Role of the Y5 neuropeptide Y receptor in feeding and obesity

Nature Medicine

Volumn 4, Issue 6, 1998, Pages 718-721

  Marsh, Donald J ^a   Hollopeter, Gunther ^a   Kafer, Kathy E ^a   Palmiter, Richard D ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LEPTIN; NEUROPEPTIDE Y; NEUROPEPTIDE Y RECEPTOR; NEUROPEPTIDE Y5 RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIET RESTRICTION; FEEDING BEHAVIOR; FEMALE; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OBESITY; PRIORITY JOURNAL; REFEEDING;

ANIMALS; BODY WEIGHT; DOSE-RESPONSE RELATIONSHIP, DRUG; FEEDING BEHAVIOR; FEMALE; GENOTYPE; HUMANS; LEPTIN; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED STRAINS; MICE, MUTANT STRAINS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; NEUROPEPTIDE Y; OBESITY; PANCREATIC POLYPEPTIDE; PEPTIDE YY; PEPTIDES, CYCLIC; PHENOTYPE; PROTEINS; RECEPTORS, NEUROPEPTIDE Y; RNA, MESSENGER; TIME FACTORS;

ANIMALIA;

EID: 0031779336     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm0698-718     Document Type: Article

References (21)

1. Allen, Y. S. et al. Neuropeptide Y distribution in the rat brain. Science 221, 877-879 (1983).
2. Clark, J. T., Kalra, P. S., Crowley, W. R. & Kalra, S. P. Neuropeptide Y and human pancreatic polypeptide stimulate feeding behavior in rats. Endocrinology 115, 427-429 (1984).
3. Stanley, B. G. & Leibowitz, S. F. Neuropeptide Y: stimulation of feeding and drinking by injection into the paraventricular nucleus. Life Sci. 35, 2635-2642 (1984).
4. Stanley, B. G. & Leibowitz, S. F. Neuropeptide Y injected in the paraventricular hypothalamus: a powerful stimulant of feeding behavior. Proc. Natl Acad. Sci. USA 82, 3940-3943 (1985).
5. Gerald, C. et al. A receptor subtype involved in neuropeptide-Y-induced food intake. Nature 382, 168-171 (1996).
6. Erickson, J. C., Hollopeter, G. & Palmiter, R. D. Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y. Science 274, 1704-1707 (1996).
7. Sanacora, G., Kershaw, M., Finkelstein, J. A. & White, J. D. Increased hypothalamic content of preproneuropeptide Y messenger ribonucleic acid in genetically obese Zucker rats and its regulation by food deprivation. Endocrinology 127, 730-737 (1990).
8. Sahu, A., Kalra, P. S. & Kalra, S. P. Food deprivation and ingestion induce reciprocal changes in neuropeptide Y concentrations in the paraventricular nucleus. Peptides 9, 83-86 (1988).
9. Kalra, S. P., Dube, M. G., Sahu, A., Phelps, C. & Kalra, P. S. Neuropeptide Y secretion increases in the paraventricular nucleus in association with increased appetite for food. Proc. Natl Acad. Sci. USA 38, 10931-10935 (1991).
10. Kalra, S. P. Appetite and body weight regulation: is it all in the brain? Neuron 19, 227-230 (1997).
11. Stanley, B. G., Magdalin, W., Seirafi, A., Nguyen, M. M. & Leibowitz, S. F. Evidence for neuropeptide Y mediation of eating produced by food deprivation and for a variant of the Y1 receptor mediating this peptide's effect. Peptides 13, 581-587 (1992).
12. Beck, B. et al. Rapid and localized alterations of neuropeptide Y in discrete hypothalamic nuclei with feeding status. Brain Res. 528, 245-249 (1990).
13. Erickson, J. C., Clegg, K. E. & Palmiter, R. D. Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y. Nature 381, 415-418 (1996).
14. Zhang, Y. et al. Positional cloning of the mouse obese gene and its human homologue. Nature 372, 425-432 (1994).
15. Stephens, T. W. et al. The role of neuropeptide Y in the antiobesity action of the obese gene product. Nature 377, 530-532 (1995).
16. Schwartz, M. W. et al. Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice. Diabetes 45, 531-535 (1996).
17. Daniels, A. J. et al. High-affinity neuropeptide Y receptor antagonists. Proc. Natl Acad. Sci. USA 92, 9067-9071 (1995).
18. Kanatani, A. et al. Potent neuropeptide Y Y1 receptor antagonist, 1229U91: blockade of neuropeptide Y-induced and physiological food intake. Endocrinology 137, 3177-3182 (1996).
19. Stanley, B. G., Daniel, D. R., Chin, A. S. & Leibowitz, S. F. Paraventricular nucleus injections of peptide YY and neuropeptide Y preferentially enhance carbohydrate ingestion. Peptides 6, 1205-1211 (1985).
20. Ball, H. J., Shine, J. & Herzog, H. Multiple promoters regulate tissue-specific expression of the human NPY-Y1 receptor gene. J. Biol. Chem. 270, 27272-27276 (1995).
21. Thomas, S. A., Matsumoto, A. M. & Palmiter, R. D. Noradrenaline is essential for mouse fetal development. Nature 374, 643-646 (1995).