Crystal structures of penicillin acylase enzyme-substrate complexes: Structural insights into the catalytic mechanism

Journal of Molecular Biology

Volumn 313, Issue 1, 2001, Pages 139-150

  McVey, Colin E ^a   Walsh, Martin A ^b   Dodson, G Guy ^a,c   Wilson, Keith S ^a   Brannigan, James A ^a  

^a UNIVERSITY OF YORK   (United Kingdom)

^b EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^c NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

Author keywords

Cryocrystallography; Crystal structure; Enzyme substrate complex; High resolution; Penicillin acylase

Indexed keywords

AMIDASE; ARGININE; ASPARAGINE; ETHYLENE GLYCOL; HYDROGEN; HYDROLASE; PENICILLIN ACYLASE; PENICILLIN DERIVATIVE; PENICILLIN G; PENICILLIN G SULFOXIDE; UNCLASSIFIED DRUG; WATER;

ARTICLE; CATALYSIS; COMPLEX FORMATION; CRYSTAL STRUCTURE; CRYSTALLIZATION; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME BINDING; ENZYME INACTIVATION; ENZYME STRUCTURE; ENZYME SUBSTRATE; GEOMETRY; HYDROGEN BOND; PRIORITY JOURNAL; PROTEIN FAMILY;

EID: 0035850792     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2001.5043     Document Type: Article

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