The sequence and crystal structure of the α-amino acid ester hydrolase from Xanthomonas citri define a new family of β-lactam antibiotic acylases

Journal of Biological Chemistry

Volumn 278, Issue 25, 2003, Pages 23076-23084

  Barends, Thomas R M ^a   Polderman Tijmes, Jolanda J ^a   Jekel, Peter A ^a   Hensgens, Charles M H ^a,b   De Vries, Erik J ^a   Janssen, Dick B ^a   Dijkstra, Bauke W ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

^b Mucovax BV   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; ANTIBIOTICS; BIOCHEMISTRY; CONFORMATIONS; CRYSTAL STRUCTURE; ESTERS; GENES; HYDROLYSIS; SYNTHESIS (CHEMICAL);

HYDROLASES;

ENZYMES;

ALPHA AMINO ACID ESTER HYDROLASE; AMOXICILLIN; AMPICILLIN; BACTERIAL ENZYME; BETA LACTAM ANTIBIOTIC; CEFADROXIL; CEFALEXIN; CEFATRIZINE; HYDROLASE; PENICILLIN G; PHENYLACETIC ACID DERIVATIVE; PHENYLGLYCINE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BACTERIAL STRAIN; CATALYSIS; CRYSTAL STRUCTURE; DRUG BINDING SITE; DRUG HYDROLYSIS; DRUG PROTEIN BINDING; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME SPECIFICITY; ENZYME STRUCTURE; ENZYME SUBSTRATE; GENE SEQUENCE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; RHODOCOCCUS; SEQUENCE HOMOLOGY; STRUCTURE ANALYSIS; XANTHOMONAS; XANTHOMONAS CITRI;

AMINO ACID SEQUENCE; BINDING SITES; CARBOXYLIC ESTER HYDROLASES; CRYSTALLOGRAPHY, X-RAY; GENOMIC LIBRARY; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; XANTHOMONAS CAMPESTRIS;

ACTINOBACTERIA (CLASS); BACTERIA (MICROORGANISMS); NEGIBACTERIA; RHODOCOCCUS; UNCULTURED ACTINOMYCETE; XANTHOMONAS; XANTHOMONAS CITRI;

EID: 0038339247     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M302246200     Document Type: Article

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