Use of aqueous two-phase systems for in situ extraction of water soluble antibiotics during their synthesis by enzymes immobilized on porous supports

Biotechnology and Bioengineering

Volumn 59, Issue 1, 1998, Pages 73-79

  Hernandez Justiz, Odette ^a   Fernandez Lafuente, Roberto ^a   Terreni, Marco ^a,b   Guisan, Jose M ^a  

^a INSTITUTO DE CATÁLISIS Y PETROLEOQUÍMICA   (Spain)

^b UNIVERSITY OF PAVIA   (Italy)

Author keywords

Aqueous two phase systems; Immobilized enzymes, continuous extraction of product; Penicillin G acylase; Synthesis of antibiotics

Indexed keywords

AMMONIUM COMPOUNDS; BIOSYNTHESIS; CATALYST SUPPORTS; ENZYME IMMOBILIZATION; ENZYME KINETICS; EXTRACTION; HYDROLYSIS; POLYETHYLENE GLYCOLS; POROUS MATERIALS; SOLUBILITY; SOLUTIONS;

AMMONIUM SULFATE; CEPHALEXIN; PARTITION COEFFICIENTS;

ANTIBIOTICS;

ANTIBIOTIC AGENT; CEFALEXIN;

ANTIBACTERIAL ACTIVITY; AQUEOUS SOLUTION; ARTICLE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME IMMOBILIZATION; ENZYME INACTIVATION; ENZYME INHIBITION; ENZYME KINETICS; ENZYME STABILITY; ESCHERICHIA COLI; EXTRACTION; HYDROLYSIS; NONHUMAN; PARTITION COEFFICIENT; TECHNIQUE;

ANTI-BACTERIAL AGENTS; BIOTECHNOLOGY; CATALYSIS; CEPHALEXIN; CEPHALOSPORINS; ENZYMES, IMMOBILIZED; ESCHERICHIA COLI; INDICATORS AND REAGENTS; KINETICS; PENICILLIN AMIDASE; SOLUBILITY; WATER;

ESCHERICHIA COLI;

EID: 0032486573     PISSN: 00063592     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0290(19980705)59:1<73::AID-BIT10>3.0.CO;2-3     Document Type: Article

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