Thermodynamically controlled synthesis of β-lactam antibiotics. Equilibrium concentrations and side-chain properties

Enzyme and Microbial Technology

Volumn 24, Issue 8-9, 1999, Pages 498-506

  Schroen C G P H ^a   Nierstrasz, V A ^a   Kroon, P J ^a   Bosma, R ^a   Janssen, A E M ^a   Beeftink, H H ^a   Tramper, J ^a  

^a WAGENINGEN UNIVERSITY   (Netherlands)

Author keywords

Lactam antibiotic; Cephalexin; Enzymatic synthesis; Penicillin acylase; Penicillin amidase; Solvents

Indexed keywords

AMINO ACIDS; ANTIBIOTICS; CATALYST DEACTIVATION; ENZYME KINETICS; GROWTH KINETICS; ORGANIC SOLVENTS; PH EFFECTS; PHASE EQUILIBRIA; PROTEINS; TEMPERATURE; THERMODYNAMIC PROPERTIES;

CEPHALEXIN; EQUILIBRIUM CONCENTRATIONS; LACTAM ANTIBIOTICS; PENICILLIN ACYLASE; PENICILLIN AMIDASE; SIDE CHAIN PROPERTIES;

BIOSYNTHESIS;

BETA LACTAM ANTIBIOTIC; CEFALEXIN; INDOLEACETIC ACID; MANDELIC ACID; ORGANIC SOLVENT; PHENYLACETIC ACID; PHENYLACETIC ACID DERIVATIVE;

ARTICLE; CAPILLARY ELECTROPHORESIS; CULTURE MEDIUM; DRUG SYNTHESIS; ENZYME ACTIVITY; EQUILIBRIUM CONSTANT; ESCHERICHIA COLI; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; PH; REACTION ANALYSIS; TEMPERATURE; THERMODYNAMICS; XANTHOMONAS;

ESCHERICHIA COLI; XANTHOMONAS CITRI;

EID: 0032922615     PISSN: 01410229     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0141-0229(98)00140-9     Document Type: Article

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