메뉴 건너뛰기




Volumn 14, Issue 4, 2013, Pages 387-407

Brain regulation of energy balance and body weight

Author keywords

Adiposity hormones; Brainstem; Brown fat adaptive thermogenesis; Energy expenditure; Food intake; Hypothalamus; Insulin resistance; Leptin resistance; Mesolimbic dopamine reward system; Obesity; Satiety hormones

Indexed keywords

AMYLIN; APOLIPOPROTEIN A4; CHOLECYSTOKININ; CILIARY NEUROTROPHIC FACTOR; FIBROBLAST GROWTH FACTOR 19; GLUCAGON LIKE PEPTIDE 1; GLUCOSE; INSULIN; LEPTIN; MELANOCORTIN; MELANOCORTIN 4 RECEPTOR; NON RECEPTOR PROTEIN TYROSINE PHOSPHATASE 2; OXYNTOMODULIN; PEPTIDE YY; PHOSPHATIDYLINOSITOL 3 KINASE; PROOPIOMELANOCORTIN; PROTEIN TYROSINE PHOSPHATASE 1B; PROTEIN TYROSINE PHOSPHATASE EPSILON; PROTIRELIN; SEROTONIN; STAT3 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 3; TOLL LIKE RECEPTOR 4;

EID: 84888205217     PISSN: 13899155     EISSN: 15732606     Source Type: Journal    
DOI: 10.1007/s11154-013-9261-9     Document Type: Article
Times cited : (125)

References (288)
  • 1
    • 84855500856 scopus 로고    scopus 로고
    • Metabolic and hedonic drives in the neural control of appetite: Who is the boss?
    • Berthoud HR. Metabolic and hedonic drives in the neural control of appetite: who is the boss? Curr Opin Neurobiol. 2011;21(6):888-96.
    • (2011) Curr Opin Neurobiol. , vol.21 , Issue.6 , pp. 888-896
    • Berthoud, H.R.1
  • 2
    • 84868270248 scopus 로고    scopus 로고
    • The neurobiology of food intake in an obesogenic environment
    • Berthoud HR. The neurobiology of food intake in an obesogenic environment. Proc Nutr Soc. 2012;71(4):478-87.
    • (2012) Proc Nutr Soc. , vol.71 , Issue.4 , pp. 478-487
    • Berthoud, H.R.1
  • 3
    • 84862138213 scopus 로고    scopus 로고
    • The role of the gut/brain axis in modulating food intake
    • Sam AH, Troke RC, Tan TM, Bewick GA. The role of the gut/brain axis in modulating food intake. Neuropharmacology. 2012;63(1):46-56.
    • (2012) Neuropharmacology , vol.63 , Issue.1 , pp. 46-56
    • Sam, A.H.1    Troke, R.C.2    Tan, T.M.3    Bewick, G.A.4
  • 4
    • 84871694003 scopus 로고    scopus 로고
    • Fibroblast growth factor-19 action in the brain reduces food intake and body weight and improves glucose tolerance in male rats
    • 23183168 1:CAS:528:DC%2BC3sXlt1emtg%3D%3D
    • Ryan KK, Kohli R, Gutierrez-Aguilar R, Gaitonde SG, Woods SC, Seeley RJ. Fibroblast growth factor-19 action in the brain reduces food intake and body weight and improves glucose tolerance in male rats. Endocrinology. 2013;154(1):9-15.
    • (2013) Endocrinology , vol.154 , Issue.1 , pp. 9-15
    • Ryan, K.K.1    Kohli, R.2    Gutierrez-Aguilar, R.3    Gaitonde, S.G.4    Woods, S.C.5    Seeley, R.J.6
  • 5
    • 0030985882 scopus 로고    scopus 로고
    • Vagal afferent and efferent contributions to the inhibition of food intake by cholecystokinin
    • 9140026 1:CAS:528:DyaK2sXjtVSns70%3D
    • Moran TH, Baldessarini AR, Salorio CF, Lowery T, Schwartz GJ. Vagal afferent and efferent contributions to the inhibition of food intake by cholecystokinin. Am J Physiol. 1997;272(4 Pt 2):R1245-51.
    • (1997) Am J Physiol , vol.272 , Issue.PART 2
    • Moran, T.H.1    Baldessarini, A.R.2    Salorio, C.F.3    Lowery, T.4    Schwartz, G.J.5
  • 6
    • 0031944277 scopus 로고    scopus 로고
    • Disordered food intake and obesity in rats lacking cholecystokinin A receptors
    • 9530226 1:CAS:528:DyaK1cXitVSjsb0%3D
    • Moran TH, Katz LF, Plata-Salaman CR, Schwartz GJ. Disordered food intake and obesity in rats lacking cholecystokinin A receptors. Am J Physiol. 1998;274(3 Pt 2):R618-25.
    • (1998) Am J Physiol , vol.274 , Issue.PART 2
    • Moran, T.H.1    Katz, L.F.2    Plata-Salaman, C.R.3    Schwartz, G.J.4
  • 8
    • 84870160038 scopus 로고    scopus 로고
    • Apolipoprotein AIV requires cholecystokinin and vagal nerves to suppress food intake
    • 23027805 1:CAS:528:DC%2BC38XhvVahtbjM
    • Lo CC, Langhans W, Georgievsky M, Arnold M, Caldwell JL, Cheng S, et al. Apolipoprotein AIV requires cholecystokinin and vagal nerves to suppress food intake. Endocrinology. 2012;153(12):5857-65.
    • (2012) Endocrinology , vol.153 , Issue.12 , pp. 5857-5865
    • Lo, C.C.1    Langhans, W.2    Georgievsky, M.3    Arnold, M.4    Caldwell, J.L.5    Cheng, S.6
  • 9
    • 77956954932 scopus 로고    scopus 로고
    • Hypothalamic integration of portal glucose signals and control of food intake and insulin sensitivity
    • 1:CAS:528:DC%2BC3cXht1SqsrnL
    • Delaere F, Magnan C, Mithieux G. Hypothalamic integration of portal glucose signals and control of food intake and insulin sensitivity. Diabetes & metabolism. 2010;36(4):257-62.
    • (2010) Diabetes & Metabolism , vol.36 , Issue.4 , pp. 257-262
    • Delaere, F.1    Magnan, C.2    Mithieux, G.3
  • 11
    • 15644365767 scopus 로고    scopus 로고
    • Decreased HDL cholesterol levels but normal lipid absorption, growth, and feeding behavior in apolipoprotein A-IV knockout mice
    • 9323588 1:CAS:528:DyaK2sXms12qtb4%3D
    • Weinstock PH, Bisgaier CL, Hayek T, Aalto-Setala K, Sehayek E, Wu L, et al. Decreased HDL cholesterol levels but normal lipid absorption, growth, and feeding behavior in apolipoprotein A-IV knockout mice. J Lipid Res. 1997;38(9):1782-94.
    • (1997) J Lipid Res , vol.38 , Issue.9 , pp. 1782-1794
    • Weinstock, P.H.1    Bisgaier, C.L.2    Hayek, T.3    Aalto-Setala, K.4    Sehayek, E.5    Wu, L.6
  • 12
    • 49349094501 scopus 로고    scopus 로고
    • Characterization of apolipoprotein A-IV in brain areas involved in energy homeostasis
    • 18577393 1:CAS:528:DC%2BD1cXhtVensrjO
    • Shen L, Pearson KJ, Xiong Y, Lo CM, Tso P, Woods SC, et al. Characterization of apolipoprotein A-IV in brain areas involved in energy homeostasis. Physiol Behav. 2008;95(1-2):161-7.
    • (2008) Physiol Behav , vol.95 , Issue.1-2 , pp. 161-167
    • Shen, L.1    Pearson, K.J.2    Xiong, Y.3    Lo, C.M.4    Tso, P.5    Woods, S.C.6
  • 14
    • 72249092928 scopus 로고    scopus 로고
    • Recent advances in understanding leptin signaling and leptin resistance
    • 19724019 1:CAS:528:DC%2BD1MXhsFOgsbjL
    • Morris DL, Rui L. Recent advances in understanding leptin signaling and leptin resistance. Am J Physiol Endocrinol Metab. 2009;297(6):E1247-59.
    • (2009) Am J Physiol Endocrinol Metab , vol.297 , Issue.6
    • Morris, D.L.1    Rui, L.2
  • 15
    • 12344277552 scopus 로고    scopus 로고
    • Diabetes, obesity, and the brain
    • 15662002 1:CAS:528:DC%2BD2MXksFyhsQ%3D%3D
    • Schwartz MW, Porte Jr D. Diabetes, obesity, and the brain. Science. 2005;307(5708):375-9.
    • (2005) Science , vol.307 , Issue.5708 , pp. 375-379
    • Schwartz, M.W.1    Porte, Jr.D.2
  • 16
    • 84856339193 scopus 로고    scopus 로고
    • Effects of amylin on eating and adiposity
    • doi: 10.1007/978-3-642-24716-3-10
    • Lutz TA. Effects of amylin on eating and adiposity. Handbook of Experimental Pharmacology. 2012;209:231-50. doi: 10.1007/978-3-642-24716-3-10.
    • (2012) Handbook of Experimental Pharmacology , vol.209 , pp. 231-250
    • Lutz, T.A.1
  • 18
    • 77955369748 scopus 로고    scopus 로고
    • Leptin directly depolarizes preproglucagon neurons in the nucleus tractus solitarius: Electrical properties of glucagon-like peptide 1 neurons
    • 20522593 1:CAS:528:DC%2BC3cXhtVOlsbrE
    • Hisadome K, Reimann F, Gribble FM, Trapp S. Leptin directly depolarizes preproglucagon neurons in the nucleus tractus solitarius: electrical properties of glucagon-like peptide 1 neurons. Diabetes. 2010;59(8):1890-8.
    • (2010) Diabetes , vol.59 , Issue.8 , pp. 1890-1898
    • Hisadome, K.1    Reimann, F.2    Gribble, F.M.3    Trapp, S.4
  • 19
    • 21044433027 scopus 로고    scopus 로고
    • Brain stem melanocortinergic modulation of meal size and identification of hypothalamic POMC projections
    • 15746303 1:CAS:528:DC%2BD2MXmvFymtr4%3D
    • Zheng H, Patterson LM, Phifer CB, Berthoud HR. Brain stem melanocortinergic modulation of meal size and identification of hypothalamic POMC projections. Am J Physiol Regul Integr Comp Physiol. 2005;289(1):R247-58.
    • (2005) Am J Physiol Regul Integr Comp Physiol , vol.289 , Issue.1
    • Zheng, H.1    Patterson, L.M.2    Phifer, C.B.3    Berthoud, H.R.4
  • 20
    • 77949413839 scopus 로고    scopus 로고
    • Paraventricular hypothalamic nucleus: Axonal projections to the brainstem
    • 20187136
    • Geerling JC, Shin JW, Chimenti PC, Loewy AD. Paraventricular hypothalamic nucleus: axonal projections to the brainstem. J Comp Neurol. 2010;518(9):1460-99.
    • (2010) J Comp Neurol , vol.518 , Issue.9 , pp. 1460-1499
    • Geerling, J.C.1    Shin, J.W.2    Chimenti, P.C.3    Loewy, A.D.4
  • 21
    • 36849003505 scopus 로고    scopus 로고
    • Visceral afferents directly activate catecholamine neurons in the solitary tract nucleus
    • 18045923 1:CAS:528:DC%2BD2sXhsVeku7bO
    • Appleyard SM, Marks D, Kobayashi K, Okano H, Low MJ, Andresen MC. Visceral afferents directly activate catecholamine neurons in the solitary tract nucleus. J Neurosci. 2007;27(48):13292-302.
    • (2007) J Neurosci , vol.27 , Issue.48 , pp. 13292-13302
    • Appleyard, S.M.1    Marks, D.2    Kobayashi, K.3    Okano, H.4    Low, M.J.5    Andresen, M.C.6
  • 22
    • 84869060663 scopus 로고    scopus 로고
    • Serotonin activates catecholamine neurons in the solitary tract nucleus by increasing spontaneous glutamate inputs
    • 23152635 1:CAS:528:DC%2BC38XhslagurvK
    • Cui RJ, Roberts BL, Zhao H, Zhu M, Appleyard SM. Serotonin activates catecholamine neurons in the solitary tract nucleus by increasing spontaneous glutamate inputs. J Neurosci. 2012;32(46):16530-8.
    • (2012) J Neurosci , vol.32 , Issue.46 , pp. 16530-16538
    • Cui, R.J.1    Roberts, B.L.2    Zhao, H.3    Zhu, M.4    Appleyard, S.M.5
  • 23
    • 84859215897 scopus 로고    scopus 로고
    • Deciphering a neuronal circuit that mediates appetite
    • 22419158 1:CAS:528:DC%2BC38Xjsleltbs%3D
    • Wu Q, Clark MS, Palmiter RD. Deciphering a neuronal circuit that mediates appetite. Nature. 2012;483(7391):594-7.
    • (2012) Nature , vol.483 , Issue.7391 , pp. 594-597
    • Wu, Q.1    Clark, M.S.2    Palmiter, R.D.3
  • 24
    • 79952267286 scopus 로고    scopus 로고
    • Ghrelin inhibits visceral afferent activation of catecholamine neurons in the solitary tract nucleus
    • 21368060 1:CAS:528:DC%2BC3MXjtVahu74%3D
    • Cui RJ, Li X, Appleyard SM. Ghrelin inhibits visceral afferent activation of catecholamine neurons in the solitary tract nucleus. J Neurosci. 2011;31(9):3484-92.
    • (2011) J Neurosci , vol.31 , Issue.9 , pp. 3484-3492
    • Cui, R.J.1    Li, X.2    Appleyard, S.M.3
  • 25
    • 57449117140 scopus 로고    scopus 로고
    • Endogenous prolactin-releasing peptide regulates food intake in rodents
    • 19033670 1:CAS:528:DC%2BD1cXhsVKgu7vN
    • Takayanagi Y, Matsumoto H, Nakata M, Mera T, Fukusumi S, Hinuma S, et al. Endogenous prolactin-releasing peptide regulates food intake in rodents. J Clin Invest. 2008;118(12):4014-24.
    • (2008) J Clin Invest , vol.118 , Issue.12 , pp. 4014-4024
    • Takayanagi, Y.1    Matsumoto, H.2    Nakata, M.3    Mera, T.4    Fukusumi, S.5    Hinuma, S.6
  • 26
    • 80755168940 scopus 로고    scopus 로고
    • CCK stimulation of GLP-1 neurons involves alpha1-adrenoceptor-mediated increase in glutamatergic synaptic inputs
    • 21885869 1:CAS:528:DC%2BC3MXhsVyisrbO
    • Hisadome K, Reimann F, Gribble FM, Trapp S. CCK stimulation of GLP-1 neurons involves alpha1-adrenoceptor-mediated increase in glutamatergic synaptic inputs. Diabetes. 2011;60(11):2701-9.
    • (2011) Diabetes , vol.60 , Issue.11 , pp. 2701-2709
    • Hisadome, K.1    Reimann, F.2    Gribble, F.M.3    Trapp, S.4
  • 27
    • 79952394105 scopus 로고    scopus 로고
    • Hyperphagia and increased fat accumulation in two models of chronic CNS glucagon-like peptide-1 loss of function
    • 21389245 1:CAS:528:DC%2BC3MXjslGqtbk%3D
    • Barrera JG, Jones KR, Herman JP, D'Alessio DA, Woods SC, Seeley RJ. Hyperphagia and increased fat accumulation in two models of chronic CNS glucagon-like peptide-1 loss of function. J Neurosci. 2011;31(10):3904-13.
    • (2011) J Neurosci , vol.31 , Issue.10 , pp. 3904-3913
    • Barrera, J.G.1    Jones, K.R.2    Herman, J.P.3    D'Alessio, D.A.4    Woods, S.C.5    Seeley, R.J.6
  • 28
    • 79952119299 scopus 로고    scopus 로고
    • Intracellular signals mediating the food intake-suppressive effects of hindbrain glucagon-like peptide-1 receptor activation
    • 21356521 1:CAS:528:DC%2BC3MXisFGrsrg%3D
    • Hayes MR, Leichner TM, Zhao S, Lee GS, Chowansky A, Zimmer D, et al. Intracellular signals mediating the food intake-suppressive effects of hindbrain glucagon-like peptide-1 receptor activation. Cell Metab. 2011;13(3):320-30.
    • (2011) Cell Metab , vol.13 , Issue.3 , pp. 320-330
    • Hayes, M.R.1    Leichner, T.M.2    Zhao, S.3    Lee, G.S.4    Chowansky, A.5    Zimmer, D.6
  • 29
    • 79957896911 scopus 로고    scopus 로고
    • Leptin receptor expression in hindbrain Glp-1 neurons regulates food intake and energy balance in mice
    • 21606595 1:CAS:528:DC%2BC3MXnsVaitrY%3D
    • Scott MM, Williams KW, Rossi J, Lee CE, Elmquist JK. Leptin receptor expression in hindbrain Glp-1 neurons regulates food intake and energy balance in mice. J Clin Invest. 2011;121(6):2413-21.
    • (2011) J Clin Invest , vol.121 , Issue.6 , pp. 2413-2421
    • Scott, M.M.1    Williams, K.W.2    Rossi, J.3    Lee, C.E.4    Elmquist, J.K.5
  • 30
    • 1842560331 scopus 로고    scopus 로고
    • Cholecystokinin-mediated suppression of feeding involves the brainstem melanocortin system
    • 15034587 1:CAS:528:DC%2BD2cXisFCisLc%3D
    • Fan W, Ellacott KL, Halatchev IG, Takahashi K, Yu P, Cone RD. Cholecystokinin-mediated suppression of feeding involves the brainstem melanocortin system. Nat Neurosci. 2004;7(4):335-6.
    • (2004) Nat Neurosci , vol.7 , Issue.4 , pp. 335-336
    • Fan, W.1    Ellacott, K.L.2    Halatchev, I.G.3    Takahashi, K.4    Yu, P.5    Cone, R.D.6
  • 31
    • 17044427583 scopus 로고    scopus 로고
    • Proopiomelanocortin neurons in nucleus tractus solitarius are activated by visceral afferents: Regulation by cholecystokinin and opioids
    • 15814788 1:CAS:528:DC%2BD2MXjtlSisrw%3D
    • Appleyard SM, Bailey TW, Doyle MW, Jin YH, Smart JL, Low MJ, et al. Proopiomelanocortin neurons in nucleus tractus solitarius are activated by visceral afferents: regulation by cholecystokinin and opioids. J Neurosci. 2005;25(14):3578-85.
    • (2005) J Neurosci , vol.25 , Issue.14 , pp. 3578-3585
    • Appleyard, S.M.1    Bailey, T.W.2    Doyle, M.W.3    Jin, Y.H.4    Smart, J.L.5    Low, M.J.6
  • 32
    • 70350371308 scopus 로고    scopus 로고
    • Nesfatin-1-regulated oxytocinergic signaling in the paraventricular nucleus causes anorexia through a leptin-independent melanocortin pathway
    • 19883614 1:CAS:528:DC%2BC3cXht1eqs78%3D
    • Maejima Y, Sedbazar U, Suyama S, Kohno D, Onaka T, Takano E, et al. Nesfatin-1-regulated oxytocinergic signaling in the paraventricular nucleus causes anorexia through a leptin-independent melanocortin pathway. Cell Metab. 2009;10(5):355-65.
    • (2009) Cell Metab , vol.10 , Issue.5 , pp. 355-365
    • Maejima, Y.1    Sedbazar, U.2    Suyama, S.3    Kohno, D.4    Onaka, T.5    Takano, E.6
  • 33
    • 34547103515 scopus 로고    scopus 로고
    • Melanocortin activation of nucleus of the solitary tract avoids anorectic tachyphylaxis and induces prolonged weight loss
    • 17389713 1:CAS:528:DC%2BD2sXosV2mtr8%3D
    • Li G, Zhang Y, Rodrigues E, Zheng D, Matheny M, Cheng KY, et al. Melanocortin activation of nucleus of the solitary tract avoids anorectic tachyphylaxis and induces prolonged weight loss. Am J Physiol Endocrinol Metab. 2007;293(1):E252-8.
    • (2007) Am J Physiol Endocrinol Metab , vol.293 , Issue.1
    • Li, G.1    Zhang, Y.2    Rodrigues, E.3    Zheng, D.4    Matheny, M.5    Cheng, K.Y.6
  • 34
    • 44949136337 scopus 로고    scopus 로고
    • Presynaptic melanocortin-4 receptors on vagal afferent fibers modulate the excitability of rat nucleus tractus solitarius neurons
    • 18463249 1:CAS:528:DC%2BD1cXlvFertrY%3D
    • Wan S, Browning KN, Coleman FH, Sutton G, Zheng H, Butler A, et al. Presynaptic melanocortin-4 receptors on vagal afferent fibers modulate the excitability of rat nucleus tractus solitarius neurons. J Neurosci. 2008;28(19):4957-66.
    • (2008) J Neurosci , vol.28 , Issue.19 , pp. 4957-4966
    • Wan, S.1    Browning, K.N.2    Coleman, F.H.3    Sutton, G.4    Zheng, H.5    Butler, A.6
  • 35
    • 33644768285 scopus 로고    scopus 로고
    • Divergent regulation of proopiomelanocortin neurons by leptin in the nucleus of the solitary tract and in the arcuate hypothalamic nucleus
    • 16505217 1:CAS:528:DC%2BD28XisVWisr4%3D
    • Huo L, Grill HJ, Bjorbaek C. Divergent regulation of proopiomelanocortin neurons by leptin in the nucleus of the solitary tract and in the arcuate hypothalamic nucleus. Diabetes. 2006;55(3):567-73.
    • (2006) Diabetes , vol.55 , Issue.3 , pp. 567-573
    • Huo, L.1    Grill, H.J.2    Bjorbaek, C.3
  • 36
    • 84873301711 scopus 로고    scopus 로고
    • Melanocortin 4 receptors reciprocally regulate sympathetic and parasympathetic preganglionic neurons
    • 23374353 1:CAS:528:DC%2BC3sXhvFaitLk%3D
    • Sohn JW, Harris LE, Berglund ED, Liu T, Vong L, Lowell BB, et al. Melanocortin 4 receptors reciprocally regulate sympathetic and parasympathetic preganglionic neurons. Cell. 2013;152(3):612-9.
    • (2013) Cell , vol.152 , Issue.3 , pp. 612-619
    • Sohn, J.W.1    Harris, L.E.2    Berglund, E.D.3    Liu, T.4    Vong, L.5    Lowell, B.B.6
  • 37
    • 0025321890 scopus 로고
    • Connections of the parabrachial nucleus with the nucleus of the solitary tract and the medullary reticular formation in the rat
    • 1691748 1:STN:280:DyaK3c3ivFGgtw%3D%3D
    • Herbert H, Moga MM, Saper CB. Connections of the parabrachial nucleus with the nucleus of the solitary tract and the medullary reticular formation in the rat. J Comp Neurol. 1990;293(4):540-80.
    • (1990) J Comp Neurol , vol.293 , Issue.4 , pp. 540-580
    • Herbert, H.1    Moga, M.M.2    Saper, C.B.3
  • 38
    • 0026662894 scopus 로고
    • Excitatory amino acids may mediate nucleus tractus solitarius input to rat parabrachial neurons
    • 1354944 1:CAS:528:DyaK38Xls1Cls7s%3D
    • Jhamandas JH, Harris KH. Excitatory amino acids may mediate nucleus tractus solitarius input to rat parabrachial neurons. Am J Physiol. 1992;263(2 Pt 2):R324-30.
    • (1992) Am J Physiol , vol.263 , Issue.PART 2
    • Jhamandas, J.H.1    Harris, K.H.2
  • 39
    • 77956172928 scopus 로고    scopus 로고
    • Ascending projections from the caudal visceral nucleus of the solitary tract to brain regions involved in food intake and energy expenditure
    • 20353764 1:CAS:528:DC%2BC3cXhtVKiurjP
    • Rinaman L. Ascending projections from the caudal visceral nucleus of the solitary tract to brain regions involved in food intake and energy expenditure. Brain Res. 2010;1350:18-34.
    • (2010) Brain Res. , vol.1350 , pp. 18-34
    • Rinaman, L.1
  • 40
    • 84856102513 scopus 로고    scopus 로고
    • GLP-1 neurons in the nucleus of the solitary tract project directly to the ventral tegmental area and nucleus accumbens to control for food intake
    • 22128031 1:CAS:528:DC%2BC38XitVegsbo%3D
    • Alhadeff AL, Rupprecht LE, Hayes MR. GLP-1 neurons in the nucleus of the solitary tract project directly to the ventral tegmental area and nucleus accumbens to control for food intake. Endocrinology. 2012;153(2):647-58.
    • (2012) Endocrinology , vol.153 , Issue.2 , pp. 647-658
    • Alhadeff, A.L.1    Rupprecht, L.E.2    Hayes, M.R.3
  • 41
    • 80054035293 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 receptors in nucleus accumbens affect food intake
    • 21994361 1:CAS:528:DC%2BC3MXhtlCgtr%2FF
    • Dossat AM, Lilly N, Kay K, Williams DL. Glucagon-like peptide 1 receptors in nucleus accumbens affect food intake. J Neurosci. 2011;31(41):14453-7.
    • (2011) J Neurosci , vol.31 , Issue.41 , pp. 14453-14457
    • Dossat, A.M.1    Lilly, N.2    Kay, K.3    Williams, D.L.4
  • 42
    • 0032436307 scopus 로고    scopus 로고
    • Leptin activates hypothalamic CART neurons projecting to the spinal cord
    • 9883730 1:CAS:528:DyaK1MXntFShsA%3D%3D
    • Elias CF, Lee C, Kelly J, Aschkenasi C, Ahima RS, Couceyro PR, et al. Leptin activates hypothalamic CART neurons projecting to the spinal cord. Neuron. 1998;21(6):1375-85.
    • (1998) Neuron , vol.21 , Issue.6 , pp. 1375-1385
    • Elias, C.F.1    Lee, C.2    Kelly, J.3    Aschkenasi, C.4    Ahima, R.S.5    Couceyro, P.R.6
  • 43
    • 84868122218 scopus 로고    scopus 로고
    • Acute selective ablation of rat insulin promoter-expressing (RIPHER) neurons defines their orexigenic nature
    • 23064638 1:CAS:528:DC%2BC38Xhsl2ktbzI
    • Rother E, Belgardt BF, Tsaousidou E, Hampel B, Waisman A, Myers Jr MG, et al. Acute selective ablation of rat insulin promoter-expressing (RIPHER) neurons defines their orexigenic nature. Proc Natl Acad Sci U S A. 2012;109(44):18132-7.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , Issue.44 , pp. 18132-18137
    • Rother, E.1    Belgardt, B.F.2    Tsaousidou, E.3    Hampel, B.4    Waisman, A.5    Myers, Jr.M.G.6
  • 44
    • 84874215150 scopus 로고    scopus 로고
    • Acute and long-term suppression of feeding behavior by pomc neurons in the brainstem and hypothalamus
    • 1:CAS:528:DC%2BC3sXhtlOjsL%2FM
    • Zhan C, Zhou J, Feng Q, Zhang JE, Lin S, Bao J, et al. Acute and long-term suppression of feeding behavior by pomc neurons in the brainstem and hypothalamus. Respectively J Neurosci. 2013;33(8):3624-32.
    • (2013) Respectively. J Neurosci. , vol.33 , Issue.8 , pp. 3624-3632
    • Zhan, C.1    Zhou, J.2    Feng, Q.3    Zhang, J.E.4    Lin, S.5    Bao, J.6
  • 45
    • 79951992387 scopus 로고    scopus 로고
    • AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training
    • 21209617 1:CAS:528:DC%2BC3MXitl2ktw%3D%3D
    • Aponte Y, Atasoy D, Sternson SM. AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training. Nat Neurosci. 2011;14(3):351-5.
    • (2011) Nat Neurosci , vol.14 , Issue.3 , pp. 351-355
    • Aponte, Y.1    Atasoy, D.2    Sternson, S.M.3
  • 46
    • 0030614331 scopus 로고    scopus 로고
    • Role of melanocortinergic neurons in feeding and the agouti obesity syndrome
    • 8990120 1:CAS:528:DyaK2sXks1Witw%3D%3D
    • Fan W, Boston BA, Kesterson RA, Hruby VJ, Cone RD. Role of melanocortinergic neurons in feeding and the agouti obesity syndrome. Nature. 1997;385(6612):165-8.
    • (1997) Nature , vol.385 , Issue.6612 , pp. 165-168
    • Fan, W.1    Boston, B.A.2    Kesterson, R.A.3    Hruby, V.J.4    Cone, R.D.5
  • 47
    • 0031662163 scopus 로고    scopus 로고
    • A frameshift mutation in human MC4R is associated with a dominant form of obesity
    • 9771699 1:CAS:528:DyaK1cXms1amsLo%3D
    • Vaisse C, Clement K, Guy-Grand B, Froguel P. A frameshift mutation in human MC4R is associated with a dominant form of obesity. Nat Genet. 1998;20(2):113-4.
    • (1998) Nat Genet , vol.20 , Issue.2 , pp. 113-114
    • Vaisse, C.1    Clement, K.2    Guy-Grand, B.3    Froguel, P.4
  • 48
    • 0033818103 scopus 로고    scopus 로고
    • Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass
    • 10973258 1:CAS:528:DC%2BD3cXmsVKrsrw%3D
    • Chen AS, Marsh DJ, Trumbauer ME, Frazier EG, Guan XM, Yu H, et al. Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass. Nat Genet. 2000;26(1):97-102.
    • (2000) Nat Genet , vol.26 , Issue.1 , pp. 97-102
    • Chen, A.S.1    Marsh, D.J.2    Trumbauer, M.E.3    Frazier, E.G.4    Guan, X.M.5    Yu, H.6
  • 49
    • 0030889192 scopus 로고    scopus 로고
    • Targeted disruption of the melanocortin-4 receptor results in obesity in mice
    • 9019399 1:CAS:528:DyaK2sXltF2nsg%3D%3D
    • Huszar D, Lynch CA, Fairchild-Huntress V, Dunmore JH, Fang Q, Berkemeier LR, et al. Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell. 1997;88(1):131-41.
    • (1997) Cell , vol.88 , Issue.1 , pp. 131-141
    • Huszar, D.1    Lynch, C.A.2    Fairchild-Huntress, V.3    Dunmore, J.H.4    Fang, Q.5    Berkemeier, L.R.6
  • 50
    • 0032492893 scopus 로고    scopus 로고
    • Hypothalamic CART is a new anorectic peptide regulated by leptin
    • 9590691 1:CAS:528:DyaK1cXjt1ansLY%3D
    • Kristensen P, Judge ME, Thim L, Ribel U, Christjansen KN, Wulff BS, et al. Hypothalamic CART is a new anorectic peptide regulated by leptin. Nature. 1998;393(6680):72-6.
    • (1998) Nature , vol.393 , Issue.6680 , pp. 72-76
    • Kristensen, P.1    Judge, M.E.2    Thim, L.3    Ribel, U.4    Christjansen, K.N.5    Wulff, B.S.6
  • 51
    • 0031820785 scopus 로고    scopus 로고
    • CART peptides in the central control of feeding and interactions with neuropeptide y
    • 9661247 1:CAS:528:DyaK1cXkt1Oisrs%3D
    • Lambert PD, Couceyro PR, McGirr KM, Dall Vechia SE, Smith Y, Kuhar MJ. CART peptides in the central control of feeding and interactions with neuropeptide Y. Synapse. 1998;29(4):293-8.
    • (1998) Synapse , vol.29 , Issue.4 , pp. 293-298
    • Lambert, P.D.1    Couceyro, P.R.2    McGirr, K.M.3    Dall Vechia, S.E.4    Smith, Y.5    Kuhar, M.J.6
  • 52
    • 27544450765 scopus 로고    scopus 로고
    • Divergence of melanocortin pathways in the control of food intake and energy expenditure
    • 16269339 1:CAS:528:DC%2BD2MXht1altLnF
    • Balthasar N, Dalgaard LT, Lee CE, Yu J, Funahashi H, Williams T, et al. Divergence of melanocortin pathways in the control of food intake and energy expenditure. Cell. 2005;123(3):493-505.
    • (2005) Cell , vol.123 , Issue.3 , pp. 493-505
    • Balthasar, N.1    Dalgaard, L.T.2    Lee, C.E.3    Yu, J.4    Funahashi, H.5    Williams, T.6
  • 53
    • 0038392755 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor
    • 12796784 1:CAS:528:DC%2BD3sXkvVKmtLg%3D
    • Xu B, Goulding EH, Zang K, Cepoi D, Cone RD, Jones KR, et al. Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor. Nat Neurosci. 2003;6(7):736-42.
    • (2003) Nat Neurosci , vol.6 , Issue.7 , pp. 736-742
    • Xu, B.1    Goulding, E.H.2    Zang, K.3    Cepoi, D.4    Cone, R.D.5    Jones, K.R.6
  • 55
    • 34548604499 scopus 로고    scopus 로고
    • Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity
    • 17728716 1:CAS:528:DC%2BD2sXhtVagtb3L
    • Parton LE, Ye CP, Coppari R, Enriori PJ, Choi B, Zhang CY, et al. Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity. Nature. 2007;449(7159):228-32.
    • (2007) Nature , vol.449 , Issue.7159 , pp. 228-232
    • Parton, L.E.1    Ye, C.P.2    Coppari, R.3    Enriori, P.J.4    Choi, B.5    Zhang, C.Y.6
  • 56
    • 0037178730 scopus 로고    scopus 로고
    • Activation of central melanocortin pathways by fenfluramine
    • 12142539 1:CAS:528:DC%2BD38XlslWrs7Y%3D
    • Heisler LK, Cowley MA, Tecott LH, Fan W, Low MJ, Smart JL, et al. Activation of central melanocortin pathways by fenfluramine. Science. 2002;297(5581):609-11.
    • (2002) Science , vol.297 , Issue.5581 , pp. 609-611
    • Heisler, L.K.1    Cowley, M.A.2    Tecott, L.H.3    Fan, W.4    Low, M.J.5    Smart, J.L.6
  • 57
    • 0028909857 scopus 로고
    • Eating disorder and epilepsy in mice lacking 5-HT2c serotonin receptors
    • 7700379 1:CAS:528:DyaK2MXkvVKqtr4%3D
    • Tecott LH, Sun LM, Akana SF, Strack AM, Lowenstein DH, Dallman MF, et al. Eating disorder and epilepsy in mice lacking 5-HT2c serotonin receptors. Nature. 1995;374(6522):542-6.
    • (1995) Nature , vol.374 , Issue.6522 , pp. 542-546
    • Tecott, L.H.1    Sun, L.M.2    Akana, S.F.3    Strack, A.M.4    Lowenstein, D.H.5    Dallman, M.F.6
  • 58
    • 0031721271 scopus 로고    scopus 로고
    • Leptin-independent hyperphagia and type 2 diabetes in mice with a mutated serotonin 5-HT2C receptor gene
    • 9771748 1:CAS:528:DyaK1cXms1Ggtrc%3D
    • Nonogaki K, Strack AM, Dallman MF, Tecott LH. Leptin-independent hyperphagia and type 2 diabetes in mice with a mutated serotonin 5-HT2C receptor gene. Nat Med. 1998;4(10):1152-6.
    • (1998) Nat Med , vol.4 , Issue.10 , pp. 1152-1156
    • Nonogaki, K.1    Strack, A.M.2    Dallman, M.F.3    Tecott, L.H.4
  • 59
    • 56349145180 scopus 로고    scopus 로고
    • 5-HT2CRs expressed by pro-opiomelanocortin neurons regulate energy homeostasis
    • Xu Y, Jones JE, Kohno D, Williams KW, Lee CE, Choi MJ, et al. 5-HT2CRs expressed by pro-opiomelanocortin neurons regulate energy homeostasis. Neuron. 2008;60(4):582-9.
    • (2008) Neuron , vol.60 , Issue.4 , pp. 582-589
    • Xu, Y.1    Jones, J.E.2    Kohno, D.3    Williams, K.W.4    Lee, C.E.5    Choi, M.J.6
  • 60
    • 33745819212 scopus 로고    scopus 로고
    • Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity
    • 16794735 1:CAS:528:DC%2BD28XmvV2ltbY%3D
    • Plum L, Ma X, Hampel B, Balthasar N, Coppari R, Munzberg H, et al. Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity. J Clin Invest. 2006;116(7):1886-901.
    • (2006) J Clin Invest , vol.116 , Issue.7 , pp. 1886-1901
    • Plum, L.1    Ma, X.2    Hampel, B.3    Balthasar, N.4    Coppari, R.5    Munzberg, H.6
  • 61
    • 79961180328 scopus 로고    scopus 로고
    • Serotonin 2C receptor activates a distinct population of arcuate pro-opiomelanocortin neurons via TRPC channels
    • 21835345 1:CAS:528:DC%2BC3MXhtVajtr7K
    • Sohn JW, Xu Y, Jones JE, Wickman K, Williams KW, Elmquist JK. Serotonin 2C receptor activates a distinct population of arcuate pro-opiomelanocortin neurons via TRPC channels. Neuron. 2011;71(3):488-97.
    • (2011) Neuron , vol.71 , Issue.3 , pp. 488-497
    • Sohn, J.W.1    Xu, Y.2    Jones, J.E.3    Wickman, K.4    Williams, K.W.5    Elmquist, J.K.6
  • 62
    • 75349092316 scopus 로고    scopus 로고
    • Leptin excites proopiomelanocortin neurons via activation of TRPC channels
    • 20107083 1:CAS:528:DC%2BC3cXhsVOqsrY%3D
    • Qiu J, Fang Y, Ronnekleiv OK, Kelly MJ. Leptin excites proopiomelanocortin neurons via activation of TRPC channels. J Neurosci. 2010;30(4):1560-5.
    • (2010) J Neurosci , vol.30 , Issue.4 , pp. 1560-1565
    • Qiu, J.1    Fang, Y.2    Ronnekleiv, O.K.3    Kelly, M.J.4
  • 63
    • 1842529267 scopus 로고    scopus 로고
    • Rapid rewiring of arcuate nucleus feeding circuits by leptin
    • 15064421 1:CAS:528:DC%2BD2cXis1ansb0%3D
    • Pinto S, Roseberry AG, Liu H, Diano S, Shanabrough M, Cai X, et al. Rapid rewiring of arcuate nucleus feeding circuits by leptin. Science. 2004;304(5667):110-5.
    • (2004) Science , vol.304 , Issue.5667 , pp. 110-115
    • Pinto, S.1    Roseberry, A.G.2    Liu, H.3    Diano, S.4    Shanabrough, M.5    Cai, X.6
  • 64
    • 79960190012 scopus 로고    scopus 로고
    • Leptin action on GABAergic neurons prevents obesity and reduces inhibitory tone to POMC neurons
    • 21745644 1:CAS:528:DC%2BC3MXoslaku7g%3D
    • Vong L, Ye C, Yang Z, Choi B, Chua Jr S, Lowell BB. Leptin action on GABAergic neurons prevents obesity and reduces inhibitory tone to POMC neurons. Neuron. 2011;71(1):142-54.
    • (2011) Neuron , vol.71 , Issue.1 , pp. 142-154
    • Vong, L.1    Ye, C.2    Yang, Z.3    Choi, B.4    Chua, Jr.S.5    Lowell, B.B.6
  • 65
    • 0035942777 scopus 로고    scopus 로고
    • Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
    • 11373681 1:CAS:528:DC%2BD3MXkt1ejt7w%3D
    • Cowley MA, Smart JL, Rubinstein M, Cerdan MG, Diano S, Horvath TL, et al. Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus. Nature. 2001;411(6836):480-4.
    • (2001) Nature , vol.411 , Issue.6836 , pp. 480-484
    • Cowley, M.A.1    Smart, J.L.2    Rubinstein, M.3    Cerdan, M.G.4    Diano, S.5    Horvath, T.L.6
  • 66
    • 27744457512 scopus 로고    scopus 로고
    • Topographic mapping of VMH - Arcuate nucleus microcircuits and their reorganization by fasting
    • 16172601 1:CAS:528:DC%2BD2MXhtVeqs7zK
    • Sternson SM, Shepherd GM, Friedman JM. Topographic mapping of VMH - arcuate nucleus microcircuits and their reorganization by fasting. Nat Neurosci. 2005;8(10):1356-63.
    • (2005) Nat Neurosci , vol.8 , Issue.10 , pp. 1356-1363
    • Sternson, S.M.1    Shepherd, G.M.2    Friedman, J.M.3
  • 67
    • 78650191226 scopus 로고    scopus 로고
    • 5-HT2CRs expressed by pro-opiomelanocortin neurons regulate insulin sensitivity in liver
    • 21037584 1:CAS:528:DC%2BC3cXhtlGrsLnP
    • Xu Y, Berglund ED, Sohn JW, Holland WL, Chuang JC, Fukuda M, et al. 5-HT2CRs expressed by pro-opiomelanocortin neurons regulate insulin sensitivity in liver. Nat Neurosci. 2010;13(12):1457-9.
    • (2010) Nat Neurosci , vol.13 , Issue.12 , pp. 1457-1459
    • Xu, Y.1    Berglund, E.D.2    Sohn, J.W.3    Holland, W.L.4    Chuang, J.C.5    Fukuda, M.6
  • 68
    • 33845867730 scopus 로고    scopus 로고
    • Inactivation of signal transducer and activator of transcription 3 in proopiomelanocortin (Pomc) neurons causes decreased pomc expression, mild obesity, and defects in compensatory refeeding
    • 17023536 1:CAS:528:DC%2BD2sXjsV2rtA%3D%3D
    • Xu AW, Ste-Marie L, Kaelin CB, Barsh GS. Inactivation of signal transducer and activator of transcription 3 in proopiomelanocortin (Pomc) neurons causes decreased pomc expression, mild obesity, and defects in compensatory refeeding. Endocrinology. 2007;148(1):72-80.
    • (2007) Endocrinology , vol.148 , Issue.1 , pp. 72-80
    • Xu, A.W.1    Ste-Marie, L.2    Kaelin, C.B.3    Barsh, G.S.4
  • 69
    • 70350389400 scopus 로고    scopus 로고
    • Dominant role of the p110beta isoform of PI3K over p110alpha in energy homeostasis regulation by POMC and AgRP neurons
    • 19883613 1:CAS:528:DC%2BC3cXht1eqs74%3D
    • Al-Qassab H, Smith MA, Irvine EE, Guillermet-Guibert J, Claret M, Choudhury AI, et al. Dominant role of the p110beta isoform of PI3K over p110alpha in energy homeostasis regulation by POMC and AgRP neurons. Cell Metab. 2009;10(5):343-54.
    • (2009) Cell Metab , vol.10 , Issue.5 , pp. 343-354
    • Al-Qassab, H.1    Smith, M.A.2    Irvine, E.E.3    Guillermet-Guibert, J.4    Claret, M.5    Choudhury, A.I.6
  • 70
    • 34547651092 scopus 로고    scopus 로고
    • AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons
    • 17671657 1:CAS:528:DC%2BD2sXoslOnsLo%3D
    • Claret M, Smith MA, Batterham RL, Selman C, Choudhury AI, Fryer LG, et al. AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons. J Clin Invest. 2007;117(8):2325-36.
    • (2007) J Clin Invest , vol.117 , Issue.8 , pp. 2325-2336
    • Claret, M.1    Smith, M.A.2    Batterham, R.L.3    Selman, C.4    Choudhury, A.I.5    Fryer, L.G.6
  • 71
    • 79952399495 scopus 로고    scopus 로고
    • Deletion of Lkb1 in pro-opiomelanocortin neurons impairs peripheral glucose homeostasis in mice
    • 21266325 1:CAS:528:DC%2BC3MXktVKksLo%3D
    • Claret M, Smith MA, Knauf C, Al-Qassab H, Woods A, Heslegrave A, et al. Deletion of Lkb1 in pro-opiomelanocortin neurons impairs peripheral glucose homeostasis in mice. Diabetes. 2011;60(3):735-45.
    • (2011) Diabetes , vol.60 , Issue.3 , pp. 735-745
    • Claret, M.1    Smith, M.A.2    Knauf, C.3    Al-Qassab, H.4    Woods, A.5    Heslegrave, A.6
  • 72
    • 84864927001 scopus 로고    scopus 로고
    • Rapamycin ameliorates age-dependent obesity associated with increased mTOR signaling in hypothalamic POMC neurons
    • 22884327 1:CAS:528:DC%2BC38XhtFKms7vK
    • Yang SB, Tien AC, Boddupalli G, Xu AW, Jan YN, Jan LY. Rapamycin ameliorates age-dependent obesity associated with increased mTOR signaling in hypothalamic POMC neurons. Neuron. 2012;75(3):425-36.
    • (2012) Neuron , vol.75 , Issue.3 , pp. 425-436
    • Yang, S.B.1    Tien, A.C.2    Boddupalli, G.3    Xu, A.W.4    Jan, Y.N.5    Jan, L.Y.6
  • 73
    • 63449109316 scopus 로고    scopus 로고
    • Critical role for hypothalamic mTOR activity in energy balance
    • 19356717 1:CAS:528:DC%2BD1MXlsFyru7s%3D
    • Mori H, Inoki K, Munzberg H, Opland D, Faouzi M, Villanueva EC, et al. Critical role for hypothalamic mTOR activity in energy balance. Cell Metab. 2009;9(4):362-74.
    • (2009) Cell Metab , vol.9 , Issue.4 , pp. 362-374
    • Mori, H.1    Inoki, K.2    Munzberg, H.3    Opland, D.4    Faouzi, M.5    Villanueva, E.C.6
  • 74
    • 80052496920 scopus 로고    scopus 로고
    • Peroxisome proliferation-associated control of reactive oxygen species sets melanocortin tone and feeding in diet-induced obesity
    • 21873987 1:CAS:528:DC%2BC3MXhtV2gt7fJ
    • Diano S, Liu ZW, Jeong JK, Dietrich MO, Ruan HB, Kim E, et al. Peroxisome proliferation-associated control of reactive oxygen species sets melanocortin tone and feeding in diet-induced obesity. Nat Med. 2011;17(9):1121-7.
    • (2011) Nat Med , vol.17 , Issue.9 , pp. 1121-1127
    • Diano, S.1    Liu, Z.W.2    Jeong, J.K.3    Dietrich, M.O.4    Ruan, H.B.5    Kim, E.6
  • 75
    • 84859416906 scopus 로고    scopus 로고
    • Role of hypothalamic proopiomelanocortin neuron autophagy in the control of appetite and leptin response
    • 22334718 1:CAS:528:DC%2BC38XlsVSmsL8%3D
    • Quan W, Kim HK, Moon EY, Kim SS, Choi CS, Komatsu M, et al. Role of hypothalamic proopiomelanocortin neuron autophagy in the control of appetite and leptin response. Endocrinology. 2012;153(4):1817-26.
    • (2012) Endocrinology , vol.153 , Issue.4 , pp. 1817-1826
    • Quan, W.1    Kim, H.K.2    Moon, E.Y.3    Kim, S.S.4    Choi, C.S.5    Komatsu, M.6
  • 76
    • 84856953003 scopus 로고    scopus 로고
    • Loss of autophagy in pro-opiomelanocortin neurons perturbs axon growth and causes metabolic dysregulation
    • 22285542 1:CAS:528:DC%2BC38XhsVeisb8%3D
    • Coupe B, Ishii Y, Dietrich MO, Komatsu M, Horvath TL, Bouret SG. Loss of autophagy in pro-opiomelanocortin neurons perturbs axon growth and causes metabolic dysregulation. Cell Metab. 2012;15(2):247-55.
    • (2012) Cell Metab , vol.15 , Issue.2 , pp. 247-255
    • Coupe, B.1    Ishii, Y.2    Dietrich, M.O.3    Komatsu, M.4    Horvath, T.L.5    Bouret, S.G.6
  • 77
    • 84863229947 scopus 로고    scopus 로고
    • Loss of autophagy in hypothalamic POMC neurons impairs lipolysis
    • 22249165 1:CAS:528:DC%2BC38Xnt1OjtQ%3D%3D
    • Kaushik S, Arias E, Kwon H, Lopez NM, Athonvarangkul D, Sahu S, et al. Loss of autophagy in hypothalamic POMC neurons impairs lipolysis. EMBO reports. 2012;13(3):258-65.
    • (2012) EMBO Reports , vol.13 , Issue.3 , pp. 258-265
    • Kaushik, S.1    Arias, E.2    Kwon, H.3    Lopez, N.M.4    Athonvarangkul, D.5    Sahu, S.6
  • 78
    • 77249146406 scopus 로고    scopus 로고
    • Segregation of acute leptin and insulin effects in distinct populations of arcuate proopiomelanocortin neurons
    • 20164331 1:CAS:528:DC%2BC3cXisVKlsbg%3D
    • Williams KW, Margatho LO, Lee CE, Choi M, Lee S, Scott MM, et al. Segregation of acute leptin and insulin effects in distinct populations of arcuate proopiomelanocortin neurons. J Neurosci. 2010;30(7):2472-9.
    • (2010) J Neurosci , vol.30 , Issue.7 , pp. 2472-2479
    • Williams, K.W.1    Margatho, L.O.2    Lee, C.E.3    Choi, M.4    Lee, S.5    Scott, M.M.6
  • 79
    • 0032130554 scopus 로고    scopus 로고
    • Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons
    • 10195157 1:CAS:528:DyaK1MXitVCgtbc%3D
    • Hahn TM, Breininger JF, Baskin DG, Schwartz MW. Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons. Nat Neurosci. 1998;1(4):271-2.
    • (1998) Nat Neurosci , vol.1 , Issue.4 , pp. 271-272
    • Hahn, T.M.1    Breininger, J.F.2    Baskin, D.G.3    Schwartz, M.W.4
  • 80
    • 79953307878 scopus 로고    scopus 로고
    • Rapid, reversible activation of AgRP neurons drives feeding behavior in mice
    • 21364278 1:CAS:528:DC%2BC3MXksFahs70%3D
    • Krashes MJ, Koda S, Ye C, Rogan SC, Adams AC, Cusher DS, et al. Rapid, reversible activation of AgRP neurons drives feeding behavior in mice. J Clin Invest. 2011;121(4):1424-8.
    • (2011) J Clin Invest , vol.121 , Issue.4 , pp. 1424-1428
    • Krashes, M.J.1    Koda, S.2    Ye, C.3    Rogan, S.C.4    Adams, A.C.5    Cusher, D.S.6
  • 81
    • 27344431720 scopus 로고    scopus 로고
    • NPY/AgRP neurons are essential for feeding in adult mice but can be ablated in neonates
    • 16254186 1:CAS:528:DC%2BD2MXhtFChsLjI
    • Luquet S, Perez FA, Hnasko TS, Palmiter RD. NPY/AgRP neurons are essential for feeding in adult mice but can be ablated in neonates. Science. 2005;310(5748):683-5.
    • (2005) Science , vol.310 , Issue.5748 , pp. 683-685
    • Luquet, S.1    Perez, F.A.2    Hnasko, T.S.3    Palmiter, R.D.4
  • 82
    • 27344433932 scopus 로고    scopus 로고
    • Agouti-related peptide-expressing neurons are mandatory for feeding
    • 16158063 1:CAS:528:DC%2BD2MXhtVeqs7zI
    • Gropp E, Shanabrough M, Borok E, Xu AW, Janoschek R, Buch T, et al. Agouti-related peptide-expressing neurons are mandatory for feeding. Nat Neurosci. 2005;8(10):1289-91.
    • (2005) Nat Neurosci , vol.8 , Issue.10 , pp. 1289-1291
    • Gropp, E.1    Shanabrough, M.2    Borok, E.3    Xu, A.W.4    Janoschek, R.5    Buch, T.6
  • 83
    • 0030764741 scopus 로고    scopus 로고
    • Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein
    • 9311920 1:CAS:528:DyaK2sXmsV2ltrw%3D
    • Ollmann MM, Wilson BD, Yang YK, Kerns JA, Chen Y, Gantz I, et al. Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein. Science. 1997;278(5335):135-8
    • (1997) Science , vol.278 , Issue.5335 , pp. 135-138
    • Ollmann, M.M.1    Wilson, B.D.2    Yang, Y.K.3    Kerns, J.A.4    Chen, Y.5    Gantz, I.6
  • 84
    • 50249120768 scopus 로고    scopus 로고
    • Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance
    • 19160495 1:CAS:528:DC%2BD1cXhtVamur3N
    • Tong Q, Ye CP, Jones JE, Elmquist JK, Lowell BB. Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance. Nat Neurosci. 2008;11(9):998-1000.
    • (2008) Nat Neurosci , vol.11 , Issue.9 , pp. 998-1000
    • Tong, Q.1    Ye, C.P.2    Jones, J.E.3    Elmquist, J.K.4    Lowell, B.B.5
  • 85
    • 84864711337 scopus 로고    scopus 로고
    • Deconstruction of a neural circuit for hunger
    • 22801496 1:CAS:528:DC%2BC38XhtFWjtrfE
    • Atasoy D, Betley JN, Su HH, Sternson SM. Deconstruction of a neural circuit for hunger. Nature. 2012;488(7410):172-7.
    • (2012) Nature , vol.488 , Issue.7410 , pp. 172-177
    • Atasoy, D.1    Betley, J.N.2    Su, H.H.3    Sternson, S.M.4
  • 86
    • 0031779336 scopus 로고    scopus 로고
    • Role of the Y5 neuropeptide y receptor in feeding and obesity
    • 9623983 1:CAS:528:DyaK1cXjsFylsrw%3D
    • Marsh DJ, Hollopeter G, Kafer KE, Palmiter RD. Role of the Y5 neuropeptide Y receptor in feeding and obesity. Nat Med. 1998;4(6):718-21.
    • (1998) Nat Med , vol.4 , Issue.6 , pp. 718-721
    • Marsh, D.J.1    Hollopeter, G.2    Kafer, K.E.3    Palmiter, R.D.4
  • 87
    • 0032417697 scopus 로고    scopus 로고
    • Obesity and mild hyperinsulinemia found in neuropeptide Y-Y1 receptor-deficient mice
    • 9861026 1:CAS:528:DyaK1MXhvFeitA%3D%3D
    • Kushi A, Sasai H, Koizumi H, Takeda N, Yokoyama M, Nakamura M. Obesity and mild hyperinsulinemia found in neuropeptide Y-Y1 receptor-deficient mice. Proc Natl Acad Sci U S A. 1998;95(26):15659-64.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , Issue.26 , pp. 15659-15664
    • Kushi, A.1    Sasai, H.2    Koizumi, H.3    Takeda, N.4    Yokoyama, M.5    Nakamura, M.6
  • 88
    • 84863092267 scopus 로고    scopus 로고
    • Y1 and Y5 receptors are both required for the regulation of food intake and energy homeostasis in mice
    • 22768253 1:CAS:528:DC%2BC38XpvVais7g%3D
    • Nguyen AD, Mitchell NF, Lin S, Macia L, Yulyaningsih E, Baldock PA, et al. Y1 and Y5 receptors are both required for the regulation of food intake and energy homeostasis in mice. PLoS One. 2012;7(6):e40191.
    • (2012) PLoS One , vol.7 , Issue.6 , pp. 40191
    • Nguyen, A.D.1    Mitchell, N.F.2    Lin, S.3    Macia, L.4    Yulyaningsih, E.5    Baldock, P.A.6
  • 89
    • 0029946644 scopus 로고    scopus 로고
    • Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide y
    • 8632796 1:CAS:528:DyaK28XjsVWgtr8%3D
    • Erickson JC, Clegg KE, Palmiter RD. Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y. Nature. 1996;381(6581):415-21.
    • (1996) Nature , vol.381 , Issue.6581 , pp. 415-421
    • Erickson, J.C.1    Clegg, K.E.2    Palmiter, R.D.3
  • 90
    • 67549112681 scopus 로고    scopus 로고
    • Loss of GABAergic signaling by AgRP neurons to the parabrachial nucleus leads to starvation
    • 19563755
    • Wu Q, Boyle MP, Palmiter RD. Loss of GABAergic signaling by AgRP neurons to the parabrachial nucleus leads to starvation. Cell. 2009;137(7):1225-34.
    • (2009) Cell , vol.137 , Issue.7 , pp. 1225-1234
    • Wu, Q.1    Boyle, M.P.2    Palmiter, R.D.3
  • 91
    • 84863012024 scopus 로고    scopus 로고
    • Fasting activation of AgRP neurons requires NMDA receptors and involves spinogenesis and increased excitatory tone
    • 22325203
    • Liu T, Kong D, Shah BP, Ye C, Koda S, Saunders A, et al. Fasting activation of AgRP neurons requires NMDA receptors and involves spinogenesis and increased excitatory tone. Neuron. 2012;73(3):511-22.
    • (2012) Neuron , vol.73 , Issue.3 , pp. 511-522
    • Liu, T.1    Kong, D.2    Shah, B.P.3    Ye, C.4    Koda, S.5    Saunders, A.6
  • 92
    • 80052922112 scopus 로고    scopus 로고
    • Hunger states switch a flip-flop memory circuit via a synaptic AMPK-dependent positive feedback loop
    • 21925320 1:CAS:528:DC%2BC3MXhtF2htL7K
    • Yang Y, Atasoy D, Su HH, Sternson SM. Hunger states switch a flip-flop memory circuit via a synaptic AMPK-dependent positive feedback loop. Cell. 2011;146(6):992-1003.
    • (2011) Cell , vol.146 , Issue.6 , pp. 992-1003
    • Yang, Y.1    Atasoy, D.2    Su, H.H.3    Sternson, S.M.4
  • 93
    • 84861976352 scopus 로고    scopus 로고
    • FoxO1 target Gpr17 activates AgRP neurons to regulate food intake
    • 22682251 1:CAS:528:DC%2BC38XosVaktro%3D
    • Ren H, Orozco IJ, Su Y, Suyama S, Gutierrez-Juarez R, Horvath TL, et al. FoxO1 target Gpr17 activates AgRP neurons to regulate food intake. Cell. 2012;149(6):1314-26.
    • (2012) Cell , vol.149 , Issue.6 , pp. 1314-1326
    • Ren, H.1    Orozco, I.J.2    Su, Y.3    Suyama, S.4    Gutierrez-Juarez, R.5    Horvath, T.L.6
  • 94
    • 42649105456 scopus 로고    scopus 로고
    • Hypothalamic CaMKK2 contributes to the regulation of energy balance
    • 18460329 1:CAS:528:DC%2BD1cXmtFeitbc%3D
    • Anderson KA, Ribar TJ, Lin F, Noeldner PK, Green MF, Muehlbauer MJ, et al. Hypothalamic CaMKK2 contributes to the regulation of energy balance. Cell Metab. 2008;7(5):377-88.
    • (2008) Cell Metab , vol.7 , Issue.5 , pp. 377-388
    • Anderson, K.A.1    Ribar, T.J.2    Lin, F.3    Noeldner, P.K.4    Green, M.F.5    Muehlbauer, M.J.6
  • 95
    • 49649122302 scopus 로고    scopus 로고
    • UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals
    • 18668043 1:CAS:528:DC%2BD1cXpvVaisr0%3D
    • Andrews ZB, Liu ZW, Walllingford N, Erion DM, Borok E, Friedman JM, et al. UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals. Nature. 2008;454(7206):846-51.
    • (2008) Nature , vol.454 , Issue.7206 , pp. 846-851
    • Andrews, Z.B.1    Liu, Z.W.2    Walllingford, N.3    Erion, D.M.4    Borok, E.5    Friedman, J.M.6
  • 96
    • 33845582594 scopus 로고    scopus 로고
    • A central thermogenic-like mechanism in feeding regulation: An interplay between arcuate nucleus T3 and UCP2
    • 17189204 1:CAS:528:DC%2BD2sXpsV2jsg%3D%3D
    • Coppola A, Liu ZW, Andrews ZB, Paradis E, Roy MC, Friedman JM, et al. A central thermogenic-like mechanism in feeding regulation: an interplay between arcuate nucleus T3 and UCP2. Cell Metab. 2007;5(1):21-33.
    • (2007) Cell Metab , vol.5 , Issue.1 , pp. 21-33
    • Coppola, A.1    Liu, Z.W.2    Andrews, Z.B.3    Paradis, E.4    Roy, M.C.5    Friedman, J.M.6
  • 97
    • 79960951346 scopus 로고    scopus 로고
    • Autophagy in hypothalamic AgRP neurons regulates food intake and energy balance
    • 21803288 1:CAS:528:DC%2BC3MXpsFKitLc%3D
    • Kaushik S, Rodriguez-Navarro JA, Arias E, Kiffin R, Sahu S, Schwartz GJ, et al. Autophagy in hypothalamic AgRP neurons regulates food intake and energy balance. Cell Metab. 2011;14(2):173-83.
    • (2011) Cell Metab , vol.14 , Issue.2 , pp. 173-183
    • Kaushik, S.1    Rodriguez-Navarro, J.A.2    Arias, E.3    Kiffin, R.4    Sahu, S.5    Schwartz, G.J.6
  • 98
    • 9644260563 scopus 로고    scopus 로고
    • Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes
    • 15467829 1:CAS:528:DC%2BD2cXot12gtr0%3D
    • Lin X, Taguchi A, Park S, Kushner JA, Li F, Li Y, et al. Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes. J Clin Invest. 2004;114(7):908-16.
    • (2004) J Clin Invest , vol.114 , Issue.7 , pp. 908-916
    • Lin, X.1    Taguchi, A.2    Park, S.3    Kushner, J.A.4    Li, F.5    Li, Y.6
  • 100
    • 10744232925 scopus 로고    scopus 로고
    • Essential role of STAT3 in body weight and glucose homeostasis
    • 14673160 1:CAS:528:DC%2BD2cXhtVWmsQ%3D%3D
    • Cui Y, Huang L, Elefteriou F, Yang G, Shelton JM, Giles JE, et al. Essential role of STAT3 in body weight and glucose homeostasis. Mol Cell Biol. 2004;24(1):258-69.
    • (2004) Mol Cell Biol , vol.24 , Issue.1 , pp. 258-269
    • Cui, Y.1    Huang, L.2    Elefteriou, F.3    Yang, G.4    Shelton, J.M.5    Giles, J.E.6
  • 101
    • 0036153668 scopus 로고    scopus 로고
    • Knockout mice lacking steroidogenic factor 1 are a novel genetic model of hypothalamic obesity
    • 11796516 1:CAS:528:DC%2BD38XosFWqtA%3D%3D
    • Majdic G, Young M, Gomez-Sanchez E, Anderson P, Szczepaniak LS, Dobbins RL, et al. Knockout mice lacking steroidogenic factor 1 are a novel genetic model of hypothalamic obesity. Endocrinology. 2002;143(2):607-14.
    • (2002) Endocrinology , vol.143 , Issue.2 , pp. 607-614
    • Majdic, G.1    Young, M.2    Gomez-Sanchez, E.3    Anderson, P.4    Szczepaniak, L.S.5    Dobbins, R.L.6
  • 102
    • 79960617185 scopus 로고    scopus 로고
    • Steroidogenic factor 1 directs programs regulating diet-induced thermogenesis and leptin action in the ventral medial hypothalamic nucleus
    • 21636788 1:CAS:528:DC%2BC3MXovFenu7w%3D
    • Kim KW, Zhao L, Donato Jr J, Kohno D, Xu Y, Elias CF, et al. Steroidogenic factor 1 directs programs regulating diet-induced thermogenesis and leptin action in the ventral medial hypothalamic nucleus. Proc Natl Acad Sci U S A. 2011;108(26):10673-8.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , Issue.26 , pp. 10673-10678
    • Kim, K.W.1    Zhao, L.2    Donato, Jr.J.3    Kohno, D.4    Xu, Y.5    Elias, C.F.6
  • 103
    • 30644473109 scopus 로고    scopus 로고
    • Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis
    • 16423694 1:CAS:528:DC%2BD28Xht1SrtbY%3D
    • Dhillon H, Zigman JM, Ye C, Lee CE, McGovern RA, Tang V, et al. Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis. Neuron. 2006;49(2):191-203.
    • (2006) Neuron , vol.49 , Issue.2 , pp. 191-203
    • Dhillon, H.1    Zigman, J.M.2    Ye, C.3    Lee, C.E.4    McGovern, R.A.5    Tang, V.6
  • 104
    • 80052700953 scopus 로고    scopus 로고
    • SIRT1 deacetylase in SF1 neurons protects against metabolic imbalance
    • 21907137 1:CAS:528:DC%2BC3MXhtFGltbnJ
    • Ramadori G, Fujikawa T, Anderson J, Berglund ED, Frazao R, Michan S, et al. SIRT1 deacetylase in SF1 neurons protects against metabolic imbalance. Cell Metab. 2011;14(3):301-12.
    • (2011) Cell Metab , vol.14 , Issue.3 , pp. 301-312
    • Ramadori, G.1    Fujikawa, T.2    Anderson, J.3    Berglund, E.D.4    Frazao, R.5    Michan, S.6
  • 105
    • 84455185218 scopus 로고    scopus 로고
    • Type 2 corticotropin-releasing factor receptor in the ventromedial nucleus of hypothalamus is critical in regulating feeding and lipid metabolism in white adipose tissue
    • 22067315 1:CAS:528:DC%2BC38XovFWmtg%3D%3D
    • Chao H, Digruccio M, Chen P, Li C. Type 2 corticotropin-releasing factor receptor in the ventromedial nucleus of hypothalamus is critical in regulating feeding and lipid metabolism in white adipose tissue. Endocrinology. 2012;153(1):166-76.
    • (2012) Endocrinology , vol.153 , Issue.1 , pp. 166-176
    • Chao, H.1    Digruccio, M.2    Chen, P.3    Li, C.4
  • 106
    • 34247616021 scopus 로고    scopus 로고
    • Synaptic glutamate release by ventromedial hypothalamic neurons is part of the neurocircuitry that prevents hypoglycemia
    • 17488640 1:CAS:528:DC%2BD2sXmt1ajsr4%3D
    • Tong Q, Ye C, McCrimmon RJ, Dhillon H, Choi B, Kramer MD, et al. Synaptic glutamate release by ventromedial hypothalamic neurons is part of the neurocircuitry that prevents hypoglycemia. Cell Metab. 2007;5(5):383-93.
    • (2007) Cell Metab , vol.5 , Issue.5 , pp. 383-393
    • Tong, Q.1    Ye, C.2    McCrimmon, R.J.3    Dhillon, H.4    Choi, B.5    Kramer, M.D.6
  • 107
    • 85027958110 scopus 로고    scopus 로고
    • Weighing in the role of BDNF in the central control of eating behavior
    • 22012072 1:CAS:528:DC%2BC3MXhsFOjt7bK
    • Cordeira J, Rios M. Weighing in the role of BDNF in the central control of eating behavior. Mol Neurobiol. 2011;44(3):441-8.
    • (2011) Mol Neurobiol , vol.44 , Issue.3 , pp. 441-448
    • Cordeira, J.1    Rios, M.2
  • 109
    • 0034653422 scopus 로고    scopus 로고
    • BDNF regulates eating behavior and locomotor activity in mice
    • 10716929 1:CAS:528:DC%2BD3cXit1GmsLg%3D
    • Kernie SG, Liebl DJ, Parada LF. BDNF regulates eating behavior and locomotor activity in mice. Embo J. 2000;19(6):1290-300.
    • (2000) Embo J , vol.19 , Issue.6 , pp. 1290-1300
    • Kernie, S.G.1    Liebl, D.J.2    Parada, L.F.3
  • 110
    • 34548451564 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor in the hypothalamic paraventricular nucleus increases energy expenditure by elevating metabolic rate
    • 17567712 1:CAS:528:DC%2BD2sXhtVOqtrfP
    • Wang C, Bomberg E, Billington C, Levine A, Kotz CM. Brain-derived neurotrophic factor in the hypothalamic paraventricular nucleus increases energy expenditure by elevating metabolic rate. Am J Physiol Regul Integr Comp Physiol. 2007;293(3):R992-R1002.
    • (2007) Am J Physiol Regul Integr Comp Physiol , vol.293 , Issue.3
    • Wang, C.1    Bomberg, E.2    Billington, C.3    Levine, A.4    Kotz, C.M.5
  • 111
    • 34548462036 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor in the ventromedial nucleus of the hypothalamus reduces energy intake
    • 17553842 1:CAS:528:DC%2BD2sXhtVOqtrfE
    • Wang C, Bomberg E, Levine A, Billington C, Kotz CM. Brain-derived neurotrophic factor in the ventromedial nucleus of the hypothalamus reduces energy intake. Am J Physiol Regul Integr Comp Physiol. 2007;293(3):R1037-45.
    • (2007) Am J Physiol Regul Integr Comp Physiol , vol.293 , Issue.3
    • Wang, C.1    Bomberg, E.2    Levine, A.3    Billington, C.4    Kotz, C.M.5
  • 112
    • 77951743757 scopus 로고    scopus 로고
    • Chronic administration of brain-derived neurotrophic factor in the hypothalamic paraventricular nucleus reverses obesity induced by high-fat diet
    • 20164202 1:CAS:528:DC%2BC3cXmt1KlsLg%3D
    • Wang C, Godar RJ, Billington CJ, Kotz CM. Chronic administration of brain-derived neurotrophic factor in the hypothalamic paraventricular nucleus reverses obesity induced by high-fat diet. Am J Physiol Regul Integr Comp Physiol. 2010;298(5):R1320-32.
    • (2010) Am J Physiol Regul Integr Comp Physiol , vol.298 , Issue.5
    • Wang, C.1    Godar, R.J.2    Billington, C.J.3    Kotz, C.M.4
  • 113
    • 84856406415 scopus 로고    scopus 로고
    • BDNF and glucocorticoids regulate corticotrophin-releasing hormone (CRH) homeostasis in the hypothalamus
    • 22232675 1:CAS:528:DC%2BC38XislWksb0%3D
    • Jeanneteau FD, Lambert WM, Ismaili N, Bath KG, Lee FS, Garabedian MJ, et al. BDNF and glucocorticoids regulate corticotrophin-releasing hormone (CRH) homeostasis in the hypothalamus. Proc Natl Acad Sci U S A. 2012;109(4):1305-10.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , Issue.4 , pp. 1305-1310
    • Jeanneteau, F.D.1    Lambert, W.M.2    Ismaili, N.3    Bath, K.G.4    Lee, F.S.5    Garabedian, M.J.6
  • 114
    • 77956005564 scopus 로고    scopus 로고
    • Long-term infusion of brain-derived neurotrophic factor reduces food intake and body weight via a corticotrophin-releasing hormone pathway in the paraventricular nucleus of the hypothalamus
    • 20561155 1:CAS:528:DC%2BC3cXhtFerur7M
    • Toriya M, Maekawa F, Maejima Y, Onaka T, Fujiwara K, Nakagawa T, et al. Long-term infusion of brain-derived neurotrophic factor reduces food intake and body weight via a corticotrophin-releasing hormone pathway in the paraventricular nucleus of the hypothalamus. J Neuroendocrinol. 2010;22(9):987-95.
    • (2010) J Neuroendocrinol , vol.22 , Issue.9 , pp. 987-995
    • Toriya, M.1    Maekawa, F.2    Maejima, Y.3    Onaka, T.4    Fujiwara, K.5    Nakagawa, T.6
  • 115
    • 84859560308 scopus 로고    scopus 로고
    • Dendritically targeted Bdnf mRNA is essential for energy balance and response to leptin
    • 22426422 1:CAS:528:DC%2BC38XktVartbg%3D
    • Liao GY, An JJ, Gharami K, Waterhouse EG, Vanevski F, Jones KR, et al. Dendritically targeted Bdnf mRNA is essential for energy balance and response to leptin. Nat Med. 2012;18(4):564-71.
    • (2012) Nat Med , vol.18 , Issue.4 , pp. 564-571
    • Liao, G.Y.1    An, J.J.2    Gharami, K.3    Waterhouse, E.G.4    Vanevski, F.5    Jones, K.R.6
  • 116
    • 72449209171 scopus 로고    scopus 로고
    • PACAP neurons in the hypothalamic ventromedial nucleus are targets of central leptin signaling
    • 19940178 1:CAS:528:DC%2BD1MXhsFCgtLzF
    • Hawke Z, Ivanov TR, Bechtold DA, Dhillon H, Lowell BB, Luckman SM. PACAP neurons in the hypothalamic ventromedial nucleus are targets of central leptin signaling. J Neurosci. 2009;29(47):14828-35.
    • (2009) J Neurosci , vol.29 , Issue.47 , pp. 14828-14835
    • Hawke, Z.1    Ivanov, T.R.2    Bechtold, D.A.3    Dhillon, H.4    Lowell, B.B.5    Luckman, S.M.6
  • 117
    • 0032569615 scopus 로고    scopus 로고
    • Induction of neuropeptide y expression in dorsomedial hypothalamus of diet-induced obese mice
    • 9855291 1:CAS:528:DyaK1cXotV2kt7k%3D
    • Guan XM, Yu H, Trumbauer M, Frazier E, Van der Ploeg LH, Chen H. Induction of neuropeptide Y expression in dorsomedial hypothalamus of diet-induced obese mice. Neuroreport. 1998;9(15):3415-9.
    • (1998) Neuroreport , vol.9 , Issue.15 , pp. 3415-3419
    • Guan, X.M.1    Yu, H.2    Trumbauer, M.3    Frazier, E.4    Van Der Ploeg, L.H.5    Chen, H.6
  • 118
    • 84875821516 scopus 로고    scopus 로고
    • Efferent projections of NPY expressing neurons of the dorsomedial hypothalamus in chronic hyperphagic models
    • Lee SJ, Kirigiti M, Lindsley SR, Loche A, Madden CJ, Morrison SF, et al. Efferent projections of NPY expressing neurons of the dorsomedial hypothalamus in chronic hyperphagic models. J Comp Neurol. 2013;521(8)1891-914.
    • (2013) J Comp Neurol. , vol.521 , Issue.8 , pp. 1891-1914
    • Lee, S.J.1    Kirigiti, M.2    Lindsley, S.R.3    Loche, A.4    Madden, C.J.5    Morrison, S.F.6
  • 119
    • 84869875771 scopus 로고    scopus 로고
    • Dorsomedial hypothalamic NPY and energy balance control
    • 23083763 1:CAS:528:DC%2BC38XhsFCgtb7P
    • Bi S, Kim YJ, Zheng F. Dorsomedial hypothalamic NPY and energy balance control. Neuropeptides. 2012;46(6):309-14.
    • (2012) Neuropeptides , vol.46 , Issue.6 , pp. 309-314
    • Bi, S.1    Kim, Y.J.2    Zheng, F.3
  • 120
    • 0142116115 scopus 로고    scopus 로고
    • Acute food deprivation and chronic food restriction differentially affect hypothalamic NPY mRNA expression
    • 12842868 1:CAS:528:DC%2BD3sXpt1Okt7s%3D
    • Bi S, Robinson BM, Moran TH. Acute food deprivation and chronic food restriction differentially affect hypothalamic NPY mRNA expression. Am J Physiol Regul Integr Comp Physiol. 2003;285(5):R1030-6.
    • (2003) Am J Physiol Regul Integr Comp Physiol , vol.285 , Issue.5
    • Bi, S.1    Robinson, B.M.2    Moran, T.H.3
  • 121
    • 58149377292 scopus 로고    scopus 로고
    • Role of dorsomedial hypothalamic neuropeptide y in modulating food intake and energy balance
    • 19129396 1:CAS:528:DC%2BD1MXhtVOjsLo%3D
    • Yang L, Scott KA, Hyun J, Tamashiro KL, Tray N, Moran TH, et al. Role of dorsomedial hypothalamic neuropeptide Y in modulating food intake and energy balance. J Neurosci. 2009;29(1):179-90.
    • (2009) J Neurosci , vol.29 , Issue.1 , pp. 179-190
    • Yang, L.1    Scott, K.A.2    Hyun, J.3    Tamashiro, K.L.4    Tray, N.5    Moran, T.H.6
  • 122
    • 3843119853 scopus 로고    scopus 로고
    • Differential roles for cholecystokinin a receptors in energy balance in rats and mice
    • 15123537 1:CAS:528:DC%2BD2cXmtlCqsbw%3D
    • Bi S, Scott KA, Kopin AS, Moran TH. Differential roles for cholecystokinin a receptors in energy balance in rats and mice. Endocrinology. 2004;145(8):3873-80.
    • (2004) Endocrinology , vol.145 , Issue.8 , pp. 3873-3880
    • Bi, S.1    Scott, K.A.2    Kopin, A.S.3    Moran, T.H.4
  • 123
    • 0019760938 scopus 로고
    • Hypothalamic paraventricular nucleus lesions produce overeating and obesity in the rat
    • 7335803 1:STN:280:DyaL387ltFCquw%3D%3D
    • Leibowitz SF, Hammer NJ, Chang K. Hypothalamic paraventricular nucleus lesions produce overeating and obesity in the rat. Physiol Behav. 1981;27(6):1031-40.
    • (1981) Physiol Behav , vol.27 , Issue.6 , pp. 1031-1040
    • Leibowitz, S.F.1    Hammer, N.J.2    Chang, K.3
  • 124
    • 84860476819 scopus 로고    scopus 로고
    • Ablation of Sim1 neurons causes obesity through hyperphagia and reduced energy expenditure
    • Xi D, Gandhi N, Lai M, Kublaoui BM. Ablation of Sim1 neurons causes obesity through hyperphagia and reduced energy expenditure. PLoS One. 2012;7(4):e36453.
    • (2012) PLoS One , vol.7 , Issue.4
    • Xi, D.1    Gandhi, N.2    Lai, M.3    Kublaoui, B.M.4
  • 125
    • 77949416159 scopus 로고    scopus 로고
    • Postnatal Sim1 deficiency causes hyperphagic obesity and reduced Mc4r and oxytocin expression
    • 20220015 1:CAS:528:DC%2BC3cXlvVKmsr4%3D
    • Tolson KP, Gemelli T, Gautron L, Elmquist JK, Zinn AR, Kublaoui BM. Postnatal Sim1 deficiency causes hyperphagic obesity and reduced Mc4r and oxytocin expression. J Neurosci. 2010;30(10):3803-12.
    • (2010) J Neurosci , vol.30 , Issue.10 , pp. 3803-3812
    • Tolson, K.P.1    Gemelli, T.2    Gautron, L.3    Elmquist, J.K.4    Zinn, A.R.5    Kublaoui, B.M.6
  • 126
    • 17844401704 scopus 로고    scopus 로고
    • Anatomy and regulation of the central melanocortin system
    • 15856065 1:CAS:528:DC%2BD2MXjsFyktbo%3D
    • Cone RD. Anatomy and regulation of the central melanocortin system. Nat Neurosci. 2005;8(5):571-8.
    • (2005) Nat Neurosci , vol.8 , Issue.5 , pp. 571-578
    • Cone, R.D.1
  • 127
    • 4444370704 scopus 로고    scopus 로고
    • Suprachiasmatic GABAergic inputs to the paraventricular nucleus control plasma glucose concentrations in the rat via sympathetic innervation of the liver
    • 15342726 1:CAS:528:DC%2BD2cXns1OqsLY%3D
    • Kalsbeek A, La Fleur S, Van Heijningen C, Buijs RM. Suprachiasmatic GABAergic inputs to the paraventricular nucleus control plasma glucose concentrations in the rat via sympathetic innervation of the liver. J Neurosci. 2004;24(35):7604-13.
    • (2004) J Neurosci , vol.24 , Issue.35 , pp. 7604-7613
    • Kalsbeek, A.1    La Fleur, S.2    Van Heijningen, C.3    Buijs, R.M.4
  • 128
    • 33847105586 scopus 로고    scopus 로고
    • Electrical inhibition of identified anorexigenic POMC neurons by orexin/hypocretin
    • 17301161 1:CAS:528:DC%2BD2sXitl2gur0%3D
    • Ma X, Zubcevic L, Bruning JC, Ashcroft FM, Burdakov D. Electrical inhibition of identified anorexigenic POMC neurons by orexin/hypocretin. J Neurosci. 2007;27(7):1529-33.
    • (2007) J Neurosci , vol.27 , Issue.7 , pp. 1529-1533
    • Ma, X.1    Zubcevic, L.2    Bruning, J.C.3    Ashcroft, F.M.4    Burdakov, D.5
  • 129
    • 35248885157 scopus 로고    scopus 로고
    • Hypothalamic neuronal histamine mediates the thyrotropin-releasing hormone-induced suppression of food intake
    • 17760865 1:CAS:528:DC%2BD2sXhtlSitLfM
    • Gotoh K, Fukagawa K, Fukagawa T, Noguchi H, Kakuma T, Sakata T, et al. Hypothalamic neuronal histamine mediates the thyrotropin-releasing hormone-induced suppression of food intake. J Neurochem. 2007;103(3):1102-10.
    • (2007) J Neurochem , vol.103 , Issue.3 , pp. 1102-1110
    • Gotoh, K.1    Fukagawa, K.2    Fukagawa, T.3    Noguchi, H.4    Kakuma, T.5    Sakata, T.6
  • 130
    • 84863296844 scopus 로고    scopus 로고
    • Thyrotropin-releasing hormone (TRH) inhibits melanin-concentrating hormone neurons: Implications for TRH-mediated anorexic and arousal actions
    • 22378876 1:CAS:528:DC%2BC38XjslKjtLk%3D
    • Zhang X, van den Pol AN. Thyrotropin-releasing hormone (TRH) inhibits melanin-concentrating hormone neurons: implications for TRH-mediated anorexic and arousal actions. J Neurosci. 2012;32(9):3032-43.
    • (2012) J Neurosci , vol.32 , Issue.9 , pp. 3032-3043
    • Zhang, X.1    Van Den Pol, A.N.2
  • 131
    • 84869096114 scopus 로고    scopus 로고
    • Thyrotropin-releasing hormone-containing axons innervate histaminergic neurons in the tuberomammillary nucleus
    • 23063458 1:CAS:528:DC%2BC38XhsFymt73J
    • Sarvari A, Farkas E, Kadar A, Zseli G, Fuzesi T, Lechan RM, et al. Thyrotropin-releasing hormone-containing axons innervate histaminergic neurons in the tuberomammillary nucleus. Brain Res. 2012;1488:72-80.
    • (2012) Brain Res. , vol.1488 , pp. 72-80
    • Sarvari, A.1    Farkas, E.2    Kadar, A.3    Zseli, G.4    Fuzesi, T.5    Lechan, R.M.6
  • 132
    • 65549114213 scopus 로고    scopus 로고
    • Excitation of histaminergic tuberomamillary neurons by thyrotropin-releasing hormone
    • 19357273 1:CAS:528:DC%2BD1MXkvVymsrc%3D
    • Parmentier R, Kolbaev S, Klyuch BP, Vandael D, Lin JS, Selbach O, et al. Excitation of histaminergic tuberomamillary neurons by thyrotropin-releasing hormone. J Neurosci. 2009;29(14):4471-83.
    • (2009) J Neurosci , vol.29 , Issue.14 , pp. 4471-4483
    • Parmentier, R.1    Kolbaev, S.2    Klyuch, B.P.3    Vandael, D.4    Lin, J.S.5    Selbach, O.6
  • 133
    • 0036945823 scopus 로고    scopus 로고
    • Targeted disruption of H3 receptors results in changes in brain histamine tone leading to an obese phenotype
    • 12488429 1:CAS:528:DC%2BD38XpslWmsLk%3D
    • Takahashi K, Suwa H, Ishikawa T, Kotani H. Targeted disruption of H3 receptors results in changes in brain histamine tone leading to an obese phenotype. J Clin Invest. 2002;110(12):1791-9.
    • (2002) J Clin Invest , vol.110 , Issue.12 , pp. 1791-1799
    • Takahashi, K.1    Suwa, H.2    Ishikawa, T.3    Kotani, H.4
  • 134
    • 4344658781 scopus 로고    scopus 로고
    • Involvement of hypothalamic histamine H1 receptor in the regulation of feeding rhythm and obesity
    • 15331534 1:CAS:528:DC%2BD2cXns1Shsro%3D
    • Masaki T, Chiba S, Yasuda T, Noguchi H, Kakuma T, Watanabe T, et al. Involvement of hypothalamic histamine H1 receptor in the regulation of feeding rhythm and obesity. Diabetes. 2004;53(9):2250-60.
    • (2004) Diabetes , vol.53 , Issue.9 , pp. 2250-2260
    • Masaki, T.1    Chiba, S.2    Yasuda, T.3    Noguchi, H.4    Kakuma, T.5    Watanabe, T.6
  • 135
    • 1842713084 scopus 로고    scopus 로고
    • High leptin level is accompanied with decreased long leptin receptor transcript in histamine deficient transgenic mice
    • 15081545 1:CAS:528:DC%2BD2cXjtV2gt7k%3D
    • Hegyi K, Fulop KA, Kovacs KJ, Falus A, Toth S. High leptin level is accompanied with decreased long leptin receptor transcript in histamine deficient transgenic mice. Immunol Lett. 2004;92(1-2):193-7.
    • (2004) Immunol Lett , vol.92 , Issue.1-2 , pp. 193-197
    • Hegyi, K.1    Fulop, K.A.2    Kovacs, K.J.3    Falus, A.4    Toth, S.5
  • 136
    • 0035825643 scopus 로고    scopus 로고
    • Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver
    • 11217863 1:CAS:528:DC%2BD3MXht1yntLs%3D
    • Abel ED, Peroni O, Kim JK, Kim YB, Boss O, Hadro E, et al. Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver. Nature. 2001;409(6821):729-33.
    • (2001) Nature , vol.409 , Issue.6821 , pp. 729-733
    • Abel, E.D.1    Peroni, O.2    Kim, J.K.3    Kim, Y.B.4    Boss, O.5    Hadro, E.6
  • 137
    • 78649413249 scopus 로고    scopus 로고
    • Regulation of thyrotropin-releasing hormone-expressing neurons in paraventricular nucleus of the hypothalamus by signals of adiposity
    • 20943814 1:CAS:528:DC%2BC3MXhsVenu7g%3D
    • Ghamari-Langroudi M, Vella KR, Srisai D, Sugrue ML, Hollenberg AN, Cone RD. Regulation of thyrotropin-releasing hormone-expressing neurons in paraventricular nucleus of the hypothalamus by signals of adiposity. Mol Endocrinol. 2010;24(12):2366-81.
    • (2010) Mol Endocrinol , vol.24 , Issue.12 , pp. 2366-2381
    • Ghamari-Langroudi, M.1    Vella, K.R.2    Srisai, D.3    Sugrue, M.L.4    Hollenberg, A.N.5    Cone, R.D.6
  • 138
    • 0342858793 scopus 로고    scopus 로고
    • Alpha-Melanocyte-stimulating hormone is contained in nerve terminals innervating thyrotropin-releasing hormone-synthesizing neurons in the hypothalamic paraventricular nucleus and prevents fasting-induced suppression of prothyrotropin-releasing hormone gene expression
    • 10662844 1:CAS:528:DC%2BD3cXitVOku70%3D
    • Fekete C, Legradi G, Mihaly E, Huang QH, Tatro JB, Rand WM, et al. alpha-Melanocyte-stimulating hormone is contained in nerve terminals innervating thyrotropin-releasing hormone-synthesizing neurons in the hypothalamic paraventricular nucleus and prevents fasting-induced suppression of prothyrotropin-releasing hormone gene expression. J Neurosci. 2000;20(4):1550-8.
    • (2000) J Neurosci , vol.20 , Issue.4 , pp. 1550-1558
    • Fekete, C.1    Legradi, G.2    Mihaly, E.3    Huang, Q.H.4    Tatro, J.B.5    Rand, W.M.6
  • 139
    • 0034998139 scopus 로고    scopus 로고
    • Neuropeptide y has a central inhibitory action on the hypothalamic-pituitary-thyroid axis
    • 11356711 1:CAS:528:DC%2BD3MXjvFGnsLY%3D
    • Fekete C, Kelly J, Mihaly E, Sarkar S, Rand WM, Legradi G, et al. Neuropeptide Y has a central inhibitory action on the hypothalamic-pituitary- thyroid axis. Endocrinology. 2001;142(6):2606-13.
    • (2001) Endocrinology , vol.142 , Issue.6 , pp. 2606-2613
    • Fekete, C.1    Kelly, J.2    Mihaly, E.3    Sarkar, S.4    Rand, W.M.5    Legradi, G.6
  • 140
    • 84858833689 scopus 로고    scopus 로고
    • Roles of oxytocin neurones in the control of stress, energy metabolism, and social behaviour
    • 22353547 1:CAS:528:DC%2BC38XlsFKrsbY%3D
    • Onaka T, Takayanagi Y, Yoshida M. Roles of oxytocin neurones in the control of stress, energy metabolism, and social behaviour. J Neuroendocrinol. 2012;24(4):587-98.
    • (2012) J Neuroendocrinol , vol.24 , Issue.4 , pp. 587-598
    • Onaka, T.1    Takayanagi, Y.2    Yoshida, M.3
  • 141
    • 79551665635 scopus 로고    scopus 로고
    • Neuropeptide exocytosis involving synaptotagmin-4 and oxytocin in hypothalamic programming of body weight and energy balance
    • 21315262 1:CAS:528:DC%2BC3MXhvFert74%3D
    • Zhang G, Bai H, Zhang H, Dean C, Wu Q, Li J, et al. Neuropeptide exocytosis involving synaptotagmin-4 and oxytocin in hypothalamic programming of body weight and energy balance. Neuron. 2011;69(3):523-35.
    • (2011) Neuron , vol.69 , Issue.3 , pp. 523-535
    • Zhang, G.1    Bai, H.2    Zhang, H.3    Dean, C.4    Wu, Q.5    Li, J.6
  • 142
    • 84870168750 scopus 로고    scopus 로고
    • Inactivation of Socs3 in the hypothalamus enhances the hindbrain response to endogenous satiety signals via oxytocin signaling
    • 23197703 1:CAS:528:DC%2BC38XhslOqtL3P
    • Matarazzo V, Schaller F, Nedelec E, Benani A, Penicaud L, Muscatelli F, et al. Inactivation of Socs3 in the hypothalamus enhances the hindbrain response to endogenous satiety signals via oxytocin signaling. J Neurosci. 2012;32(48):17097-107.
    • (2012) J Neurosci , vol.32 , Issue.48 , pp. 17097-17107
    • Matarazzo, V.1    Schaller, F.2    Nedelec, E.3    Benani, A.4    Penicaud, L.5    Muscatelli, F.6
  • 143
    • 3042819531 scopus 로고    scopus 로고
    • Evidence that paraventricular nucleus oxytocin neurons link hypothalamic leptin action to caudal brain stem nuclei controlling meal size
    • 15044184 1:CAS:528:DC%2BD2cXmtVeks7Y%3D
    • Blevins JE, Schwartz MW, Baskin DG. Evidence that paraventricular nucleus oxytocin neurons link hypothalamic leptin action to caudal brain stem nuclei controlling meal size. Am J Physiol Regul Integr Comp Physiol. 2004;287(1):R87-96.
    • (2004) Am J Physiol Regul Integr Comp Physiol , vol.287 , Issue.1
    • Blevins, J.E.1    Schwartz, M.W.2    Baskin, D.G.3
  • 144
    • 84866481242 scopus 로고    scopus 로고
    • An obligate role of oxytocin neurons in diet induced energy expenditure
    • 23028821 1:CAS:528:DC%2BC38XhsVWlsb7M
    • Wu Z, Xu Y, Zhu Y, Sutton AK, Zhao R, Lowell BB, et al. An obligate role of oxytocin neurons in diet induced energy expenditure. PLoS One. 2012;7(9):e45167.
    • (2012) PLoS One , vol.7 , Issue.9 , pp. 45167
    • Wu, Z.1    Xu, Y.2    Zhu, Y.3    Sutton, A.K.4    Zhao, R.5    Lowell, B.B.6
  • 145
    • 0024502612 scopus 로고
    • Central corticotropin-releasing factor administration prevents the excessive body weight gain of genetically obese (fa/fa) rats
    • 2536319 1:CAS:528:DyaL1MXhs1Kgtbk%3D
    • Rohner-Jeanrenaud F, Walker CD, Greco-Perotto R, Jeanrenaud B. Central corticotropin-releasing factor administration prevents the excessive body weight gain of genetically obese (fa/fa) rats. Endocrinology. 1989;124(2):733-9.
    • (1989) Endocrinology , vol.124 , Issue.2 , pp. 733-739
    • Rohner-Jeanrenaud, F.1    Walker, C.D.2    Greco-Perotto, R.3    Jeanrenaud, B.4
  • 146
    • 20244380014 scopus 로고    scopus 로고
    • Orexins and orexin receptors: A family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior
    • 9491897 1:CAS:528:DyaK1cXhsVKntr4%3D
    • Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H, et al. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell. 1998;92(4):573-85.
    • (1998) Cell , vol.92 , Issue.4 , pp. 573-585
    • Sakurai, T.1    Amemiya, A.2    Ishii, M.3    Matsuzaki, I.4    Chemelli, R.M.5    Tanaka, H.6
  • 149
    • 2442538044 scopus 로고    scopus 로고
    • Physiological properties of hypothalamic MCH neurons identified with selective expression of reporter gene after recombinant virus infection
    • 15157424
    • van den Pol AN, Acuna-Goycolea C, Clark KR, Ghosh PK. Physiological properties of hypothalamic MCH neurons identified with selective expression of reporter gene after recombinant virus infection. Neuron. 2004;42(4):635-52.
    • (2004) Neuron , vol.42 , Issue.4 , pp. 635-652
    • Van Den Pol, A.N.1    Acuna-Goycolea, C.2    Clark, K.R.3    Ghosh, P.K.4
  • 150
    • 0026766094 scopus 로고
    • The melanin-concentrating hormone system of the rat brain: An immuno- and hybridization histochemical characterization
    • 1522246 1:CAS:528:DyaK38XksVSrtb8%3D
    • Bittencourt JC, Presse F, Arias C, Peto C, Vaughan J, Nahon JL, et al. The melanin-concentrating hormone system of the rat brain: an immuno- and hybridization histochemical characterization. J Comp Neurol. 1992;319(2):218-45.
    • (1992) J Comp Neurol , vol.319 , Issue.2 , pp. 218-245
    • Bittencourt, J.C.1    Presse, F.2    Arias, C.3    Peto, C.4    Vaughan, J.5    Nahon, J.L.6
  • 151
    • 13344279395 scopus 로고    scopus 로고
    • A role for melanin-concentrating hormone in the central regulation of feeding behaviour
    • 8637571 1:CAS:528:DyaK28XhvVahs7Y%3D
    • Qu D, Ludwig DS, Gammeltoft S, Piper M, Pelleymounter MA, Cullen MJ, et al. A role for melanin-concentrating hormone in the central regulation of feeding behaviour. Nature. 1996;380(6571):243-7.
    • (1996) Nature , vol.380 , Issue.6571 , pp. 243-247
    • Qu, D.1    Ludwig, D.S.2    Gammeltoft, S.3    Piper, M.4    Pelleymounter, M.A.5    Cullen, M.J.6
  • 152
    • 0035134670 scopus 로고    scopus 로고
    • Melanin-concentrating hormone overexpression in transgenic mice leads to obesity and insulin resistance
    • 11160162 1:CAS:528:DC%2BD3MXhtVGiur0%3D
    • Ludwig DS, Tritos NA, Mastaitis JW, Kulkarni R, Kokkotou E, Elmquist J, et al. Melanin-concentrating hormone overexpression in transgenic mice leads to obesity and insulin resistance. J Clin Invest. 2001;107(3):379-86.
    • (2001) J Clin Invest , vol.107 , Issue.3 , pp. 379-386
    • Ludwig, D.S.1    Tritos, N.A.2    Mastaitis, J.W.3    Kulkarni, R.4    Kokkotou, E.5    Elmquist, J.6
  • 153
    • 0032542294 scopus 로고    scopus 로고
    • Mice lacking melanin-concentrating hormone are hypophagic and lean
    • 9872314 1:CAS:528:DyaK1MXisVeisw%3D%3D
    • Shimada M, Tritos NA, Lowell BB, Flier JS, Maratos-Flier E. Mice lacking melanin-concentrating hormone are hypophagic and lean. Nature. 1998;396(6712):670-4.
    • (1998) Nature , vol.396 , Issue.6712 , pp. 670-674
    • Shimada, M.1    Tritos, N.A.2    Lowell, B.B.3    Flier, J.S.4    Maratos-Flier, E.5
  • 154
    • 0034807075 scopus 로고    scopus 로고
    • Cloning of a novel G protein-coupled receptor, SLT, a subtype of the melanin-concentrating hormone receptor
    • 11355873 1:CAS:528:DC%2BD3MXjsFWht7c%3D
    • Mori M, Harada M, Terao Y, Sugo T, Watanabe T, Shimomura Y, et al. Cloning of a novel G protein-coupled receptor, SLT, a subtype of the melanin-concentrating hormone receptor. Biochem Biophys Res Commun. 2001;283(5):1013-8.
    • (2001) Biochem Biophys Res Commun , vol.283 , Issue.5 , pp. 1013-1018
    • Mori, M.1    Harada, M.2    Terao, Y.3    Sugo, T.4    Watanabe, T.5    Shimomura, Y.6
  • 155
    • 0035827647 scopus 로고    scopus 로고
    • Molecular cloning and functional characterization of MCH2, a novel human MCH receptor
    • 11274220 1:CAS:528:DC%2BD3MXktlKnsL8%3D
    • Hill J, Duckworth M, Murdock P, Rennie G, Sabido-David C, Ames RS, et al. Molecular cloning and functional characterization of MCH2, a novel human MCH receptor. J Biol Chem. 2001;276(23):20125-9.
    • (2001) J Biol Chem , vol.276 , Issue.23 , pp. 20125-20129
    • Hill, J.1    Duckworth, M.2    Murdock, P.3    Rennie, G.4    Sabido-David, C.5    Ames, R.S.6
  • 156
    • 0035912709 scopus 로고    scopus 로고
    • Identification and characterization of a second melanin-concentrating hormone receptor, MCH-2R
    • 11404457 1:CAS:528:DC%2BD3MXkslWls7c%3D
    • Sailer AW, Sano H, Zeng Z, McDonald TP, Pan J, Pong SS, et al. Identification and characterization of a second melanin-concentrating hormone receptor, MCH-2R. Proc Natl Acad Sci U S A. 2001;98(13):7564-9.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , Issue.13 , pp. 7564-7569
    • Sailer, A.W.1    Sano, H.2    Zeng, Z.3    McDonald, T.P.4    Pan, J.5    Pong, S.S.6
  • 157
    • 0035912663 scopus 로고    scopus 로고
    • Identification and characterization of a melanin-concentrating hormone receptor
    • 11416225 1:CAS:528:DC%2BD3MXkslWlsL8%3D
    • An S, Cutler G, Zhao JJ, Huang SG, Tian H, Li W, et al. Identification and characterization of a melanin-concentrating hormone receptor. Proc Natl Acad Sci U S A. 2001;98(13):7576-81.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , Issue.13 , pp. 7576-7581
    • An, S.1    Cutler, G.2    Zhao, J.J.3    Huang, S.G.4    Tian, H.5    Li, W.6
  • 158
    • 0035860811 scopus 로고    scopus 로고
    • Identification and pharmacological characterization of a novel human melanin-concentrating hormone receptor, mch-r2
    • 11459838 1:CAS:528:DC%2BD3MXmvFCltL8%3D
    • Wang S, Behan J, O'Neill K, Weig B, Fried S, Laz T, et al. Identification and pharmacological characterization of a novel human melanin-concentrating hormone receptor, mch-r2. J Biol Chem. 2001;276(37):34664-70.
    • (2001) J Biol Chem , vol.276 , Issue.37 , pp. 34664-34670
    • Wang, S.1    Behan, J.2    O'Neill, K.3    Weig, B.4    Fried, S.5    Laz, T.6
  • 159
    • 0037022667 scopus 로고    scopus 로고
    • Melanin-concentrating hormone 1 receptor-deficient mice are lean, hyperactive, and hyperphagic and have altered metabolism
    • 11867747 1:CAS:528:DC%2BD38Xit1Cqsb0%3D
    • Marsh DJ, Weingarth DT, Novi DE, Chen HY, Trumbauer ME, Chen AS, et al. Melanin-concentrating hormone 1 receptor-deficient mice are lean, hyperactive, and hyperphagic and have altered metabolism. Proc Natl Acad Sci U S A. 2002;99(5):3240-5.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , Issue.5 , pp. 3240-3245
    • Marsh, D.J.1    Weingarth, D.T.2    Novi, D.E.3    Chen, H.Y.4    Trumbauer, M.E.5    Chen, A.S.6
  • 160
    • 0032909651 scopus 로고    scopus 로고
    • Viral gene delivery selectively restores feeding and prevents lethality of dopamine-deficient mice
    • 10027299 1:CAS:528:DyaK1MXhtVGhsr0%3D
    • Szczypka MS, Mandel RJ, Donahue BA, Snyder RO, Leff SE, Palmiter RD. Viral gene delivery selectively restores feeding and prevents lethality of dopamine-deficient mice. Neuron. 1999;22(1):167-78.
    • (1999) Neuron , vol.22 , Issue.1 , pp. 167-178
    • Szczypka, M.S.1    Mandel, R.J.2    Donahue, B.A.3    Snyder, R.O.4    Leff, S.E.5    Palmiter, R.D.6
  • 161
    • 34447650048 scopus 로고    scopus 로고
    • Is dopamine a physiologically relevant mediator of feeding behavior?
    • 17604133 1:CAS:528:DC%2BD2sXotlajurk%3D
    • Palmiter RD. Is dopamine a physiologically relevant mediator of feeding behavior? Trends in neurosciences. 2007;30(8):375-81.
    • (2007) Trends in Neurosciences , vol.30 , Issue.8 , pp. 375-381
    • Palmiter, R.D.1
  • 162
    • 0021718376 scopus 로고
    • The control of firing pattern in nigral dopamine neurons: Burst firing
    • 6150071 1:CAS:528:DyaL2MXhvVarsA%3D%3D
    • Grace AA, Bunney BS. The control of firing pattern in nigral dopamine neurons: burst firing. J Neurosci. 1984;4(11):2877-90.
    • (1984) J Neurosci , vol.4 , Issue.11 , pp. 2877-2890
    • Grace, A.A.1    Bunney, B.S.2
  • 163
    • 33744929396 scopus 로고    scopus 로고
    • Hierarchical control of dopamine neuron-firing patterns by nicotinic receptors
    • 16772172 1:CAS:528:DC%2BD28XmsVOjs7w%3D
    • Mameli-Engvall M, Evrard A, Pons S, Maskos U, Svensson TH, Changeux JP, et al. Hierarchical control of dopamine neuron-firing patterns by nicotinic receptors. Neuron. 2006;50(6):911-21.
    • (2006) Neuron , vol.50 , Issue.6 , pp. 911-921
    • Mameli-Engvall, M.1    Evrard, A.2    Pons, S.3    Maskos, U.4    Svensson, T.H.5    Changeux, J.P.6
  • 164
    • 84858626050 scopus 로고    scopus 로고
    • Activation of VTA GABA neurons disrupts reward consumption
    • 22445345
    • van Zessen R, Phillips JL, Budygin EA, Stuber GD. Activation of VTA GABA neurons disrupts reward consumption. Neuron. 2012;73(6):1184-94.
    • (2012) Neuron , vol.73 , Issue.6 , pp. 1184-1194
    • Van Zessen, R.1    Phillips, J.L.2    Budygin, E.A.3    Stuber, G.D.4
  • 165
    • 0028913804 scopus 로고
    • Ventral tegmental injections of a selective mu or delta opioid enhance feeding in food-deprived rats
    • 7606445 1:CAS:528:DyaK2MXktFeksrw%3D
    • Noel MB, Wise RA. Ventral tegmental injections of a selective mu or delta opioid enhance feeding in food-deprived rats. Brain Res. 1995;673(2):304-12.
    • (1995) Brain Res , vol.673 , Issue.2 , pp. 304-312
    • Noel, M.B.1    Wise, R.A.2
  • 166
    • 84860432466 scopus 로고    scopus 로고
    • Cholinergic modulation of food and drug satiety and withdrawal
    • 22465312 1:CAS:528:DC%2BC38XlsFCrsLY%3D
    • Avena NM, Rada PV. Cholinergic modulation of food and drug satiety and withdrawal. Physiol Behav. 2012;106(3):332-6.
    • (2012) Physiol Behav , vol.106 , Issue.3 , pp. 332-336
    • Avena, N.M.1    Rada, P.V.2
  • 167
    • 45349095604 scopus 로고    scopus 로고
    • Opioid reward 'liking' and 'wanting' in the nucleus accumbens
    • 18513761 1:CAS:528:DC%2BD1cXnt1Citr0%3D
    • Pecina S. Opioid reward 'liking' and 'wanting' in the nucleus accumbens. Physiol Behav. 2008;94(5):675-80.
    • (2008) Physiol Behav , vol.94 , Issue.5 , pp. 675-680
    • Pecina, S.1
  • 168
    • 84856481281 scopus 로고    scopus 로고
    • The role of the endocannabinoid system in the neuroendocrine regulation of energy balance
    • 21824982 1:CAS:528:DC%2BC38XjtFKitr8%3D
    • Bermudez-Silva FJ, Cardinal P, Cota D. The role of the endocannabinoid system in the neuroendocrine regulation of energy balance. J Psychopharmacol. 2012;26(1):114-24.
    • (2012) J Psychopharmacol , vol.26 , Issue.1 , pp. 114-124
    • Bermudez-Silva, F.J.1    Cardinal, P.2    Cota, D.3
  • 169
    • 0035848818 scopus 로고    scopus 로고
    • Leptin-regulated endocannabinoids are involved in maintaining food intake
    • 11298451
    • Di Marzo V, Goparaju SK, Wang L, Liu J, Batkai S, Jarai Z, et al. Leptin-regulated endocannabinoids are involved in maintaining food intake. Nature. 2001;410(6830):822-5.
    • (2001) Nature , vol.410 , Issue.6830 , pp. 822-825
    • Di Marzo, V.1    Goparaju, S.K.2    Wang, L.3    Liu, J.4    Batkai, S.5    Jarai, Z.6
  • 170
    • 0022483161 scopus 로고
    • Evidence implicating descending fibers in self-stimulation of the medial forebrain bundle
    • 3486258 1:STN:280:DyaL287pvVyrtw%3D%3D
    • Bielajew C, Shizgal P. Evidence implicating descending fibers in self-stimulation of the medial forebrain bundle. J Neurosci. 1986;6(4):919-29.
    • (1986) J Neurosci , vol.6 , Issue.4 , pp. 919-929
    • Bielajew, C.1    Shizgal, P.2
  • 171
    • 0019570656 scopus 로고
    • A portrait of the substrate for self-stimulation
    • 6264530 1:STN:280:DyaL3M3isVChsg%3D%3D
    • Gallistel CR, Shizgal P, Yeomans JS. A portrait of the substrate for self-stimulation. Psychol Rev. 1981;88(3):228-73.
    • (1981) Psychol Rev , vol.88 , Issue.3 , pp. 228-273
    • Gallistel, C.R.1    Shizgal, P.2    Yeomans, J.S.3
  • 172
    • 0000043617 scopus 로고
    • Self-stimulation of the brain; Its use to study local effects of hunger, sex, and drugs
    • 13506579 1:STN:280:DyaG1c%2FkvFenug%3D%3D
    • Olds J. Self-stimulation of the brain; its use to study local effects of hunger, sex, and drugs. Science. 1958;127(3294):315-24.
    • (1958) Science , vol.127 , Issue.3294 , pp. 315-324
    • Olds, J.1
  • 173
    • 0001015875 scopus 로고
    • Identical "feeding" and "rewarding" systems in the lateral hypothalamus of rats
    • 14469788 1:STN:280:DyaF38%2FntFanuw%3D%3D
    • Margules DL, Olds J. Identical "feeding" and "rewarding" systems in the lateral hypothalamus of rats. Science. 1962;135(3501):374-5.
    • (1962) Science , vol.135 , Issue.3501 , pp. 374-375
    • Margules, D.L.1    Olds, J.2
  • 174
    • 25644432796 scopus 로고    scopus 로고
    • A role for lateral hypothalamic orexin neurons in reward seeking
    • 16100511 1:CAS:528:DC%2BD2MXhtVajs7vL
    • Harris GC, Wimmer M, Aston-Jones G. A role for lateral hypothalamic orexin neurons in reward seeking. Nature. 2005;437(7058):556-9.
    • (2005) Nature , vol.437 , Issue.7058 , pp. 556-559
    • Harris, G.C.1    Wimmer, M.2    Aston-Jones, G.3
  • 175
    • 79955795275 scopus 로고    scopus 로고
    • Chronic loss of melanin-concentrating hormone affects motivational aspects of feeding in the rat
    • 21573180 1:CAS:528:DC%2BC3MXmtVKqtbs%3D
    • Mul JD, la Fleur SE, Toonen PW, Afrasiab-Middelman A, Binnekade R, Schetters D, et al. Chronic loss of melanin-concentrating hormone affects motivational aspects of feeding in the rat. PLoS One. 2011;6(5):e19600.
    • (2011) PLoS One , vol.6 , Issue.5 , pp. 19600
    • Mul, J.D.1    La Fleur, S.E.2    Toonen, P.W.3    Afrasiab-Middelman, A.4    Binnekade, R.5    Schetters, D.6
  • 176
    • 35348824334 scopus 로고    scopus 로고
    • Orexin signaling in the ventral tegmental area is required for high-fat appetite induced by opioid stimulation of the nucleus accumbens
    • 17928449 1:CAS:528:DC%2BD2sXht1Wnsb%2FL
    • Zheng H, Patterson LM, Berthoud HR. Orexin signaling in the ventral tegmental area is required for high-fat appetite induced by opioid stimulation of the nucleus accumbens. J Neurosci. 2007;27(41):11075-82.
    • (2007) J Neurosci , vol.27 , Issue.41 , pp. 11075-11082
    • Zheng, H.1    Patterson, L.M.2    Berthoud, H.R.3
  • 177
    • 66149147508 scopus 로고    scopus 로고
    • The melanin-concentrating hormone system modulates cocaine reward
    • 19342492 1:CAS:528:DC%2BD1MXlsV2ju7Y%3D
    • Chung S, Hopf FW, Nagasaki H, Li CY, Belluzzi JD, Bonci A, et al. The melanin-concentrating hormone system modulates cocaine reward. Proc Natl Acad Sci U S A. 2009;106(16):6772-7.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , Issue.16 , pp. 6772-6777
    • Chung, S.1    Hopf, F.W.2    Nagasaki, H.3    Li, C.Y.4    Belluzzi, J.D.5    Bonci, A.6
  • 178
    • 79951699573 scopus 로고    scopus 로고
    • Reward mechanisms in obesity: New insights and future directions
    • 21338878 1:CAS:528:DC%2BC3MXit1Kntb0%3D
    • Kenny PJ. Reward mechanisms in obesity: new insights and future directions. Neuron. 2011;69(4):664-79.
    • (2011) Neuron , vol.69 , Issue.4 , pp. 664-679
    • Kenny, P.J.1
  • 179
    • 33748540764 scopus 로고    scopus 로고
    • Leptin receptor signaling in midbrain dopamine neurons regulates feeding
    • 16982424 1:CAS:528:DC%2BD28XhtVGls7zP
    • Hommel JD, Trinko R, Sears RM, Georgescu D, Liu ZW, Gao XB, et al. Leptin receptor signaling in midbrain dopamine neurons regulates feeding. Neuron. 2006;51(6):801-10.
    • (2006) Neuron , vol.51 , Issue.6 , pp. 801-810
    • Hommel, J.D.1    Trinko, R.2    Sears, R.M.3    Georgescu, D.4    Liu, Z.W.5    Gao, X.B.6
  • 180
    • 33748541108 scopus 로고    scopus 로고
    • Leptin regulation of the mesoaccumbens dopamine pathway
    • 16982425 1:CAS:528:DC%2BD28XhtVGls7zI
    • Fulton S, Pissios P, Manchon RP, Stiles L, Frank L, Pothos EN, et al. Leptin regulation of the mesoaccumbens dopamine pathway. Neuron. 2006;51(6):811-22.
    • (2006) Neuron , vol.51 , Issue.6 , pp. 811-822
    • Fulton, S.1    Pissios, P.2    Manchon, R.P.3    Stiles, L.4    Frank, L.5    Pothos, E.N.6
  • 181
    • 67849092898 scopus 로고    scopus 로고
    • Leptin acts via leptin receptor-expressing lateral hypothalamic neurons to modulate the mesolimbic dopamine system and suppress feeding
    • 19656487 1:CAS:528:DC%2BD1MXhsVChsLrP
    • Leinninger GM, Jo YH, Leshan RL, Louis GW, Yang H, Barrera JG, et al. Leptin acts via leptin receptor-expressing lateral hypothalamic neurons to modulate the mesolimbic dopamine system and suppress feeding. Cell Metab. 2009;10(2):89-98.
    • (2009) Cell Metab , vol.10 , Issue.2 , pp. 89-98
    • Leinninger, G.M.1    Jo, Y.H.2    Leshan, R.L.3    Louis, G.W.4    Yang, H.5    Barrera, J.G.6
  • 182
    • 80052707655 scopus 로고    scopus 로고
    • Leptin action via neurotensin neurons controls orexin, the mesolimbic dopamine system and energy balance
    • 21907138 1:CAS:528:DC%2BC3MXhtFGltbnK
    • Leinninger GM, Opland DM, Jo YH, Faouzi M, Christensen L, Cappellucci LA, et al. Leptin action via neurotensin neurons controls orexin, the mesolimbic dopamine system and energy balance. Cell Metab. 2011;14(3):313-23.
    • (2011) Cell Metab , vol.14 , Issue.3 , pp. 313-323
    • Leinninger, G.M.1    Opland, D.M.2    Jo, Y.H.3    Faouzi, M.4    Christensen, L.5    Cappellucci, L.A.6
  • 183
    • 84875906445 scopus 로고    scopus 로고
    • Insulin induces long-term depression of ventral tegmental area dopamine neurons via endocannabinoids
    • 23354329 1:CAS:528:DC%2BC3sXhsVaqsbo%3D
    • Labouebe G, Liu S, Dias C, Zou H, Wong JC, Karunakaran S, et al. Insulin induces long-term depression of ventral tegmental area dopamine neurons via endocannabinoids. Nat Neurosci. 2013;16(3):300-8.
    • (2013) Nat Neurosci , vol.16 , Issue.3 , pp. 300-308
    • Labouebe, G.1    Liu, S.2    Dias, C.3    Zou, H.4    Wong, J.C.5    Karunakaran, S.6
  • 184
    • 33748560432 scopus 로고    scopus 로고
    • Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite
    • 17060947 1:CAS:528:DC%2BD28XhtlWgsbnO
    • Abizaid A, Liu ZW, Andrews ZB, Shanabrough M, Borok E, Elsworth JD, et al. Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite. J Clin Invest. 2006;116(12):3229-39.
    • (2006) J Clin Invest , vol.116 , Issue.12 , pp. 3229-3239
    • Abizaid, A.1    Liu, Z.W.2    Andrews, Z.B.3    Shanabrough, M.4    Borok, E.5    Elsworth, J.D.6
  • 185
    • 42649116436 scopus 로고    scopus 로고
    • Ghrelin modulates brain activity in areas that control appetitive behavior
    • 18460331 1:CAS:528:DC%2BD1cXmtFeiur8%3D
    • Malik S, McGlone F, Bedrossian D, Dagher A. Ghrelin modulates brain activity in areas that control appetitive behavior. Cell Metab. 2008;7(5):400-9.
    • (2008) Cell Metab , vol.7 , Issue.5 , pp. 400-409
    • Malik, S.1    McGlone, F.2    Bedrossian, D.3    Dagher, A.4
  • 186
    • 84868013714 scopus 로고    scopus 로고
    • Direct control of brown adipose tissue thermogenesis by central nervous system glucagon-like peptide-1 receptor signaling
    • 22933116 1:CAS:528:DC%2BC38Xhsl2it7rN
    • Lockie SH, Heppner KM, Chaudhary N, Chabenne JR, Morgan DA, Veyrat-Durebex C, et al. Direct control of brown adipose tissue thermogenesis by central nervous system glucagon-like peptide-1 receptor signaling. Diabetes. 2012;61(11):2753-62.
    • (2012) Diabetes , vol.61 , Issue.11 , pp. 2753-2762
    • Lockie, S.H.1    Heppner, K.M.2    Chaudhary, N.3    Chabenne, J.R.4    Morgan, D.A.5    Veyrat-Durebex, C.6
  • 187
    • 84860850964 scopus 로고    scopus 로고
    • BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions
    • 22579288 1:CAS:528:DC%2BC38XntFant7w%3D
    • Whittle AJ, Carobbio S, Martins L, Slawik M, Hondares E, Vazquez MJ, et al. BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions. Cell. 2012;149(4):871-85.
    • (2012) Cell , vol.149 , Issue.4 , pp. 871-885
    • Whittle, A.J.1    Carobbio, S.2    Martins, L.3    Slawik, M.4    Hondares, E.5    Vazquez, M.J.6
  • 188
    • 84865421329 scopus 로고    scopus 로고
    • Hypothalamic CB1 cannabinoid receptors regulate energy balance in mice
    • 22778221 1:CAS:528:DC%2BC38Xhtlagt7fL
    • Cardinal P, Bellocchio L, Clark S, Cannich A, Klugmann M, Lutz B, et al. Hypothalamic CB1 cannabinoid receptors regulate energy balance in mice. Endocrinology. 2012;153(9):4136-43.
    • (2012) Endocrinology , vol.153 , Issue.9 , pp. 4136-4143
    • Cardinal, P.1    Bellocchio, L.2    Clark, S.3    Cannich, A.4    Klugmann, M.5    Lutz, B.6
  • 189
    • 84866276013 scopus 로고    scopus 로고
    • Beta(1) Adrenergic receptor is key to cold- and diet-induced thermogenesis in mice
    • 22728333 1:CAS:528:DC%2BC38XhsVGitrjJ
    • Ueta CB, Fernandes GW, Capelo LP, Fonseca TL, Maculan FD, Gouveia CH, et al. beta(1) Adrenergic receptor is key to cold- and diet-induced thermogenesis in mice. J Endocrinol. 2012;214(3):359-65.
    • (2012) J Endocrinol , vol.214 , Issue.3 , pp. 359-365
    • Ueta, C.B.1    Fernandes, G.W.2    Capelo, L.P.3    Fonseca, T.L.4    Maculan, F.D.5    Gouveia, C.H.6
  • 190
    • 0028838836 scopus 로고
    • Targeted disruption of the beta 3-adrenergic receptor gene
    • 7493988 1:CAS:528:DyaK2MXpvVOgsbo%3D
    • Susulic VS, Frederich RC, Lawitts J, Tozzo E, Kahn BB, Harper ME, et al. Targeted disruption of the beta 3-adrenergic receptor gene. J Biol Chem. 1995;270(49):29483-92.
    • (1995) J Biol Chem , vol.270 , Issue.49 , pp. 29483-29492
    • Susulic, V.S.1    Frederich, R.C.2    Lawitts, J.3    Tozzo, E.4    Kahn, B.B.5    Harper, M.E.6
  • 191
    • 0037008157 scopus 로고    scopus 로고
    • BetaAR signaling required for diet-induced thermogenesis and obesity resistance
    • 12161655 1:CAS:528:DC%2BD38XlvV2jsbw%3D
    • Bachman ES, Dhillon H, Zhang CY, Cinti S, Bianco AC, Kobilka BK, et al. betaAR signaling required for diet-induced thermogenesis and obesity resistance. Science. 2002;297(5582):843-5.
    • (2002) Science , vol.297 , Issue.5582 , pp. 843-845
    • Bachman, E.S.1    Dhillon, H.2    Zhang, C.Y.3    Cinti, S.4    Bianco, A.C.5    Kobilka, B.K.6
  • 192
    • 2942595922 scopus 로고    scopus 로고
    • Identification of sympathetic premotor neurons in medullary raphe regions mediating fever and other thermoregulatory functions
    • 15190110 1:CAS:528:DC%2BD2cXltFCguro%3D
    • Nakamura K, Matsumura K, Hubschle T, Nakamura Y, Hioki H, Fujiyama F, et al. Identification of sympathetic premotor neurons in medullary raphe regions mediating fever and other thermoregulatory functions. J Neurosci. 2004;24(23):5370-80.
    • (2004) J Neurosci , vol.24 , Issue.23 , pp. 5370-5380
    • Nakamura, K.1    Matsumura, K.2    Hubschle, T.3    Nakamura, Y.4    Hioki, H.5    Fujiyama, F.6
  • 193
    • 84868012864 scopus 로고    scopus 로고
    • GABAergic RIP-Cre neurons in the arcuate nucleus selectively regulate energy expenditure
    • 23101631 1:CAS:528:DC%2BC38XhsF2htrzL
    • Kong D, Tong Q, Ye C, Koda S, Fuller PM, Krashes MJ, et al. GABAergic RIP-Cre neurons in the arcuate nucleus selectively regulate energy expenditure. Cell. 2012;151(3):645-57.
    • (2012) Cell , vol.151 , Issue.3 , pp. 645-657
    • Kong, D.1    Tong, Q.2    Ye, C.3    Koda, S.4    Fuller, P.M.5    Krashes, M.J.6
  • 194
    • 84873043752 scopus 로고    scopus 로고
    • Alpha2 Adrenergic receptor-mediated inhibition of thermogenesis
    • 23365239 1:CAS:528:DC%2BC3sXitVels74%3D
    • Madden CJ, Tupone D, Cano G, Morrison SF. alpha2 Adrenergic receptor-mediated inhibition of thermogenesis. J Neurosci. 2013;33(5):2017-28.
    • (2013) J Neurosci , vol.33 , Issue.5 , pp. 2017-2028
    • Madden, C.J.1    Tupone, D.2    Cano, G.3    Morrison, S.F.4
  • 195
    • 77954394705 scopus 로고    scopus 로고
    • Inhibition of brown adipose tissue thermogenesis by neurons in the ventrolateral medulla and in the nucleus tractus solitarius
    • 20410479 1:CAS:528:DC%2BC3cXpsVOrtL4%3D
    • Cao WH, Madden CJ, Morrison SF. Inhibition of brown adipose tissue thermogenesis by neurons in the ventrolateral medulla and in the nucleus tractus solitarius. Am J Physiol Regul Integr Comp Physiol. 2010;299(1):R277-90.
    • (2010) Am J Physiol Regul Integr Comp Physiol , vol.299 , Issue.1
    • Cao, W.H.1    Madden, C.J.2    Morrison, S.F.3
  • 196
    • 70349323422 scopus 로고    scopus 로고
    • Parallel preoptic pathways for thermoregulation
    • 19776281 1:CAS:528:DC%2BD1MXht1ertb3J
    • Yoshida K, Li X, Cano G, Lazarus M, Saper CB. Parallel preoptic pathways for thermoregulation. J Neurosci. 2009;29(38):11954-64.
    • (2009) J Neurosci , vol.29 , Issue.38 , pp. 11954-11964
    • Yoshida, K.1    Li, X.2    Cano, G.3    Lazarus, M.4    Saper, C.B.5
  • 197
    • 33846167116 scopus 로고    scopus 로고
    • The dorsomedial hypothalamus: A new player in thermoregulation
    • 16959861 1:CAS:528:DC%2BD2sXisFGit7Y%3D
    • Dimicco JA, Zaretsky DV. The dorsomedial hypothalamus: a new player in thermoregulation. Am J Physiol Regul Integr Comp Physiol. 2007;292(1):R47-63.
    • (2007) Am J Physiol Regul Integr Comp Physiol , vol.292 , Issue.1
    • Dimicco, J.A.1    Zaretsky, D.V.2
  • 198
    • 79955635264 scopus 로고    scopus 로고
    • Knockdown of NPY expression in the dorsomedial hypothalamus promotes development of brown adipocytes and prevents diet-induced obesity
    • 21531339 1:CAS:528:DC%2BC3MXlsFals7k%3D
    • Chao PT, Yang L, Aja S, Moran TH, Bi S. Knockdown of NPY expression in the dorsomedial hypothalamus promotes development of brown adipocytes and prevents diet-induced obesity. Cell Metab. 2011;13(5):573-83.
    • (2011) Cell Metab , vol.13 , Issue.5 , pp. 573-583
    • Chao, P.T.1    Yang, L.2    Aja, S.3    Moran, T.H.4    Bi, S.5
  • 199
    • 84873518501 scopus 로고    scopus 로고
    • Adaptive thermogenesis in adipocytes: Is beige the new brown?
    • 23388824 1:CAS:528:DC%2BC3sXjt1Cgtr0%3D
    • Wu J, Cohen P, Spiegelman BM. Adaptive thermogenesis in adipocytes: is beige the new brown? Genes Dev. 2013;27(3):234-50.
    • (2013) Genes Dev , vol.27 , Issue.3 , pp. 234-250
    • Wu, J.1    Cohen, P.2    Spiegelman, B.M.3
  • 200
    • 84862702609 scopus 로고    scopus 로고
    • Loss of histaminergic modulation of thermoregulation and energy homeostasis in obese mice
    • 22579982 1:CAS:528:DC%2BC38XptVGmtLY%3D
    • Sethi J, Sanchez-Alavez M, Tabarean IV. Loss of histaminergic modulation of thermoregulation and energy homeostasis in obese mice. Neuroscience. 2012;217:84-95.
    • (2012) Neuroscience , vol.217 , pp. 84-95
    • Sethi, J.1    Sanchez-Alavez, M.2    Tabarean, I.V.3
  • 202
    • 80052156758 scopus 로고    scopus 로고
    • Leptin action in the dorsomedial hypothalamus increases sympathetic tone to brown adipose tissue in spite of systemic leptin resistance
    • 21865462 1:CAS:528:DC%2BC3MXhtFCisLnN
    • Enriori PJ, Sinnayah P, Simonds SE, Garcia Rudaz C, Cowley MA. Leptin action in the dorsomedial hypothalamus increases sympathetic tone to brown adipose tissue in spite of systemic leptin resistance. J Neurosci. 2011;31(34):12189-97.
    • (2011) J Neurosci , vol.31 , Issue.34 , pp. 12189-12197
    • Enriori, P.J.1    Sinnayah, P.2    Simonds, S.E.3    Garcia Rudaz, C.4    Cowley, M.A.5
  • 203
    • 79551555006 scopus 로고    scopus 로고
    • Melanocortin-4 receptors expressed by cholinergic neurons regulate energy balance and glucose homeostasis
    • 21284986 1:CAS:528:DC%2BC3MXhtlaisr0%3D
    • Rossi J, Balthasar N, Olson D, Scott M, Berglund E, Lee CE, et al. Melanocortin-4 receptors expressed by cholinergic neurons regulate energy balance and glucose homeostasis. Cell Metab. 2011;13(2):195-204.
    • (2011) Cell Metab , vol.13 , Issue.2 , pp. 195-204
    • Rossi, J.1    Balthasar, N.2    Olson, D.3    Scott, M.4    Berglund, E.5    Lee, C.E.6
  • 204
    • 84873362255 scopus 로고    scopus 로고
    • Arcuate NPY Controls Sympathetic Output and BAT Function via a Relay of Tyrosine Hydroxylase Neurons in the PVN
    • 23395170 1:CAS:528:DC%2BC3sXitFeqsL0%3D
    • Shi YC, Lau J, Lin Z, Zhang H, Zhai L, Sperk G, et al. Arcuate NPY Controls Sympathetic Output and BAT Function via a Relay of Tyrosine Hydroxylase Neurons in the PVN. Cell Metab. 2013;17(2):236-48.
    • (2013) Cell Metab , vol.17 , Issue.2 , pp. 236-248
    • Shi, Y.C.1    Lau, J.2    Lin, Z.3    Zhang, H.4    Zhai, L.5    Sperk, G.6
  • 205
    • 80053899725 scopus 로고    scopus 로고
    • Distinct hypothalamic neurons mediate estrogenic effects on energy homeostasis and reproduction
    • 21982706 1:CAS:528:DC%2BC3MXht12rtLrN
    • Xu Y, Nedungadi TP, Zhu L, Sobhani N, Irani BG, Davis KE, et al. Distinct hypothalamic neurons mediate estrogenic effects on energy homeostasis and reproduction. Cell Metab. 2011;14(4):453-65.
    • (2011) Cell Metab , vol.14 , Issue.4 , pp. 453-465
    • Xu, Y.1    Nedungadi, T.P.2    Zhu, L.3    Sobhani, N.4    Irani, B.G.5    Davis, K.E.6
  • 206
    • 77956431307 scopus 로고    scopus 로고
    • Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance
    • 20802499 1:CAS:528:DC%2BC3cXhtVyiu7rN
    • Lopez M, Varela L, Vazquez MJ, Rodriguez-Cuenca S, Gonzalez CR, Velagapudi VR, et al. Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance. Nat Med. 2010;16(9):1001-8.
    • (2010) Nat Med , vol.16 , Issue.9 , pp. 1001-1008
    • Lopez, M.1    Varela, L.2    Vazquez, M.J.3    Rodriguez-Cuenca, S.4    Gonzalez, C.R.5    Velagapudi, V.R.6
  • 207
    • 80052739107 scopus 로고    scopus 로고
    • White to brown fat phenotypic switch induced by genetic and environmental activation of a hypothalamic-adipocyte axis
    • 21907139 1:CAS:528:DC%2BC3MXhtFGltbnL
    • Cao L, Choi EY, Liu X, Martin A, Wang C, Xu X, et al. White to brown fat phenotypic switch induced by genetic and environmental activation of a hypothalamic-adipocyte axis. Cell Metab. 2011;14(3):324-38.
    • (2011) Cell Metab , vol.14 , Issue.3 , pp. 324-338
    • Cao, L.1    Choi, E.Y.2    Liu, X.3    Martin, A.4    Wang, C.5    Xu, X.6
  • 209
    • 80155147930 scopus 로고    scopus 로고
    • An orexinergic projection from perifornical hypothalamus to raphe pallidus increases rat brown adipose tissue thermogenesis
    • 22049437 1:CAS:528:DC%2BC3MXhsVKmsL3N
    • Tupone D, Madden CJ, Cano G, Morrison SF. An orexinergic projection from perifornical hypothalamus to raphe pallidus increases rat brown adipose tissue thermogenesis. J Neurosci. 2011;31(44):15944-55.
    • (2011) J Neurosci , vol.31 , Issue.44 , pp. 15944-15955
    • Tupone, D.1    Madden, C.J.2    Cano, G.3    Morrison, S.F.4
  • 210
    • 84867149519 scopus 로고    scopus 로고
    • Behavioral responses to orexin, orexin receptor gene expression, and spontaneous physical activity contribute to individual sensitivity to obesity
    • 22829584 1:CAS:528:DC%2BC38Xhs1ygsbbL
    • Perez-Leighton CE, Boland K, Teske JA, Billington C, Kotz CM. Behavioral responses to orexin, orexin receptor gene expression, and spontaneous physical activity contribute to individual sensitivity to obesity. Am J Physiol Endocrinol Metab. 2012;303(7):E865-74.
    • (2012) Am J Physiol Endocrinol Metab , vol.303 , Issue.7
    • Perez-Leighton, C.E.1    Boland, K.2    Teske, J.A.3    Billington, C.4    Kotz, C.M.5
  • 211
    • 51149096739 scopus 로고    scopus 로고
    • Melanocortin-4 receptor mRNA expressed in sympathetic outflow neurons to brown adipose tissue: Neuroanatomical and functional evidence
    • 18550869 1:CAS:528:DC%2BD1cXhtVakt7jI
    • Song CK, Vaughan CH, Keen-Rhinehart E, Harris RB, Richard D, Bartness TJ. Melanocortin-4 receptor mRNA expressed in sympathetic outflow neurons to brown adipose tissue: neuroanatomical and functional evidence. Am J Physiol Regul Integr Comp Physiol. 2008;295(2):R417-28.
    • (2008) Am J Physiol Regul Integr Comp Physiol , vol.295 , Issue.2
    • Song, C.K.1    Vaughan, C.H.2    Keen-Rhinehart, E.3    Harris, R.B.4    Richard, D.5    Bartness, T.J.6
  • 212
    • 39549085551 scopus 로고    scopus 로고
    • The role of the thyrotropin-releasing hormone (TRH) neuron as a metabolic sensor
    • 18279013 1:CAS:528:DC%2BD1cXitVKntrY%3D
    • Hollenberg AN. The role of the thyrotropin-releasing hormone (TRH) neuron as a metabolic sensor. Thyroid. 2008;18(2):131-9.
    • (2008) Thyroid , vol.18 , Issue.2 , pp. 131-139
    • Hollenberg, A.N.1
  • 213
    • 42949100803 scopus 로고    scopus 로고
    • The hypothalamic-pituitary-adrenal-axis in the regulation of energy balance
    • 18275977 1:CAS:528:DC%2BD1cXlslyjsr0%3D
    • Nieuwenhuizen AG, Rutters F. The hypothalamic-pituitary-adrenal-axis in the regulation of energy balance. Physiol Behav. 2008;94(2):169-77.
    • (2008) Physiol Behav , vol.94 , Issue.2 , pp. 169-177
    • Nieuwenhuizen, A.G.1    Rutters, F.2
  • 214
    • 39549099705 scopus 로고    scopus 로고
    • Neuroendocrine control of food intake
    • 18061414 1:CAS:528:DC%2BD1cXkvFOjtL0%3D
    • Valassi E, Scacchi M, Cavagnini F. Neuroendocrine control of food intake. Nutr Metab Cardiovasc Dis. 2008;18(2):158-68.
    • (2008) Nutr Metab Cardiovasc Dis , vol.18 , Issue.2 , pp. 158-168
    • Valassi, E.1    Scacchi, M.2    Cavagnini, F.3
  • 215
    • 62749179047 scopus 로고    scopus 로고
    • Stimulation of orexin/hypocretin neurones by thyrotropin-releasing hormone
    • 19204048 1:CAS:528:DC%2BD1MXnt1GntL0%3D
    • Gonzalez JA, Horjales-Araujo E, Fugger L, Broberger C, Burdakov D. Stimulation of orexin/hypocretin neurones by thyrotropin-releasing hormone. J Physiol. 2009;587(Pt 6):1179-86.
    • (2009) J Physiol , vol.587 , Issue.PART 6 , pp. 1179-1186
    • Gonzalez, J.A.1    Horjales-Araujo, E.2    Fugger, L.3    Broberger, C.4    Burdakov, D.5
  • 216
    • 64849092435 scopus 로고    scopus 로고
    • Thyrotropin-releasing hormone increases behavioral arousal through modulation of hypocretin/orexin neurons
    • 19321767 1:CAS:528:DC%2BD1MXktVSqt7k%3D
    • Hara J, Gerashchenko D, Wisor JP, Sakurai T, Xie X, Kilduff TS. Thyrotropin-releasing hormone increases behavioral arousal through modulation of hypocretin/orexin neurons. J Neurosci. 2009;29(12):3705-14.
    • (2009) J Neurosci , vol.29 , Issue.12 , pp. 3705-3714
    • Hara, J.1    Gerashchenko, D.2    Wisor, J.P.3    Sakurai, T.4    Xie, X.5    Kilduff, T.S.6
  • 217
    • 33747451335 scopus 로고    scopus 로고
    • Corticotropin releasing factor increases in brown adipose tissue thermogenesis and heart rate through dorsomedial hypothalamus and medullary raphe pallidus
    • 16580142 1:CAS:528:DC%2BD28Xks1Wrsb8%3D
    • Cerri M, Morrison SF. Corticotropin releasing factor increases in brown adipose tissue thermogenesis and heart rate through dorsomedial hypothalamus and medullary raphe pallidus. Neuroscience. 2006;140(2):711-21.
    • (2006) Neuroscience , vol.140 , Issue.2 , pp. 711-721
    • Cerri, M.1    Morrison, S.F.2
  • 218
    • 64149087193 scopus 로고    scopus 로고
    • Neurons in the paraventricular nucleus of the hypothalamus inhibit sympathetic outflow to brown adipose tissue
    • 19129373 1:CAS:528:DC%2BD1MXjtFGkurY%3D
    • Madden CJ, Morrison SF. Neurons in the paraventricular nucleus of the hypothalamus inhibit sympathetic outflow to brown adipose tissue. Am J Physiol Regul Integr Comp Physiol. 2009;296(3):R831-43.
    • (2009) Am J Physiol Regul Integr Comp Physiol , vol.296 , Issue.3
    • Madden, C.J.1    Morrison, S.F.2
  • 219
    • 84950170753 scopus 로고
    • Colocalization of neuropeptide y immunoreactivity in brainstem catecholaminergic neurons that project to the paraventricular nucleus of the hypothalamus
    • 3840810 1:STN:280:DyaL28%2FmtVaitw%3D%3D
    • Sawchenko PE, Swanson LW, Grzanna R, Howe PR, Bloom SR, Polak JM. Colocalization of neuropeptide Y immunoreactivity in brainstem catecholaminergic neurons that project to the paraventricular nucleus of the hypothalamus. J Comp Neurol. 1985;241(2):138-53.
    • (1985) J Comp Neurol , vol.241 , Issue.2 , pp. 138-153
    • Sawchenko, P.E.1    Swanson, L.W.2    Grzanna, R.3    Howe, P.R.4    Bloom, S.R.5    Polak, J.M.6
  • 220
    • 33746308184 scopus 로고    scopus 로고
    • The TRH neuron: A hypothalamic integrator of energy metabolism
    • 16876577 1:CAS:528:DC%2BD28XhtFyru7bN
    • Lechan RM, Fekete C. The TRH neuron: a hypothalamic integrator of energy metabolism. Progress in brain research. 2006;153:209-35.
    • (2006) Progress in Brain Research. , vol.153 , pp. 209-235
    • Lechan, R.M.1    Fekete, C.2
  • 221
    • 84873827677 scopus 로고    scopus 로고
    • Gut hormones and obesity: Physiology and therapies
    • 23374716 1:CAS:528:DC%2BC3sXpsVOqsLc%3D
    • Scott R, Tan T, Bloom S. Gut hormones and obesity: physiology and therapies. Vitamins and hormones. 2013;91:143-94.
    • (2013) Vitamins and Hormones. , vol.91 , pp. 143-194
    • Scott, R.1    Tan, T.2    Bloom, S.3
  • 222
    • 84887210234 scopus 로고    scopus 로고
    • Integration of sensory information via central thermoregulatory leptin targets
    • doi: 10.1016/j.physbeh.2013.02.014
    • Rezai-Zadeh K, Munzberg H. Integration of sensory information via central thermoregulatory leptin targets. Physiol Behav. 2013. doi: 10.1016/j.physbeh. 2013.02.014.
    • (2013) Physiol Behav
    • Rezai-Zadeh, K.1    Munzberg, H.2
  • 223
    • 84870502357 scopus 로고    scopus 로고
    • Hepatic glucokinase modulates obesity predisposition by regulating BAT thermogenesis via neural signals
    • 23217261 1:CAS:528:DC%2BC38XhslymtrfL
    • Tsukita S, Yamada T, Uno K, Takahashi K, Kaneko K, Ishigaki Y, et al. Hepatic glucokinase modulates obesity predisposition by regulating BAT thermogenesis via neural signals. Cell Metab. 2012;16(6):825-32.
    • (2012) Cell Metab , vol.16 , Issue.6 , pp. 825-832
    • Tsukita, S.1    Yamada, T.2    Uno, K.3    Takahashi, K.4    Kaneko, K.5    Ishigaki, Y.6
  • 224
    • 84871273516 scopus 로고    scopus 로고
    • Duodenal lipid sensing activates vagal afferents to regulate non-shivering brown fat thermogenesis in rats
    • 23251649 1:CAS:528:DC%2BC3sXht1Clsg%3D%3D
    • Blouet C, Schwartz GJ. Duodenal lipid sensing activates vagal afferents to regulate non-shivering brown fat thermogenesis in rats. PLoS One. 2012;7(12):e51898.
    • (2012) PLoS One , vol.7 , Issue.12 , pp. 51898
    • Blouet, C.1    Schwartz, G.J.2
  • 225
    • 0035172040 scopus 로고    scopus 로고
    • Transcriptional regulation of the thyrotropin-releasing hormone gene by leptin and melanocortin signaling
    • 11134186 1:CAS:528:DC%2BD3MXitVOmtg%3D%3D
    • Harris M, Aschkenasi C, Elias CF, Chandrankunnel A, Nillni EA, Bjoorbaek C, et al. Transcriptional regulation of the thyrotropin-releasing hormone gene by leptin and melanocortin signaling. J Clin Invest. 2001;107(1):111-20.
    • (2001) J Clin Invest , vol.107 , Issue.1 , pp. 111-120
    • Harris, M.1    Aschkenasi, C.2    Elias, C.F.3    Chandrankunnel, A.4    Nillni, E.A.5    Bjoorbaek, C.6
  • 226
    • 11144358404 scopus 로고    scopus 로고
    • Role of signal transducer and activator of transcription 3 in regulation of hypothalamic trh gene expression by leptin
    • 14764629 1:CAS:528:DC%2BD2cXjsV2jsb4%3D
    • Huo L, Munzberg H, Nillni EA, Bjorbaek C. Role of signal transducer and activator of transcription 3 in regulation of hypothalamic trh gene expression by leptin. Endocrinology. 2004;145(5):2516-23.
    • (2004) Endocrinology , vol.145 , Issue.5 , pp. 2516-2523
    • Huo, L.1    Munzberg, H.2    Nillni, E.A.3    Bjorbaek, C.4
  • 227
    • 2042506366 scopus 로고    scopus 로고
    • Leptin signaling targets the thyrotropin-releasing hormone gene promoter in vivo
    • 14764630 1:CAS:528:DC%2BD2cXjsVyqu7c%3D
    • Guo F, Bakal K, Minokoshi Y, Hollenberg AN. Leptin signaling targets the thyrotropin-releasing hormone gene promoter in vivo. Endocrinology. 2004;145(5):2221-7.
    • (2004) Endocrinology , vol.145 , Issue.5 , pp. 2221-2227
    • Guo, F.1    Bakal, K.2    Minokoshi, Y.3    Hollenberg, A.N.4
  • 228
    • 79551512119 scopus 로고    scopus 로고
    • Leptin-receptor-expressing neurons in the dorsomedial hypothalamus and median preoptic area regulate sympathetic brown adipose tissue circuits
    • 21289197 1:CAS:528:DC%2BC3MXhvFGrsrs%3D
    • Zhang Y, Kerman IA, Laque A, Nguyen P, Faouzi M, Louis GW, et al. Leptin-receptor-expressing neurons in the dorsomedial hypothalamus and median preoptic area regulate sympathetic brown adipose tissue circuits. J Neurosci. 2011;31(5):1873-84.
    • (2011) J Neurosci , vol.31 , Issue.5 , pp. 1873-1884
    • Zhang, Y.1    Kerman, I.A.2    Laque, A.3    Nguyen, P.4    Faouzi, M.5    Louis, G.W.6
  • 229
    • 84860766886 scopus 로고    scopus 로고
    • Importance of reward and prefrontal circuitry in hunger and satiety: Prader-Willi syndrome vs simple obesity
    • 1:CAS:528:DC%2BC38XmvVertrw%3D
    • Holsen LM, Savage CR, Martin LE, Bruce AS, Lepping RJ, Ko E, et al. Importance of reward and prefrontal circuitry in hunger and satiety: Prader-Willi syndrome vs simple obesity. Int J Obes (Lond). 2012;36(5):638-47.
    • (2012) Int J Obes (Lond). , vol.36 , Issue.5 , pp. 638-647
    • Holsen, L.M.1    Savage, C.R.2    Martin, L.E.3    Bruce, A.S.4    Lepping, R.J.5    Ko, E.6
  • 230
    • 70449635660 scopus 로고    scopus 로고
    • Hindbrain leptin receptor stimulation enhances the anorexic response to cholecystokinin
    • 19726710 1:CAS:528:DC%2BD1MXhsValsbbN
    • Williams DL, Baskin DG, Schwartz MW. Hindbrain leptin receptor stimulation enhances the anorexic response to cholecystokinin. Am J Physiol Regul Integr Comp Physiol. 2009;297(5):R1238-46.
    • (2009) Am J Physiol Regul Integr Comp Physiol , vol.297 , Issue.5
    • Williams, D.L.1    Baskin, D.G.2    Schwartz, M.W.3
  • 231
    • 72649103549 scopus 로고    scopus 로고
    • Endogenous leptin signaling in the caudal nucleus tractus solitarius and area postrema is required for energy balance regulation
    • 20074530 1:CAS:528:DC%2BC3cXlt1Kksrw%3D
    • Hayes MR, Skibicka KP, Leichner TM, Guarnieri DJ, DiLeone RJ, Bence KK, et al. Endogenous leptin signaling in the caudal nucleus tractus solitarius and area postrema is required for energy balance regulation. Cell Metab. 2010;11(1):77-83.
    • (2010) Cell Metab , vol.11 , Issue.1 , pp. 77-83
    • Hayes, M.R.1    Skibicka, K.P.2    Leichner, T.M.3    Guarnieri, D.J.4    Dileone, R.J.5    Bence, K.K.6
  • 232
    • 25144523930 scopus 로고    scopus 로고
    • Identification of SH2-B as a key regulator of leptin sensitivity, energy balance, and body weight in mice
    • 16098827 1:CAS:528:DC%2BD2MXps12ht7o%3D
    • Ren D, Li M, Duan C, Rui L. Identification of SH2-B as a key regulator of leptin sensitivity, energy balance, and body weight in mice. Cell Metabolism. 2005;2(2):95-104.
    • (2005) Cell Metabolism , vol.2 , Issue.2 , pp. 95-104
    • Ren, D.1    Li, M.2    Duan, C.3    Rui, L.4
  • 233
    • 33846822094 scopus 로고    scopus 로고
    • Neuronal SH2B1 is essential for controlling energy and glucose homeostasis
    • 17235396 1:CAS:528:DC%2BD2sXhs1Oqtrw%3D
    • Ren D, Zhou Y, Morris D, Li M, Li Z, Rui L. Neuronal SH2B1 is essential for controlling energy and glucose homeostasis. J Clin Invest. 2007;117(2):397-406.
    • (2007) J Clin Invest , vol.117 , Issue.2 , pp. 397-406
    • Ren, D.1    Zhou, Y.2    Morris, D.3    Li, M.4    Li, Z.5    Rui, L.6
  • 234
    • 58149163141 scopus 로고    scopus 로고
    • Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity
    • 19079260 1:CAS:528:DC%2BD1cXhsV2hsrjO
    • Thorleifsson G, Walters GB, Gudbjartsson DF, Steinthorsdottir V, Sulem P, Helgadottir A, et al. Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. Nat Genet. 2009;41(1):18-24.
    • (2009) Nat Genet , vol.41 , Issue.1 , pp. 18-24
    • Thorleifsson, G.1    Walters, G.B.2    Gudbjartsson, D.F.3    Steinthorsdottir, V.4    Sulem, P.5    Helgadottir, A.6
  • 235
    • 58149163142 scopus 로고    scopus 로고
    • Six new loci associated with body mass index highlight a neuronal influence on body weight regulation
    • 19079261 1:CAS:528:DC%2BD1cXhsV2hsrnK
    • Willer CJ, Speliotes EK, Loos RJ, Li S, Lindgren CM, Heid IM, et al. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet. 2009;41(1):25-34.
    • (2009) Nat Genet , vol.41 , Issue.1 , pp. 25-34
    • Willer, C.J.1    Speliotes, E.K.2    Loos, R.J.3    Li, S.4    Lindgren, C.M.5    Heid, I.M.6
  • 236
    • 33846853084 scopus 로고    scopus 로고
    • The SH2B gene is associated with serum leptin and body fat in normal female twins
    • 17228025 1:CAS:528:DC%2BD2sXosVeisr4%3D
    • Jamshidi Y, Snieder H, Ge D, Spector TD, O'Dell SD. The SH2B gene is associated with serum leptin and body fat in normal female twins. Obesity (Silver Spring). 2007;15(1):5-9.
    • (2007) Obesity (Silver Spring). , vol.15 , Issue.1 , pp. 5-9
    • Jamshidi, Y.1    Snieder, H.2    Ge, D.3    Spector, T.D.4    O'Dell, S.D.5
  • 237
    • 78049337953 scopus 로고    scopus 로고
    • Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
    • 20935630 1:CAS:528:DC%2BC3cXht1KmsL%2FN
    • Speliotes EK, Willer CJ, Berndt SI, Monda KL, Thorleifsson G, Jackson AU, et al. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet. 2010;42(11):937-48.
    • (2010) Nat Genet , vol.42 , Issue.11 , pp. 937-948
    • Speliotes, E.K.1    Willer, C.J.2    Berndt, S.I.3    Monda, K.L.4    Thorleifsson, G.5    Jackson, A.U.6
  • 238
    • 77955165654 scopus 로고    scopus 로고
    • Evaluation of genetic susceptibility loci for obesity in Chinese women
    • 20616199
    • Shi J, Long J, Gao YT, Lu W, Cai Q, Wen W, et al. Evaluation of genetic susceptibility loci for obesity in Chinese women. Am J Epidemiol. 2010;172(3):244-54.
    • (2010) Am J Epidemiol , vol.172 , Issue.3 , pp. 244-254
    • Shi, J.1    Long, J.2    Gao, Y.T.3    Lu, W.4    Cai, Q.5    Wen, W.6
  • 239
    • 77952746932 scopus 로고    scopus 로고
    • Implication of genetic variants near NEGR1, SEC16B, TMEM18, ETV5/DGKG, GNPDA2, LIN7C/BDNF, MTCH2, BCDIN3D/FAIM2, SH2B1, FTO, MC4R, and KCTD15 with obesity and type 2 diabetes in 7705 Chinese
    • 20215397 1:CAS:528:DC%2BC3cXmtFensL4%3D
    • Ng MC, Tam CH, So WY, Ho JS, Chan AW, Lee HM, et al. Implication of genetic variants near NEGR1, SEC16B, TMEM18, ETV5/DGKG, GNPDA2, LIN7C/BDNF, MTCH2, BCDIN3D/FAIM2, SH2B1, FTO, MC4R, and KCTD15 with obesity and type 2 diabetes in 7705 Chinese. J Clin Endocrinol Metab. 2010;95(5):2418-25.
    • (2010) J Clin Endocrinol Metab , vol.95 , Issue.5 , pp. 2418-2425
    • Ng, M.C.1    Tam, C.H.2    So, W.Y.3    Ho, J.S.4    Chan, A.W.5    Lee, H.M.6
  • 240
    • 80052840370 scopus 로고    scopus 로고
    • Genome-wide population-based association study of extremely overweight young adults-the GOYA study
    • 21935397 1:CAS:528:DC%2BC3MXht1OmsrbN
    • Paternoster L, Evans DM, Nohr EA, Holst C, Gaborieau V, Brennan P, et al. Genome-wide population-based association study of extremely overweight young adults-the GOYA study. PLoS One. 2011;6(9):e24303.
    • (2011) PLoS One , vol.6 , Issue.9 , pp. 24303
    • Paternoster, L.1    Evans, D.M.2    Nohr, E.A.3    Holst, C.4    Gaborieau, V.5    Brennan, P.6
  • 241
    • 80052397686 scopus 로고    scopus 로고
    • Studies of metabolic phenotypic correlates of 15 obesity associated gene variants
    • 21912638 1:CAS:528:DC%2BC3MXht1WrtbfP
    • Sandholt CH, Vestmar MA, Bille DS, Borglykke A, Almind K, Hansen L, et al. Studies of metabolic phenotypic correlates of 15 obesity associated gene variants. PLoS One. 2011;6(9):e23531.
    • (2011) PLoS One , vol.6 , Issue.9 , pp. 23531
    • Sandholt, C.H.1    Vestmar, M.A.2    Bille, D.S.3    Borglykke, A.4    Almind, K.5    Hansen, L.6
  • 242
    • 77952956214 scopus 로고    scopus 로고
    • Novel obesity risk loci do not determine distribution of body fat depots: A whole-body MRI/MRS study
    • 19910938
    • Haupt A, Thamer C, Heni M, Machicao F, Machann J, Schick F, et al. Novel obesity risk loci do not determine distribution of body fat depots: a whole-body MRI/MRS study. Obesity (Silver Spring). 2010;18(6):1212-7.
    • (2010) Obesity (Silver Spring). , vol.18 , Issue.6 , pp. 1212-1217
    • Haupt, A.1    Thamer, C.2    Heni, M.3    Machicao, F.4    Machann, J.5    Schick, F.6
  • 243
    • 64549158008 scopus 로고    scopus 로고
    • Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden
    • 19164386
    • Renstrom F, Payne F, Nordstrom A, Brito EC, Rolandsson O, Hallmans G, et al. Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden. Hum Mol Genet. 2009;18(8):1489-96.
    • (2009) Hum Mol Genet , vol.18 , Issue.8 , pp. 1489-1496
    • Renstrom, F.1    Payne, F.2    Nordstrom, A.3    Brito, E.C.4    Rolandsson, O.5    Hallmans, G.6
  • 244
    • 77957912843 scopus 로고    scopus 로고
    • Genes and lifestyle factors in obesity: Results from 12,462 subjects from MONICA/KORA
    • 1:CAS:528:DC%2BC3cXht1Kms73O
    • Holzapfel C, Grallert H, Huth C, Wahl S, Fischer B, Doring A, et al. Genes and lifestyle factors in obesity: results from 12,462 subjects from MONICA/KORA. Int J Obes (Lond). 2010;34(10):1538-45.
    • (2010) Int J Obes (Lond) , vol.34 , Issue.10 , pp. 1538-1545
    • Holzapfel, C.1    Grallert, H.2    Huth, C.3    Wahl, S.4    Fischer, B.5    Doring, A.6
  • 245
    • 82955227645 scopus 로고    scopus 로고
    • The SH2B1 obesity locus is associated with myocardial infarction in diabetic patients and with NO synthase activity in endothelial cells
    • 21907990 1:CAS:528:DC%2BC3MXhsFCqsr%2FK
    • Prudente S, Morini E, Larmon J, Andreozzi F, Di Pietro N, Nigro A, et al. The SH2B1 obesity locus is associated with myocardial infarction in diabetic patients and with NO synthase activity in endothelial cells. Atherosclerosis. 2011;219(2):667-72.
    • (2011) Atherosclerosis , vol.219 , Issue.2 , pp. 667-672
    • Prudente, S.1    Morini, E.2    Larmon, J.3    Andreozzi, F.4    Di Pietro, N.5    Nigro, A.6
  • 246
    • 80155133629 scopus 로고    scopus 로고
    • Computed tomography analysis of the association between the SH2B1 rs7498665 single-nucleotide polymorphism and visceral fat area
    • 21796141 1:CAS:528:DC%2BC3MXhtlKitL3L
    • Hotta K, Kitamoto T, Kitamoto A, Mizusawa S, Matsuo T, Nakata Y, et al. Computed tomography analysis of the association between the SH2B1 rs7498665 single-nucleotide polymorphism and visceral fat area. J Hum Genet. 2011;56(10):716-9.
    • (2011) J Hum Genet , vol.56 , Issue.10 , pp. 716-719
    • Hotta, K.1    Kitamoto, T.2    Kitamoto, A.3    Mizusawa, S.4    Matsuo, T.5    Nakata, Y.6
  • 247
    • 80052540977 scopus 로고    scopus 로고
    • Association of genetic variants for susceptibility to obesity with type 2 diabetes in Japanese individuals
    • 21369819 1:CAS:528:DC%2BC3MXlslWgtLk%3D
    • Takeuchi F, Yamamoto K, Katsuya T, Nabika T, Sugiyama T, Fujioka A, et al. Association of genetic variants for susceptibility to obesity with type 2 diabetes in Japanese individuals. Diabetologia. 2011;54(6):1350-9.
    • (2011) Diabetologia , vol.54 , Issue.6 , pp. 1350-1359
    • Takeuchi, F.1    Yamamoto, K.2    Katsuya, T.3    Nabika, T.4    Sugiyama, T.5    Fujioka, A.6
  • 248
    • 70349783304 scopus 로고    scopus 로고
    • Obesity genes identified in genome-wide association studies are associated with adiposity measures and potentially with nutrient-specific food preference
    • 19692490 1:CAS:528:DC%2BD1MXhtFyru7jL
    • Bauer F, Elbers CC, Adan RA, Loos RJ, Onland-Moret NC, Grobbee DE, et al. Obesity genes identified in genome-wide association studies are associated with adiposity measures and potentially with nutrient-specific food preference. Am J Clin Nutr. 2009;90(4):951-9.
    • (2009) Am J Clin Nutr , vol.90 , Issue.4 , pp. 951-959
    • Bauer, F.1    Elbers, C.C.2    Adan, R.A.3    Loos, R.J.4    Onland-Moret, N.C.5    Grobbee, D.E.6
  • 250
    • 84858282155 scopus 로고    scopus 로고
    • Implication of European-derived adiposity loci in African Americans
    • 1:CAS:528:DC%2BC38XktVansbs%3D
    • Hester JM, Wing MR, Li J, Palmer ND, Xu J, Hicks PJ, et al. Implication of European-derived adiposity loci in African Americans. Int J Obes (Lond). 2012;36(3):465-73.
    • (2012) Int J Obes (Lond). , vol.36 , Issue.3 , pp. 465-473
    • Hester, J.M.1    Wing, M.R.2    Li, J.3    Palmer, N.D.4    Xu, J.5    Hicks, P.J.6
  • 251
    • 76349083132 scopus 로고    scopus 로고
    • Large, rare chromosomal deletions associated with severe early-onset obesity
    • 19966786 1:CAS:528:DC%2BD1MXhsFWksbrL
    • Bochukova EG, Huang N, Keogh J, Henning E, Purmann C, Blaszczyk K, et al. Large, rare chromosomal deletions associated with severe early-onset obesity. Nature. 2010;463(7281):666-70.
    • (2010) Nature , vol.463 , Issue.7281 , pp. 666-670
    • Bochukova, E.G.1    Huang, N.2    Keogh, J.3    Henning, E.4    Purmann, C.5    Blaszczyk, K.6
  • 252
    • 84870541022 scopus 로고    scopus 로고
    • Human SH2B1 mutations are associated with maladaptive behaviors and obesity
    • 23160192 1:CAS:528:DC%2BC38XhvVaktL7I
    • Doche ME, Bochukova EG, Su HW, Pearce LR, Keogh JM, Henning E, et al. Human SH2B1 mutations are associated with maladaptive behaviors and obesity. J Clin Invest. 2012;122(12):4732-6.
    • (2012) J Clin Invest , vol.122 , Issue.12 , pp. 4732-4736
    • Doche, M.E.1    Bochukova, E.G.2    Su, H.W.3    Pearce, L.R.4    Keogh, J.M.5    Henning, E.6
  • 253
    • 6344243617 scopus 로고    scopus 로고
    • SH2-B promotes insulin receptor substrate 1 (IRS1)- and IRS2-mediated activation of the phosphatidylinositol 3-kinase pathway in response to leptin
    • 15316008 1:CAS:528:DC%2BD2cXot1yhu7s%3D
    • Duan C, Li M, Rui L. SH2-B promotes insulin receptor substrate 1 (IRS1)- and IRS2-mediated activation of the phosphatidylinositol 3-kinase pathway in response to leptin. J Biol Chem. 2004;279(42):43684-91.
    • (2004) J Biol Chem , vol.279 , Issue.42 , pp. 43684-43691
    • Duan, C.1    Li, M.2    Rui, L.3
  • 254
    • 34548370733 scopus 로고    scopus 로고
    • SH2B1 Enhances Leptin Signaling by Both Janus Kinase 2 Tyr813 Phosphorylation-Dependent and -Independent Mechanisms
    • 17565041 1:CAS:528:DC%2BD2sXhtVSqtb%2FF
    • Li Z, Zhou Y, Carter-Su C, Myers Jr MG, Rui L. SH2B1 Enhances Leptin Signaling by Both Janus Kinase 2 Tyr813 Phosphorylation-Dependent and -Independent Mechanisms. Mol Endocrinol. 2007;21(9):2270-81.
    • (2007) Mol Endocrinol , vol.21 , Issue.9 , pp. 2270-2281
    • Li, Z.1    Zhou, Y.2    Carter-Su, C.3    Myers, Jr.M.G.4    Rui, L.5
  • 255
    • 84866735424 scopus 로고    scopus 로고
    • Rho-kinase regulates energy balance by targeting hypothalamic leptin receptor signaling
    • 22941110 1:CAS:528:DC%2BC38Xht12jsLnJ
    • Huang H, Kong D, Byun KH, Ye C, Koda S, Lee DH, et al. Rho-kinase regulates energy balance by targeting hypothalamic leptin receptor signaling. Nat Neurosci. 2012;15(10):1391-8.
    • (2012) Nat Neurosci , vol.15 , Issue.10 , pp. 1391-1398
    • Huang, H.1    Kong, D.2    Byun, K.H.3    Ye, C.4    Koda, S.5    Lee, D.H.6
  • 256
    • 79851497711 scopus 로고    scopus 로고
    • Lipoprotein receptor LRP1 regulates leptin signaling and energy homeostasis in the adult central nervous system
    • 21264353 1:CAS:528:DC%2BC3MXhtVSjsr4%3D
    • Liu Q, Zhang J, Zerbinatti C, Zhan Y, Kolber BJ, Herz J, et al. Lipoprotein receptor LRP1 regulates leptin signaling and energy homeostasis in the adult central nervous system. PLoS Biol. 2011;9(1):e1000575.
    • (2011) PLoS Biol , vol.9 , Issue.1 , pp. 1000575
    • Liu, Q.1    Zhang, J.2    Zerbinatti, C.3    Zhan, Y.4    Kolber, B.J.5    Herz, J.6
  • 257
    • 33845572889 scopus 로고    scopus 로고
    • Studies on the physiological functions of the melanocortin system
    • 17077189 1:CAS:528:DC%2BD2sXns1WrtQ%3D%3D
    • Cone RD. Studies on the physiological functions of the melanocortin system. Endocr Rev. 2006;27(7):736-49.
    • (2006) Endocr Rev , vol.27 , Issue.7 , pp. 736-749
    • Cone, R.D.1
  • 258
    • 0028134706 scopus 로고
    • Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain
    • 7854347 1:CAS:528:DyaK2cXmvFeiurY%3D
    • Mountjoy KG, Mortrud MT, Low MJ, Simerly RB, Cone RD. Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain. Mol Endocrinol. 1994;8(10):1298-308.
    • (1994) Mol Endocrinol , vol.8 , Issue.10 , pp. 1298-1308
    • Mountjoy, K.G.1    Mortrud, M.T.2    Low, M.J.3    Simerly, R.B.4    Cone, R.D.5
  • 259
    • 0031838353 scopus 로고    scopus 로고
    • Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans
    • 9620771 1:CAS:528:DyaK1cXls1Crt7o%3D
    • Krude H, Biebermann H, Luck W, Horn R, Brabant G, Gruters A. Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans. Nat Genet. 1998;19(2):155-7.
    • (1998) Nat Genet , vol.19 , Issue.2 , pp. 155-157
    • Krude, H.1    Biebermann, H.2    Luck, W.3    Horn, R.4    Brabant, G.5    Gruters, A.6
  • 260
    • 36849071229 scopus 로고    scopus 로고
    • Leptin activates hypothalamic acetyl-CoA carboxylase to inhibit food intake
    • 17956983 1:CAS:528:DC%2BD2sXht1ymtrjK
    • Gao S, Kinzig KP, Aja S, Scott KA, Keung W, Kelly S, et al. Leptin activates hypothalamic acetyl-CoA carboxylase to inhibit food intake. Proc Natl Acad Sci U S A. 2007;104(44):17358-63.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , Issue.44 , pp. 17358-17363
    • Gao, S.1    Kinzig, K.P.2    Aja, S.3    Scott, K.A.4    Keung, W.5    Kelly, S.6
  • 261
    • 0018090354 scopus 로고
    • Insulin receptors are widely distributed in the central nervous system of the rat
    • 205798 1:CAS:528:DyaE1cXkvVCqt7g%3D
    • Havrankova J, Roth J, Brownstein M. Insulin receptors are widely distributed in the central nervous system of the rat. Nature. 1978;272(5656):827-9.
    • (1978) Nature , vol.272 , Issue.5656 , pp. 827-829
    • Havrankova, J.1    Roth, J.2    Brownstein, M.3
  • 262
    • 0033944152 scopus 로고    scopus 로고
    • Insulin activates ATP-sensitive K + channels in hypothalamic neurons of lean, but not obese rats
    • 10903566 1:CAS:528:DC%2BD3cXlsVOhsLc%3D
    • Spanswick D, Smith MA, Mirshamsi S, Routh VH, Ashford ML. Insulin activates ATP-sensitive K + channels in hypothalamic neurons of lean, but not obese rats. Nat Neurosci. 2000;3(8):757-8.
    • (2000) Nat Neurosci , vol.3 , Issue.8 , pp. 757-758
    • Spanswick, D.1    Smith, M.A.2    Mirshamsi, S.3    Routh, V.H.4    Ashford, M.L.5
  • 263
    • 0018621289 scopus 로고
    • Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons
    • 116135 1:CAS:528:DyaL3cXht1agtrc%3D
    • Woods SC, Lotter EC, McKay LD, Porte Jr D. Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons. Nature. 1979;282(5738):503-5.
    • (1979) Nature , vol.282 , Issue.5738 , pp. 503-505
    • Woods, S.C.1    Lotter, E.C.2    McKay, L.D.3    Porte, Jr.D.4
  • 264
    • 0028924906 scopus 로고
    • Effect of intracerebroventricular insulin infusion on diabetic hyperphagia and hypothalamic neuropeptide gene expression
    • 7859932 1:CAS:528:DyaK2MXjtlCks7o%3D
    • Sipols AJ, Baskin DG, Schwartz MW. Effect of intracerebroventricular insulin infusion on diabetic hyperphagia and hypothalamic neuropeptide gene expression. Diabetes. 1995;44(2):147-51.
    • (1995) Diabetes , vol.44 , Issue.2 , pp. 147-151
    • Sipols, A.J.1    Baskin, D.G.2    Schwartz, M.W.3
  • 265
    • 0026710057 scopus 로고
    • Inhibition of hypothalamic neuropeptide y gene expression by insulin
    • 1597158 1:CAS:528:DyaK38XksVSqur8%3D
    • Schwartz MW, Sipols AJ, Marks JL, Sanacora G, White JD, Scheurink A, et al. Inhibition of hypothalamic neuropeptide Y gene expression by insulin. Endocrinology. 1992;130(6):3608-16.
    • (1992) Endocrinology , vol.130 , Issue.6 , pp. 3608-3616
    • Schwartz, M.W.1    Sipols, A.J.2    Marks, J.L.3    Sanacora, G.4    White, J.D.5    Scheurink, A.6
  • 266
    • 0034703229 scopus 로고    scopus 로고
    • Role of brain insulin receptor in control of body weight and reproduction
    • 11000114 1:CAS:528:DC%2BD3cXmvVClsLY%3D
    • Bruning JC, Gautam D, Burks DJ, Gillette J, Schubert M, Orban PC, et al. Role of brain insulin receptor in control of body weight and reproduction. Science. 2000;289(5487):2122-5.
    • (2000) Science , vol.289 , Issue.5487 , pp. 2122-2125
    • Bruning, J.C.1    Gautam, D.2    Burks, D.J.3    Gillette, J.4    Schubert, M.5    Orban, P.C.6
  • 267
    • 0036267472 scopus 로고    scopus 로고
    • Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats
    • Obici S, Feng Z, Karkanias G, Baskin DG, Rossetti L. Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats. Nat Neurosci. 2002;5(6):566-72.
    • (2002) Nat Neurosci , vol.5 , Issue.6 , pp. 566-572
    • Obici, S.1    Feng, Z.2    Karkanias, G.3    Baskin, D.G.4    Rossetti, L.5
  • 268
    • 84874637798 scopus 로고    scopus 로고
    • Reversal of diet-induced obesity increases insulin transport into cerebrospinal fluid and restores sensitivity to the anorexic action of central insulin in male rats
    • 23337529 1:CAS:528:DC%2BC3sXjsF2rsbo%3D
    • Begg DP, Mul JD, Liu M, Reedy BM, D'Alessio DA, Seeley RJ, et al. Reversal of diet-induced obesity increases insulin transport into cerebrospinal fluid and restores sensitivity to the anorexic action of central insulin in male rats. Endocrinology. 2013;154(3):1047-54.
    • (2013) Endocrinology , vol.154 , Issue.3 , pp. 1047-1054
    • Begg, D.P.1    Mul, J.D.2    Liu, M.3    Reedy, B.M.4    D'Alessio, D.A.5    Seeley, R.J.6
  • 269
    • 33845866857 scopus 로고    scopus 로고
    • Inflammation and metabolic disorders
    • 17167474 1:CAS:528:DC%2BD28XhtlShtrzK
    • Hotamisligil GS. Inflammation and metabolic disorders. Nature. 2006;444(7121):860-7.
    • (2006) Nature , vol.444 , Issue.7121 , pp. 860-867
    • Hotamisligil, G.S.1
  • 270
    • 84855459760 scopus 로고    scopus 로고
    • Obesity is associated with hypothalamic injury in rodents and humans
    • 22201683 1:CAS:528:DC%2BC38XkvFCltw%3D%3D
    • Thaler JP, Yi CX, Schur EA, Guyenet SJ, Hwang BH, Dietrich MO, et al. Obesity is associated with hypothalamic injury in rodents and humans. J Clin Invest. 2012;122(1):153-62.
    • (2012) J Clin Invest , vol.122 , Issue.1 , pp. 153-162
    • Thaler, J.P.1    Yi, C.X.2    Schur, E.A.3    Guyenet, S.J.4    Hwang, B.H.5    Dietrich, M.O.6
  • 271
    • 58849149821 scopus 로고    scopus 로고
    • Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: Implications for the pathogenesis of obesity
    • 19144836 1:CAS:528:DC%2BD1MXhtVKrurw%3D
    • Milanski M, Degasperi G, Coope A, Morari J, Denis R, Cintra DE, et al. Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: implications for the pathogenesis of obesity. J Neurosci. 2009;29(2):359-70.
    • (2009) J Neurosci , vol.29 , Issue.2 , pp. 359-370
    • Milanski, M.1    Degasperi, G.2    Coope, A.3    Morari, J.4    Denis, R.5    Cintra, D.E.6
  • 272
    • 84861918690 scopus 로고    scopus 로고
    • Inhibition of hypothalamic inflammation reverses diet-induced insulin resistance in the liver
    • 22522614 1:CAS:528:DC%2BC38XotlGquro%3D
    • Milanski M, Arruda AP, Coope A, Ignacio-Souza LM, Nunez CE, Roman EA, et al. Inhibition of hypothalamic inflammation reverses diet-induced insulin resistance in the liver. Diabetes. 2012;61(6):1455-62.
    • (2012) Diabetes , vol.61 , Issue.6 , pp. 1455-1462
    • Milanski, M.1    Arruda, A.P.2    Coope, A.3    Ignacio-Souza, L.M.4    Nunez, C.E.5    Roman, E.A.6
  • 273
    • 52949096557 scopus 로고    scopus 로고
    • Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity
    • 18854155 1:CAS:528:DC%2BD1cXht1Gkt7nP
    • Zhang X, Zhang G, Zhang H, Karin M, Bai H, Cai D. Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity. Cell. 2008;135(1):61-73.
    • (2008) Cell , vol.135 , Issue.1 , pp. 61-73
    • Zhang, X.1    Zhang, G.2    Zhang, H.3    Karin, M.4    Bai, H.5    Cai, D.6
  • 274
    • 84867051812 scopus 로고    scopus 로고
    • IKKbeta/NF-kappaB disrupts adult hypothalamic neural stem cells to mediate a neurodegenerative mechanism of dietary obesity and pre-diabetes
    • 22940906 1:CAS:528:DC%2BC38Xht12jtrnO
    • Li J, Tang Y, Cai D. IKKbeta/NF-kappaB disrupts adult hypothalamic neural stem cells to mediate a neurodegenerative mechanism of dietary obesity and pre-diabetes. Nat Cell Biol. 2012;14(10):999-1012.
    • (2012) Nat Cell Biol , vol.14 , Issue.10 , pp. 999-1012
    • Li, J.1    Tang, Y.2    Cai, D.3
  • 275
    • 57849115277 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress plays a central role in development of leptin resistance
    • 19117545 1:CAS:528:DC%2BD1MXptFWquw%3D%3D
    • Ozcan L, Ergin AS, Lu A, Chung J, Sarkar S, Nie D, et al. Endoplasmic reticulum stress plays a central role in development of leptin resistance. Cell Metab. 2009;9(1):35-51.
    • (2009) Cell Metab , vol.9 , Issue.1 , pp. 35-51
    • Ozcan, L.1    Ergin, A.S.2    Lu, A.3    Chung, J.4    Sarkar, S.5    Nie, D.6
  • 276
    • 79960897419 scopus 로고    scopus 로고
    • Hypoxia-inducible factor directs POMC gene to mediate hypothalamic glucose sensing and energy balance regulation
    • 21814490 1:CAS:528:DC%2BC3MXhtVOju7vM
    • Zhang H, Zhang G, Gonzalez FJ, Park SM, Cai D. Hypoxia-inducible factor directs POMC gene to mediate hypothalamic glucose sensing and energy balance regulation. PLoS Biol. 2011;9(7):e1001112.
    • (2011) PLoS Biol , vol.9 , Issue.7 , pp. 1001112
    • Zhang, H.1    Zhang, G.2    Gonzalez, F.J.3    Park, S.M.4    Cai, D.5
  • 277
    • 84855426656 scopus 로고    scopus 로고
    • Remodeling of the arcuate nucleus energy-balance circuit is inhibited in obese mice
    • 22201680 1:CAS:528:DC%2BC38XkvFCltg%3D%3D
    • McNay DE, Briancon N, Kokoeva MV, Maratos-Flier E, Flier JS. Remodeling of the arcuate nucleus energy-balance circuit is inhibited in obese mice. J Clin Invest. 2012;122(1):142-52.
    • (2012) J Clin Invest , vol.122 , Issue.1 , pp. 142-152
    • McNay, D.E.1    Briancon, N.2    Kokoeva, M.V.3    Maratos-Flier, E.4    Flier, J.S.5
  • 278
    • 77957053600 scopus 로고    scopus 로고
    • Synaptic input organization of the melanocortin system predicts diet-induced hypothalamic reactive gliosis and obesity
    • 20679202 1:CAS:528:DC%2BC3cXhtVKqu7zI
    • Horvath TL, Sarman B, Garcia-Caceres C, Enriori PJ, Sotonyi P, Shanabrough M, et al. Synaptic input organization of the melanocortin system predicts diet-induced hypothalamic reactive gliosis and obesity. Proc Natl Acad Sci U S A. 2010;107(33):14875-80.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , Issue.33 , pp. 14875-14880
    • Horvath, T.L.1    Sarman, B.2    Garcia-Caceres, C.3    Enriori, P.J.4    Sotonyi, P.5    Shanabrough, M.6
  • 279
    • 74949114118 scopus 로고    scopus 로고
    • De novo neurogenesis in adult hypothalamus as a compensatory mechanism to regulate energy balance
    • 20071537 1:CAS:528:DC%2BC3cXhtFahtb8%3D
    • Pierce AA, Xu AW. De novo neurogenesis in adult hypothalamus as a compensatory mechanism to regulate energy balance. J Neurosci. 2010;30(2):723-30.
    • (2010) J Neurosci , vol.30 , Issue.2 , pp. 723-730
    • Pierce, A.A.1    Xu, A.W.2
  • 280
    • 0034712047 scopus 로고    scopus 로고
    • Mammalian neural stem cells
    • 10688783 1:CAS:528:DC%2BD3cXhsV2qtrg%3D
    • Gage FH. Mammalian neural stem cells. Science. 2000;287(5457):1433-8.
    • (2000) Science , vol.287 , Issue.5457 , pp. 1433-1438
    • Gage, F.H.1
  • 281
    • 84862776637 scopus 로고    scopus 로고
    • Tanycytes of the hypothalamic median eminence form a diet-responsive neurogenic niche
    • 22446882 1:CAS:528:DC%2BC38XksVegtL8%3D
    • Lee DA, Bedont JL, Pak T, Wang H, Song J, Miranda-Angulo A, et al. Tanycytes of the hypothalamic median eminence form a diet-responsive neurogenic niche. Nat Neurosci. 2012;15(5):700-2.
    • (2012) Nat Neurosci , vol.15 , Issue.5 , pp. 700-702
    • Lee, D.A.1    Bedont, J.L.2    Pak, T.3    Wang, H.4    Song, J.5    Miranda-Angulo, A.6
  • 282
    • 84875986205 scopus 로고    scopus 로고
    • Fgf10-expressing tanycytes add new neurons to the appetite/energy-balance regulating centers of the postnatal and adult hypothalamus
    • 23554498 1:CAS:528:DC%2BC3sXhtlyjtL%2FF
    • Haan N, Goodman T, Najdi-Samiei A, Stratford CM, Rice R, El Agha E, et al. Fgf10-expressing tanycytes add new neurons to the appetite/energy-balance regulating centers of the postnatal and adult hypothalamus. J Neurosci. 2013;33(14):6170-80.
    • (2013) J Neurosci , vol.33 , Issue.14 , pp. 6170-6180
    • Haan, N.1    Goodman, T.2    Najdi-Samiei, A.3    Stratford, C.M.4    Rice, R.5    El Agha, E.6
  • 283
    • 27344441682 scopus 로고    scopus 로고
    • Neurogenesis in the hypothalamus of adult mice: Potential role in energy balance
    • 16254185 1:CAS:528:DC%2BD2MXhtFChsLjP
    • Kokoeva MV, Yin H, Flier JS. Neurogenesis in the hypothalamus of adult mice: potential role in energy balance. Science. 2005;310(5748):679-83.
    • (2005) Science , vol.310 , Issue.5748 , pp. 679-683
    • Kokoeva, M.V.1    Yin, H.2    Flier, J.S.3
  • 284
    • 3042793425 scopus 로고    scopus 로고
    • Neural activity triggers neuronal oxidative metabolism followed by astrocytic glycolysis
    • 15232110 1:CAS:528:DC%2BD2cXlt1Cqs7k%3D
    • Kasischke KA, Vishwasrao HD, Fisher PJ, Zipfel WR, Webb WW. Neural activity triggers neuronal oxidative metabolism followed by astrocytic glycolysis. Science. 2004;305(5680):99-103.
    • (2004) Science , vol.305 , Issue.5680 , pp. 99-103
    • Kasischke, K.A.1    Vishwasrao, H.D.2    Fisher, P.J.3    Zipfel, W.R.4    Webb, W.W.5
  • 286
    • 84874156024 scopus 로고    scopus 로고
    • Regional astrogliosis in the mouse hypothalamus in response to obesity
    • Buckman LB, Thompson MM, Moreno HN, Ellacott KL. Regional astrogliosis in the mouse hypothalamus in response to obesity. J Comp Neurol. 2013;521(6):1322-33.
    • (2013) J Comp Neurol , vol.521 , Issue.6 , pp. 1322-1333
    • Buckman, L.B.1    Thompson, M.M.2    Moreno, H.N.3    Ellacott, K.L.4
  • 287
    • 84874439635 scopus 로고    scopus 로고
    • Gliotransmission and brain glucose sensing: Critical role of endozepines
    • 23160530 1:CAS:528:DC%2BC3sXjsFGrurc%3D
    • Lanfray D, Arthaud S, Ouellet J, Compere V, Do Rego JL, Leprince J, et al. Gliotransmission and brain glucose sensing: critical role of endozepines. Diabetes. 2013;62(3):801-10.
    • (2013) Diabetes , vol.62 , Issue.3 , pp. 801-810
    • Lanfray, D.1    Arthaud, S.2    Ouellet, J.3    Compere, V.4    Do Rego, J.L.5    Leprince, J.6
  • 288
    • 84875883939 scopus 로고    scopus 로고
    • Tanycytic VEGF-A Boosts Blood-Hypothalamus Barrier Plasticity and Access of Metabolic Signals to the Arcuate Nucleus in Response to Fasting
    • 23562080 1:CAS:528:DC%2BC3sXltFCrur8%3D
    • Langlet F, Levin BE, Luquet S, Mazzone M, Messina A, Dunn-Meynell AA, et al. Tanycytic VEGF-A Boosts Blood-Hypothalamus Barrier Plasticity and Access of Metabolic Signals to the Arcuate Nucleus in Response to Fasting. Cell Metab. 2013;17(4):607-17.
    • (2013) Cell Metab , vol.17 , Issue.4 , pp. 607-617
    • Langlet, F.1    Levin, B.E.2    Luquet, S.3    Mazzone, M.4    Messina, A.5    Dunn-Meynell, A.A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.