PI3-Kinase γ Promotes Rap1a-Mediated Activation of Myeloid Cell Integrin α4β1, Leading to Tumor Inflammation and Growth

PLoS ONE

Volumn 8, Issue 4, 2013, Pages

  Schmid, Michael C ^a   Franco, Irene ^b   Kang, Sang Won ^c   Hirsch, Emilio ^b   Quilliam, Lawrence A ^d   Varner, Judith A ^a,e  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b UNIVERSITY OF TURIN   (Italy)

^c Ewha Womans University   (South Korea)

^d INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; GUANINE NUCLEOTIDE EXCHANGE FACTOR; PHOSPHATIDYLINOSITOL 3 KINASE GAMMA; PHOSPHOLIPASE C GAMMA; PROTEIN CALDAG GEF I; PROTEIN CALDAG GEF II; PROTEIN RIAM; RAP PROTEIN; RAS PROXIMATE 1A PROTEIN; REGULATOR PROTEIN; UNCLASSIFIED DRUG; VERY LATE ACTIVATION ANTIGEN 3;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CELL ADHESION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; FEMALE; INFLAMMATION; LIGAND BINDING; MOLECULAR PATHOLOGY; MOUSE; NONHUMAN; PROTEIN CONFORMATION; SIGNAL TRANSDUCTION; TUMOR GROWTH; TUMOR INFLAMMATION;

ANIMALS; CLASS IB PHOSPHATIDYLINOSITOL 3-KINASE; FEMALE; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; INFLAMMATION; INTEGRIN ALPHA4BETA1; LIGANDS; MICE; MICE, KNOCKOUT; MYELOID CELLS; NEOPLASMS; PHOSPHOLIPASE C GAMMA; PROTEIN BINDING; PROTEIN CONFORMATION; RAP1 GTP-BINDING PROTEINS;

EID: 84875678385     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0060226     Document Type: Article

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