Current state and perspectives of penicillin G acylase-based biocatalyses

Applied Microbiology and Biotechnology

Volumn 98, Issue 7, 2014, Pages 2867-2879

  Marešová, Helena ^a   Plačková, Martina ^a,b   Grulich, Michal ^a,b   Kyslík, Pavel ^a  

^a INSTITUTE OF MICROBIOLOGY   (Czech Republic)

^b CHARLES UNIVERSITY   (Czech Republic)

Author keywords

Enantioselectivity; Kinetically controlled syntheses; Penicillin G acylase; lactam biocatalysis

Indexed keywords

ANTIBIOTICS; ENANTIOSELECTIVITY; INDUSTRY;

BIOCATALYSIS; ENZYMATIC SYNTHESIS; INDUSTRIAL POTENTIALS; INDUSTRIAL PROCESSS; KINETICALLY CONTROLLED; LARGE-SCALE APPLICATIONS; PENICILLIN G ACYLASE; PHARMACEUTICAL INDUSTRY;

ENZYMES;

ALPHA AMINO ACID ESTER HYDROLASES; AMINO ACID DERIVATIVE; ANTIBIOTIC AGENT; BETA LACTAM; CEPHALOSPORIN; CEPHALOSPORIN ACYLASE; HYDROLASE; PENICILLIN AMIDASE; PENICILLIN V; PENICILLIN V ACYLASE; PRODRUG; SEMISYNTHETIC LACTAM ANTIBIOTIC; UNCLASSIFIED DRUG;

ANTIBIOTICS; BIOTECHNOLOGY; BIOTRANSFORMATION; CATALYSIS; ENZYME ACTIVITY; LABORATORY METHOD; PHARMACEUTICAL INDUSTRY; REACTION KINETICS;

BIOCATALYSIS; DRUG ACTIVATION; DRUG SYNTHESIS; ENANTIOSELECTIVITY; ENZYME MECHANISM; ENZYME SPECIFICITY; HYDROLYSIS; REACTION ANALYSIS; REVIEW;

ANTI-BACTERIAL AGENTS; BIOTECHNOLOGY; CEPHALOSPORINS; PENICILLIN AMIDASE; TECHNOLOGY, PHARMACEUTICAL;

EID: 84898849899     PISSN: 01757598     EISSN: 14320614     Source Type: Journal    
DOI: 10.1007/s00253-013-5492-7     Document Type: Review

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