-
1
-
-
28844448182
-
Oncogenic PI3K deregulates transcription and translation
-
DOI 10.1038/nrc1753
-
Bader AG, Kang S, Zhao L, Vogt PK. Oncogenic PI3K deregulates transcription and translation. Nat Rev Cancer 2005;5:921-9. (Pubitemid 41766781)
-
(2005)
Nature Reviews Cancer
, vol.5
, Issue.12
, pp. 921-929
-
-
Bader, A.G.1
Kang, S.2
Zhao, L.3
Vogt, P.K.4
-
2
-
-
39749141485
-
The regulation and function of class III PI3Ks: Novel roles for Vps34
-
Backer JM. The regulation and function of class III PI3Ks: novel roles for Vps34. Biochem J 2008;410:1-17.
-
(2008)
Biochem J
, vol.410
, pp. 1-17
-
-
Backer, J.M.1
-
3
-
-
0028110018
-
Vps34p required for yeast vacuolar protein sorting is a multiple specificity kinase that exhibits both protein kinase and phosphatidylinositol- specific PI 3-kinase activities
-
Stack JH, Emr SD. Vps34p required for yeast vacuolar protein sorting is a multiple specificity kinase that exhibits both protein kinase and phosphatidylinositol-specific PI 3-kinase activities. J Biol Chem 1994;269:31552-62.
-
(1994)
J Biol Chem
, vol.269
, pp. 31552-31562
-
-
Stack, J.H.1
Emr, S.D.2
-
4
-
-
0033202945
-
Rab5 regulates motility of early endosomes on microtubules
-
Nielsen E, Severin F, Backer JM, Hyman AA, Zerial M. Rab5 regulates motility of early endosomes on microtubules. Nat Cell Biol 1999;1:376-82. (Pubitemid 129493581)
-
(1999)
Nature Cell Biology
, vol.1
, Issue.6
, pp. 376-382
-
-
Nielsen, E.1
Severin, F.2
Backer, J.M.3
Hyman, A.A.4
Zerial, M.5
-
5
-
-
0036300306
-
Role of Rab5 in the recruitment of hVps34/p150 to the early endosome
-
DOI 10.1034/j.1600-0854.2002.30605.x
-
Murray JT, Panaretou C, Stenmark H, Miaczynska M, Backer JM. Role of Rab5 in the recruitment of hVps34/p150 to the early endosome. Traffic 2002;3:416-27. (Pubitemid 34746409)
-
(2002)
Traffic
, vol.3
, Issue.6
, pp. 416-427
-
-
Murray, J.T.1
Panaretou, C.2
Stenmark, H.3
Miaczynska, M.4
Backer, J.M.5
-
6
-
-
0035494493
-
Distinct roles of class I and class III phosphatidylinositol 3-kinases in phagosome formation and maturation
-
DOI 10.1083/jcb.200107069
-
Vieira OV, Botelho RJ, Rameh L, et al. Distinct roles of class I and class III phosphatidylinositol 3-kinases in phagosome formation and maturation. J Cell Biol 2001;155:19-25. (Pubitemid 34286204)
-
(2001)
Journal of Cell Biology
, vol.155
, Issue.1
, pp. 19-25
-
-
Vieira, O.V.1
Botelho, R.J.2
Rameh, L.3
Brachmann, S.M.4
Matsuo, T.5
Davidson, H.W.6
Schreiber, A.7
Backer, J.M.8
Cantley, L.C.9
Grinstein, S.10
-
7
-
-
33745685061
-
Activation of the phosphatidylinositol 3-kinase Vps34 by a G protein á subunit at the endosomes
-
Slessareva JE, Routt SM, Temple B, Bankaitis VA, Dohlman HG. Activation of the phosphatidylinositol 3-kinase Vps34 by a G protein á subunit at the endosomes. Cell 2006;126:191-203.
-
(2006)
Cell
, vol.126
, pp. 191-203
-
-
Slessareva, J.E.1
Routt, S.M.2
Temple, B.3
Bankaitis, V.A.4
Dohlman, H.G.5
-
8
-
-
0033978633
-
Distinct classes of phosphatidylinositol 3'-kinases are involved in signaling pa7thways that control macroautophagy in HT-29 cells
-
DOI 10.1074/jbc.275.2.992
-
Petiot A, Ogier-Denis E, Blommaart EF, Meijer AJ, Codogno P. Distinct classes of phosphatidylinositol 3′-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells. J Biol Chem 2000;275:992-8. (Pubitemid 30051145)
-
(2000)
Journal of Biological Chemistry
, vol.275
, Issue.2
, pp. 992-998
-
-
Petiot, A.1
Ogier-Denis, E.2
Blommaart, E.F.C.3
Meijer, A.J.4
Codogno, P.5
-
9
-
-
33847743064
-
hVps34, an ancient player, enters a growing game: mTOR complex 1/S6K1 signaling
-
Nobukuni T, Kozma SC, Thomas G. hVps34, an ancient player, enters a growing game: mTOR complex 1/S6K1 signaling. Curr Opin Cell Biol 2007;19:135-41.
-
(2007)
Curr Opin Cell Biol
, vol.19
, pp. 135-141
-
-
Nobukuni, T.1
Kozma, S.C.2
Thomas, G.3
-
10
-
-
25444457577
-
hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase
-
Byfield MP, Murray JT, Backer JM. hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase. J Biol Chem 2005;280:33076-82.
-
(2005)
J Biol Chem
, vol.280
, pp. 33076-33082
-
-
Byfield, M.P.1
Murray, J.T.2
Backer, J.M.3
-
11
-
-
26444575415
-
Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase
-
DOI 10.1073/pnas.0506925102
-
Nobukuni T, Joaquin M, Roccio M, et al. Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase. Proc Natl Acad Sci U S A 2005;102:14238-43. (Pubitemid 41429682)
-
(2005)
Proceedings of the National Academy of Sciences of the United States of America
, vol.102
, Issue.40
, pp. 14238-14243
-
-
Nobukuni, T.1
Joaquin, M.2
Roccio, M.3
Dann, S.G.4
Kim, S.Y.5
Gulati, P.6
Byfield, M.P.7
Backer, J.M.8
Natt, F.9
Bos, J.L.10
Zwartkruis, F.J.T.11
Thomas, G.12
-
12
-
-
34249679614
-
mTOR complex 1-6K1 signaling: At the crossroads of obesity, diabetes and cancer
-
Dann SG, Selvaraj A, Thomas G. mTOR complex 1-6K1 signaling: at the crossroads of obesity, diabetes and cancer. Trends Mol Med 2007;13:252-9.
-
(2007)
Trends Mol Med
, vol.13
, pp. 252-259
-
-
Dann, S.G.1
Selvaraj, A.2
Thomas, G.3
-
13
-
-
0035895375
-
New responsibilities for the PI3K regulatory subunit p85á
-
Okkenhaug K, Vanhaesebroeck B. New responsibilities for the PI3K regulatory subunit p85á. Sci STKE 2001;65:1-5.
-
(2001)
Sci STKE
, vol.65
, pp. 1-5
-
-
Okkenhaug, K.1
Vanhaesebroeck, B.2
-
14
-
-
0028074316
-
Phosphatidylinositol-3-OH kinase as a direct target of Ras
-
DOI 10.1038/370527a0
-
Rodriguez-Viciana P, Warne PH, Dhand R, et al. Phosphatidylinositol- 3-OH kinase as a direct target of Ras. Nature 1994;370:527-32. (Pubitemid 24264918)
-
(1994)
Nature
, vol.370
, Issue.6490
, pp. 527-532
-
-
Rodriguez-Viciana, P.1
Warne, P.H.2
Dhand, R.3
Vanhaesebroeck, B.4
Gout, I.5
Fry, M.J.6
Waterfield, M.D.7
Downward, J.8
-
15
-
-
0029990003
-
Activation of phosphoinositide 3-kinase by interaction with Ras and by point mutation
-
Rodriguez-Viciana P, Warne PH, Vanhaesebroeck B, Waterfield MD, Downward J. Activation of phosphoinositide 3-kinase by interaction with Ras and by point mutation. EMBO J 1996;15:2442-51. (Pubitemid 26151184)
-
(1996)
EMBO Journal
, vol.15
, Issue.10
, pp. 2442-2451
-
-
Rodriguez-Viciana, P.1
Warne, P.H.2
Vanhaesebroeck, B.3
Waterfield, M.D.4
Downward, J.5
-
16
-
-
0033174034
-
Phosphatidylinositol-3-OH kinases are Rab5 effectors
-
Christoforidis S, Miaczynska M, Ashman K, et al. Phosphatidylinositol- 3-OH kinases are Rab5 effectors. Nat Cell Biol 1999;4:249-52. (Pubitemid 129500945)
-
(1999)
Nature Cell Biology
, vol.1
, Issue.4
, pp. 249-252
-
-
Christoforidis, S.1
Miaczynska, M.2
Ashman, K.3
Wilm, M.4
Zhao, L.5
Yip, S.-C.6
Waterfield, M.D.7
Backer, J.M.8
Zerial, M.9
-
17
-
-
4544235743
-
C-Src and cooperating partners in human cancer
-
DOI 10.1016/j.ccr.2004.09.001, PII S1535610804002429
-
Ishizawar R, Parsons SJ. c-Src and cooperating partners in human cancer. Cancer Cell 2004;6:209-14. (Pubitemid 39222033)
-
(2004)
Cancer Cell
, vol.6
, Issue.3
, pp. 209-214
-
-
Ishizawar, R.1
Parsons, S.J.2
-
18
-
-
0031439247
-
Cellular functions regulated by Src family kinases
-
Thomas SM, Brugge JS. Cellular functions regulated by Src family kinases. Annu Rev Cell Dev Biol 1997;13:513-609.
-
(1997)
Annu Rev Cell Dev Biol
, vol.13
, pp. 513-609
-
-
Thomas, S.M.1
Brugge, J.S.2
-
19
-
-
0034466985
-
Tyrosine kinase signaling in breast cancer: Epidermal growth factor receptor and c-Src interactions in breast cancer
-
Biscardi JS, Ishizawar RC, Silva CM, Parsons SJ. Tyrosine kinase signaling in breast cancer: epidermal growth factor receptor and c-Src interactions in breast cancer. Breast Cancer Res 2000;2: 203-10.
-
(2000)
Breast Cancer Res
, vol.2
, pp. 203-210
-
-
Biscardi, J.S.1
Ishizawar, R.C.2
Silva, C.M.3
Parsons, S.J.4
-
20
-
-
0034693877
-
Role of Src expression and activation in human cancer
-
Irby RB, Yeatman TJ. Role of Src expression and activation in human cancer. Oncogene 2000;19:5636-42.
-
(2000)
Oncogene
, vol.19
, pp. 5636-5642
-
-
Irby, R.B.1
Yeatman, T.J.2
-
21
-
-
0033043254
-
Rapamycin-resistant phosphorylation of the initiation factor-4E-binding protein (4E-BP1) in v-SRC-transformed hamster fibroblasts
-
DOI 10.1002/(SICI)1097-0215(19990611)81:6<963::AID-IJC20>3.0.CO;2-C
-
Tuhackova Z, Sovova V, Sloncova E, Proud CG. Rapamycin-resistant phosphorylation of the initiation factor-4E-binding protein (4E-BP1) in v-src transformed hamster fibroblasts. Int J Cancer 1999;81:963-9. (Pubitemid 29249984)
-
(1999)
International Journal of Cancer
, vol.81
, Issue.6
, pp. 963-969
-
-
Tuhackova, Z.1
Sovova, V.2
Sloncova, E.3
Proud, C.G.4
-
22
-
-
0037103769
-
The Src-family tyrosine inhibitor PP1 interferes with the activation of ribosomal protein S6 kinase
-
Shah OJ, Kimball SR, Jefferson LS. The Src-family tyrosine inhibitor PP1 interferes with the activation of ribosomal protein S6 kinase. Biochem J 2002;366:57-62.
-
(2002)
Biochem J
, vol.366
, pp. 57-62
-
-
Shah, O.J.1
Kimball, S.R.2
Jefferson, L.S.3
-
23
-
-
0032978365
-
Transformation by v-Src: Ras-MAPK and PI3K-mTOR mediate parallel pathways
-
Penuel E, Martin GS. Transformation by v-src: Ras-MAPK and PI3K-mTOR mediate parallel pathways. Mol Biol Cell 1999;10: 1693-703. (Pubitemid 29272625)
-
(1999)
Molecular Biology of the Cell
, vol.10
, Issue.6
, pp. 1693-1703
-
-
Penuel, E.1
Martin, G.S.2
-
24
-
-
0000153275
-
Transformation activity of Cdc42 requires a region unique to Rho-related proteins
-
Wu WJ, Lin R, Cerione RA, Manor D. Transformation activity of Cdc42 requires a region unique to Rho-related proteins. J Biol Chem 1998;273:16655-8.
-
(1998)
J Biol Chem
, vol.273
, pp. 16655-16658
-
-
Wu, W.J.1
Lin, R.2
Cerione, R.A.3
Manor, D.4
-
25
-
-
0141426629
-
Activated Cdc42 sequesters c-Cbl and prevents EGFR degradation
-
Wu WJ, Tu S, Cerione RA. Activated Cdc42 sequesters c-Cbl and prevents EGFR degradation. Cell 2003;114:715-25.
-
(2003)
Cell
, vol.114
, pp. 715-725
-
-
Wu, W.J.1
Tu, S.2
Cerione, R.A.3
-
27
-
-
0032517624
-
Distinct roles for the p110a and hVPS34 phosphatidylinositol 3′-kinases in vesicular trafficking, regulation of the actin cytoskeleton, and mitogenesis
-
Siddhanta U, McIlroy J, Shah A, Zhang Y, Backer JM. Distinct roles for the p110a and hVPS34 phosphatidylinositol 3′-kinases in vesicular trafficking, regulation of the actin cytoskeleton, and mitogenesis. J Cell Biol 1998;143:1647-59.
-
(1998)
J Cell Biol
, vol.143
, pp. 1647-1659
-
-
Siddhanta, U.1
McIlroy, J.2
Shah, A.3
Zhang, Y.4
Backer, J.M.5
-
30
-
-
33645742736
-
Growth and motility inhibition of breast cancer cells by epidermal growth factor receptor degradation is correlated with inactivation of Cdc42
-
Hirsch DS, Shen Y, Wu WJ. Growth and motility inhibition of breast cancer cells by epidermal growth factor receptor degradation is correlated with inactivation of Cdc42. Cancer Res 2006;66: 3523-30.
-
(2006)
Cancer Res
, vol.66
, pp. 3523-3530
-
-
Hirsch, D.S.1
Shen, Y.2
Wu, W.J.3
-
31
-
-
33745307617
-
Ras, PI(3)K and mTOR signalling controls tumour cell growth
-
Shaw RJ, Cantley LC. Ras, PI(3)K and mTOR signalling controls tumour cell growth. Nature 2006;441:424-30.
-
(2006)
Nature
, vol.441
, pp. 424-430
-
-
Shaw, R.J.1
Cantley, L.C.2
-
32
-
-
23144434356
-
KinasePhos: A web tool identifying protein kinase-specific phosphorylation sites
-
Huang HD, Lee TY, Tseng SW, Horng JT. KinasePhos: a web tool identifying protein kinase-specific phosphorylation sites. Nucleic Acids Res 2005;33:W226-9.
-
(2005)
Nucleic Acids Res
, vol.33
-
-
Huang, H.D.1
Lee, T.Y.2
Tseng, S.W.3
Horng, J.T.4
-
33
-
-
77950510375
-
PtdIns(3)P controls cytokinesis through KIF13A-mediated recruitment of FYVE-CENT to the midbody
-
Sagona AP, Nezis IP, Pedersen NM, et al. PtdIns(3)P controls cytokinesis through KIF13A-mediated recruitment of FYVE-CENT to the midbody. Nat Cell Biol 2010;12:362-71.
-
(2010)
Nat Cell Biol
, vol.12
, pp. 362-371
-
-
Sagona, A.P.1
Nezis, I.P.2
Pedersen, N.M.3
-
34
-
-
0027256130
-
A membrane-associated complex containing the Vps15 protein kinase and the Vps34 PI 3-kinase is essential for protein sorting to the yeast lysosome-like vacuole
-
Stack JH, Herman PK, Schu PV, Emr SD. A membrane-associated complex containing the Vps15 protein kinase and the Vps34 PI 3-kinase is essential for protein sorting to the yeast lysosome-like vacuole. EMBO J 1993;15:2195-204.
-
(1993)
EMBO J
, vol.15
, pp. 2195-2204
-
-
Stack, J.H.1
Herman, P.K.2
Schu, P.V.3
Emr, S.D.4
-
35
-
-
77950212231
-
Shaping development of autophagy inhibitors with the structure of the lipid kinase Vps34
-
Miller S, Tavshanjian B, Oleksy A, et al. Shaping development of autophagy inhibitors with the structure of the lipid kinase Vps34. Science 2010;327:1638-42.
-
(2010)
Science
, vol.327
, pp. 1638-1642
-
-
Miller, S.1
Tavshanjian, B.2
Oleksy, A.3
-
36
-
-
16644393213
-
The PIK3CA gene is mutated with high frequency in human breast cancers
-
Bachman KE, Argani P, Samuels Y, et al. The PIK3CA gene is mutated with high frequency in human breast cancers. Cancer Biol Ther 2004;3:772-5.
-
(2004)
Cancer Biol Ther
, vol.3
, pp. 772-775
-
-
Bachman, K.E.1
Argani, P.2
Samuels, Y.3
|