Enzymatic synthesis of amoxicillin via a one-pot enzymatic hydrolysis and condensation cascade process in the presence of organic co-solvents

Applied Biochemistry and Biotechnology

Volumn 160, Issue 7, 2010, Pages 2026-2035

  Wu, Qi ^a   Chen, Chun Xiu ^a   Du, Li Li ^a   Lin, Xian Fu ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

Amoxicillin; Cascade; Enzymatic synthesis; Penicillin G acylase; Penicillin G potassium salt

Indexed keywords

AMOXICILLIN; ENZYMATIC SYNTHESIS; PENICILLIN G; PENICILLIN G ACYLASE; POTASSIUM SALTS;

COST REDUCTION; DRUG PRODUCTS; ENZYMATIC HYDROLYSIS; ESTERS; ETHYLENE; ETHYLENE GLYCOL; SALTS;

SYNTHESIS (CHEMICAL);

4 HYDROXYPHENYLGLYCINE METHYL ESTER; 6 AMINOPENICILLANIC ACID; AMOXICILLIN; BETA LACTAM ANTIBIOTIC; ESTER DERIVATIVE; ETHYLENE GLYCOL; ORGANIC SOLVENT; PENICILLIN AMIDASE; PENICILLIN G POTASSIUM; POTASSIUM SALT; SODIUM DIHYDROGEN PHOSPHATE; UNCLASSIFIED DRUG;

ALKALINITY; ARTICLE; CATALYSIS; CONCENTRATION (PARAMETERS); DRUG SYNTHESIS; ENZYME KINETICS; ENZYME SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; ONE POT SYNTHESIS; PH; POLYMERIZATION; REACTION ANALYSIS; TEMPERATURE SENSITIVITY;

AMOXICILLIN; BIOCATALYSIS; ENZYMES, IMMOBILIZED; ETHYLENE GLYCOL; GLYCINE; HYDROLYSIS; PENICILLIN AMIDASE; PENICILLIN G; PHOSPHORIC ACIDS; SOLVENTS; TEMPERATURE;

EID: 77949916427     PISSN: 02732289     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12010-009-8847-x     Document Type: Article

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