-
1
-
-
78649466467
-
CNS leptin and insulin action in the control of energy homeostasis
-
Belgardt BF, Brüning JC (2010) CNS leptin and insulin action in the control of energy homeostasis. Ann N Y Acad Sci 1212:97-113.
-
(2010)
Ann N y Acad Sci
, vol.1212
, pp. 97-113
-
-
Belgardt, B.F.1
Brüning, J.C.2
-
2
-
-
72449184473
-
Integrative neurobiology of energy homeostasis-neurocircuits, signals and mediators
-
Sánchez-Lasheras C, Könner AC, Brüning JC (2010) Integrative neurobiology of energy homeostasis-neurocircuits, signals and mediators. Front Neuroendocrinol 31:4-15.
-
(2010)
Front Neuroendocrinol
, vol.31
, pp. 4-15
-
-
Sánchez-Lasheras, C.1
Könner, A.C.2
Brüning, J.C.3
-
3
-
-
68949120737
-
Control of energy homeostasis by insulin and leptin: Targeting the arcuate nucleus and beyond
-
Könner AC, Klöckener T, Brüning JC (2009) Control of energy homeostasis by insulin and leptin: Targeting the arcuate nucleus and beyond. Physiol Behav 97:632-638.
-
(2009)
Physiol Behav
, vol.97
, pp. 632-638
-
-
Könner, A.C.1
Klöckener, T.2
Brüning, J.C.3
-
4
-
-
84868130278
-
Hypothalamic lesions and adiposity in the rat
-
Hetherington (1940) Hypothalamic lesions and adiposity in the rat. Nutr Rev 41(4): 124-127.
-
(1940)
Nutr Rev
, vol.41
, Issue.4
, pp. 124-127
-
-
Hetherington1
-
5
-
-
0000092595
-
Recovery from the failure to eat produced by hypothalamic lesions
-
Teitelbaum P, Stellar E (1954) Recovery from the failure to eat produced by hypothalamic lesions. Science 120:894-895.
-
(1954)
Science
, vol.120
, pp. 894-895
-
-
Teitelbaum, P.1
Stellar, E.2
-
6
-
-
0025852445
-
A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin mu chain gene
-
Kitamura D, Roes J, Kühn R, Rajewsky K (1991) A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin mu chain gene. Nature 350: 423-426.
-
(1991)
Nature
, vol.350
, pp. 423-426
-
-
Kitamura, D.1
Roes, J.2
Kühn, R.3
Rajewsky, K.4
-
7
-
-
0023631457
-
Genetic ablation: Targeted expression of a toxin gene causes microphthalmia in transgenic mice
-
Breitman ML, et al. (1987) Genetic ablation: Targeted expression of a toxin gene causes microphthalmia in transgenic mice. Science 238:1563-1565.
-
(1987)
Science
, vol.238
, pp. 1563-1565
-
-
Breitman, M.L.1
-
8
-
-
0023669148
-
Cell lineage ablation in transgenic mice by cell-specific expression of a toxin gene
-
Palmiter RD, et al. (1987) Cell lineage ablation in transgenic mice by cell-specific expression of a toxin gene. Cell 50:435-443.
-
(1987)
Cell
, vol.50
, pp. 435-443
-
-
Palmiter, R.D.1
-
9
-
-
0034899321
-
Diphtheria toxin receptor-mediated conditional and targeted cell ablation in transgenic mice
-
Saito M, et al. (2001) Diphtheria toxin receptor-mediated conditional and targeted cell ablation in transgenic mice. Nat Biotechnol 19:746-750.
-
(2001)
Nat Biotechnol
, vol.19
, pp. 746-750
-
-
Saito, M.1
-
10
-
-
21444454735
-
A Cre-inducible diphtheria toxin receptor mediates cell lineage ablation after toxin administration
-
Buch T, et al. (2005) A Cre-inducible diphtheria toxin receptor mediates cell lineage ablation after toxin administration. Nat Methods 2:419-426.
-
(2005)
Nat Methods
, vol.2
, pp. 419-426
-
-
Buch, T.1
-
11
-
-
27344431720
-
NPY/AgRP neurons are essential for feeding in adult mice but can be ablated in neonates
-
Luquet S, Perez FA, Hnasko TS, Palmiter RD (2005) NPY/AgRP neurons are essential for feeding in adult mice but can be ablated in neonates. Science 310:683-685.
-
(2005)
Science
, vol.310
, pp. 683-685
-
-
Luquet, S.1
Perez, F.A.2
Hnasko, T.S.3
Palmiter, R.D.4
-
12
-
-
18644375874
-
In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens
-
Jung S, et al. (2002) In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens. Immunity 17:211-220.
-
(2002)
Immunity
, vol.17
, pp. 211-220
-
-
Jung, S.1
-
13
-
-
27344433932
-
Agouti-related peptide-expressing neurons are mandatory for feeding
-
Gropp E, et al. (2005) Agouti-related peptide-expressing neurons are mandatory for feeding. Nat Neurosci 8:1289-1291.
-
(2005)
Nat Neurosci
, vol.8
, pp. 1289-1291
-
-
Gropp, E.1
-
14
-
-
0030010181
-
Characterization of melanocortin receptor subtype expression in murine adipose tissues and in the 3T3-L1 cell line
-
Boston BA, Cone RD (1996) Characterization of melanocortin receptor subtype expression in murine adipose tissues and in the 3T3-L1 cell line. Endocrinology 137:2043-2050.
-
(1996)
Endocrinology
, vol.137
, pp. 2043-2050
-
-
Boston, B.A.1
Cone, R.D.2
-
15
-
-
34047250799
-
Peripheral effect of alpha-melanocyte-stimulating hormone on fatty acid oxidation in skeletal muscle
-
An JJ, et al. (2007) Peripheral effect of alpha-melanocyte-stimulating hormone on fatty acid oxidation in skeletal muscle. J Biol Chem 282:2862-2870.
-
(2007)
J Biol Chem
, vol.282
, pp. 2862-2870
-
-
An, J.J.1
-
16
-
-
2942631413
-
Proopiomelanocortin and energy balance: Insights from human and murine genetics
-
Coll AP, Farooqi IS, Challis BG, Yeo GS, O'Rahilly S (2004) Proopiomelanocortin and energy balance: Insights from human and murine genetics. J Clin Endocrinol Metab 89:2557-2562.
-
(2004)
J Clin Endocrinol Metab
, vol.89
, pp. 2557-2562
-
-
Coll, A.P.1
Farooqi, I.S.2
Challis, B.G.3
Yeo, G.S.4
O'Rahilly, S.5
-
17
-
-
32444449631
-
Glucocorticoids exacerbate obesity and insulin resistance in neuron-specific proopiomelanocortin-deficient mice
-
Smart JL, Tolle V, Low MJ (2006) Glucocorticoids exacerbate obesity and insulin resistance in neuron-specific proopiomelanocortin-deficient mice. J Clin Invest 116:495-505.
-
(2006)
J Clin Invest
, vol.116
, pp. 495-505
-
-
Smart, J.L.1
Tolle, V.2
Low, M.J.3
-
18
-
-
41549108590
-
PDK1 deficiency in POMC-expressing cells reveals FOXO1- dependent and -independent pathways in control of energy homeostasis and stress response
-
Belgardt BF, et al. (2008) PDK1 deficiency in POMC-expressing cells reveals FOXO1- dependent and -independent pathways in control of energy homeostasis and stress response. Cell Metab 7:291-301.
-
(2008)
Cell Metab
, vol.7
, pp. 291-301
-
-
Belgardt, B.F.1
-
19
-
-
0032920479
-
Glucocorticoid replacement, but not corticotropin-releasing hormone deficiency, prevents adrenalectomy-induced anorexia in mice
-
Jacobson L (1999) Glucocorticoid replacement, but not corticotropin-releasing hormone deficiency, prevents adrenalectomy-induced anorexia in mice. Endocrinology 140:310-317.
-
(1999)
Endocrinology
, vol.140
, pp. 310-317
-
-
Jacobson, L.1
-
20
-
-
0037705396
-
A spoonful of sugar: Feedback signals of energy stores and corticosterone regulate responses to chronic stress
-
Dallman MF, et al. (2003) A spoonful of sugar: Feedback signals of energy stores and corticosterone regulate responses to chronic stress. Physiol Behav 79:3-12.
-
(2003)
Physiol Behav
, vol.79
, pp. 3-12
-
-
Dallman, M.F.1
-
21
-
-
0034101423
-
Analysis of the Cremediated recombination driven by rat insulin promoter in embryonic and adult mouse pancreas
-
Gannon M, Shiota C, Postic C, Wright CV, Magnuson M (2000) Analysis of the Cremediated recombination driven by rat insulin promoter in embryonic and adult mouse pancreas. Genesis 26:139-142.
-
(2000)
Genesis
, vol.26
, pp. 139-142
-
-
Gannon, M.1
Shiota, C.2
Postic, C.3
Wright, C.V.4
Magnuson, M.5
-
22
-
-
20144389727
-
The role of insulin receptor substrate 2 in hypothalamic and beta cell function
-
Choudhury AI, et al. (2005) The role of insulin receptor substrate 2 in hypothalamic and beta cell function. J Clin Invest 115:940-950.
-
(2005)
J Clin Invest
, vol.115
, pp. 940-950
-
-
Choudhury, A.I.1
-
23
-
-
10744232925
-
Essential role of STAT3 in body weight and glucose homeostasis
-
Cui Y, et al. (2004) Essential role of STAT3 in body weight and glucose homeostasis. Mol Cell Biol 24:258-269.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 258-269
-
-
Cui, Y.1
-
24
-
-
78650039585
-
The hypothalamus and β-cell connection in the gene-targeting era
-
Schwartz MW, Guyenet SJ, Cirulli V (2010) The hypothalamus and β-cell connection in the gene-targeting era. Diabetes 59:2991-2993.
-
(2010)
Diabetes
, vol.59
, pp. 2991-2993
-
-
Schwartz, M.W.1
Guyenet, S.J.2
Cirulli, V.3
-
25
-
-
0034121735
-
Adult insulin- and glucagon-producing cells differentiate from two independent cell lineages
-
Herrera PL (2000) Adult insulin- and glucagon-producing cells differentiate from two independent cell lineages. Development 127:2317-2322.
-
(2000)
Development
, vol.127
, pp. 2317-2322
-
-
Herrera, P.L.1
-
26
-
-
0034488835
-
Z/EG, a double reporter mouse line that expresses enhanced green fluorescent protein upon Cre-mediated excision
-
Novak A, Guo C, Yang W, Nagy A, Lobe CG (2000) Z/EG, a double reporter mouse line that expresses enhanced green fluorescent protein upon Cre-mediated excision. Genesis 28:147-155.
-
(2000)
Genesis
, vol.28
, pp. 147-155
-
-
Novak, A.1
Guo, C.2
Yang, W.3
Nagy, A.4
Lobe, C.G.5
-
27
-
-
77956107701
-
Direct innervation and modulation of orexin neurons by lateral hypothalamic LepRb neurons
-
Louis GW, Leinninger GM, Rhodes CJ, Myers MG, Jr. (2010) Direct innervation and modulation of orexin neurons by lateral hypothalamic LepRb neurons. J Neurosci 30: 11278-11287.
-
(2010)
J Neurosci
, vol.30
, pp. 11278-11287
-
-
Louis, G.W.1
Leinninger, G.M.2
Rhodes, C.J.3
Myers Jr., M.G.4
-
28
-
-
0037069503
-
Transneuronal tracing of diverse CNS circuits by Cre-mediated induction of wheat germ agglutinin in transgenic mice
-
Braz JM, Rico B, Basbaum AI (2002) Transneuronal tracing of diverse CNS circuits by Cre-mediated induction of wheat germ agglutinin in transgenic mice. Proc Natl Acad Sci USA 99:15148-15153.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 15148-15153
-
-
Braz, J.M.1
Rico, B.2
Basbaum, A.I.3
-
29
-
-
34548860424
-
Brain fatty acid synthase activates PPARalpha to maintain energy homeostasis
-
Chakravarthy MV, et al. (2007) Brain fatty acid synthase activates PPARalpha to maintain energy homeostasis. J Clin Invest 117:2539-2552.
-
(2007)
J Clin Invest
, vol.117
, pp. 2539-2552
-
-
Chakravarthy, M.V.1
-
30
-
-
2342510386
-
Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation
-
Dor Y, Brown J, Martinez OI, Melton DA (2004) Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation. Nature 429:41-46.
-
(2004)
Nature
, vol.429
, pp. 41-46
-
-
Dor, Y.1
Brown, J.2
Martinez, O.I.3
Melton, D.A.4
-
31
-
-
0032898369
-
Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase
-
Postic C, et al. (1999) Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase. J Biol Chem 274:305-315.
-
(1999)
J Biol Chem
, vol.274
, pp. 305-315
-
-
Postic, C.1
-
32
-
-
33646384957
-
RIP-Cre revisited, evidence for impairments of pancreatic beta-cell function
-
Lee JY, et al. (2006) RIP-Cre revisited, evidence for impairments of pancreatic beta-cell function. J Biol Chem 281:2649-2653.
-
(2006)
J Biol Chem
, vol.281
, pp. 2649-2653
-
-
Lee, J.Y.1
-
33
-
-
0003633755
-
-
Committee on Care and Use of Laboratory Animals (Natl Inst Health, Bethesda), DHHS Publ No (NIH) 85-23
-
Committee on Care and Use of Laboratory Animals (1985) Guide for the Care and Use of Laboratory Animals (Natl Inst Health, Bethesda), DHHS Publ No (NIH) 85-23
-
(1985)
Guide for the Care and Use of Laboratory Animals
-
-
-
34
-
-
2942733252
-
Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis
-
Balthasar N, et al. (2004) Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis. Neuron 42:983-991.
-
(2004)
Neuron
, vol.42
, pp. 983-991
-
-
Balthasar, N.1
-
35
-
-
77950532905
-
Hypothalamic and pituitary c-Jun N-terminal kinase 1 signaling coordinately regulates glucose metabolism
-
Belgardt BF, et al. (2010) Hypothalamic and pituitary c-Jun N-terminal kinase 1 signaling coordinately regulates glucose metabolism. Proc Natl Acad Sci USA 107: 6028-6033.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 6028-6033
-
-
Belgardt, B.F.1
-
36
-
-
70349484212
-
MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity
-
Kleinridders A, et al. (2009) MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity. Cell Metab 10:249-259.
-
(2009)
Cell Metab
, vol.10
, pp. 249-259
-
-
Kleinridders, A.1
-
37
-
-
36448941416
-
Enhanced leptin-stimulated Pi3k activation in the CNS promotes white adipose tissue transdifferentiation
-
Plum L, et al. (2007) Enhanced leptin-stimulated Pi3k activation in the CNS promotes white adipose tissue transdifferentiation. Cell Metab 6:431-445.
-
(2007)
Cell Metab
, vol.6
, pp. 431-445
-
-
Plum, L.1
-
38
-
-
33746075210
-
Gp130 signaling in proopiomelanocortin neurons mediates the acute anorectic response to centrally applied ciliary neurotrophic factor
-
Janoschek R, et al. (2006) gp130 signaling in proopiomelanocortin neurons mediates the acute anorectic response to centrally applied ciliary neurotrophic factor. Proc Natl Acad Sci USA 103:10707-10712.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 10707-10712
-
-
Janoschek, R.1
|