Endogenous prolactin-releasing peptide regulates food intake in rodents

Journal of Clinical Investigation

Volumn 118, Issue 12, 2008, Pages 4014-4024

  Takayanagi, Yuki ^a   Matsumoto, Hirokazu ^b   Nakata, Masanori ^a   Mera, Takashi ^c   Fukusumi, Shoji ^b   Hinuma, Shuji ^b   Ueta, Yoichi ^c   Yada, Toshihiko ^a   Leng, Gareth ^d   Onaka, Tatsushi ^a  

^a JICHI MEDICAL UNIVERSITY   (Japan)

^b TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

^c UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

^d UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLECYSTOKININ; LEPTIN; MONOCLONAL ANTIBODY; PROLACTIN RELEASING FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; FOOD INTAKE; HORMONAL REGULATION; MALE; MOUSE; NEUROENDOCRINOLOGY; NONHUMAN; OBESITY; PRIORITY JOURNAL; SATIETY; SIGNAL TRANSDUCTION; SOLITARY TRACT NUCLEUS;

ADIPOSITY; ANIMALS; ANTIBODIES, MONOCLONAL; APPETITE REGULATION; CHOLECYSTOKININ; ENERGY METABOLISM; HYPERPHAGIA; INTESTINES; LEPTIN; MICE; MICE, KNOCKOUT; NEURONS; OBESITY; PHENOTYPE; PROLACTIN; SIGNAL TRANSDUCTION; SOLITARY NUCLEUS;

EID: 57449117140     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI34682     Document Type: Article

References (43)

1. Murphy, K.G., and Bloom, S.R. 2006. Gut hormones and the regulation of energy homeostasis. Nature. 444:854-859.
2. Schwartz, G.J. 2006. Integrative capacity of the caudal brainstem in the control of food intake. Philos. Trans. R. Soc. Lond. B Biol. Sci. 361:1275-1280.
3. Broberger, C., and Hökfelt, T. 2001. Hypothalamic and vagal neuropeptide circuitries regulating food intake. Physiol. Behav. 74:669-682.
4. Palkovits, M., Kiss, J.Z., Beinfeld, M.C., and Williams, T.H. 1982. Cholecystokinin in the nucleus of the solitary tract of the rat: evidence for its vagal origin. Brain Res. 252:386-390.
5. Luckman, S.M. 1992. Fos-like immunoreactivity in the brainstem of the rat following peripheral administration of cholecystokinin. J. Neuroendocrinol. 4:149-152.
6. Chen, C., Dun, S.L., Dun, N.J., and Chang, J.K. 1999. Prolactin-releasing peptide-immunoreactivity in A1 and A2 noradrenergic neurons of the rat medulla. Brain Res. 822:276-279.
7. Hinuma, S., et al. 1998. A prolactin-releasing peptide in the brain. Nature. 393:272-276.
8. Maruyama, M., et al. 1999. Immunocytochemical localization of prolactin-releasing peptide in the rat brain. Endocrinology. 140:2326-2333.
9. Ibata, Y., et al. 2000. Morphological survey of prolactin-releasing peptide and its receptor with special reference to their functional roles in the brain. Neurosci. Res. 38:223-230.
10. Lawrence, C.B., Celsi, F., Brennand, J., and Luckman, S.M. 2000. Alternative role for prolactin-releasing peptide in the regulation of food intake. Nat. Neurosci. 3:645-646.
11. Lawrence, C.B., Ellacott, K.L., and Luckman, S.M. 2002. PRL-releasing peptide reduces food intake and may mediate satiety signaling. Endocrinology. 143:360-367.
12. Ellacott, K.L., Lawrence, C.B., Rothwell, N.J., and Luckman, S.M. 2002. PRL-releasing peptide interacts with leptin to reduce food intake and body weight. Endocrinology. 143:368-374.
13. Lawrence, C.B., Liu, Y.L., Stock, M.J., and Luckman, S.M. 2004. Anorectic actions of prolactin-releasing peptide are mediated by corticotropin-releasing hormone receptors. Am. J. Physiol. Regul. Integr. Comp. Physiol. 286:R101-R107.
14. Ellacott, K.L., Lawrence, C.B., Pritchard, L.E., and Luckman, S.M. 2003. Repeated administration of the anorectic factor prolactin-releasing peptide leads to tolerance to its effects on energy homeostasis. Am. J. Physiol. Regul. Integr. Comp. Physiol. 285:R1005-R1010.
15. Bjursell, M., Lennerås, M., Göransson, M., Elmgren, A., and Bohlooly-Y, M. 2007. GPR10 deficiency in mice results in altered energy expenditure and obesity. Biochem. Biophys. Res. Commun. 363:633-638.
16. Maruyama, M., et al. 2001. Prolactin-releasing peptide as a novel stress mediator in the central nervous system. Endocrinology. 142:2032-2038.
17. Matsumoto, H., et al. 2000. Stimulation of corticotropin-releasing hormone-mediated adrenocorticotropin secretion by central administration of prolactin-releasing peptide in rats. Neurosci. Lett. 285:234-238.
18. Morales, T., and Sawchenko, P.E. 2003. Brainstem prolactin-releasing peptide neurons are sensitive to stress and lactation. Neuroscience. 121:771-778.
19. Zhu, L.L., and Onaka, T. 2003. Facilitative role of prolactin-releasing peptide neurons in oxytocin cell activation after conditioned-fear stimuli. Neuroscience. 118:1045-1053.
20. Laurent, P., et al. 2005. The prolactin-releasing peptide antagonizes the opioid system through its receptor GPR10. Nat. Neurosci. 8:1735-1741.
21. Gu, W., Geddes, B.J., Zhang, C., Foley, K.P., and Stricker-Krongrad, A. 2004. The prolactin-releasing peptide receptor (GPR10) regulates body weight homeostasis in mice. J. Mol. Neurosci. 22:93-103.
22. Bechtold, D.A., and Luckman, S.M. 2006. Prolactin-releasing Peptide mediates cholecystokinin-induced satiety in mice. Endocrinology. 147:4723-4729.
23. Bi, S., Scott, K.A., Kopin, A.S., and Moran, T.H. 2004. Differential roles for cholecystokinin a receptors in energy balance in rats and mice. Endocrinology. 145:3873-3880.
24. Bechtold, D.A., and Luckman, S.M. 2007. The role of RFamide peptides in feeding. J. Endocrinol. 192:3-15.
25. Fukusumi, S., Fujii, R., and Hinuma, S. 2006. Recent advances in mammalian RFamide peptides: the discovery and functional analyses of PrRP, RFRPs and QRFP. Peptides. 27:1073-1086.
26. Ohiwa, N., et al. 2007. Possible inhibitory role of prolactin-releasing peptide for ACTH release associated with running stress. Am. J. Physiol. Regul. Integr. Comp. Physiol. 292:R497-R504.
27. Onaka, T. 2004. Neural pathways controlling central and peripheral oxytocin release during stress. J. Neuroendocrinol. 16:308-312.
28. Fraser, K.A., and Davison, J.S. 1993. Meal-induced c-fos expression in brain stem is not dependent on cholecystokinin release. Am. J. Physiol. 265:R235-R239.
29. Rinaman, L., Baker, E.A., Hoffman, G.E., Stricker, E.M., and Verbalis, J.G. 1998. Medullary c-Fos activation in rats after ingestion of a satiating meal. Am. J. Physiol. 275:R262-R268.
30. Johnstone, L.E., Fong, T.M., and Leng, G. 2006. Neuronal activation in the hypothalamus and brainstem during feeding in rats. Cell Metab. 4:313-321.
31. Rinaman, L. 2003. Hindbrain noradrenergic lesions attenuate anorexia and alter central cFos expression in rats after gastric viscerosensory stimulation. J. Neurosci. 23:10084-10092.
32. Onaka, T., Luckman, S.M., Antonijevic, I., Palmer, J.R., and Leng, G. 1995. Involvement of the noradrenergic afferents from the nucleus tractus solitarii to the supraoptic nucleus in oxytocin release after peripheral cholecystokinin octapeptide in the rat. Neuroscience. 66:403-412.
33. Grabauskas, G., et al. 2004. Prolactin-releasing peptide affects gastric motor function in rat by modulating synaptic transmission in the dorsal vagal complex. J. Physiol. 561:821-839.
34. Hübschle, T., et al. 2001. Leptin-induced nuclear translocation of STAT3 immunoreactivity in hypothalamic nuclei involved in body weight regulation. J. Neurosci. 21:2413-2424.
35. Huo, L., Maeng, L., Bjørbaek, C., and Grill, H.J. 2007. Leptin and the control of food intake: neurons in the nucleus of the solitary tract are activated by both gastric distension and leptin. Endocrinology. 148:2189-2197.
36. Mera, T., et al. 2007. Downregulation of prolactin-releasing peptide gene expression in the hypothalamus and brainstem of diabetic rats. Peptides. 28:1596-1604.
37. Mera, T., et al. 2006. Prolactin-releasing peptide is a potent mediator of stress responses in the brain through the hypothalamic paraventricular nucleus. Neuroscience. 141:1069-1086.
38. Engström, M., Brandt, A., Wurster, S., Savola, J.M., and Panula, P. 2003. Prolactin releasing peptide has high affinity and efficacy at neuropeptide FF2 receptors. J. Pharmacol. Exp. Ther. 305:825-832.
39. Ellacott, K.L., et al. 2005. Characterization of a naturally-occurring polymorphism in the UHR-1 gene encoding the putative rat prolactin-releasing peptide receptor. Peptides. 26:675-681.
40. Kawakami, K., Onaka, T., Iwase, M., Homma, I., and Ikeda, K. 2005. Hyperphagia and obesity in Na,K-ATPase alpha2 subunit-defective mice. Obes. Res. 13:1661-1671.
41. Hashimoto, H., et al. 2007. Parathyroid hormone-related protein induces cachectic syndromes without directly modulating the expression of hypothalamic feeding-regulating peptides. Clin. Cancer Res. 13:292-298.
42. Yamamoto, Y., Ueta, Y., Yamashita, H., Asayama, K., and Shirahata, A. 2002. Expressions of the preproorexin and orexin type 2 receptor genes in obese rat. Peptides. 23:1689-1696.
43. Nomura, M., et al. 2003. Enhanced up-regulation of corticotropin- releasing hormone gene expression in response to restraint stress in the hypothalamic paraventricular nucleus of oxytocin gene-deficient male mice. J. Neuroendocrinol. 15:1054-1061.