Use of enzyme penicillin acylase in selective amidation/amide hydrolysis to resolve ethyl 3-amino-4-pentynoate isomers

Bioorganic and Medicinal Chemistry

Volumn 7, Issue 10, 1999, Pages 2221-2229

  Topgi, Ravindra S ^a   Ng, John S ^a   Landis, Bryan ^b   Wang, Ping ^b   Behling, James R ^a  

^a R and D   (United States)

^b MONSANTO COMPANY   (United States)

Author keywords

amino acid; Acylation; Deacylation; Penicillin acylase; Resolve

Indexed keywords

AMIDE; ANTITHROMBOCYTIC AGENT; BETA AMINO ACID; ETHYL 3 AMINO 4 PENTYNOIC ACID; PENICILLIN AMIDASE; PHENYLACETIC ACID; UNCLASSIFIED DRUG; XEMILOFIBAN;

ACYLATION; AMIDATION; ARTICLE; CATALYSIS; CHIRALITY; DEACYLATION; DRUG STRUCTURE; ENANTIOMER; HYDROLYSIS; PH; STEREOCHEMISTRY;

ACYLATION; AMIDES; AMINO ACIDS; BENZAMIDINES; CHEMISTRY, ORGANIC; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ESCHERICHIA COLI; HYDROLYSIS; ISOMERISM; PENICILLIN AMIDASE; PLATELET AGGREGATION INHIBITORS; SUBSTRATE SPECIFICITY;

EID: 0032874447     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(99)00155-8     Document Type: Article

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