메뉴 건너뛰기




Volumn 106, Issue 48, 2009, Pages 20312-20317

Ras is an indispensable coregulator of the class IB phosphoinositide 3-kinase p87/p110γ

Author keywords

Confocal life cell imaging; G protein; Mast cells; Receptor signaling

Indexed keywords

G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN BETA SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN GAMMA SUBUNIT; MONOMER; P110 GAMMA PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN; PROTEIN P101; PROTEIN P87; RAS PROTEIN; UNCLASSIFIED DRUG;

EID: 73949143149     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0905506106     Document Type: Article
Times cited : (67)

References (48)
  • 1
    • 33847239467 scopus 로고    scopus 로고
    • PI3Kδ and PI3Kγ: Partners in crime in inflammation in rheumatoid arthritis and beyond?
    • Rommel C, Camps M, Ji H (2007) PI3Kδ and PI3Kγ: Partners in crime in inflammation in rheumatoid arthritis and beyond? Nat Rev Immunol 7:191-201.
    • (2007) Nat Rev Immunol , vol.7 , pp. 191-201
    • Rommel, C.1    Camps, M.2    Ji, H.3
  • 2
    • 0034635452 scopus 로고    scopus 로고
    • Central role for G protein-coupled phosphoinositide 3-kinase γ in inflammation
    • Hirsch E, et al. (2000) Central role for G protein-coupled phosphoinositide 3-kinase γ in inflammation. Science 287:1049-1053.
    • (2000) Science , vol.287 , pp. 1049-1053
    • Hirsch, E.1
  • 3
    • 0034635264 scopus 로고    scopus 로고
    • Function of PI3Kγ in thymocyte development, T cell activation, and neutrophil migration
    • Sasaki T, et al. (2000) Function of PI3Kγ in thymocyte development, T cell activation, and neutrophil migration. Science 287:1040-1046.
    • (2000) Science , vol.287 , pp. 1040-1046
    • Sasaki, T.1
  • 4
    • 0036200415 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase γ is an essential amplifier of mast cell function
    • Laffargue M, et al. (2002) Phosphoinositide 3-kinase γ is an essential amplifier of mast cell function. Immunity 16:441-451.
    • (2002) Immunity , vol.16 , pp. 441-451
    • Laffargue, M.1
  • 5
    • 0037323892 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase γ: A key modulator in inflammation and allergy
    • Wymann MP, et al. (2003) Phosphoinositide 3-kinase γ: A key modulator in inflammation and allergy. Biochem Soc Trans 31:275-280.
    • (2003) Biochem Soc Trans , vol.31 , pp. 275-280
    • Wymann, M.P.1
  • 6
    • 24744435115 scopus 로고    scopus 로고
    • Blockade of PI3Kγ suppresses joint inflammation and damage in mouse models of rheumatoid arthritis
    • Camps M, et al. (2005) Blockade of PI3Kγ suppresses joint inflammation and damage in mouse models of rheumatoid arthritis. Nat Med 11:936-943.
    • (2005) Nat Med , vol.11 , pp. 936-943
    • Camps, M.1
  • 7
    • 24744449495 scopus 로고    scopus 로고
    • PI3Kγ inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus
    • Barber DF, et al. (2005) PI3Kγ inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus. Nat Med 11:933-935.
    • (2005) Nat Med , vol.11 , pp. 933-935
    • Barber, D.F.1
  • 8
    • 34249951624 scopus 로고    scopus 로고
    • Deletion of the phosphoinositide 3-kinase p110γ gene attenuates murine atherosclerosis
    • Chang JD, et al. (2007) Deletion of the phosphoinositide 3-kinase p110γ gene attenuates murine atherosclerosis. Proc Natl Acad Sci USA 104:8077-8082.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 8077-8082
    • Chang, J.D.1
  • 9
    • 33750525089 scopus 로고    scopus 로고
    • PI3Kγ inhibition: Towards an "aspirin of the 21st century"?
    • Rückle T, Schwarz MK, Rommel C (2006) PI3Kγ inhibition: Towards an "aspirin of the 21st century"? Nat Rev Drug Discov 5:903-918.
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 903-918
    • Rückle, T.1    Schwarz, M.K.2    Rommel, C.3
  • 11
    • 33645551286 scopus 로고    scopus 로고
    • Signaling through PI3Kγ: A common platform for leukocyte, platelet and cardiovascular stress sensing
    • Hirsch E, et al. (2006) Signaling through PI3Kγ: A common platform for leukocyte, platelet and cardiovascular stress sensing. Thromb Haemost 95:29-35.
    • (2006) Thromb Haemost , vol.95 , pp. 29-35
    • Hirsch, E.1
  • 12
    • 4344714889 scopus 로고    scopus 로고
    • PI3Kγ modulates the cardiac response to chronic pressure overload by distinct kinase-dependent and -independent effects
    • Patrucco E, et al. (2004) PI3Kγ modulates the cardiac response to chronic pressure overload by distinct kinase-dependent and -independent effects. Cell 118:375-387.
    • (2004) Cell , vol.118 , pp. 375-387
    • Patrucco, E.1
  • 13
    • 0035464192 scopus 로고    scopus 로고
    • Resistance to thromboembolism in PI3Kγ-deficient mice
    • Hirsch E, et al. (2001) Resistance to thromboembolism in PI3Kγ-deficient mice. FASEB J 15:2019-2021.
    • (2001) FASEB J , vol.15 , pp. 2019-2021
    • Hirsch, E.1
  • 14
    • 0035851213 scopus 로고    scopus 로고
    • 2+ channels
    • 2+ channels. Circ Res 89:692-699.
    • (2001) Circ Res , vol.89 , pp. 692-699
    • Macrez, N.1
  • 16
    • 61849126233 scopus 로고    scopus 로고
    • Fine-tuning the immune response with PI3K
    • Fruman DA, Bismuth G (2009) Fine-tuning the immune response with PI3K. Immunol Rev 228:253-272.
    • (2009) Immunol Rev , vol.228 , pp. 253-272
    • Fruman, D.A.1    Bismuth, G.2
  • 17
    • 33846621025 scopus 로고    scopus 로고
    • Antigen receptor signaling: A distinctive role for the p110δ isoform of PI3K
    • Okkenhaug K, Ali K, Vanhaesebroeck B (2007). Antigen receptor signaling: A distinctive role for the p110δ isoform of PI3K. Trends Immunol 28:80-87.
    • (2007) Trends Immunol , vol.28 , pp. 80-87
    • Okkenhaug, K.1    Ali, K.2    Vanhaesebroeck, B.3
  • 18
    • 44349119736 scopus 로고    scopus 로고
    • Angiogenesis selectively requires the p110α isoform of PI3K to control endothelial cell migration
    • Graupera M, et al. (2008) Angiogenesis selectively requires the p110α isoform of PI3K to control endothelial cell migration. Nature 453:662-666.
    • (2008) Nature , vol.453 , pp. 662-666
    • Graupera, M.1
  • 19
    • 46149106818 scopus 로고    scopus 로고
    • The p110β isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110γ
    • Guillermet-Guibert J, et al. (2008). The p110β isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110γ. Proc Natl Acad Sci USA 105:8292-8297.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 8292-8297
    • Guillermet-Guibert, J.1
  • 20
    • 55649084906 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase p110β activity: Key role in metabolism and mammary gland cancer but not development
    • Ciraolo E, et al. (2008). Phosphoinositide 3-kinase p110β activity: Key role in metabolism and mammary gland cancer but not development. Sci Signal 1:ra3.
    • (2008) Sci Signal , vol.1
    • Ciraolo, E.1
  • 21
    • 49649087385 scopus 로고    scopus 로고
    • Essential roles of PI3K-p110β in cell growth, metabolism and tumorigenesis
    • Jia S, et al. (2008) Essential roles of PI3K-p110β in cell growth, metabolism and tumorigenesis. Nature 454:776-779.
    • (2008) Nature , vol.454 , pp. 776-779
    • Jia, S.1
  • 22
    • 0029090212 scopus 로고
    • Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase
    • Stoyanov B, et al. (1995) Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase. Science 269:690-693.
    • (1995) Science , vol.269 , pp. 690-693
    • Stoyanov, B.1
  • 23
    • 0030869757 scopus 로고    scopus 로고
    • Heterodimeric phosphoinositide 3-kinase consisting of p85 and p110β is synergistically activated by the βγ subunits of G proteins and phosphotyrosyl peptide
    • Kurosu H, et al. (1997) Heterodimeric phosphoinositide 3-kinase consisting of p85 and p110β is synergistically activated by the βγ subunits of G proteins and phosphotyrosyl peptide. J Biol Chem 272:24252-24256.
    • (1997) J Biol Chem , vol.272 , pp. 24252-24256
    • Kurosu, H.1
  • 24
    • 0034607469 scopus 로고    scopus 로고
    • Gβγ is a highly selective activator of phospholipid-dependent enzymes
    • Maier U, et al. (2000) Gβγ is a highly selective activator of phospholipid-dependent enzymes. J Biol Chem 275:13746-13754.
    • (2000) J Biol Chem , vol.275 , pp. 13746-13754
    • Maier, U.1
  • 25
    • 0037501368 scopus 로고    scopus 로고
    • Identification and characterization of the autophosphorylation sites of phosphoinositide 3-kinase isoforms β and γ
    • Czupalla C, et al. (2003) Identification and characterization of the autophosphorylation sites of phosphoinositide 3-kinase isoforms β and γ. J Biol Chem 278:11536-11545.
    • (2003) J Biol Chem , vol.278 , pp. 11536-11545
    • Czupalla, C.1
  • 26
    • 0030611707 scopus 로고    scopus 로고
    • Purification and characterization of Gβγ-responsive phosphoinositide 3-kinases from pig platelet cytosol
    • Tang X, Downes CP (1997) Purification and characterization of Gβγ-responsive phosphoinositide 3-kinases from pig platelet cytosol. J Biol Chem 272:14193-14199.
    • (1997) J Biol Chem , vol.272 , pp. 14193-14199
    • Tang, X.1    Downes, C.P.2
  • 27
    • 35148839928 scopus 로고    scopus 로고
    • PI3Kγ is a key regulator of inflammatory responses and cardiovascular homeostasis
    • Hawkins PT, Stephens LR (2007) PI3Kγ is a key regulator of inflammatory responses and cardiovascular homeostasis. Science 318:64-66.
    • (2007) Science , vol.318 , pp. 64-66
    • Hawkins, P.T.1    Stephens, L.R.2
  • 28
    • 0032828890 scopus 로고    scopus 로고
    • Roles of non-catalytic subunits in Gβγ-induced activation of class I phosphoinositide 3-kinase isoforms β and γ
    • Maier U, Babich A, Nürnberg B (1999) Roles of non-catalytic subunits in Gβγ-induced activation of class I phosphoinositide 3-kinase isoforms β and γ. J Biol Chem 274:29311-29317.
    • (1999) J Biol Chem , vol.274 , pp. 29311-29317
    • Maier, U.1    Babich, A.2    Nürnberg, B.3
  • 29
    • 0030887632 scopus 로고    scopus 로고
    • The Gβγ sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101
    • Stephens LR, et al. (1997) The Gβγ sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101. Cell 89:105-114.
    • (1997) Cell , vol.89 , pp. 105-114
    • Stephens, L.R.1
  • 30
    • 14244266719 scopus 로고    scopus 로고
    • Assigning functional domains within the p101 regulatory subunit of phosphoinositide 3-kinase γ
    • Voigt P, Brock C, Nürnberg B, Schaefer M (2005) Assigning functional domains within the p101 regulatory subunit of phosphoinositide 3-kinase γ. J Biol Chem 280:5121-5127.
    • (2005) J Biol Chem , vol.280 , pp. 5121-5127
    • Voigt, P.1    Brock, C.2    Nürnberg, B.3    Schaefer, M.4
  • 31
    • 33744518663 scopus 로고    scopus 로고
    • PIKAP, a novel regulatory subunit of phosphoinositide 3-kinase gamma that is highly expressed in heart and interacts with PDE3B
    • PIKAP, a novel regulatory subunit of phosphoinositide 3-kinase gamma that is highly expressed in heart and interacts with PDE3B. J Biol Chem 281:9977-9986.
    • (2006) J Biol Chem , vol.281 , pp. 9977-9986
    • Voigt, P.1    Dorner, M.B.2    Schaefer, M.3
  • 32
    • 15744363780 scopus 로고    scopus 로고
    • p84, a new Gβγ-activated regulatory subunit of the type IB phosphoinositide 3-kinase p110γ
    • Suire S, et al. (2005) p84, a new Gβγ-activated regulatory subunit of the type IB phosphoinositide 3-kinase p110γ. Curr Biol 15:566-570.
    • (2005) Curr Biol , vol.15 , pp. 566-570
    • Suire, S.1
  • 34
    • 68149168062 scopus 로고    scopus 로고
    • Finding partners for PI3Kγ: When 84 is better than 101
    • Balla T (2009) Finding partners for PI3Kγ: When 84 is better than 101. Sci Signal 2:e35.
    • (2009) Sci Signal , vol.2
    • Balla, T.1
  • 35
    • 0037421204 scopus 로고    scopus 로고
    • Roles of Gβγ in membrane recruitment and activation of p110γ/p101 phosphoinositide 3-kinase γ
    • Brock C, et al. (2003) Roles of Gβγ in membrane recruitment and activation of p110γ/p101 phosphoinositide 3-kinase γ. J Cell Biol 160:89-99.
    • (2003) J Cell Biol , vol.160 , pp. 89-99
    • Brock, C.1
  • 36
    • 59749099895 scopus 로고    scopus 로고
    • Pasteurella multocida toxin activates Gβγ dimers of heterotrimeric G proteins
    • Preuss I, Kurig B, Nürnberg B, Orth JH, Aktories K (2009) Pasteurella multocida toxin activates Gβγ dimers of heterotrimeric G proteins. Cell Signal 21:551-558.
    • (2009) Cell Signal , vol.21 , pp. 551-558
    • Preuss, I.1    Kurig, B.2    Nürnberg, B.3    Orth, J.H.4    Aktories, K.5
  • 37
    • 0033635157 scopus 로고    scopus 로고
    • Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase γ
    • Pacold ME, et al. (2000) Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase γ. Cell 103:931-943.
    • (2000) Cell , vol.103 , pp. 931-943
    • Pacold, M.E.1
  • 38
    • 0037046799 scopus 로고    scopus 로고
    • Activation of phosphoinositide 3-kinase γ by Ras
    • Suire S, Hawkins P, Stephens L (2002) Activation of phosphoinositide 3-kinase γ by Ras. Curr Biol 12:1068-1075.
    • (2002) Curr Biol , vol.12 , pp. 1068-1075
    • Suire, S.1    Hawkins, P.2    Stephens, L.3
  • 39
    • 0030932131 scopus 로고    scopus 로고
    • Individual rate constants for the interaction of Ras proteins with GTPase-activating proteins determined by fluorescence spectroscopy
    • Ahmadian MR, Hoffmann U, Goody RS, Wittinghofer A (1997) Individual rate constants for the interaction of Ras proteins with GTPase-activating proteins determined by fluorescence spectroscopy. Biochemistry 36:4535-4541.
    • (1997) Biochemistry , vol.36 , pp. 4535-4541
    • Ahmadian, M.R.1    Hoffmann, U.2    Goody, R.S.3    Wittinghofer, A.4
  • 40
    • 2442689239 scopus 로고    scopus 로고
    • Signaling specificity by Ras family GTPases is determined by the full spectrum of effectors they regulate
    • Rodriguez-Viciana P, Sabatier C, McCormick F (2004) Signaling specificity by Ras family GTPases is determined by the full spectrum of effectors they regulate. Mol Cell Biol 24:4943-4954.
    • (2004) Mol Cell Biol , vol.24 , pp. 4943-4954
    • Rodriguez-Viciana, P.1    Sabatier, C.2    McCormick, F.3
  • 41
    • 34547895443 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinases as a common platform for multi-hormone signaling
    • Hirsch E, Costa C, Ciraolo E (2007) Phosphoinositide 3-kinases as a common platform for multi-hormone signaling. J Endocrinol 194:243-256.
    • (2007) J Endocrinol , vol.194 , pp. 243-256
    • Hirsch, E.1    Costa, C.2    Ciraolo, E.3
  • 42
    • 51849128358 scopus 로고    scopus 로고
    • Class I PI3K in oncogenic cellular transformation
    • Zhao L, Vogt PK (2008) Class I PI3K in oncogenic cellular transformation. Oncogene 27:5486-5496.
    • (2008) Oncogene , vol.27 , pp. 5486-5496
    • Zhao, L.1    Vogt, P.K.2
  • 43
    • 0035951771 scopus 로고    scopus 로고
    • Regulation of a novel human phospholipase C, PLCε, through membrane targeting by Ras
    • Song C, et al. (2001) Regulation of a novel human phospholipase C, PLCε, through membrane targeting by Ras. J Biol Chem 276:2752-2757.
    • (2001) J Biol Chem , vol.276 , pp. 2752-2757
    • Song, C.1
  • 45
    • 33750523841 scopus 로고    scopus 로고
    • Gβγs and the Ras binding domain of p110γ are both important regulators of PI3Kγ signalling in neutrophils
    • Suire S, et al. (2006) Gβγs and the Ras binding domain of p110γ are both important regulators of PI3Kγ signalling in neutrophils. Nat Cell Biol 8:1303-1309.
    • (2006) Nat Cell Biol , vol.8 , pp. 1303-1309
    • Suire, S.1
  • 46
    • 0035960738 scopus 로고    scopus 로고
    • Regulating c-Ras function: Cholesterol depletion affects caveolin association, GTP loading, and signaling
    • Kranenburg O, Verlaan I, Moolenaar WH (2001) Regulating c-Ras function: Cholesterol depletion affects caveolin association, GTP loading, and signaling. Curr Biol 11:1880-1884.
    • (2001) Curr Biol , vol.11 , pp. 1880-1884
    • Kranenburg, O.1    Verlaan, I.2    Moolenaar, W.H.3
  • 47
    • 0032516835 scopus 로고    scopus 로고
    • Cholesterol depletion of caveolae causes hyperactivation of extracellular signal-related kinase (ERK)
    • Furuchi T, Anderson RG (1998) Cholesterol depletion of caveolae causes hyperactivation of extracellular signal-related kinase (ERK). J Biol Chem 273:21099-21104.
    • (1998) J Biol Chem , vol.273 , pp. 21099-21104
    • Furuchi, T.1    Anderson, R.G.2
  • 48
    • 69549118209 scopus 로고    scopus 로고
    • Gβγ- copurified lipid kinase impurity from Sf9 cells
    • Shymanets A, Ahmadian MR, Nürnberg B (2009) Gβγ- copurified lipid kinase impurity from Sf9 cells. Protein Pept Lett 16:1053-1056.
    • (2009) Protein Pept Lett , vol.16 , pp. 1053-1056
    • Shymanets, A.1    Ahmadian, M.R.2    Nürnberg, B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.