Biotechnological advances on Penicillin G acylase: Pharmaceutical implications, unique expression mechanism and production strategies

Biotechnology Advances

Volumn 31, Issue 8, 2013, Pages 1319-1332

  Srirangan, Kajan ^a   Orr, Valerie ^a   Akawi, Lamees ^a   Westbrook, Adam ^a   Moo Young, Murray ^a   Chou, C Perry ^a  

^a UNIVERSITY OF WATERLOO   (Canada)

Author keywords

lactam antibiotics; Escherichia coli; Industrial enzyme; Penicillin; Penicillin chemistry; Penicillin G acylase; Posttranslational processing; Recombinant protein; Semisynthetic antibiotics

Indexed keywords

BIOTECHNOLOGICAL ADVANCES; ENZYMATIC TRANSFORMATION; INDUSTRIAL ENZYMES; PENICILLIN; PENICILLIN G ACYLASE; PHARMACEUTICAL IMPLICATIONS; POST-TRANSLATIONAL PROCESSING; SEMI-SYNTHETIC DERIVATIVES;

ANTIBIOTICS; BIOTECHNOLOGY; ENZYMES; ESCHERICHIA COLI; RECOMBINANT PROTEINS; SEWAGE TREATMENT PLANTS;

BIOHAZARDS;

ANTIBIOTICS; DRUG; ENZYME; INDUSTRIAL PRODUCTION; PROTEIN; RECOMBINATION;

ESCHERICHIA COLI;

7-AMINOCEPHALOSPORANIC ACID; AMINO ACID; C REACTIVE PROTEIN; DISSOLVED OXYGEN; DNA; INDUSTRIAL ENZYME; MACROGOL; MESSENGER RNA; NUCLEOTIDE; PENICILLIN AMIDASE; PENICILLIN DERIVATIVE; PENICILLIN G; PENICILLIN V ACYLASE; PEPTIDOGLYCAN; PHENYLACETIC ACID; POLYVINYL ALCOHOL; PROSTAGLANDIN A; RECOMBINANT PROTEIN; RNA; TRANSFER RNA; TRICARBOXYLIC ACID; TRIGGER FACTOR;

(S/H); 6-AMINOPENICILLIANIC ACID; 6-APA; 7-ACA; 7-ADCA; 7-AMINO-DESACETOXYCEPHALONSPORIC ACID; AA; AFPGA; BACTEROICIN RELEASE PROTEIN; BIOTECHNOLOGY; BRP; CAMP RECEPTOR PROTEIN; D-(-)-4-HYDROXYPHENYLGLYCINE AMIDE; D-(-)-4-HYDROXYPHENYLGLYCINE METHYL ESTER; D-(-)-HPGA; D-(-)-HPGM; D-(-)-PGA; D-(-)-PGM; D-(-)-PHENYLGLYCINE AMIDE; D-(-)-PHENYLGLYCINE METHYL ESTER; D-AMINO ACID OXIDASE; DAO; DO; ECPGA; ESCHERICHIA COLI; GA; GLUTARYL ACYLASE; HEAT-SHOCK PROTEIN; HSP; IM; INNER MEMBRANE; IPTG; ISOPROPYL-Β-D-THIO-GALACTOSIDE; KCPGA; LEADERLESS; LL; MESSENGER-RNA; METHODOLOGY; MICROBIOLOGY; N-TERMINAL NUCLEOPHILIC; NT; NTN; OM; OUTER MEMBRANE; PAA; PEG; PENG; PENICILLIN CHEMISTRY; PG; PGA FROM A. FAECALIS; PGA FROM E. COLI; PGA FROM K. CRYOCRESCENS; PGA FROM P. RETTGERI; PGA FROM T. THERMOPHILES; PROTEIN PROCESSING; PRPGA; RBS; REVIEW; RIBOSOME BINDING SITE; SEMI-SYNTHETIC PENICILLIN; SEMISYNTHETIC ANTIBIOTICS; SEMISYNTHETIC CEPHALOSPORINS; SSC; SSP; SYNTHESIS/HYDROLYSIS; TANGENTIAL FLOW FILTRATION ANION-EXCHANGE MEMBRANE CHROMATOGRAPHY; TAT; TCA; TF; TFF-AMEC; TRANSFER-RNA; TTPGA; TWIN-ARG TRANSLOCATION; Β-LACTAM ANTIBIOTICS; ΒLA;

(S/H); 6-AMINOPENICILLIANIC ACID; 6-APA; 7-ACA; 7-ADCA; 7-AMINO-DESACETOXYCEPHALONSPORIC ACID; 7-AMINOCEPHALOSPORANIC ACID; AA; AFPGA; AMINO ACID; BACTEROICIN RELEASE PROTEIN; BRP; CAMP RECEPTOR PROTEIN; CRP; D-(-)-4-HYDROXYPHENYLGLYCINE AMIDE; D-(-)-4-HYDROXYPHENYLGLYCINE METHYL ESTER; D-(-)-HPGA; D-(-)-HPGM; D-(-)-PGA; D-(-)-PGM; D-(-)-PHENYLGLYCINE AMIDE; D-(-)-PHENYLGLYCINE METHYL ESTER; D-AMINO ACID OXIDASE; DAO; DEOXYRIBONUCLEIC ACID; DISSOLVED OXYGEN; DNA; DO; ECPGA; ESCHERICHIA COLI; GA; GLUTARYL ACYLASE; HEAT-SHOCK PROTEIN; HSP; IM; INDUSTRIAL ENZYME; INNER MEMBRANE; IPTG; ISOPROPYL-Β-D-THIO-GALACTOSIDE; KCPGA; LEADERLESS; LL; MESSENGER-RNA; MRNA; N-TERMINAL NUCLEOPHILIC; NT; NTN; NUCLEOTIDES; OM; OUTER MEMBRANE; PAA; PEG; PENG; PENICILLIN; PENICILLIN CHEMISTRY; PENICILLIN G; PENICILLIN G ACYLASE; PENICILLIN V ACYLASE; PEPTIDOGLYCAN; PG; PGA; PGA FROM A. FAECALIS; PGA FROM E. COLI; PGA FROM K. CRYOCRESCENS; PGA FROM P. RETTGERI; PGA FROM T. THERMOPHILES; PHENYLACETIC ACID; POLYETHYLENE GLYCOL; POSTTRANSLATIONAL PROCESSING; PRPGA; PVA; RBS; RECOMBINANT PROTEIN; RIBONUCLEIC ACID; RIBOSOME BINDING SITE; RNA; SEMI-SYNTHETIC PENICILLIN; SEMISYNTHETIC ANTIBIOTICS; SEMISYNTHETIC CEPHALOSPORINS; SSC; SSP; SYNTHESIS/HYDROLYSIS; TANGENTIAL FLOW FILTRATION ANION-EXCHANGE MEMBRANE CHROMATOGRAPHY; TAT; TCA; TF; TFF-AMEC; TRANSFER-RNA; TRICARBOXYLIC ACID; TRIGGER FACTOR; TRNA; TTPGA; TWIN-ARG TRANSLOCATION; Β-LACTAM ANTIBIOTICS; ΒLA;

BIOTECHNOLOGY; ESCHERICHIA COLI; INDUSTRIAL MICROBIOLOGY; PENICILLIN AMIDASE; RECOMBINANT PROTEINS;

EID: 84888010720     PISSN: 07349750     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biotechadv.2013.05.006     Document Type: Review

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