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Volumn 46, Issue 4, 2008, Pages 461-466

Enhanced enzymatic production of cephalexin at high substrate concentration with in situ product removal by complexation

Author keywords

Cephalexin; Complexation; Enzymatic synthesis; In situ product removal; Penicillin G acylase

Indexed keywords

CEPHALEXIN; ENZYMATIC SYNTHESIS; HIGH SUBSTRATE CONCENTRATIONS; IMMOBILIZED PENICILLIN G ACYLASE; PENICILLIN G ACYLASE; PHENYLGLYCINE METHYL ESTERS; SITU PRODUCT REMOVAL; SUBSTRATE CONCENTRATIONS;

EID: 56849083561     PISSN: 13309862     EISSN: 13342606     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (17)

References (18)
  • 1
    • 28344455686 scopus 로고    scopus 로고
    • Kinetics of β-lactam antibiotics synthesis by penicillin G acylase (PGA) from the viewpoint of the industrial enzymatic reactor optimization
    • R.C. Giordano, M.P. Ribeiro, R.L. Giordano, Kinetics of β-lactam antibiotics synthesis by penicillin G acylase (PGA) from the viewpoint of the industrial enzymatic reactor optimization, Biotechnol. Adv. 24 (2006) 27-41.
    • (2006) Biotechnol. Adv , vol.24 , pp. 27-41
    • Giordano, R.C.1    Ribeiro, M.P.2    Giordano, R.L.3
  • 4
    • 2342517327 scopus 로고    scopus 로고
    • Optimization of cephalexin synthesis with immobilized penicillin acylase in ethylene glycol medium at low temperatures
    • A. Illanes, M.S. Anjarí, C. Altamirano, C. Aguirre, Optimization of cephalexin synthesis with immobilized penicillin acylase in ethylene glycol medium at low temperatures, J. Mol Catal. B-Enzym. 30 (2004) 95-103.
    • (2004) J. Mol Catal. B-Enzym , vol.30 , pp. 95-103
    • Illanes, A.1    Anjarí, M.S.2    Altamirano, C.3    Aguirre, C.4
  • 7
    • 4444282342 scopus 로고    scopus 로고
    • Mathematical modeling of batch and semibatch reactors for the enzymatic synthesis of amoxicillin
    • L.R.B. Gonçalves, R.L.C. Giordano, R.C. Giordano, Mathematical modeling of batch and semibatch reactors for the enzymatic synthesis of amoxicillin, Process Biochem. 40 (2005) 247-256.
    • (2005) Process Biochem , vol.40 , pp. 247-256
    • Gonçalves, L.R.B.1    Giordano, R.L.C.2    Giordano, R.C.3
  • 8
    • 0033213860 scopus 로고    scopus 로고
    • Application of in situ product-removal techniques to biocatalytic processes
    • G.J. Lye, J.M. Woodley, Application of in situ product-removal techniques to biocatalytic processes, Trends Biotechnol. 17 (1999) 395-402.
    • (1999) Trends Biotechnol , vol.17 , pp. 395-402
    • Lye, G.J.1    Woodley, J.M.2
  • 10
    • 0029329135 scopus 로고
    • Equilibria for the adsorption of antibiotics onto neutral polymeric sorbents: Experimental and modeling studies
    • M.V. Chaubal, G.F. Payne, C.H. Reynolds, R.L. Albright, Equilibria for the adsorption of antibiotics onto neutral polymeric sorbents: Experimental and modeling studies, Biotechnol. Bioeng. 47 (1995) 215-226.
    • (1995) Biotechnol. Bioeng , vol.47 , pp. 215-226
    • Chaubal, M.V.1    Payne, G.F.2    Reynolds, C.H.3    Albright, R.L.4
  • 11
    • 0032486573 scopus 로고    scopus 로고
    • Use of aqueous two-phase systems for in situ extraction of water soluble antibiotics during their synthesis by enzymes immobilized on porous supports
    • O. Hernandez-Justiz, R. Femandez-Lafuente, M. Terrini, J.M. Guisan, Use of aqueous two-phase systems for in situ extraction of water soluble antibiotics during their synthesis by enzymes immobilized on porous supports, Biotechnol. Bioeng. 59 (1998) 73-79.
    • (1998) Biotechnol. Bioeng , vol.59 , pp. 73-79
    • Hernandez-Justiz, O.1    Femandez-Lafuente, R.2    Terrini, M.3    Guisan, J.M.4
  • 12
    • 0034597401 scopus 로고    scopus 로고
    • Penicillin acylase-catalyzed synthesis of ampicillin in 'aqueous solution-precipitate' systems. High substrate concentration and supersaturation effect
    • M.I. Youshko, L.M. van Langen, E. de Vroom, H.M. Moody, F. van Rantwijk, R.A. Sheldon, V.K. Švedas, Penicillin acylase-catalyzed synthesis of ampicillin in 'aqueous solution-precipitate' systems. High substrate concentration and supersaturation effect, J. Mol. Catal. B-Enzym. 10 (2000) 509-515.
    • (2000) J. Mol. Catal. B-Enzym , vol.10 , pp. 509-515
    • Youshko, M.I.1    van Langen, L.M.2    de Vroom, E.3    Moody, H.M.4    van Rantwijk, F.5    Sheldon, R.A.6    Švedas, V.K.7
  • 13
    • 19444367193 scopus 로고    scopus 로고
    • Selectivity of the enzymatic synthesis of ampicillin by E. coli PGA in the presence of high concentrations of substrates
    • M.P.A. Ribeiro, A.L.O. Ferreira, R.L.C. Giordano, R.C. Giordano, Selectivity of the enzymatic synthesis of ampicillin by E. coli PGA in the presence of high concentrations of substrates, J. Mol. Catal. B-Enzym. 33 (2005) 81-86.
    • (2005) J. Mol. Catal. B-Enzym , vol.33 , pp. 81-86
    • Ribeiro, M.P.A.1    Ferreira, A.L.O.2    Giordano, R.L.C.3    Giordano, R.C.4
  • 14
    • 21644446446 scopus 로고    scopus 로고
    • Synthesis of cephalexin in organic medium at high substrate concentrations and low enzyme to substrate ratio
    • A. Illanes, C. Altamirano, M. Fuentes, F. Zamorano, C. Aguirre, Synthesis of cephalexin in organic medium at high substrate concentrations and low enzyme to substrate ratio, J. Mol. Catal. B-Enzym. 35 (2005) 45-51.
    • (2005) J. Mol. Catal. B-Enzym , vol.35 , pp. 45-51
    • Illanes, A.1    Altamirano, C.2    Fuentes, M.3    Zamorano, F.4    Aguirre, C.5
  • 15
    • 1942531627 scopus 로고    scopus 로고
    • Semi-continuous enzymatic synthesis of cefaclor enhanced by in situ product removal
    • L. Yang, D. Wei, Y. Zhang, Semi-continuous enzymatic synthesis of cefaclor enhanced by in situ product removal, J. Chem. Technol. Biotechnol. 79 (2004) 480-485.
    • (2004) J. Chem. Technol. Biotechnol , vol.79 , pp. 480-485
    • Yang, L.1    Wei, D.2    Zhang, Y.3
  • 16
    • 0002083389 scopus 로고
    • Evaluation of determination of 6-aminopenicillinic acid, by p-dimethylaminobenzaldehyde
    • J.G. Shewale, K.K. Kumar, G.R. Ambekar, Evaluation of determination of 6-aminopenicillinic acid, by p-dimethylaminobenzaldehyde, Biotechnol. Tech. 1 (1987) 69-72.
    • (1987) Biotechnol. Tech , vol.1 , pp. 69-72
    • Shewale, J.G.1    Kumar, K.K.2    Ambekar, G.R.3
  • 17
    • 0242409137 scopus 로고    scopus 로고
    • Synthesis of cephalexin in ethylene glycol with glyoxyl-agarose immobilized penicillin acylase: Temperature and pH optimisation
    • A. Illanes, Z. Cabrera, L. Wilson, C. Aguirre, Synthesis of cephalexin in ethylene glycol with glyoxyl-agarose immobilized penicillin acylase: Temperature and pH optimisation, Process Biochem. 39 (2003) 111-117.
    • (2003) Process Biochem , vol.39 , pp. 111-117
    • Illanes, A.1    Cabrera, Z.2    Wilson, L.3    Aguirre, C.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.