Acetobacter turbidans α-amino acid ester hydrolase: How a single mutation improves an antibiotic-producing enzyme

Journal of Biological Chemistry

Volumn 281, Issue 9, 2006, Pages 5804-5810

  Barends, Thomas R M ^a   Polderman Tijmes, Jolanda J ^a   Jekel, Peter A ^a   Williams, Christopher ^a   Wybenga, Gjalt ^a   Janssen, Dick B ^a   Dijkstra, Bauke W ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; ANTIBIOTICS; BACTERIA; BIOSYNTHESIS; CRYSTAL STRUCTURE; ESTERS; HYDROLYSIS; MUTAGENESIS;

ACETOBACTER TURBIDANS; D-PHENYLGLYCINE; MUTATION;

ENZYMES;

ALPHA AMINO ACID; AMPICILLIN; BETA LACTAM; DEXTRO PHENYLGLYCINE; ESTER; GLYCINE DERIVATIVE; HYDROLASE; HYDROXYL GROUP; UNCLASSIFIED DRUG; 2 PHENYLGLYCINE; 2-PHENYLGLYCINE; ALPHA AMINO ACID ESTERASE; ALPHA-AMINO ACID ESTERASE; ANTIINFECTIVE AGENT; CARBOXYLESTERASE; DRUG DERIVATIVE; GLYCINE; LACTAM;

ACETOBACTER; ARTICLE; CATALYSIS; CRYSTAL STRUCTURE; ENZYME SYNTHESIS; HYDROLYSIS; PRIORITY JOURNAL; BINDING SITE; BIOSYNTHESIS; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME SPECIFICITY; ENZYMOLOGY; GENETICS; METABOLISM; MOLECULAR GENETICS; MUTATION; PROTEIN QUATERNARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

ACETOBACTER PASTEURIANUS; BACTERIA (MICROORGANISMS);

ACETOBACTER; ANTI-BACTERIAL AGENTS; BINDING SITES; CARBOXYLIC ESTER HYDROLASES; CRYSTALLOGRAPHY, X-RAY; GLYCINE; LACTAMS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY; SUBSTRATE SPECIFICITY;

EID: 33646845162     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M511187200     Document Type: Article

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