Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 3, 2005, Pages 802-807

  Kang, Sohye ^a   Bader, Andreas G ^a   Vogt, Peter K ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Akt; Oncogenic transformation; p110 ; PIK3CA

Indexed keywords

INITIATION FACTOR 4E BINDING PROTEIN 1; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RAPAMYCIN; S6 KINASE; TARGET OF RAPAMYCIN KINASE;

ANIMAL TISSUE; ARTICLE; CELL ONCOGENE; CELL TRANSFORMATION; CHICK EMBRYO; CONTROLLED STUDY; EMBRYO; ENZYME PHOSPHORYLATION; GENE; GENE MUTATION; HUMAN; MALIGNANT TRANSFORMATION; NONHUMAN; PIK3CA GENE; PRIORITY JOURNAL; SOMATIC MUTATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CARRIER PROTEINS; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; CHICK EMBRYO; FIBROBLASTS; HUMANS; MUTATION, MISSENSE; NEOPLASMS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RIBOSOMAL PROTEIN S6 KINASES; SIGNAL TRANSDUCTION;

ANIMALIA; GALLUS GALLUS;

EID: 14144252004     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0408864102     Document Type: Article

References (46)

1. Shayesteh, L., Lu, Y., Kuo, W. L., Baldocchi, R., Godfrey, T., Collins, C., Pinkel, D., Powell, B., Mills, G. B. & Gray, J. W. (1999) Nat. Genet. 21, 99-102.
2. Philp, A. J., Campbell, I. G., Leet, C., Vincan, E., Rockman, S. P., Whitehead, R. H., Thomas, R. J. & Phillips, W. A. (2001) Cancer Res. 61, 7426-7429.
3. Cantley, L. C. & Neel, B. G. (1999) Proc. Natl. Acad. Sci. USA 96, 4240-4245.
4. Wang, S. I., Puc, J., Li, J., Bruce, J. N., Cairns, P., Sidransky, D. & Parsons, R. (1997) Cancer Res. 57, 4183-4186.
5. Yokoyama, Y., Wan, X., Shinohara, A., Takahashi, S., Takahashi, Y., Niwa, K. & Tamaya, T. (2000) Int. J. Mol. Med. 6, 47-50.
6. Celebi, J. T., Shendrik, I., Silvers, D. N. & Peacocke, M. (2000) J. Med. Genet. 37, 653-657.
7. Ringel, M. D., Hayre, N., Saito, J., Saunier, B., Schuppert, F., Burch, H., Bernet, V., Burman, K. D., Kohn, L. D. & Saji, M. (2001) Cancer Res. 61, 6105-6111.
8. Bellacosa, A., de Feo, D., Godwin, A. K., Bell, D. W., Cheng, J. Q., Altomare, D. A., Wan, M., Dubeau, L., Scambia, G. & Masciullo, V. (1995) Int. J. Cancer 64, 280-285.
9. Bellacosa, A., Testa, J. R., Staal, S. P. & Tsichlis, P. N. (1991) Science 254, 274-277.
10. Chang, H. W., Aoki, M., Fruman, D., Auger, K. R., Bellacosa, A., Tsichlis, P. N., Cantley, L. C., Roberts, T. M. & Vogt, P. K. (1997) Science 276, 1848-1850.
11. Bachman, K. E., Argani, P., Samuels, Y., Silliman, N., Ptak, J., Szabo, S., Konishi, H., Karakas, B., Blair, B. G., Lin, C., et al. (2004) Cancer Biol. Ther. 3, e49-e52.
12. Broderick, D. K., Di, C., Parrett, T. J., Samuels, Y. R., Cummins, J. M., McLendon, R. E., Fults, D. W., Velculescu, V. E., Bigner, D. D. & Yan, H. (2004) Cancer Res. 64, 5048-5050.
13. Samuels, Y., Wang, Z., Bardelli, A., Silliman, N., Ptak, J., Szabo, S., Yan, H., Gazdar, A., Powell, S. M., Riggins, G. J., et al. (2004) Science 304, 554.
14. Bos, T. J., Monteclaro, F. S., Mitsunobu, F., Ball, A. R., Jr., Chang, C. H., Nishimura, T. & Vogt, P. K. (1990) Genes Dev. 4, 1677-1687.
15. Duff, R. G. & Vogt, P. K. (1969) Virology 39, 18-30.
16. Aoki, M., Schetter, C., Himly, M., Batista, O., Chang, H. W. & Vogt, P. K. (2000) J. Biol. Chem. 275, 6267-6275.
17. Walsh, J. P., Caldwell, K. K. & Majerus, P. W. (1991) Proc. Natl. Acad. Sci. USA 88, 9184-9187.
18. Scheid, M. P. & Woodgett, J. R. (2001) Nat. Rev. Mol. Cell. Biol. 2, 760-768.
19. Vivanco, I. & Sawyers, C. L. (2002) Nat. Rev. Cancer 2, 489-501.
20. Aoki, M., Blazek, E. & Vogt, P. K. (2001) Proc. Natl. Acad. Sci. USA 98, 136-141.
21. Harris, T. E. & Lawrence, J. C., Jr. (2003) Sci. STKE 2003, re15.
22. Hay, N. & Sonenberg, N. (2004) Genes Dev. 18, 1926-1945.
23. Alessi, D. R., James, S. R., Downes, C. P., Holmes, A. B., Gaffney, P. R., Reese, C. B. & Cohen, P. (1997) Curr. Biol. 7, 261-269.
24. Williams, M. R., Arthur, J. S., Balendran, A., van der Kaay, J., Poli, V., Cohen, P. & Alessi, D. R. (2000) Curr. Biol. 10, 439-448.
25. Feng, J., Park, J., Cron, P., Hess, D. & Hemmings, B. A. (2004) J. Biol. Chem. 279, 41189-41196.
26. Liu, A. X., Testa, J. R., Hamilton, T. C., Jove, R., Nicosia, S. V. & Cheng, J. Q. (1998) Cancer Res. 58, 2973-2977.
27. Franke, T. F., Yang, S. I., Chan, T. O., Datta, K., Kazlauskas, A., Morrison, D. K., Kaplan, D. R. & Tsichlis, P. N. (1995) Cell 81, 727-736.
28. Downward, J. (2004) Semin. Cell. Dev. Biol. 15, 177-182.
29. Fresno Vara, J. A., Casado, E., de Castro, J., Cejas, P., Belda-Iniesta, C. & Gonzalez-Baron, M. (2004) Cancer Treat. Rev. 30, 193-204.
30. Bacus, S. S., Altomare, D. A., Lyass, L., Chin, D. M., Farrell, M. P., Gurova, K., Gudkov, A. & Testa, J. R. (2002) Oncogene 21, 3532-3540.
31. Knuefermann, C., Lu, Y., Liu, B., Jin, W., Liang, K., Wu, L., Schmidt, M., Mills, G. B., Mendelsohn, J. & Fan, Z. (2003) Oncogene 22, 3205-3212.
32. Dufner, A. & Thomas, G. (1999) Exp. Cell Res. 253, 100-109.
33. Jefferies, H. B., Fumagalli, S., Dennis, P. B., Reinhard, C., Pearson, R. B. & Thomas, G. (1997) EMBO J. 16, 3693-3704.
34. Schwab, M. S., Kim, S. H., Terada, N., Edfjall, C., Kozma, S. C., Thomas, G. & Maller, J. L. (1999) Mol. Cell. Biol. 19, 2485-2494.
35. Brunn, G. J., Hudson, C. C., Sekulic, A., Williams, J. M., Hosoi, H., Houghton, P. J., Lawrence, J. C., Jr., & Abraham, R. T. (1997) Science 277, 99-101.
36. Gingras, A. C., Gygi, S. P., Raught, B., Polakiewicz, R. D., Abraham, R. T., Hoekstra, M. F., Aebersold, R. & Sonenberg, N. (1999) Genes Dev. 13, 1422-1437.
37. Gingras, A. C., Kennedy, S. G., O'Leary, M. A., Sonenberg, N. & Hay, N. (1998) Genes Dev. 12, 502-513.
38. Burnett, P. E., Barrow, R. K., Cohen, N. A., Snyder, S. H. & Sabatini, D. M. (1998) Proc. Natl. Acad. Sci. USA 95, 1432-1437.
39. Gingras, A. C., Raught, B. & Sonenberg, N. (1999) Annu. Rev. Biochem. 68, 913-963.
40. Sonenberg, N. & Gingras, A. C. (1998) Curr. Opin. Cell Biol. 10, 268-275.
41. Neshat, M. S., Mellinghoff, I. K., Tran, C., Stiles, B., Thomas, G., Petersen, R., Frost, P., Gibbons, J. J., Wu, H. & Sawyers, C. L. (2001) Proc. Natl. Acad. Sci. USA 98, 10314-10319.
42. Podsypanina, K., Lee, R. T., Politis, C., Hennessy, I., Crane, A., Puc, J., Neshat, M., Wang, H., Yang, L., Gibbons, J., et al. (2001) Proc. Natl. Acad. Sci. USA 98, 10320-10325.
43. Druker, B. J., Sawyers, C. L., Kantarjian, H., Resta, D. J., Reese, S. F., Ford, J. M., Capdeville, R. & Talpaz, M. (2001) N. Engl. J. Med. 344, 1038-1042.
44. O'Brien, S. G., Guilhot, F., Larson, R. A., Gathmann, I., Baccarani, M., Cervantes, F., Cornelissen, J. J., Fischer, T., Hochhaus, A., Hughes, T., et al. (2003) N. Engl. J. Med. 348, 994-1004.
45. Pao, W., Miller, V., Zakowski, M., Doherty, J., Politi, K., Sarkaria, I., Singh, B., Heelan, R., Rusch, V., Fulton, L., et al. (2004) Proc. Natl. Acad. Sci. USA 101, 13306-13311.
46. Natale, R. B. (2004) Semin. Oncol. 31, 23-30.