Quantitative characterization of the nucleophile reactivity in penicillin acylase-catalyzed acyl transfer reactions

Biochimica et Biophysica Acta - Proteins and Proteomics

Volumn 1599, Issue 1-2, 2002, Pages 134-140

  Youshko, Maxim I ^a   Chilov, Ghermes G ^a   Shcherbakova, Tatyana A ^a   Švedas, Vytas K ^a  

^a MOSCOW STATE UNIVERSITY   (Russian Federation)

Author keywords

Lactam antibiotic; Enzymatic synthesis; Enzyme kinetics; Nucleophile reactivity; Penicillin acylase

Indexed keywords

6 AMINOPENICILLANIC ACID; 7 AMINODESACETOXYCEPHALOSPORANIC ACID; AMOXICILLIN; AMPICILLIN; ANTIBIOTIC AGENT; BACTERIAL ENZYME; CEFALEXIN; CEPHALOSPORANIC ACID DERIVATIVE; ISOENZYME; PENICILLIN ACYLASE; UNCLASSIFIED DRUG; 7-AMINODESACETOXYCEPHALOSPORANIC ACID; CEPHALOSPORIN DERIVATIVE; DRUG DERIVATIVE; PENICILLANIC ACID; PENICILLIN AMIDASE;

ARTICLE; CATALYST; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG SYNTHESIS; ENZYME ANALYSIS; ENZYME MECHANISM; ENZYME REACTOR; ENZYME STRUCTURE; ENZYME SYNTHESIS; ESCHERICHIA COLI; NONHUMAN; PRIORITY JOURNAL; PROTEOMICS; QUANTITATIVE ANALYSIS; REACTION OPTIMIZATION; CATALYSIS; ENZYME SPECIFICITY; METABOLISM;

CATALYSIS; CEPHALOSPORINS; PENICILLANIC ACID; PENICILLIN AMIDASE; SUBSTRATE SPECIFICITY;

EID: 0042904786     PISSN: 15709639     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1570-9639(02)00413-2     Document Type: Article

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