Hybrid penicillin acylases with improved properties for synthesis of β-lactam antibiotics

Enzyme and Microbial Technology

Volumn 40, Issue 5, 2007, Pages 1335-1344

  Jager, Simon A W ^a   Jekel, Peter A ^a   Janssen, Dick B ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

Ampicillin; Biocatalysis; Cephalexin; Directed evolution; Gene shuffling; Penicillin acylase; Synthesis

Indexed keywords

AMPICILLIN; DIRECTED EVOLUTION; GENE SHUFFLING; PENICILLIN ACYLASE;

ANTIBIOTICS; BIOCATALYSTS; ESCHERICHIA COLI; GENE ENCODING; GROWTH KINETICS; MUTAGENESIS; SYNTHESIS (CHEMICAL);

ENZYME ACTIVITY;

6 AMINOPENICILLANIC ACID; AMIDASE; AMOXICILLIN; AMPICILLIN; BETA LACTAM ANTIBIOTIC; CEFADROXIL; CEFALEXIN; PENICILLIN ACYLASE; UNCLASSIFIED DRUG;

ACYLATION; ANTIMICROBIAL ACTIVITY; ARTICLE; BIOCATALYST; CATALYSIS; ENZYME SYNTHESIS; ESCHERICHIA COLI; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; KLUYVERA CRYOCRESCENS; MOLECULAR CLONING; NONHUMAN; POINT MUTATION; PROVIDENCIA RETTGERI; SEQUENCE ANALYSIS;

ESCHERICHIA COLI; KLUYVERA CRYOCRESCENS; PROVIDENCIA RETTGERI;

EID: 33847614353     PISSN: 01410229     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.enzmictec.2006.10.014     Document Type: Article

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