-
1
-
-
33847239467
-
PI3Kδ and PI3Kγ: Partners in crime in inflammation in rheumatoid arthritis and beyond?
-
Rommel C, Camps M, Ji H (2007) PI3Kδ and PI3Kγ: Partners in crime in inflammation in rheumatoid arthritis and beyond? Nat Rev Immunol 7:191-201.
-
(2007)
Nat Rev Immunol
, vol.7
, pp. 191-201
-
-
Rommel, C.1
Camps, M.2
Ji, H.3
-
2
-
-
0034635452
-
Central role for G protein-coupled phosphoinositide 3-kinase γ in inflammation
-
Hirsch E, et al. (2000) Central role for G protein-coupled phosphoinositide 3-kinase γ in inflammation. Science 287:1049-1053.
-
(2000)
Science
, vol.287
, pp. 1049-1053
-
-
Hirsch, E.1
-
3
-
-
0034635264
-
Function of PI3Kγ in thymocyte development, T cell activation, and neutrophil migration
-
Sasaki T, et al. (2000) Function of PI3Kγ in thymocyte development, T cell activation, and neutrophil migration. Science 287:1040-1046.
-
(2000)
Science
, vol.287
, pp. 1040-1046
-
-
Sasaki, T.1
-
4
-
-
0036200415
-
Phosphoinositide 3-kinase γ is an essential amplifier of mast cell function
-
Laffargue M, et al. (2002) Phosphoinositide 3-kinase γ is an essential amplifier of mast cell function. Immunity 16:441-451.
-
(2002)
Immunity
, vol.16
, pp. 441-451
-
-
Laffargue, M.1
-
5
-
-
0037323892
-
Phosphoinositide 3-kinase γ: A key modulator in inflammation and allergy
-
Wymann MP, et al. (2003) Phosphoinositide 3-kinase γ: A key modulator in inflammation and allergy. Biochem Soc Trans 31:275-280.
-
(2003)
Biochem Soc Trans
, vol.31
, pp. 275-280
-
-
Wymann, M.P.1
-
6
-
-
24744435115
-
Blockade of PI3Kγ suppresses joint inflammation and damage in mouse models of rheumatoid arthritis
-
Camps M, et al. (2005) Blockade of PI3Kγ suppresses joint inflammation and damage in mouse models of rheumatoid arthritis. Nat Med 11:936-943.
-
(2005)
Nat Med
, vol.11
, pp. 936-943
-
-
Camps, M.1
-
7
-
-
24744449495
-
PI3Kγ inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus
-
Barber DF, et al. (2005) PI3Kγ inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus. Nat Med 11:933-935.
-
(2005)
Nat Med
, vol.11
, pp. 933-935
-
-
Barber, D.F.1
-
8
-
-
34249951624
-
Deletion of the phosphoinositide 3-kinase p110γ gene attenuates murine atherosclerosis
-
Chang JD, et al. (2007) Deletion of the phosphoinositide 3-kinase p110γ gene attenuates murine atherosclerosis. Proc Natl Acad Sci USA 104:8077-8082.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 8077-8082
-
-
Chang, J.D.1
-
9
-
-
33750525089
-
PI3Kγ inhibition: Towards an "aspirin of the 21st century"?
-
Rückle T, Schwarz MK, Rommel C (2006) PI3Kγ inhibition: Towards an "aspirin of the 21st century"? Nat Rev Drug Discov 5:903-918.
-
(2006)
Nat Rev Drug Discov
, vol.5
, pp. 903-918
-
-
Rückle, T.1
Schwarz, M.K.2
Rommel, C.3
-
11
-
-
33645551286
-
Signaling through PI3Kγ: A common platform for leukocyte, platelet and cardiovascular stress sensing
-
Hirsch E, et al. (2006) Signaling through PI3Kγ: A common platform for leukocyte, platelet and cardiovascular stress sensing. Thromb Haemost 95:29-35.
-
(2006)
Thromb Haemost
, vol.95
, pp. 29-35
-
-
Hirsch, E.1
-
12
-
-
4344714889
-
PI3Kγ modulates the cardiac response to chronic pressure overload by distinct kinase-dependent and -independent effects
-
Patrucco E, et al. (2004) PI3Kγ modulates the cardiac response to chronic pressure overload by distinct kinase-dependent and -independent effects. Cell 118:375-387.
-
(2004)
Cell
, vol.118
, pp. 375-387
-
-
Patrucco, E.1
-
13
-
-
0035464192
-
Resistance to thromboembolism in PI3Kγ-deficient mice
-
Hirsch E, et al. (2001) Resistance to thromboembolism in PI3Kγ-deficient mice. FASEB J 15:2019-2021.
-
(2001)
FASEB J
, vol.15
, pp. 2019-2021
-
-
Hirsch, E.1
-
14
-
-
0035851213
-
2+ channels
-
2+ channels. Circ Res 89:692-699.
-
(2001)
Circ Res
, vol.89
, pp. 692-699
-
-
Macrez, N.1
-
16
-
-
61849126233
-
Fine-tuning the immune response with PI3K
-
Fruman DA, Bismuth G (2009) Fine-tuning the immune response with PI3K. Immunol Rev 228:253-272.
-
(2009)
Immunol Rev
, vol.228
, pp. 253-272
-
-
Fruman, D.A.1
Bismuth, G.2
-
17
-
-
33846621025
-
Antigen receptor signaling: A distinctive role for the p110δ isoform of PI3K
-
Okkenhaug K, Ali K, Vanhaesebroeck B (2007). Antigen receptor signaling: A distinctive role for the p110δ isoform of PI3K. Trends Immunol 28:80-87.
-
(2007)
Trends Immunol
, vol.28
, pp. 80-87
-
-
Okkenhaug, K.1
Ali, K.2
Vanhaesebroeck, B.3
-
18
-
-
44349119736
-
Angiogenesis selectively requires the p110α isoform of PI3K to control endothelial cell migration
-
Graupera M, et al. (2008) Angiogenesis selectively requires the p110α isoform of PI3K to control endothelial cell migration. Nature 453:662-666.
-
(2008)
Nature
, vol.453
, pp. 662-666
-
-
Graupera, M.1
-
19
-
-
46149106818
-
The p110β isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110γ
-
Guillermet-Guibert J, et al. (2008). The p110β isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110γ. Proc Natl Acad Sci USA 105:8292-8297.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 8292-8297
-
-
Guillermet-Guibert, J.1
-
20
-
-
55649084906
-
Phosphoinositide 3-kinase p110β activity: Key role in metabolism and mammary gland cancer but not development
-
Ciraolo E, et al. (2008). Phosphoinositide 3-kinase p110β activity: Key role in metabolism and mammary gland cancer but not development. Sci Signal 1:ra3.
-
(2008)
Sci Signal
, vol.1
-
-
Ciraolo, E.1
-
21
-
-
49649087385
-
Essential roles of PI3K-p110β in cell growth, metabolism and tumorigenesis
-
Jia S, et al. (2008) Essential roles of PI3K-p110β in cell growth, metabolism and tumorigenesis. Nature 454:776-779.
-
(2008)
Nature
, vol.454
, pp. 776-779
-
-
Jia, S.1
-
22
-
-
0029090212
-
Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase
-
Stoyanov B, et al. (1995) Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase. Science 269:690-693.
-
(1995)
Science
, vol.269
, pp. 690-693
-
-
Stoyanov, B.1
-
23
-
-
0030869757
-
Heterodimeric phosphoinositide 3-kinase consisting of p85 and p110β is synergistically activated by the βγ subunits of G proteins and phosphotyrosyl peptide
-
Kurosu H, et al. (1997) Heterodimeric phosphoinositide 3-kinase consisting of p85 and p110β is synergistically activated by the βγ subunits of G proteins and phosphotyrosyl peptide. J Biol Chem 272:24252-24256.
-
(1997)
J Biol Chem
, vol.272
, pp. 24252-24256
-
-
Kurosu, H.1
-
24
-
-
0034607469
-
Gβγ is a highly selective activator of phospholipid-dependent enzymes
-
Maier U, et al. (2000) Gβγ is a highly selective activator of phospholipid-dependent enzymes. J Biol Chem 275:13746-13754.
-
(2000)
J Biol Chem
, vol.275
, pp. 13746-13754
-
-
Maier, U.1
-
25
-
-
0037501368
-
Identification and characterization of the autophosphorylation sites of phosphoinositide 3-kinase isoforms β and γ
-
Czupalla C, et al. (2003) Identification and characterization of the autophosphorylation sites of phosphoinositide 3-kinase isoforms β and γ. J Biol Chem 278:11536-11545.
-
(2003)
J Biol Chem
, vol.278
, pp. 11536-11545
-
-
Czupalla, C.1
-
26
-
-
0030611707
-
Purification and characterization of Gβγ-responsive phosphoinositide 3-kinases from pig platelet cytosol
-
Tang X, Downes CP (1997) Purification and characterization of Gβγ-responsive phosphoinositide 3-kinases from pig platelet cytosol. J Biol Chem 272:14193-14199.
-
(1997)
J Biol Chem
, vol.272
, pp. 14193-14199
-
-
Tang, X.1
Downes, C.P.2
-
27
-
-
35148839928
-
PI3Kγ is a key regulator of inflammatory responses and cardiovascular homeostasis
-
Hawkins PT, Stephens LR (2007) PI3Kγ is a key regulator of inflammatory responses and cardiovascular homeostasis. Science 318:64-66.
-
(2007)
Science
, vol.318
, pp. 64-66
-
-
Hawkins, P.T.1
Stephens, L.R.2
-
28
-
-
0032828890
-
Roles of non-catalytic subunits in Gβγ-induced activation of class I phosphoinositide 3-kinase isoforms β and γ
-
Maier U, Babich A, Nürnberg B (1999) Roles of non-catalytic subunits in Gβγ-induced activation of class I phosphoinositide 3-kinase isoforms β and γ. J Biol Chem 274:29311-29317.
-
(1999)
J Biol Chem
, vol.274
, pp. 29311-29317
-
-
Maier, U.1
Babich, A.2
Nürnberg, B.3
-
29
-
-
0030887632
-
The Gβγ sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101
-
Stephens LR, et al. (1997) The Gβγ sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101. Cell 89:105-114.
-
(1997)
Cell
, vol.89
, pp. 105-114
-
-
Stephens, L.R.1
-
30
-
-
14244266719
-
Assigning functional domains within the p101 regulatory subunit of phosphoinositide 3-kinase γ
-
Voigt P, Brock C, Nürnberg B, Schaefer M (2005) Assigning functional domains within the p101 regulatory subunit of phosphoinositide 3-kinase γ. J Biol Chem 280:5121-5127.
-
(2005)
J Biol Chem
, vol.280
, pp. 5121-5127
-
-
Voigt, P.1
Brock, C.2
Nürnberg, B.3
Schaefer, M.4
-
31
-
-
33744518663
-
PIKAP, a novel regulatory subunit of phosphoinositide 3-kinase gamma that is highly expressed in heart and interacts with PDE3B
-
PIKAP, a novel regulatory subunit of phosphoinositide 3-kinase gamma that is highly expressed in heart and interacts with PDE3B. J Biol Chem 281:9977-9986.
-
(2006)
J Biol Chem
, vol.281
, pp. 9977-9986
-
-
Voigt, P.1
Dorner, M.B.2
Schaefer, M.3
-
32
-
-
15744363780
-
p84, a new Gβγ-activated regulatory subunit of the type IB phosphoinositide 3-kinase p110γ
-
Suire S, et al. (2005) p84, a new Gβγ-activated regulatory subunit of the type IB phosphoinositide 3-kinase p110γ. Curr Biol 15:566-570.
-
(2005)
Curr Biol
, vol.15
, pp. 566-570
-
-
Suire, S.1
-
34
-
-
68149168062
-
Finding partners for PI3Kγ: When 84 is better than 101
-
Balla T (2009) Finding partners for PI3Kγ: When 84 is better than 101. Sci Signal 2:e35.
-
(2009)
Sci Signal
, vol.2
-
-
Balla, T.1
-
35
-
-
0037421204
-
Roles of Gβγ in membrane recruitment and activation of p110γ/p101 phosphoinositide 3-kinase γ
-
Brock C, et al. (2003) Roles of Gβγ in membrane recruitment and activation of p110γ/p101 phosphoinositide 3-kinase γ. J Cell Biol 160:89-99.
-
(2003)
J Cell Biol
, vol.160
, pp. 89-99
-
-
Brock, C.1
-
36
-
-
59749099895
-
Pasteurella multocida toxin activates Gβγ dimers of heterotrimeric G proteins
-
Preuss I, Kurig B, Nürnberg B, Orth JH, Aktories K (2009) Pasteurella multocida toxin activates Gβγ dimers of heterotrimeric G proteins. Cell Signal 21:551-558.
-
(2009)
Cell Signal
, vol.21
, pp. 551-558
-
-
Preuss, I.1
Kurig, B.2
Nürnberg, B.3
Orth, J.H.4
Aktories, K.5
-
37
-
-
0033635157
-
Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase γ
-
Pacold ME, et al. (2000) Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase γ. Cell 103:931-943.
-
(2000)
Cell
, vol.103
, pp. 931-943
-
-
Pacold, M.E.1
-
38
-
-
0037046799
-
Activation of phosphoinositide 3-kinase γ by Ras
-
Suire S, Hawkins P, Stephens L (2002) Activation of phosphoinositide 3-kinase γ by Ras. Curr Biol 12:1068-1075.
-
(2002)
Curr Biol
, vol.12
, pp. 1068-1075
-
-
Suire, S.1
Hawkins, P.2
Stephens, L.3
-
39
-
-
0030932131
-
Individual rate constants for the interaction of Ras proteins with GTPase-activating proteins determined by fluorescence spectroscopy
-
Ahmadian MR, Hoffmann U, Goody RS, Wittinghofer A (1997) Individual rate constants for the interaction of Ras proteins with GTPase-activating proteins determined by fluorescence spectroscopy. Biochemistry 36:4535-4541.
-
(1997)
Biochemistry
, vol.36
, pp. 4535-4541
-
-
Ahmadian, M.R.1
Hoffmann, U.2
Goody, R.S.3
Wittinghofer, A.4
-
40
-
-
2442689239
-
Signaling specificity by Ras family GTPases is determined by the full spectrum of effectors they regulate
-
Rodriguez-Viciana P, Sabatier C, McCormick F (2004) Signaling specificity by Ras family GTPases is determined by the full spectrum of effectors they regulate. Mol Cell Biol 24:4943-4954.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 4943-4954
-
-
Rodriguez-Viciana, P.1
Sabatier, C.2
McCormick, F.3
-
41
-
-
34547895443
-
Phosphoinositide 3-kinases as a common platform for multi-hormone signaling
-
Hirsch E, Costa C, Ciraolo E (2007) Phosphoinositide 3-kinases as a common platform for multi-hormone signaling. J Endocrinol 194:243-256.
-
(2007)
J Endocrinol
, vol.194
, pp. 243-256
-
-
Hirsch, E.1
Costa, C.2
Ciraolo, E.3
-
42
-
-
51849128358
-
Class I PI3K in oncogenic cellular transformation
-
Zhao L, Vogt PK (2008) Class I PI3K in oncogenic cellular transformation. Oncogene 27:5486-5496.
-
(2008)
Oncogene
, vol.27
, pp. 5486-5496
-
-
Zhao, L.1
Vogt, P.K.2
-
43
-
-
0035951771
-
Regulation of a novel human phospholipase C, PLCε, through membrane targeting by Ras
-
Song C, et al. (2001) Regulation of a novel human phospholipase C, PLCε, through membrane targeting by Ras. J Biol Chem 276:2752-2757.
-
(2001)
J Biol Chem
, vol.276
, pp. 2752-2757
-
-
Song, C.1
-
44
-
-
0028241533
-
Activation of Raf as a result of recruitment to the plasma membrane
-
Stokoe D, Macdonald SG, Cadwallader K, Symons M, Hancock JF (1994) Activation of Raf as a result of recruitment to the plasma membrane. Science 264:1463-1467.
-
(1994)
Science
, vol.264
, pp. 1463-1467
-
-
Stokoe, D.1
Macdonald, S.G.2
Cadwallader, K.3
Symons, M.4
Hancock, J.F.5
-
45
-
-
33750523841
-
Gβγs and the Ras binding domain of p110γ are both important regulators of PI3Kγ signalling in neutrophils
-
Suire S, et al. (2006) Gβγs and the Ras binding domain of p110γ are both important regulators of PI3Kγ signalling in neutrophils. Nat Cell Biol 8:1303-1309.
-
(2006)
Nat Cell Biol
, vol.8
, pp. 1303-1309
-
-
Suire, S.1
-
46
-
-
0035960738
-
Regulating c-Ras function: Cholesterol depletion affects caveolin association, GTP loading, and signaling
-
Kranenburg O, Verlaan I, Moolenaar WH (2001) Regulating c-Ras function: Cholesterol depletion affects caveolin association, GTP loading, and signaling. Curr Biol 11:1880-1884.
-
(2001)
Curr Biol
, vol.11
, pp. 1880-1884
-
-
Kranenburg, O.1
Verlaan, I.2
Moolenaar, W.H.3
-
47
-
-
0032516835
-
Cholesterol depletion of caveolae causes hyperactivation of extracellular signal-related kinase (ERK)
-
Furuchi T, Anderson RG (1998) Cholesterol depletion of caveolae causes hyperactivation of extracellular signal-related kinase (ERK). J Biol Chem 273:21099-21104.
-
(1998)
J Biol Chem
, vol.273
, pp. 21099-21104
-
-
Furuchi, T.1
Anderson, R.G.2
|