Neural activity triggers neuronal oxidative metabolism followed by astrocytic glycolysis

Science

Volumn 305, Issue 5680, 2004, Pages 99-103

  Kasischke, Karl A ^a   Vishwasrao, Harshad D ^a   Fisher, Patricia J ^b   Zipfel, Warren R ^a   Webb, Watt W ^a  

^a School of Operations Research and Industrial Engineering   (United States)

^b NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN; FLUORESCENCE; MEDICAL IMAGING; METABOLISM; OXIDATION; PHOTONS; PHYSIOLOGY;

NEUROMETABOLIC COUPLING; OXIDATIVE METABOLISM;

NEUROLOGY;

LACTIC ACID; NICOTINAMIDE ADENINE DINUCLEOTIDE;

BIOLOGY;

AEROBIC METABOLISM; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN METABOLISM; BRAIN TISSUE; CONTROLLED STUDY; ENERGY METABOLISM; FLUORESCENCE MICROSCOPY; GLYCOLYSIS; NERVE CELL; NERVE CONDUCTION; NEUROIMAGING; NEUROPHYSIOLOGY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; THREE DIMENSIONAL IMAGING;

ANIMALS; ASTROCYTES; CITRIC ACID CYCLE; CYTOPLASM; DENDRITES; ELECTRON TRANSPORT; FLUORESCENCE; GLYCOLYSIS; HIPPOCAMPUS; LACTIC ACID; MITOCHONDRIA; NAD; NEURONS; OXIDATION-REDUCTION; OXYGEN CONSUMPTION; PYRAMIDAL CELLS; RATS; RATS, SPRAGUE-DAWLEY; SPECTROMETRY, FLUORESCENCE;

ANIMALIA;

EID: 3042793425     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1096485     Document Type: Article

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31. We thank R. S. Balaban, L. Pellerin, and D. Piston for discussions and I. Tullis and A. Heikal for technical advice. K.A.K. thanks R. Love, F. Bergmann, S. Hess, B. T. Hyman, and A. C. Ludolph for support. Dedicated to Keiko Tsuno-Kasischke (20 October 2003). This research was conducted in the Developmental Resource for Biophysical Imaging Opto Electronics, a NIH-NIBIB resource. Supported by the Deutsche Forschungsgemeinschaft (KA1490/2-1 and 2-2) and the National Institutes of Health (P41-EB001976-16).