Physiological characterisation of Penicillium chrysogenum strains expressing the expandase gene from Streptomyces clavuligerus during batch cultivations. Growth and adipoyl-7-aminodeacetoxycephalosporanic acid production

Applied Microbiology and Biotechnology

Volumn 57, Issue 3, 2001, Pages 357-362

  Robin, J ^a   Jakobsen, M ^a   Beyer, M ^a   Noorman, H ^a   Nielsen, J ^a  

^a TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

6 AMINOPENICILLANIC ACID; ADIPIC ACID; ADIPOYL 7 AMINODEACETOXYCEPHALOSPORANIC ACID; AMIDASE; BACTERIAL ENZYME; BETA LACTAM; CEPHALOSPORANIC ACID DERIVATIVE; CEPHALOSPORIN; FRUCTOSE; GLUCONIC ACID; GLUCOSE; PROTEIN EXPANDASE; SUCROSE; UNCLASSIFIED DRUG;

BIOTECHNOLOGY;

ARTICLE; BIOMASS; BIOSYNTHESIS; CHEMICAL STRUCTURE; CONTROLLED STUDY; DEGRADATION; FERMENTATION; GENE EXPRESSION; METABOLISM; NONHUMAN; PENICILLIUM CHRYSOGENUM; STRAIN DIFFERENCE; STREPTOMYCES CLAVULIGERUS;

ADIPIC ACIDS; CEPHALOSPORINS; FRUCTOSE; GLUCONATES; GLUCOSE; INTRAMOLECULAR TRANSFERASES; MUTAGENESIS, INSERTIONAL; PENICILLANIC ACID; PENICILLIN-BINDING PROTEINS; PENICILLIUM CHRYSOGENUM; STREPTOMYCES; SUCROSE;

ACTINOBACTERIA (CLASS); BACTERIA (MICROORGANISMS); PENICILLIUM; PENICILLIUM CHRYSOGENUM; STREPTOMYCES CLAVULIGERUS; UNCULTURED ACTINOMYCETE;

EID: 0034788786     PISSN: 01757598     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002530100787     Document Type: Article

References (8)

1. Inactivation of deacetoxycephalosporin C synthase in extracts of Streptomyces clavuligerus during bioconversion of penicillin G to deacetoxycephalosporin G
2. Isolation of deacetoxycephalosporin C from fermentation broths of Penicillium chrysogenum transformants: Construction of a new fungal biosynthetic pathway
3. Elucidation of conditions allowing conversion of penicillin G and other penicillins to deacetoxy-cephalosporins by resting cells and extracts of Streptomyces clavuligerus NP1
4. Production of cephalosporin intermediates by feeding adipic acid to recombinant Penicillium chrysogenum strains expressing ring expansion activity
5. The β-lactam antibiotics: Past, present and future
6. Conversion of penicillin N to cephalosporins by cell-free extracts of Cephalosporium acremonium
7. Culture fluorescence measurements during batch and fed-batch cultivations with Penicillium chrysogenum
8. Environmentally safe production of 7-amino-deacetoxycephalosporanic acid (7-ADCA) using recombinant strains of Acremonium chrysogenum