Unexpected enantioselectivity and activity of penicillin acylase in the resolution of methyl 2,2-dimethyl-1,3-dioxane-4-carboxylate

Journal of Molecular Catalysis B: Enzymatic

Volumn 22, Issue 1-2, 2003, Pages 55-59

  Yao, Yiming ^a   Lalonde, Jim J ^a  

^a Altus Pharmaceuticals Inc   (United States)

Author keywords

C3 chiral synthon; Dioxalane; Enantioselective kinetic resolution; Methyl 2,2 dimethyl 1,3 dioxane 4 carboxylate; Penicillin acylase

Indexed keywords

CATALYST ACTIVITY; ENZYMES; ESTERS; HYDROLYSIS; PH EFFECTS;

ENANTIOSELECTIVITY;

CATALYSIS;

CARBOXYLIC ACID DERIVATIVE; ESTER; METHYL 2,2 DIMETHYL 1,3 DIOXANE 4 CARBOXYLATE; PENICILLIN AMIDASE; PENICILLIN G; PHENYLACETIC ACID; UNCLASSIFIED DRUG;

ACIDITY; ALKALINITY; ARTICLE; CATALYSIS; COMPARATIVE STUDY; CONCENTRATION (PARAMETERS); ENANTIOSELECTIVITY; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME MECHANISM; ENZYME SUBSTRATE; ESCHERICHIA COLI; HYDROLYSIS; PH; TEMPERATURE DEPENDENCE;

EID: 0037375170     PISSN: 13811177     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1381-1177(03)00004-3     Document Type: Article

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