An activating Pik3ca mutation coupled with Pten loss is sufficient to initiate ovarian tumorigenesis in mice

Journal of Clinical Investigation

Volumn 122, Issue 2, 2012, Pages 553-557

  Kinross, Kathryn M ^a   Montgomery, Karen G ^a   Kleinschmidt, Margarete ^a   Waring, Paul ^b   Ivetac, Ivan ^a   Tikoo, Anjali ^a   Saad, Mirette ^a,b   Hare, Lauren ^a,c   Roh, Vincent ^a   Mantamadiotis, Theo ^b   Sheppard, Karen E ^a,b   Ryland, Georgina L ^a,c   Campbell, Ian G ^a,b   Gorringe, Kylie L ^a,b   Christensen, James G ^d   Cullinane, Carleen ^a,b   Hicks, Rodney J ^a,b   Pearson, Richard B ^a,b,c   Johnstone, Ricky W ^a,b   McArthur, Grant A ^a,b   Phillips, Wayne A ^a,b,c   more..

^a PETER MACCALLUM CANCER CENTRE   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c MONASH UNIVERSITY   (Australia)

^d PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

K RAS PROTEIN; PF 04691502; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE CA; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER GROWTH; CANCER INHIBITION; CARCINOGENESIS; CONTROLLED STUDY; ENZYME ACTIVATION; FEMALE; GENE DELETION; GENE MUTATION; HETEROZYGOTE; HISTOPATHOLOGY; MOUSE; NONHUMAN; OVARY ADENOCARCINOMA; PRIORITY JOURNAL;

ANIMALS; CELL TRANSFORMATION, NEOPLASTIC; FEMALE; HUMANS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MUTATION; OVARIAN NEOPLASMS; OVARY; PHOSPHATIDYLINOSITOL 3-KINASES; PTEN PHOSPHOHYDROLASE; SURVIVAL RATE;

EID: 84856527983     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI59309     Document Type: Article

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