Engineering of Penicillium chrysogenum for fermentative production of a novel carbamoylated cephem antibiotic precursor

Metabolic Engineering

Volumn 11, Issue 2, 2009, Pages 125-137

  Harris, Diana M ^a,b   Westerlaken, Ilja ^c   Schipper, Dick ^c   van der Krogt, Zita A ^a,b   Gombert, Andreas K ^a,b   Sutherland, John ^d   Raamsdonk, Leonie M ^e   van den Berg, Marco A ^e   Bovenberg, Roel A L ^e   Pronk, Jack T ^a,b   Daran, Jean Marc ^a,b  

^a DELFT UNIVERSITY OF TECHNOLOGY   (Netherlands)

^b KLUYVER CENTRE FOR GENOMICS OF INDUSTRIAL FERMENTATION   (Netherlands)

^c DSM FOOD SPECIALTIES   (Netherlands)

^d UNIVERSITY OF MANCHESTER   (United Kingdom)

^e DSM RESOLVE   (Netherlands)

Author keywords

Adipoyl 7 amino 3 carbamoyloxymethyl 3 cephem 4 carboxylic acid; Carbamoylated cephem antibiotics; Metabolic engineering; Penicillium chrysogenum

Indexed keywords

ACREMONIUM; ADIPATE; ADIPIC ACIDS; ADIPOYL-7-AMINO-3-CARBAMOYLOXYMETHYL-3-CEPHEM-4-CARBOXYLIC ACID; CARBAMOYLATED CEPHEM ANTIBIOTICS; FERMENTATIVE PRODUCTIONS; METABOLIC ENGINEERING; OXIDATION PATHWAYS; OXIDATIVE STRESS RESPONSE; PENICILLIUM CHRYSOGENUM; PUTATIVE GENES; STREPTOMYCES CLAVULIGERUS; SYNTHON; TRANSCRIPT LEVELS; TRANSCRIPTIONAL RESPONSE; TRANSCRIPTOME; TRANSCRIPTOME ANALYSIS;

AMINATION; AMINES; ANTIBIOTICS; CARBOXYLIC ACIDS; METABOLISM; ORGANIC ACIDS; OXIDATION; SEWAGE TREATMENT PLANTS;

GENES;

ADIPIC ACID; ADIPOYL 7 AMINO 3 CARBAMOYLOXYMETHYL 3 CEPHEM 4 CARBOXYLIC ACID; CEPHALOSPORIN; CEPHEM DERIVATIVE; PENICILLIN G; TRANSCRIPTOME; UNCLASSIFIED DRUG;

ARTICLE; CARBAMOYLATION; CATABOLISM; CEPHALOSPORIUM ACREMONIUM; FATTY ACID OXIDATION; FERMENTATION; METABOLIC ENGINEERING; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PENICILLIUM CHRYSOGENUM; PRIORITY JOURNAL; STREPTOMYCES CLAVULIGERUS;

ACREMONIUM; CEPHALOSPORINS; GENETIC ENHANCEMENT; PENICILLIUM CHRYSOGENUM; RECOMBINANT PROTEINS; STREPTOMYCES;

ACREMONIUM CHRYSOGENUM; PENICILLIUM CHRYSOGENUM; STREPTOMYCES CLAVULIGERUS;

EID: 61349128396     PISSN: 10967176     EISSN: 10967184     Source Type: Journal    
DOI: 10.1016/j.ymben.2008.12.003     Document Type: Article

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