-
1
-
-
51849111556
-
Pi3k pathway alterations in cancer: Variations on a theme
-
Yuan TL, Cantley LC. PI3K pathway alterations in cancer: variations on a theme. Oncogene 2008;27:5497-510.
-
(2008)
Oncogene
, vol.27
, pp. 5497-510
-
-
Yuan, T.L.1
Cantley, L.C.2
-
2
-
-
68849130702
-
Targeting the pi3k/akt/mtor signaling network in acute myelogenous leukemia
-
Martelli AM, Evangelisti C, Chiarini F, Grimaldi C, Manzoli L, McCubrey JA. Targeting the PI3K/AKT/mTOR signaling network in acute myelogenous leukemia. Expert Opin Investig Drugs 2009;18: 1333-49.
-
(2009)
Expert Opin Investig Drugs
, vol.18
, pp. 1333-49
-
-
Martelli, A.M.1
Evangelisti, C.2
Chiarini, F.3
Grimaldi, C.4
Manzoli, L.5
McCubrey, J.A.6
-
3
-
-
22544444889
-
Essential role for the p110delta isoform in phosphoinositide 3- kinase activation and cell proliferation in acute myeloid leukemia
-
Sujobert P, Bardet V, Cornillet-Lefebvre P, Hayflick JS, Prie N, Verdier F, et al. Essential role for the p110delta isoform in phosphoinositide 3- kinase activation and cell proliferation in acute myeloid leukemia. Blood 2005;106:1063-6.
-
(2005)
Blood
, vol.106
, pp. 10636
-
-
Sujobert, P.1
Bardet, V.2
Cornillet-Lefebvre, P.3
Hayflick, J.S.4
Prie, N.5
Verdier, F.6
-
4
-
-
77949672430
-
Autocrine igf-1/igf-1r signaling is responsible for constitutive pi3k/akt activation in acute myeloid leukemia: Therapeutic value of neutralizing anti-igf-1r antibody
-
Chapuis N, Tamburini J, Cornillet-Lefebvre P, Gillot L, Bardet V, Willems L, et al. Autocrine IGF-1/IGF-1R signaling is responsible for constitutive PI3K/Akt activation in acute myeloid leukemia: therapeutic value of neutralizing anti-IGF-1R antibody. Haematologica 2010;95: 415-23.
-
(2010)
Haematologica
, vol.95
, pp. 415-23
-
-
Chapuis, N.1
Tamburini, J.2
Cornillet-Lefebvre, P.3
Gillot, L.4
Bardet, V.5
Willems, L.6
-
5
-
-
34250788809
-
AKT/PKB signaling: Navigating downstream
-
DOI 10.1016/j.cell.2007.06.009, PII S0092867407007751
-
Manning BD, Cantley LC. AKT/PKB signaling: navigating downstream. Cell 2007;129:1261-74. Clinical trial: www.clinicaltrials.gov. (Pubitemid 46962095)
-
(2007)
Cell
, vol.129
, Issue.7
, pp. 1261-1274
-
-
Manning, B.D.1
Cantley, L.C.2
-
6
-
-
0042528617
-
Recent advances in the development of anticancer agents targeting cell death inhibitors in the Bcl-2 protein family
-
DOI 10.1038/sj.leu.2403029
-
Shangary S, Johnson DE. Recent advances in the development of anticancer agents targeting cell death inhibitors in the Bcl-2 protein family. Leukemia 2003;17:1470-81. (Pubitemid 36986949)
-
(2003)
Leukemia
, vol.17
, Issue.8
, pp. 1470-1481
-
-
Shangary, S.1
Johnson, D.E.2
-
7
-
-
20444486559
-
An inhibitor of Bcl-2 family proteins induces regression of solid tumours
-
DOI 10.1038/nature03579
-
Oltersdorf T, Elmore SW, Shoemaker AR, Armstrong RC, Augeri DJ, Belli BA, et al. An inhibitor of Bcl-2 family proteins induces regression of solid tumours. Nature 2005;435:677-81. (Pubitemid 40825512)
-
(2005)
Nature
, vol.435
, Issue.7042
, pp. 677-681
-
-
Oltersdorf, T.1
Elmore, S.W.2
Shoemaker, A.R.3
Armstrong, R.C.4
Augeri, D.J.5
Belli, B.A.6
Bruncko, M.7
Deckwerth, T.L.8
Dinges, J.9
Hajduk, P.J.10
Joseph, M.K.11
Kitada, S.12
Korsmeyer, S.J.13
Kunzer, A.R.14
Letai, A.15
Li, C.16
Mitten, M.J.17
Nettesheim, D.G.18
Ng, S.19
Nimmer, P.M.20
O'Connor, J.M.21
Oleksijew, A.22
Petros, A.M.23
Reed, J.C.24
Shen, W.25
Tahir, S.K.26
Thompson, C.B.27
Tomaselli, K.J.28
Wang, B.29
Wendt, M.D.30
Zhang, H.31
Fesik, S.W.32
Rosenberg, S.H.33
more..
-
8
-
-
78649630259
-
Navitoclax, a targeted high-affinity inhibitor of bcl-2, in lymphoid malignancies: A phase 1 dose-escalation study of safety, pharmacokinetics, pharmacodynamics, and antitumour activity
-
Wilson WH, O'Connor OA, Czuczman MS, LaCasce AS, Gerecitano JF, Leonard JP, et al. Navitoclax, a targeted high-affinity inhibitor of BCL-2, in lymphoid malignancies: a phase 1 dose-escalation study of safety, pharmacokinetics, pharmacodynamics, and antitumour activity. Lancet Oncol 2010;11:1149-59.
-
(2010)
Lancet Oncol
, vol.11
, pp. 1149-59
-
-
Wilson, W.H.1
O'Connor, O.A.2
Czuczman, M.S.3
LaCasce, A.S.4
Gerecitano, J.F.5
Leonard, J.P.6
-
9
-
-
79251602618
-
Pi3k inhibitors prime neuroblastoma cells for chemotherapy by shifting the balance towards pro-apoptotic bcl-2 proteins and enhanced mitochondrial apoptosis
-
Bender A, Opel D, Naumann I, Kappler R, Friedman L, von SD, et al. PI3K inhibitors prime neuroblastoma cells for chemotherapy by shifting the balance towards pro-apoptotic Bcl-2 proteins and enhanced mitochondrial apoptosis. Oncogene 2011;30:494-503.
-
(2011)
Oncogene
, vol.30
, pp. 494-503
-
-
Bender, A.1
Opel, D.2
Naumann, I.3
Kappler, R.4
Friedman L Von, S.D.5
-
10
-
-
73349137309
-
The bh3-only protein bim plays a critical role in leukemia cell death triggered by concomitant inhibition of the pi3k/akt and mek/ erk1/2 pathways
-
Rahmani M, Anderson A, Habibi JR, Crabtree TR, Mayo M, Harada H, et al. The BH3-only protein Bim plays a critical role in leukemia cell death triggered by concomitant inhibition of the PI3K/Akt and MEK/ ERK1/2 pathways. Blood 2009;114:4507-16.
-
(2009)
Blood
, vol.114
, pp. 4507-16
-
-
Rahmani, M.1
Anderson, A.2
Habibi, J.R.3
Crabtree, T.R.4
Mayo, M.5
Harada, H.6
-
11
-
-
0034283981
-
Apoptosis is rapidly triggered by antisense depletion of MCL-1 in differentiating U937 cells
-
Moulding DA, Giles RV, Spiller DG, White MR, Tidd DM, Edwards SW. Apoptosis is rapidly triggered by antisense depletion of MCL-1 in differentiating U937 cells. Blood 2000;96:1756-63. (Pubitemid 30661059)
-
(2000)
Blood
, vol.96
, Issue.5
, pp. 1756-1763
-
-
Moulding, D.A.1
Giles, R.V.2
Spiller, D.G.3
White, M.R.H.4
Tidd, D.M.5
Edwards, S.W.6
-
12
-
-
17444405985
-
Direct transcriptional regulation of Bim by FoxO3a mediates STI571-induced apoptosis in Bcr-Abl-expressing cells
-
DOI 10.1038/sj.onc.1208421
-
Essafi A, Fernandez de MS, Hassen YA, Soeiro I, Mufti GJ, Thomas NS, et al. Direct transcriptional regulation of Bim by FoxO3a mediates STI571-induced apoptosis in Bcr-Abl-expressing cells. Oncogene 2005;24:2317-29. (Pubitemid 40546691)
-
(2005)
Oncogene
, vol.24
, Issue.14
, pp. 2317-2329
-
-
Essafi, A.1
Fernandez De Mattos, S.2
Hassen, Y.A.M.3
Soeiro, I.4
Mufti, G.J.5
Thomas, N.S.B.6
Medema, R.H.7
Lam, E.W.-F.8
-
13
-
-
10744230034
-
FoxO3a transcriptional regulation of bim controls apoptosis in paclitaxel-treated breast cancer cell lines
-
DOI 10.1074/jbc.M309523200
-
Sunters A, Fernandez de MS, Stahl M, Brosens JJ, Zoumpoulidou G, Saunders CA, et al. FoxO3a transcriptional regulation of Bim controls apoptosis in paclitaxel-treated breast cancer cell lines. J Biol Chem 2003;278:49795-805. (Pubitemid 37548813)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.50
, pp. 49795-49805
-
-
Sunters, A.1
Fernandez De Mattos, S.2
Stahl, M.3
Brosens, J.J.4
Zoumpoulidou, G.5
Saunders, C.A.6
Coffer, P.J.7
Medema, R.H.8
Coombes, R.C.9
Lam, E.W.-F.10
-
14
-
-
33750628289
-
Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia
-
DOI 10.1016/j.ccr.2006.10.006, PII S1535610806003138
-
Konopleva M, Contractor R, Tsao T, Samudio I, Ruvolo PP, Kitada S, et al. Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia. Cancer Cell 2006;10: 375-88. (Pubitemid 44693472)
-
(2006)
Cancer Cell
, vol.10
, Issue.5
, pp. 375-388
-
-
Konopleva, M.1
Contractor, R.2
Tsao, T.3
Samudio, I.4
Ruvolo, P.P.5
Kitada, S.6
Deng, X.7
Zhai, D.8
Shi, Y.-X.9
Sneed, T.10
Verhaegen, M.11
Soengas, M.12
Ruvolo, V.R.13
McQueen, T.14
Schober, W.D.15
Watt, J.C.16
Jiffar, T.17
Ling, X.18
Marini, F.C.19
Harris, D.20
Dietrich, M.21
Estrov, Z.22
McCubrey, J.23
May, W.S.24
Reed, J.C.25
Andreeff, M.26
more..
-
15
-
-
33750834023
-
The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized
-
DOI 10.1016/j.ccr.2006.08.027, PII S1535610806002911
-
van Delft MF, Wei AH, Mason KD, Vandenberg CJ, Chen L, Czabotar PE, et al. The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized. Cancer Cell 2006;10:389-99. (Pubitemid 44711953)
-
(2006)
Cancer Cell
, vol.10
, Issue.5
, pp. 389-399
-
-
Van Delft, M.F.1
Wei, A.H.2
Mason, K.D.3
Vandenberg, C.J.4
Chen, L.5
Czabotar, P.E.6
Willis, S.N.7
Scott, C.L.8
Day, C.L.9
Cory, S.10
Adams, J.M.11
Roberts, A.W.12
Huang, D.C.S.13
-
16
-
-
33846674886
-
Mcl-1 down-regulation potentiates ABT-737 lethality by cooperatively inducing Bak activation and Bax translocation
-
DOI 10.1158/0008-5472.CAN-06-3964
-
Chen S, Dai Y, Harada H, Dent P, Grant S. Mcl-1 down-regulation potentiates ABT-737 lethality by cooperatively inducing Bak activation and Bax translocation. Cancer Res 2007;67:782-91. (Pubitemid 46192219)
-
(2007)
Cancer Research
, vol.67
, Issue.2
, pp. 782-791
-
-
Chen, S.1
Dai, Y.2
Harada, H.3
Dent, P.4
Grant, S.5
-
17
-
-
33845994359
-
Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737
-
DOI 10.1172/JCI28281
-
Del GMV, Brown JR, Certo M, Love TM, Novina CD, Letai A. Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737. J Clin Invest 2007;117:112-21. (Pubitemid 46048458)
-
(2007)
Journal of Clinical Investigation
, vol.117
, Issue.1
, pp. 112-121
-
-
Moore, V.D.G.1
Brown, J.R.2
Certo, M.3
Love, T.M.4
Novina, C.D.5
Letai, A.6
-
18
-
-
27444436166
-
Apoptosis induced by the kinase inhibitor BAY 43-9006 in human leukemia cells involves down-regulation of Mcl-1 through inhibition of translation
-
DOI 10.1074/jbc.M506551200
-
Rahmani M, Davis EM, Bauer C, Dent P, Grant S. Apoptosis induced by the kinase inhibitor BAY 43-9006 in human leukemia cells involves down-regulation of Mcl-1 through inhibition of translation. J Biol Chem 2005;280:35217-27. (Pubitemid 41532709)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.42
, pp. 35217-35227
-
-
Rahmani, M.1
Davis, E.M.2
Bauer, C.3
Dent, P.4
Grant, S.5
-
19
-
-
78649911452
-
Melanoma differentiation associated gene-7/interleukin-24 potently induces apoptosis in human myeloid leukemia cells through a process regulated by endoplasmic reticulum stress
-
Rahmani M, Mayo M, Dash R, Sokhi UK, Dmitriev IP, Sarkar D, et al. Melanoma differentiation associated gene-7/interleukin-24 potently induces apoptosis in human myeloid leukemia cells through a process regulated by endoplasmic reticulum stress. Mol Pharmacol 2010; 78:1096-104.
-
(2010)
Mol Pharmacol
, vol.78
, pp. 1096-104
-
-
Rahmani, M.1
Mayo, M.2
Dash, R.3
Sokhi, U.K.4
Dmitriev, I.P.5
Sarkar, D.6
-
20
-
-
0036347348
-
The histone deacetylase inhibitor sodium butyrate interacts synergistically with phorbol myristate acetate (PMA) to induce mitochondrial damage and apoptosis in human myeloid leukemia cells through a tumor necrosis factor-α-mediated process
-
DOI 10.1006/excr.2002.5548
-
Rahmani M, Dai Y, Grant S. The histone deacetylase inhibitor sodium butyrate interacts synergistically with phorbol myristate acetate (PMA) to induce mitochondrial damage and apoptosis in human myeloid leukemia cells through a tumor necrosis factor-alpha-mediated process. Exp Cell Res 2002;277:31-47. (Pubitemid 34948338)
-
(2002)
Experimental Cell Research
, vol.277
, Issue.1
, pp. 31-47
-
-
Rahmani, M.1
Dai, Y.2
Grant, S.3
-
21
-
-
0345734267
-
Coadministration of the heat shock protein 90 antagonist 17-allylamino- 17- demethoxygeldanamycin with suberoylanilide hydroxamic acid or sodium butyrate synergistically induces apoptosis in human leukemia cells
-
Rahmani M, Yu C, Dai Y, Reese E, Ahmed W, Dent P, et al. Coadministration of the heat shock protein 90 antagonist 17-allylamino- 17- demethoxygeldanamycin with suberoylanilide hydroxamic acid or sodium butyrate synergistically induces apoptosis in human leukemia cells. Cancer Res 2003;63:8420-7.
-
(2003)
Cancer Res
, vol.63
, pp. 84207
-
-
Rahmani, M.1
Yu, C.2
Dai, Y.3
Reese, E.4
Ahmed, W.5
Dent, P.6
-
22
-
-
84859627981
-
Mek inhibition enhances abt-737-induced leukemia cell apoptosis via prevention of erk-activated mcl-1 induction and modulation of mcl-1/bim complex
-
KonoplevaM, Milella M, Ruvolo P, Watts JC, RicciardiMR, Korchin B, et al. MEK inhibition enhances ABT-737-induced leukemia cell apoptosis via prevention of ERK-activated MCL-1 induction and modulation of MCL-1/BIM complex. Leukemia 2012;26: 778-87.
-
(2012)
Leukemia
, vol.26
, pp. 778-87
-
-
Konopleva, M.1
Milella, M.2
Ruvolo, P.3
Watts, J.C.4
Ricciardi, M.R.5
Korchin, B.6
-
23
-
-
15844422694
-
Endogenous association of bim bh3-only protein with mcl-1, bcl-xl and bcl-2 on mitochondria in human b cells
-
Gomez-Bougie P, Bataille R, Amiot M. Endogenous association of Bim BH3-only protein with Mcl-1, Bcl-xL and Bcl-2 on mitochondria in human B cells. Eur J Immunol 2005;35:971-6.
-
(2005)
Eur J Immunol
, vol.35
, pp. 9716
-
-
Gomez-Bougie, P.1
Bataille, R.2
Amiot, M.3
-
24
-
-
19944432123
-
Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function
-
DOI 10.1016/j.molcel.2004.12.030, PII S1097276505010403
-
Chen L, Willis SN, Wei A, Smith BJ, Fletcher JI, Hinds MG, et al. Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function. Mol Cell 2005;17: 393-403. (Pubitemid 40193310)
-
(2005)
Molecular Cell
, vol.17
, Issue.3
, pp. 393-403
-
-
Chen, L.1
Willis, S.N.2
Wei, A.3
Smith, B.J.4
Fletcher, J.I.5
Hinds, M.G.6
Colman, P.M.7
Day, C.L.8
Adams, J.M.9
Huang, D.C.S.10
-
25
-
-
0029683606
-
The axis-inducing activity, stability, and subcellular distribution of β-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3
-
Yost C, Torres M, Miller JR, Huang E, Kimelman D, Moon RT. The axisinducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3. Genes Dev 1996;10:1443-54. (Pubitemid 26260702)
-
(1996)
Genes and Development
, vol.10
, Issue.12
, pp. 1443-1454
-
-
Yost, C.1
Torres, M.2
Miller, J.R.3
Huang, E.4
Kimelman, D.5
Moon, R.T.6
-
26
-
-
2942650133
-
The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation
-
DOI 10.1073/pnas.0402770101
-
Welcker M, Orian A, Jin J, Grim JE, Harper JW, Eisenman RN, et al. The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation- dependent c-Myc protein degradation. Proc Natl Acad Sci U S A 2004;101:9085-90. (Pubitemid 38781615)
-
(2004)
Proceedings of the National Academy of Sciences of the United States of America
, vol.101
, Issue.24
, pp. 9085-9090
-
-
Welcker, M.1
Orian, A.2
Jin, J.3
Grim, J.A.4
Harper, J.W.5
Eisenman, R.N.6
Clurman, B.E.7
-
27
-
-
78349273297
-
Dual inhibition of pi3k and mtorc1/2 signaling by nvp-bez235 as a new therapeutic strategy for acute myeloid leukemia
-
Chapuis N, Tamburini J, Green AS, Vignon C, Bardet V, Neyret A, et al. Dual inhibition of PI3K and mTORC1/2 signaling by NVP-BEZ235 as a new therapeutic strategy for acute myeloid leukemia. Clin Cancer Res 2010;16:5424-35.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 5424-35
-
-
Chapuis, N.1
Tamburini, J.2
Green, A.S.3
Vignon, C.4
Bardet, V.5
Neyret, A.6
-
28
-
-
51649088622
-
Pi-103, a dual inhibitor of class ia phosphatidylinositide 3-kinase and mtor, has antileukemic activity in aml
-
Park S, Chapuis N, Bardet V, Tamburini J, Gallay N, Willems L, et al. PI-103, a dual inhibitor of Class IA phosphatidylinositide 3-kinase and mTOR, has antileukemic activity in AML. Leukemia 2008;22: 1698-706.
-
(2008)
Leukemia
, vol.22
, pp. 1698-706
-
-
Park, S.1
Chapuis, N.2
Bardet, V.3
Tamburini, J.4
Gallay, N.5
Willems, L.6
-
29
-
-
35348822482
-
Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies
-
DOI 10.1126/science.1142946
-
Stommel JM, Kimmelman AC, Ying H, Nabioullin R, Ponugoti AH, Wiedemeyer R, et al. Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies. Science 2007; 318:287-90. (Pubitemid 47574858)
-
(2007)
Science
, vol.318
, Issue.5848
, pp. 287-290
-
-
Stommel, J.M.1
Kimmelman, A.C.2
Ying, H.3
Nabioullin, R.4
Ponugoti, A.H.5
Wiedemeyer, R.6
Stegh, A.H.7
Bradner, J.E.8
Ligon, K.L.9
Brennan, C.10
Chin, L.11
DePinho, R.A.12
-
30
-
-
0142057138
-
CIP1/WAF1 induction rather than AKT inhibition
-
DOI 10.1038/sj.onc.1206646
-
Rahmani M, Yu C, Reese E, Ahmed W, Hirsch K, Dent P, et al. Inhibition of PI-3 kinase sensitizes human leukemic cells to histone deacetylase inhibitor-mediated apoptosis through p44/42 MAP kinase inactivation and abrogation of p21(CIP1/WAF1) induction rather than AKT inhibition. Oncogene 2003;22:6231-42. (Pubitemid 37281653)
-
(2003)
Oncogene
, vol.22
, Issue.40
, pp. 6231-6242
-
-
Rahmani, M.1
Yu, C.2
Reese, E.3
Ahmed, W.4
Hirsch, K.5
Dent, P.6
Grant, S.7
-
31
-
-
15944406971
-
Coadministration of histone deacetylase inhibitors and perifosine synergistically induces apoptosis in human leukemia cells through Akt and ERK1/2 inactivation and the generation of ceramide and reactive oxygen species
-
DOI 10.1158/0008-5472.CAN-04-2440
-
Rahmani M, Reese E, Dai Y, Bauer C, Payne SG, Dent P, et al. Coadministration of histone deacetylase inhibitors and perifosine synergistically induces apoptosis in human leukemia cells through Akt and ERK1/2 inactivation and the generation of ceramide and reactive oxygen species. Cancer Res 2005;65:2422-32. (Pubitemid 40490154)
-
(2005)
Cancer Research
, vol.65
, Issue.6
, pp. 2422-2432
-
-
Rahmani, M.1
Reese, E.2
Dai, Y.3
Bauer, C.4
Payne, S.G.5
Dent, P.6
Spiegel, S.7
Grant, S.8
-
32
-
-
0037446980
-
The lethal effects of pharmacological cyclin-dependent kinase inhibitors in human leukemia cells proceed through a phosphatidylinositol 3-kinase/Akt-dependent process
-
Yu C, Rahmani M, Dai Y, Conrad D, Krystal G, Dent P, et al. The lethal effects of pharmacological cyclin-dependent kinase inhibitors in human leukemia cells proceed through a phosphatidylinositol 3-kinase/Akt-dependent process. Cancer Res 2003;63: 1822-33. (Pubitemid 36460844)
-
(2003)
Cancer Research
, vol.63
, Issue.8
, pp. 1822-1833
-
-
Yu, C.1
Rahmani, M.2
Dai, Y.3
Conrad, D.4
Krystal, G.5
Dent, P.6
Grant, S.7
-
33
-
-
33644954099
-
Loss of the tissue-specific proapoptotic bh3-only protein nbk/bik is a unifying feature of renal cell carcinoma
-
Sturm I, Stephan C, Gillissen B, Siebert R, Janz M, Radetzki S, et al. Loss of the tissue-specific proapoptotic BH3-only protein Nbk/Bik is a unifying feature of renal cell carcinoma. Cell Death Differ 2006;13:619- 27.
-
(2006)
Cell Death Differ
, vol.13
, pp. 619-627
-
-
Sturm, I.1
Stephan, C.2
Gillissen, B.3
Siebert, R.4
Janz, M.5
Radetzki, S.6
-
34
-
-
35548967197
-
Frequent loss of expression of the pro-apoptotic protein Bim in renal cell carcinoma: Evidence for contribution to apoptosis resistance
-
DOI 10.1038/sj.onc.1210510, PII 1210510
-
Zantl N, Weirich G, Zall H, Seiffert BM, Fischer SF, Kirschnek S, et al. Frequent loss of expression of the pro-apoptotic protein Bim in renal cell carcinoma: evidence for contribution to apoptosis resistance. Oncogene 2007;26:7038-48. (Pubitemid 350014613)
-
(2007)
Oncogene
, vol.26
, Issue.49
, pp. 7038-7048
-
-
Zantl, N.1
Weirich, G.2
Zall, H.3
Seiffert, B.M.4
Fischer, S.F.5
Kirschnek, S.6
Hartmann, C.7
Fritsch, R.M.8
Gillissen, B.9
Daniel, P.T.10
Hacker, G.11
-
35
-
-
0031018674
-
Somatic frameshift mutations in the bax gene in colon cancers of the microsatellite mutator phenotype
-
Rampino N, Yamamoto H, Ionov Y, Li Y, Sawai H, Reed JC, et al. Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype. Science 1997;275: 967-9.
-
(1997)
Science
, vol.275
, pp. 9679
-
-
Rampino, N.1
Yamamoto, H.2
Ionov, Y.3
Li, Y.4
Sawai, H.5
Reed, J.C.6
-
36
-
-
73949096431
-
Flt3-itd up-regulatesmcl-1 to promote survival of stem cells in acute myeloid leukemia via flt3-itd-specific stat5 activation
-
Yoshimoto G, Miyamoto T, Jabbarzadeh-Tabrizi S, Iino T, Rocnik JL, Kikushige Y, et al. FLT3-ITD up-regulatesMCL-1 to promote survival of stem cells in acute myeloid leukemia via FLT3-ITD-specific STAT5 activation. Blood 2009;114:5034-43.
-
(2009)
Blood
, vol.114
, pp. 5034-43
-
-
Yoshimoto, G.1
Miyamoto, T.2
Jabbarzadeh-Tabrizi, S.3
Iino, T.4
Rocnik, J.L.5
Kikushige, Y.6
-
37
-
-
84856270102
-
Antiapoptotic mcl-1 is essential for the development and sustained growth of acute myeloid leukemia
-
Glaser SP, Lee EF, Trounson E, Bouillet P, Wei A, Fairlie WD, et al. Antiapoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemia. Genes Dev 2012;26:120-5.
-
(2012)
Genes Dev
, vol.26
, pp. 1205
-
-
Glaser, S.P.1
Lee, E.F.2
Trounson, E.3
Bouillet, P.4
Wei, A.5
Fairlie, W.D.6
-
38
-
-
73349129405
-
Differential induction of apoptosis in her2 and egfr addicted cancers following pi3k inhibition
-
Faber AC, Li D, Song Y, Liang MC, Yeap BY, Bronson RT, et al. Differential induction of apoptosis in HER2 and EGFR addicted cancers following PI3K inhibition. Proc Natl Acad Sci U S A 2009;106: 19503-8.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 195038
-
-
Faber, A.C.1
Li, D.2
Song, Y.3
Liang, M.C.4
Yeap, B.Y.5
Bronson, R.T.6
-
39
-
-
0032772367
-
The antiapoptotic gene mcl-1 is up-regulated by the phosphatidylinositol 3-kinase/Akt signaling pathway through a transcription factor complex containing CREB
-
Wang JM, Chao JR, Chen W, Kuo ML, Yen JJ, Yang-Yen HF. The antiapoptotic gene mcl-1 is up-regulated by the phosphatidylinositol 3-kinase/Akt signaling pathway through a transcription factor complex containing CREB. Mol Cell Biol 1999;19: 6195-206. (Pubitemid 29399324)
-
(1999)
Molecular and Cellular Biology
, vol.19
, Issue.9
, pp. 6195-6206
-
-
Wang, J.U.-M.1
Chao, J.-R.2
Chen, W.3
Kuo, M.-L.4
Yen, J.J.-Y.5
Yang-Yen, H.-F.6
-
40
-
-
77649286736
-
Genetic dissection of the oncogenicmtorpathway reveals druggable addiction to translational control via 4ebp-eif4e
-
Hsieh AC, Costa M, Zollo O, Davis C, Feldman ME, Testa JR, et al. Genetic dissection of the oncogenicmTORpathway reveals druggable addiction to translational control via 4EBP-eIF4E. Cancer Cell 2010;17:249-61.
-
(2010)
Cancer Cell
, vol.17
, pp. 249-61
-
-
Hsieh, A.C.1
Costa, M.2
Zollo, O.3
Davis, C.4
Feldman, M.E.5
Testa, J.R.6
-
41
-
-
33644855216
-
Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1
-
DOI 10.1016/j.molcel.2006.02.009, PII S1097276506001110
-
Maurer U, Charvet C, Wagman AS, Dejardin E, Green DR. Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1. Mol Cell 2006;21:749-60. (Pubitemid 43376126)
-
(2006)
Molecular Cell
, vol.21
, Issue.6
, pp. 749-760
-
-
Maurer, U.1
Charvet, C.2
Wagman, A.S.3
Dejardin, E.4
Green, D.R.5
-
42
-
-
79952261405
-
Scf (fbw7) regulates cellular apoptosis by targeting mcl1 for ubiquitylation and destruction
-
Inuzuka H, Shaik S, Onoyama I, Gao D, Tseng A, Maser RS, et al. SCF (FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction. Nature 2011;471:104-9.
-
(2011)
Nature
, vol.471
, pp. 1049
-
-
Inuzuka, H.1
Shaik, S.2
Onoyama, I.3
Gao, D.4
Tseng, A.5
Maser, R.S.6
-
43
-
-
77954823170
-
Glycogen synthase kinase-3 plays a central role in mediating glucocorticoid-induced apoptosis
-
Spokoini R, Kfir-Erenfeld S, Yefenof E, Sionov RV. Glycogen synthase kinase-3 plays a central role in mediating glucocorticoid-induced apoptosis. Mol Endocrinol 2010;24:1136-50.
-
(2010)
Mol Endocrinol
, vol.24
, pp. 1136-50
-
-
Spokoini, R.1
Kfir-Erenfeld, S.2
Yefenof, E.3
Sionov, R.V.4
-
44
-
-
0033851276
-
Gsk3, a master switch regulating cell-fate specification and tumorigenesis
-
Kim L, Kimmel AR. GSK3, a master switch regulating cell-fate specification and tumorigenesis. Curr Opin Genet Dev 2000;10: 508-14.
-
(2000)
Curr Opin Genet Dev
, vol.10
, pp. 508-14
-
-
Kim, L.1
Kimmel, A.R.2
-
45
-
-
80051569213
-
Distribution of bim determines mcl-1 dependence or codependence with bcl-xl/bcl-2 in mcl-1-expressing myeloma cells
-
Morales AA, Kurtoglu M, Matulis SM, Liu J, Siefker D, GutmanDM, et al. Distribution of Bim determines Mcl-1 dependence or codependence with Bcl-xL/Bcl-2 in Mcl-1-expressing myeloma cells. Blood 2011;118:1329-39.
-
(2011)
Blood
, vol.118
, pp. 1329-39
-
-
Morales, A.A.1
Kurtoglu, M.2
Matulis, S.M.3
Liu, J.4
Siefker, D.5
Gutman, D.M.6
-
46
-
-
22244464818
-
L, but not Bcl-2, until displaced by BH3-only proteins
-
DOI 10.1101/gad.1304105
-
Willis SN, Chen L, Dewson G, Wei A, Naik E, Fletcher JI, et al. Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins. Genes Dev 2005;19: 1294-305. (Pubitemid 41003019)
-
(2005)
Genes and Development
, vol.19
, Issue.11
, pp. 1294-1305
-
-
Willis, S.N.1
Chen, L.2
Dewson, G.3
Wei, A.4
Naik, E.5
Fletcher, J.I.6
Adams, J.M.7
Huang, D.C.S.8
|