Perspectives and industrial potential of PGA selectivity and promiscuity

Biotechnology Advances

Volumn 31, Issue 8, 2013, Pages 1458-1472

  Grulich, Michal ^a,b   Štěpánek, Václav ^a   Kyslík, Pavel ^a  

^a INSTITUTE OF MICROBIOLOGY   (Czech Republic)

^b CHARLES UNIVERSITY   (Czech Republic)

Author keywords

Enantioselective acylation; Enantioselective hydrolysis; Enantioselectivity; Henry reaction; Markovnikov addition reaction; Penicillin G acylase; Resolution; Transesterification

Indexed keywords

ACTIVE PHARMACEUTICAL INGREDIENTS; BIOCATALYTIC APPLICATIONS; ENANTIOSELECTIVE ACYLATION; ENANTIOSELECTIVE HYDROLYSIS; HENRY REACTIONS; LARGE-SCALE PRODUCTION; PENICILLIN G ACYLASE; PHARMACEUTICAL INDUSTRY;

ACYLATION; ADDITION REACTIONS; ANTIBIOTICS; ENZYME IMMOBILIZATION; HYDROLYSIS; INDUSTRY; OPTICAL RESOLVING POWER; TRANSESTERIFICATION;

ENANTIOSELECTIVITY;

ANTIBIOTICS; BIOTRANSFORMATION; CATALYSIS; DRUG; ENZYME; HYDROLYSIS; PEPTIDE; PHARMACEUTICAL INDUSTRY;

PROKARYOTA;

BETA LACTAM; PENICILLIN AMIDASE;

BIOCHEMISTRY; BIOTECHNOLOGY; ENANTIOSELECTIVE ACYLATION; ENANTIOSELECTIVE HYDROLYSIS; ENANTIOSELECTIVITY; ENZYME SPECIFICITY; HENRY REACTION; MARKOVNIKOV ADDITION REACTION; PHARMACEUTICS; RESOLUTION; REVIEW; STEREOISOMERISM; TRANSESTERIFICATION;

ENANTIOSELECTIVE ACYLATION; ENANTIOSELECTIVE HYDROLYSIS; ENANTIOSELECTIVITY; HENRY REACTION; MARKOVNIKOV ADDITION REACTION; PENICILLIN G ACYLASE; RESOLUTION; TRANSESTERIFICATION;

BETA-LACTAMS; BIOCHEMICAL PROCESSES; BIOTECHNOLOGY; PENICILLIN AMIDASE; STEREOISOMERISM; SUBSTRATE SPECIFICITY; TECHNOLOGY, PHARMACEUTICAL;

EID: 84887997433     PISSN: 07349750     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biotechadv.2013.07.005     Document Type: Review

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