-
1
-
-
0033574429
-
Proliferative defect and embryonic lethality in mice homozygous for adeletion in the p110alpha subunit of phosphoinositide 3-kinase
-
Bi L., Okabe I., Bernard D.J., Wynshaw-Boris A., Nussbaum R.L. Proliferative defect and embryonic lethality in mice homozygous for adeletion in the p110alpha subunit of phosphoinositide 3-kinase. J.Biol. Chem. 1999, 274:10963-10968.
-
(1999)
J.Biol. Chem.
, vol.274
, pp. 10963-10968
-
-
Bi, L.1
Okabe, I.2
Bernard, D.J.3
Wynshaw-Boris, A.4
Nussbaum, R.L.5
-
2
-
-
33644513730
-
Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis
-
Cully M., You H., Levine A.J., Mak T.W. Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis. Nat. Rev. Cancer 2006, 6:184-192.
-
(2006)
Nat. Rev. Cancer
, vol.6
, pp. 184-192
-
-
Cully, M.1
You, H.2
Levine, A.J.3
Mak, T.W.4
-
3
-
-
84876424760
-
Macrophage regulation of tumor responses to anticancer therapies
-
De Palma M., Lewis C.E. Macrophage regulation of tumor responses to anticancer therapies. Cancer Cell 2013, 23:277-286.
-
(2013)
Cancer Cell
, vol.23
, pp. 277-286
-
-
De Palma, M.1
Lewis, C.E.2
-
4
-
-
0037264633
-
Targeting RAS signalling pathways in cancer therapy
-
Downward J. Targeting RAS signalling pathways in cancer therapy. Nat. Rev. Cancer 2003, 3:11-22.
-
(2003)
Nat. Rev. Cancer
, vol.3
, pp. 11-22
-
-
Downward, J.1
-
5
-
-
57349194139
-
Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers
-
Engelman J.A., Chen L., Tan X., Crosby K., Guimaraes A.R., Upadhyay R., Maira M., McNamara K., Perera S.A., Song Y., et al. Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers. Nat. Med. 2008, 14:1351-1356.
-
(2008)
Nat. Med.
, vol.14
, pp. 1351-1356
-
-
Engelman, J.A.1
Chen, L.2
Tan, X.3
Crosby, K.4
Guimaraes, A.R.5
Upadhyay, R.6
Maira, M.7
McNamara, K.8
Perera, S.A.9
Song, Y.10
-
6
-
-
33744990592
-
Critical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulation
-
Foukas L.C., Claret M., Pearce W., Okkenhaug K., Meek S., Peskett E., Sancho S., Smith A.J., Withers D.J., Vanhaesebroeck B. Critical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulation. Nature 2006, 441:366-370.
-
(2006)
Nature
, vol.441
, pp. 366-370
-
-
Foukas, L.C.1
Claret, M.2
Pearce, W.3
Okkenhaug, K.4
Meek, S.5
Peskett, E.6
Sancho, S.7
Smith, A.J.8
Withers, D.J.9
Vanhaesebroeck, B.10
-
7
-
-
84878288766
-
RAS and RHO families of GTPases directly regulate distinct phosphoinositide 3-kinase isoforms
-
Fritsch R., de Krijger I., Fritsch K., George R., Reason B., Kumar M.S., Diefenbacher M., Stamp G., Downward J. RAS and RHO families of GTPases directly regulate distinct phosphoinositide 3-kinase isoforms. Cell 2013, 153:1050-1063.
-
(2013)
Cell
, vol.153
, pp. 1050-1063
-
-
Fritsch, R.1
de Krijger, I.2
Fritsch, K.3
George, R.4
Reason, B.5
Kumar, M.S.6
Diefenbacher, M.7
Stamp, G.8
Downward, J.9
-
8
-
-
79952261716
-
GSK1120212 (JTP-74057) is an inhibitor of MEK activity and activation with favorable pharmacokinetic properties for sustained invivo pathway inhibition
-
Gilmartin A.G., Bleam M.R., Groy A., Moss K.G., Minthorn E.A., Kulkarni S.G., Rominger C.M., Erskine S., Fisher K.E., Yang J., et al. GSK1120212 (JTP-74057) is an inhibitor of MEK activity and activation with favorable pharmacokinetic properties for sustained invivo pathway inhibition. Clin. Cancer Res. 2011, 17:989-1000.
-
(2011)
Clin. Cancer Res.
, vol.17
, pp. 989-1000
-
-
Gilmartin, A.G.1
Bleam, M.R.2
Groy, A.3
Moss, K.G.4
Minthorn, E.A.5
Kulkarni, S.G.6
Rominger, C.M.7
Erskine, S.8
Fisher, K.E.9
Yang, J.10
-
9
-
-
34249026448
-
Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice
-
Gupta S., Ramjaun A.R., Haiko P., Wang Y., Warne P.H., Nicke B., Nye E., Stamp G., Alitalo K., Downward J. Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice. Cell 2007, 129:957-968.
-
(2007)
Cell
, vol.129
, pp. 957-968
-
-
Gupta, S.1
Ramjaun, A.R.2
Haiko, P.3
Wang, Y.4
Warne, P.H.5
Nicke, B.6
Nye, E.7
Stamp, G.8
Alitalo, K.9
Downward, J.10
-
10
-
-
77956280407
-
PIK3CA mutation uncouples tumor growth and cyclin D1 regulation from MEK/ERK and mutant KRAS signaling
-
Halilovic E., She Q.B., Ye Q., Pagliarini R., Sellers W.R., Solit D.B., Rosen N. PIK3CA mutation uncouples tumor growth and cyclin D1 regulation from MEK/ERK and mutant KRAS signaling. Cancer Res. 2010, 70:6804-6814.
-
(2010)
Cancer Res.
, vol.70
, pp. 6804-6814
-
-
Halilovic, E.1
She, Q.B.2
Ye, Q.3
Pagliarini, R.4
Sellers, W.R.5
Solit, D.B.6
Rosen, N.7
-
11
-
-
77956501846
-
Modulation of K-Ras-dependent lung tumorigenesis by MicroRNA-21
-
Hatley M.E., Patrick D.M., Garcia M.R., Richardson J.A., Bassel-Duby R., van Rooij E., Olson E.N. Modulation of K-Ras-dependent lung tumorigenesis by MicroRNA-21. Cancer Cell 2010, 18:282-293.
-
(2010)
Cancer Cell
, vol.18
, pp. 282-293
-
-
Hatley, M.E.1
Patrick, D.M.2
Garcia, M.R.3
Richardson, J.A.4
Bassel-Duby, R.5
van Rooij, E.6
Olson, E.N.7
-
12
-
-
79954621532
-
Akt1 deletion prevents lung tumorigenesis by mutant K-ras
-
Hollander M.C., Maier C.R., Hobbs E.A., Ashmore A.R., Linnoila R.I., Dennis P.A. Akt1 deletion prevents lung tumorigenesis by mutant K-ras. Oncogene 2011, 30:1812-1821.
-
(2011)
Oncogene
, vol.30
, pp. 1812-1821
-
-
Hollander, M.C.1
Maier, C.R.2
Hobbs, E.A.3
Ashmore, A.R.4
Linnoila, R.I.5
Dennis, P.A.6
-
13
-
-
0035893252
-
Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras
-
Jackson E.L., Willis N., Mercer K., Bronson R.T., Crowley D., Montoya R., Jacks T., Tuveson D.A. Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras. Genes Dev. 2001, 15:3243-3248.
-
(2001)
Genes Dev.
, vol.15
, pp. 3243-3248
-
-
Jackson, E.L.1
Willis, N.2
Mercer, K.3
Bronson, R.T.4
Crowley, D.5
Montoya, R.6
Jacks, T.7
Tuveson, D.A.8
-
14
-
-
28544432790
-
The differential effects of mutant p53 alleles on advanced murine lung cancer
-
Jackson E.L., Olive K.P., Tuveson D.A., Bronson R., Crowley D., Brown M., Jacks T. The differential effects of mutant p53 alleles on advanced murine lung cancer. Cancer Res. 2005, 65:10280-10288.
-
(2005)
Cancer Res.
, vol.65
, pp. 10280-10288
-
-
Jackson, E.L.1
Olive, K.P.2
Tuveson, D.A.3
Bronson, R.4
Crowley, D.5
Brown, M.6
Jacks, T.7
-
15
-
-
33645518095
-
K-ras activation generates an inflammatory response in lung tumors
-
Ji H., Houghton A.M., Mariani T.J., Perera S., Kim C.B., Padera R., Tonon G., McNamara K., Marconcini L.A., Hezel A., et al. K-ras activation generates an inflammatory response in lung tumors. Oncogene 2006, 25:2105-2112.
-
(2006)
Oncogene
, vol.25
, pp. 2105-2112
-
-
Ji, H.1
Houghton, A.M.2
Mariani, T.J.3
Perera, S.4
Kim, C.B.5
Padera, R.6
Tonon, G.7
McNamara, K.8
Marconcini, L.A.9
Hezel, A.10
-
16
-
-
0035953550
-
Somatic activation of the K-ras oncogene causes early onset lung cancer in mice
-
Johnson L., Mercer K., Greenbaum D., Bronson R.T., Crowley D., Tuveson D.A., Jacks T. Somatic activation of the K-ras oncogene causes early onset lung cancer in mice. Nature 2001, 410:1111-1116.
-
(2001)
Nature
, vol.410
, pp. 1111-1116
-
-
Johnson, L.1
Mercer, K.2
Greenbaum, D.3
Bronson, R.T.4
Crowley, D.5
Tuveson, D.A.6
Jacks, T.7
-
17
-
-
33746394560
-
Mouse models of human non-small-cell lung cancer: raising the bar
-
Kim C.F., Jackson E.L., Kirsch D.G., Grimm J., Shaw A.T., Lane K., Kissil J., Olive K.P., Sweet-Cordero A., Weissleder R., Jacks T. Mouse models of human non-small-cell lung cancer: raising the bar. Cold Spring Harb. Symp. Quant. Biol. 2005, 70:241-250.
-
(2005)
Cold Spring Harb. Symp. Quant. Biol.
, vol.70
, pp. 241-250
-
-
Kim, C.F.1
Jackson, E.L.2
Kirsch, D.G.3
Grimm, J.4
Shaw, A.T.5
Lane, K.6
Kissil, J.7
Olive, K.P.8
Sweet-Cordero, A.9
Weissleder, R.10
Jacks, T.11
-
18
-
-
33646383684
-
A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling
-
Knight Z.A., Gonzalez B., Feldman M.E., Zunder E.R., Goldenberg D.D., Williams O., Loewith R., Stokoe D., Balla A., Toth B., et al. A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling. Cell 2006, 125:733-747.
-
(2006)
Cell
, vol.125
, pp. 733-747
-
-
Knight, Z.A.1
Gonzalez, B.2
Feldman, M.E.3
Zunder, E.R.4
Goldenberg, D.D.5
Williams, O.6
Loewith, R.7
Stokoe, D.8
Balla, A.9
Toth, B.10
-
19
-
-
27644556527
-
Reduction in the requirement of oncogenic Ras signaling to activation of PI3K/AKT pathway during tumor maintenance
-
Lim K.H., Counter C.M. Reduction in the requirement of oncogenic Ras signaling to activation of PI3K/AKT pathway during tumor maintenance. Cancer Cell 2005, 8:381-392.
-
(2005)
Cancer Cell
, vol.8
, pp. 381-392
-
-
Lim, K.H.1
Counter, C.M.2
-
20
-
-
77953930730
-
Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR
-
North-East Japan Study Group
-
Maemondo M., Inoue A., Kobayashi K., Sugawara S., Oizumi S., Isobe H., Gemma A., Harada M., Yoshizawa H., Kinoshita I., et al. Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR. N.Engl. J. Med. 2010, 362:2380-2388. North-East Japan Study Group.
-
(2010)
N.Engl. J. Med.
, vol.362
, pp. 2380-2388
-
-
Maemondo, M.1
Inoue, A.2
Kobayashi, K.3
Sugawara, S.4
Oizumi, S.5
Isobe, H.6
Gemma, A.7
Harada, M.8
Yoshizawa, H.9
Kinoshita, I.10
-
21
-
-
84859463451
-
Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity
-
Maurer T., Garrenton L.S., Oh A., Pitts K., Anderson D.J., Skelton N.J., Fauber B.P., Pan B., Malek S., Stokoe D., et al. Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity. Proc. Natl. Acad. Sci. USA 2012, 109:5299-5304.
-
(2012)
Proc. Natl. Acad. Sci. USA
, vol.109
, pp. 5299-5304
-
-
Maurer, T.1
Garrenton, L.S.2
Oh, A.3
Pitts, K.4
Anderson, D.J.5
Skelton, N.J.6
Fauber, B.P.7
Pan, B.8
Malek, S.9
Stokoe, D.10
-
22
-
-
84877630250
-
Coordinate direct input of both KRAS and IGF1 receptor to activation of PI 3-kinase in KRAS mutant lung cancer
-
Molina-Arcas M., Hancock D.C., Sheridan C., Kumar M.S., Downward J. Coordinate direct input of both KRAS and IGF1 receptor to activation of PI 3-kinase in KRAS mutant lung cancer. Cancer Discov. 2013, 3:548-563.
-
(2013)
Cancer Discov.
, vol.3
, pp. 548-563
-
-
Molina-Arcas, M.1
Hancock, D.C.2
Sheridan, C.3
Kumar, M.S.4
Downward, J.5
-
23
-
-
0347123433
-
Tumour-educated macrophages promote tumour progression and metastasis
-
Pollard J.W. Tumour-educated macrophages promote tumour progression and metastasis. Nat. Rev. Cancer 2004, 4:71-78.
-
(2004)
Nat. Rev. Cancer
, vol.4
, pp. 71-78
-
-
Pollard, J.W.1
-
26
-
-
84879071011
-
Crizotinib versus chemotherapy in advanced ALK-positive lung cancer
-
Shaw A.T., Kim D.W., Nakagawa K., Seto T., Crinó L., Ahn M.J., De Pas T., Besse B., Solomon B.J., Blackhall F., et al. Crizotinib versus chemotherapy in advanced ALK-positive lung cancer. N.Engl. J. Med. 2013, 368:2385-2394.
-
(2013)
N.Engl. J. Med.
, vol.368
, pp. 2385-2394
-
-
Shaw, A.T.1
Kim, D.W.2
Nakagawa, K.3
Seto, T.4
Crinó, L.5
Ahn, M.J.6
De Pas, T.7
Besse, B.8
Solomon, B.J.9
Blackhall, F.10
-
27
-
-
77954296394
-
4E-BP1 is a key effector of the oncogenic activation of the AKT and ERK signaling pathways that integrates their function in tumors
-
She Q.B., Halilovic E., Ye Q., Zhen W., Shirasawa S., Sasazuki T., Solit D.B., Rosen N. 4E-BP1 is a key effector of the oncogenic activation of the AKT and ERK signaling pathways that integrates their function in tumors. Cancer Cell 2010, 18:39-51.
-
(2010)
Cancer Cell
, vol.18
, pp. 39-51
-
-
She, Q.B.1
Halilovic, E.2
Ye, Q.3
Zhen, W.4
Shirasawa, S.5
Sasazuki, T.6
Solit, D.B.7
Rosen, N.8
-
28
-
-
84877863454
-
In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction
-
Shima F., Yoshikawa Y., Ye M., Araki M., Matsumoto S., Liao J., Hu L., Sugimoto T., Ijiri Y., Takeda A., et al. In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction. Proc. Natl. Acad. Sci. USA 2013, 110:8182-8187.
-
(2013)
Proc. Natl. Acad. Sci. USA
, vol.110
, pp. 8182-8187
-
-
Shima, F.1
Yoshikawa, Y.2
Ye, M.3
Araki, M.4
Matsumoto, S.5
Liao, J.6
Hu, L.7
Sugimoto, T.8
Ijiri, Y.9
Takeda, A.10
-
29
-
-
77249100829
-
Specific roles of the p110alpha isoform of phosphatidylinsositol 3-kinase in hepatic insulin signaling and metabolic regulation
-
Sopasakis V.R., Liu P., Suzuki R., Kondo T., Winnay J., Tran T.T., Asano T., Smyth G., Sajan M.P., Farese R.V., et al. Specific roles of the p110alpha isoform of phosphatidylinsositol 3-kinase in hepatic insulin signaling and metabolic regulation. Cell Metab. 2010, 11:220-230.
-
(2010)
Cell Metab.
, vol.11
, pp. 220-230
-
-
Sopasakis, V.R.1
Liu, P.2
Suzuki, R.3
Kondo, T.4
Winnay, J.5
Tran, T.T.6
Asano, T.7
Smyth, G.8
Sajan, M.P.9
Farese, R.V.10
-
30
-
-
70449995469
-
Identifying genotype-dependent efficacy of single and combined PI3K- and MAPK-pathway inhibition in cancer
-
Sos M.L., Fischer S., Ullrich R., Peifer M., Heuckmann J.M., Koker M., Heynck S., Stückrath I., Weiss J., Fischer F., et al. Identifying genotype-dependent efficacy of single and combined PI3K- and MAPK-pathway inhibition in cancer. Proc. Natl. Acad. Sci. USA 2009, 106:18351-18356.
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 18351-18356
-
-
Sos, M.L.1
Fischer, S.2
Ullrich, R.3
Peifer, M.4
Heuckmann, J.M.5
Koker, M.6
Heynck, S.7
Stückrath, I.8
Weiss, J.9
Fischer, F.10
-
31
-
-
84862649997
-
Discovery of small molecules that bind to K-Ras and inhibit Sos-mediated activation
-
Sun Q., Burke J.P., Phan J., Burns M.C., Olejniczak E.T., Waterson A.G., Lee T., Rossanese O.W., Fesik S.W. Discovery of small molecules that bind to K-Ras and inhibit Sos-mediated activation. Angew. Chem. Int. Ed. Engl. 2012, 51:6140-6143.
-
(2012)
Angew. Chem. Int. Ed. Engl.
, vol.51
, pp. 6140-6143
-
-
Sun, Q.1
Burke, J.P.2
Phan, J.3
Burns, M.C.4
Olejniczak, E.T.5
Waterson, A.G.6
Lee, T.7
Rossanese, O.W.8
Fesik, S.W.9
-
32
-
-
73649112422
-
Tobacco smoke promotes lung tumorigenesis by triggering IKKbeta- and JNK1-dependent inflammation
-
Takahashi H., Ogata H., Nishigaki R., Broide D.H., Karin M. Tobacco smoke promotes lung tumorigenesis by triggering IKKbeta- and JNK1-dependent inflammation. Cancer Cell 2010, 17:89-97.
-
(2010)
Cancer Cell
, vol.17
, pp. 89-97
-
-
Takahashi, H.1
Ogata, H.2
Nishigaki, R.3
Broide, D.H.4
Karin, M.5
-
33
-
-
7944238044
-
Somatic alterations in the human cancer genome
-
Weir B., Zhao X., Meyerson M. Somatic alterations in the human cancer genome. Cancer Cell 2004, 6:433-438.
-
(2004)
Cancer Cell
, vol.6
, pp. 433-438
-
-
Weir, B.1
Zhao, X.2
Meyerson, M.3
-
34
-
-
33750826279
-
The p110alpha isoform of PI3K is essential for proper growth factor signaling and oncogenic transformation
-
Zhao J.J., Cheng H., Jia S., Wang L., Gjoerup O.V., Mikami A., Roberts T.M. The p110alpha isoform of PI3K is essential for proper growth factor signaling and oncogenic transformation. Proc. Natl. Acad. Sci. USA 2006, 103:16296-16300.
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 16296-16300
-
-
Zhao, J.J.1
Cheng, H.2
Jia, S.3
Wang, L.4
Gjoerup, O.V.5
Mikami, A.6
Roberts, T.M.7
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