. Cell Biol. 190, 407-425
-
(2010)
J. Cell Biol.
, vol.190
, pp. 407-425
-
-
Velichkova, M.1
Juan, J.2
Kadandale, P.3
Jean, S.4
Ribeiro, I.5
Raman, V.6
Stefan, C.7
Kiger, A.A.8
-
93
-
-
79952271221
-
Phosphoinositide regulation of integrin trafficking required for muscle attachment and maintenance
-
Ribeiro, I., Yuan, L., Tanentzapf, G., Dowling, J. J. and Kiger, A. (2011) Phosphoinositide regulation of integrin trafficking required for muscle attachment and maintenance. PLoS Genet. 7, e1001295
-
(2011)
PLoS Genet.
, vol.7
-
-
Ribeiro, I.1
Yuan, L.2
Tanentzapf, G.3
Dowling, J.J.4
Kiger, A.5
-
94
-
-
4344571667
-
Impaired glucose-stimulated insulin secretion, enhanced intraperitoneal insulin tolerance, and increased β-cell mass in mice lacking the p110γ isoform of phosphoinositide 3-kinase
-
DOI 10.1210/en.2004-0028
-
MacDonald, P. E., Joseph, J. W., Yau, D., Diao, J., Asghar, Z., Dai, F., Oudit, G. Y., Patel, M. M., Backx, P. H. and Wheeler, M. B. (2004) Impaired glucose-stimulated insulin secretion, enhanced intraperitoneal insulin tolerance, and increased β-cell mass in mice lacking the p110γ isoform of phosphoinositide 3-kinase. Endocrinology 145, 4078-4083 (Pubitemid 39120555)
-
(2004)
Endocrinology
, vol.145
, Issue.9
, pp. 4078-4083
-
-
MacDonald, P.E.1
Joseph, J.W.2
Yau, D.3
Diao, J.4
Asghar, Z.5
Dai, F.6
Oudit, G.Y.7
Patel, M.M.8
Backx, P.H.9
Wheeler, M.B.10
-
95
-
-
70349146292
-
Insulin granule recruitment and exocytosis is dependent on p110γ in insulinoma and human β-cells
-
Pigeau, G. M., Kolic, J., Ball, B. J., Hoppa, M. B., Wang, Y. W., Rückle, T., Woo, M., Manning Fox, J. E. and MacDonald, P. E. (2009) Insulin granule recruitment and exocytosis is dependent on p110γ in insulinoma and human β-cells. Diabetes 58, 2084-2092
-
(2009)
Diabetes
, vol.58
, pp. 2084-2092
-
-
Pigeau, G.M.1
Kolic, J.2
Ball, B.J.3
Hoppa, M.B.4
Wang, Y.W.5
Rückle, T.6
Woo, M.7
Manning Fox, J.E.8
MacDonald, P.E.9
-
96
-
-
78649509789
-
Class IA phosphatidylinositol 3-kinase in pancreatic β cells controls insulin secretion by multiple mechanisms
-
Kaneko, K., Ueki, K., Takahashi, N., Hashimoto, S., Okamoto, M., Awazawa, M., Okazaki, Y., Ohsugi, M., Inabe, K., Umehara, T. et al. (2010) Class IA phosphatidylinositol 3-kinase in pancreatic β cells controls insulin secretion by multiple mechanisms. Cell Metab. 12, 619-632
-
(2010)
Cell Metab.
, vol.12
, pp. 619-632
-
-
Kaneko, K.1
Ueki, K.2
Takahashi, N.3
Hashimoto, S.4
Okamoto, M.5
Awazawa, M.6
Okazaki, Y.7
Ohsugi, M.8
Inabe, K.9
Umehara, T.10
-
97
-
-
84863012304
-
Two PI 3-kinases and one PI 3-phosphatase together establish the cyclic waves of phagosomal PtdIns(3)P critical for the degradation of apoptotic cells
-
Lu, N., Shen, Q., Mahoney, T. R., Neukomm, L. J., Wang, Y. and Zhou, Z. (2012) Two PI 3-kinases and one PI 3-phosphatase together establish the cyclic waves of phagosomal PtdIns(3)P critical for the degradation of apoptotic cells. PLoS Biol. 10, e1001245
-
(2012)
PLoS Biol.
, vol.10
-
-
Lu, N.1
Shen, Q.2
Mahoney, T.R.3
Neukomm, L.J.4
Wang, Y.5
Zhou, Z.6
-
98
-
-
34447543013
-
Myotubularin lipid phosphatase binds the hVPS15/hVPS34 lipid kinase complex on endosomes
-
DOI 10.1111/j.1600-0854.2007.00586.x
-
Cao, C., Laporte, J., Backer, J. M., Wandinger-Ness, A. and Stein, M. P. (2007) Myotubularin lipid phosphatase binds the hVPS15/hVPS34 lipid kinase complex on endosomes. Traffic 8, 1052-1067 (Pubitemid 47074038)
-
(2007)
Traffic
, vol.8
, Issue.8
, pp. 1052-1067
-
-
Cao, C.1
Laporte, J.2
Backer, J.M.3
Wandinger-Ness, A.4
Stein, M.-P.5
-
99
-
-
54249096642
-
Sequential actions of myotubularin lipid phosphatases regulate endosomal PI(3)P and growth factor receptor trafficking
-
Cao, C., Backer, J. M., Laporte, J., Bedrick, E. J. and Wandinger-Ness, A. (2008) Sequential actions of myotubularin lipid phosphatases regulate endosomal PI(3)P and growth factor receptor trafficking. Mol. Biol. Cell 19, 3334-3346
-
(2008)
Mol. Biol. Cell
, vol.19
, pp. 3334-3346
-
-
Cao, C.1
Backer, J.M.2
Laporte, J.3
Bedrick, E.J.4
Wandinger-Ness, A.5
-
100
-
-
0141668947
-
Genetic Analysis of the Myotubularin Family of Phosphatases in Caenorhabditis elegans
-
DOI 10.1074/jbc.M303259200
-
Xue, Y., Fares, H., Grant, B., Li, Z., Rose, A. M., Clark, S. G. and Skolnik, E. Y. (2003) Genetic analysis of the myotubularin family of phosphatases in Caenorhabditis elegans. J. Biol. Chem. 278, 34380-34386 (Pubitemid 37553283)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.36
, pp. 34380-34386
-
-
Xue, Y.1
Fares, H.2
Grant, B.3
Li, Z.4
Rose, A.M.5
Clark, S.G.6
Skolnik, E.Y.7
|